TN2009000077A1 - Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors - Google Patents

Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors

Info

Publication number: TN2009000077A1
Authority: TN; Tunisia
Prior art keywords: production; nep inhibitors; derivatives; amino; butyric acid
Prior art date: 2006-09-13

Application number

TN2009000077A

Other languages

English (en)

Inventor

David Hook

Bernhard Wietfeld

Matthias Lotz

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-13

Filing date

2009-03-06

Publication date

2010-08-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37814152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000077(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-03-06 Application filed by Novartis Ag filed Critical Novartis Ag

2010-08-19 Publication of TN2009000077A1 publication Critical patent/TN2009000077A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Materials Engineering (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TN2009000077A 2006-09-13 2009-03-06 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors TN2009000077A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06120576A EP1903027A1 (fr)	2006-09-13	2006-09-13	Procédé de préparation de l' acide amino-4 butyrique ou de ses derivés et leur utilisation pour la préparation des inhibiteurs NEP
PCT/EP2007/007913 WO2008031567A1 (fr)	2006-09-13	2007-09-11	Procédé de préparation d'acide 4-amino-butyrique substitué par biaryle ou de dérivés de celui-ci et leur utilisation pour produire des inhibiteurs de nep

Publications (1)

Publication Number	Publication Date
TN2009000077A1 true TN2009000077A1 (en)	2010-08-19

Family

ID=37814152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2009000077A TN2009000077A1 (en)	2006-09-13	2009-03-06	Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors

Country Status (28)

Country	Link
US (2)	US20090326066A1 (fr)
EP (2)	EP1903027A1 (fr)
JP (1)	JP5455627B2 (fr)
KR (1)	KR101401118B1 (fr)
CN (1)	CN101516831B (fr)
AU (1)	AU2007296889B2 (fr)
BR (1)	BRPI0716990A2 (fr)
CA (1)	CA2662393C (fr)
CO (1)	CO6190550A2 (fr)
CY (1)	CY1115696T1 (fr)
DK (1)	DK2066618T3 (fr)
ES (1)	ES2519446T3 (fr)
GT (1)	GT200900058A (fr)
HR (1)	HRP20140984T1 (fr)
IL (1)	IL196925A (fr)
MA (1)	MA30724B1 (fr)
MX (1)	MX2009002746A (fr)
MY (1)	MY146660A (fr)
NO (1)	NO341967B1 (fr)
NZ (1)	NZ574665A (fr)
PL (1)	PL2066618T3 (fr)
PT (1)	PT2066618E (fr)
RU (1)	RU2469019C2 (fr)
SG (1)	SG177205A1 (fr)
SI (1)	SI2066618T1 (fr)
TN (1)	TN2009000077A1 (fr)
WO (1)	WO2008031567A1 (fr)
ZA (1)	ZA200900779B (fr)

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EP2121578B1 (fr)	2007-01-12	2016-08-10	Novartis AG	Procédé pour la préparation d'acide 5-biphenyle-4-amino-2-methyle-pentanoique
PE20091364A1 (es)	2008-01-17	2009-10-13	Novartis Ag	Proceso para la preparacion de inhibidores de nep
SG176010A1 (en)	2009-05-28	2011-12-29	Novartis Ag	Substituted aminobutyric derivatives as neprilysin inhibitors
RS53664B1 (en)	2009-05-28	2015-04-30	Novartis Ag	SUBSTITUTED AMINOPROPIONIC ACID DERIVATIVES AS NEPRILIZINE INHIBITORS
JO2967B1 (en)	2009-11-20	2016-03-15	نوفارتس ايه جي	Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
MX2012008483A (es) *	2010-01-22	2012-08-15	Novartis Ag	Intermediarios de inhibidores de la endopeptidasa neutra y metodo de preparacion de los mismos.
CN103080077B (zh) *	2010-08-23	2015-06-10	诺华股份有限公司	用于制造nep抑制剂的中间体的制备工艺
ES2608780T3 (es)	2010-08-23	2017-04-17	Novartis Ag	Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP
PT2609075E (pt) *	2010-08-23	2016-06-03	Novartis Ag	Processo para a preparação de intermediários para o fabrico de inibidores da nep
US8993631B2 (en)	2010-11-16	2015-03-31	Novartis Ag	Method of treating contrast-induced nephropathy
US8673974B2 (en)	2010-11-16	2014-03-18	Novartis Ag	Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
AR092278A1 (es) *	2012-08-31	2015-04-08	Novartis Ag	Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
KR20150119107A (ko)	2013-02-14	2015-10-23	노파르티스 아게	개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체
DK2956464T3 (en)	2013-02-14	2018-07-16	Novartis Ag	Substituted bisphenyl-butane phosphonic acid derivatives as NEP (neutral endopeptidase) inhibitors
CN104230865B (zh) *	2013-06-13	2018-01-09	上海翰森生物医药科技有限公司	联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
JP2016528271A (ja) *	2013-08-21	2016-09-15	ディーピーエックスホールディングスビー．ブイ．	□新規な中間体を経由するビフェニルアラニノールの合成
CN105461587A (zh) *	2014-08-27	2016-04-06	上海翰森生物医药科技有限公司	Ahu-377半钙盐晶型及其制备方法和应用
WO2016029828A1 (fr) *	2014-08-27	2016-03-03	上海翰森生物医药科技有限公司	Acide crystallin libre, sel hemicalcique et sel d'alpha-phényléthylamine de ahu-377 et son procédé de préparation et son application
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WO2016074651A1 (fr)	2014-11-14	2016-05-19	Zentiva, K.S.	Procédé de préparation, d'isolation et de purification de formes pharmaceutiquement applicables de ahu-377
CN104557600B (zh) *	2015-01-26	2016-05-04	苏州明锐医药科技有限公司	沙库比曲的制备方法
TW201632493A (zh)	2015-02-13	2016-09-16	諾華公司	新穎方法
CN105884644B (zh) *	2015-02-15	2020-06-09	深圳信立泰药业股份有限公司	一种中性内肽酶抑制剂盐优势形态及其制备方法
CN106146351B (zh) *	2015-04-03	2020-09-11	博瑞生物医药（苏州）股份有限公司	制备联芳基取代的4-氨基-丁酸或其衍生物的方法
CN106065006B (zh) *	2015-04-22	2020-06-05	深圳信立泰药业股份有限公司	一种中性内肽酶抑制剂盐晶型及其制备方法
CN106187808A (zh) *	2015-05-08	2016-12-07	苏州鹏旭医药科技有限公司	Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
CN104860894B (zh) *	2015-06-10	2017-05-17	北京博全健医药科技有限公司	一种抗心衰药lcz696的制备方法
ES2837084T3 (es)	2015-07-02	2021-06-29	Novartis Ag	Sales de calcio se sacubitril
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CN105061263B (zh) *	2015-08-11	2017-03-15	苏州楚凯药业有限公司	一种nep抑制剂中间体的制备方法
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CN105523964B (zh) *	2015-12-09	2017-05-24	苏州楚凯药业有限公司	一种抗心衰药物中间体的制备方法
CN105348209B (zh)	2015-12-09	2017-12-26	浙江天宇药业股份有限公司	一种抗心衰药lcz696的制备方法
AU2016366795B2 (en) *	2015-12-10	2019-06-13	Novartis Ag	New process and intermediates
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WO2017141193A1 (fr) *	2016-02-16	2017-08-24	Sun Pharmaceutical Industries Limited	Procédé de préparation de sacubitril ou de ses sels
CN105924355B (zh) *	2016-05-11	2018-08-17	浙江宏元药业有限公司	沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
US20190256454A1 (en)	2016-07-05	2019-08-22	Novartis Ag	New process for early sacubitril intermediates
US10851059B2 (en)	2016-08-17	2020-12-01	Novartis Ag	Processes and intermediates for NEP inhibitor synthesis
CN106380421B (zh) *	2016-08-26	2017-12-08	中国科学院上海有机化学研究所	沙库必曲的合成方法
WO2018069833A1 (fr)	2016-10-10	2018-04-19	Laurus Labs Limited	Forme amorphe stable d'un complexe de sacubitril-valsartan trisodique et ses procédés de préparation
CN106631903A (zh) *	2016-12-16	2017-05-10	重庆市碚圣医药科技股份有限公司	一种lcz‑696关键中间体的制备方法
CN110088079A (zh) *	2016-12-23	2019-08-02	诺华股份有限公司	用于早期沙卡布曲中间体的新方法
CN107011203B (zh) *	2017-04-28	2019-03-29	江苏阿尔法药业有限公司	一种lcz696中间体ahu-377的制备方法
CN107522628A (zh) *	2017-09-20	2017-12-29	吉尔生化（上海）有限公司	一种l‑3‑（6‑乙酰基‑2‑萘胺基）‑2‑氨基丙酸的合成方法
CN108084058A (zh) *	2017-12-15	2018-05-29	江苏中邦制药有限公司	一种lcz696中间体的制备方法
CN108373423B (zh) *	2018-04-28	2020-10-23	成都苑东生物制药股份有限公司	一种沙库比曲缬沙坦复合物和/或共晶关键中间体沙库比曲钙的制备方法
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CN109503404A (zh) *	2018-12-28	2019-03-22	凯瑞斯德生化(苏州)有限公司	一种lcz-696关键中间体的制备方法
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CN113321600B (zh) *	2020-02-28	2024-06-14	四川科伦药物研究院有限公司	制备手性联芳基取代的4-氨基-丁酸及其衍生物的方法
CN113387841A (zh) *	2020-03-13	2021-09-14	凯特立斯（深圳）科技有限公司	一种沙库必曲中间体的合成方法
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JP7064527B2 (ja) *	2020-05-01	2022-05-10	ノバルティスアーゲー	サクビトリルカルシウム塩
CN112480179A (zh) *	2020-11-24	2021-03-12	苏州鹏旭医药科技有限公司	一种取代二茂铁基二膦均相催化剂配体
CN112745246A (zh) *	2020-12-30	2021-05-04	重庆市碚圣医药科技股份有限公司	一种沙库必曲中间体的纯化方法
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2006
- 2006-09-13 EP EP06120576A patent/EP1903027A1/fr not_active Ceased
2007
- 2007-09-11 HR HRP20140984TT patent/HRP20140984T1/hr unknown
- 2007-09-11 MY MYPI20090644A patent/MY146660A/en unknown
- 2007-09-11 SI SI200731518T patent/SI2066618T1/sl unknown
- 2007-09-11 CA CA2662393A patent/CA2662393C/fr active Active
- 2007-09-11 WO PCT/EP2007/007913 patent/WO2008031567A1/fr active Application Filing
- 2007-09-11 AU AU2007296889A patent/AU2007296889B2/en active Active
- 2007-09-11 SG SG2011091998A patent/SG177205A1/en unknown
- 2007-09-11 DK DK07818108.8T patent/DK2066618T3/da active
- 2007-09-11 KR KR1020097007380A patent/KR101401118B1/ko active Active
- 2007-09-11 JP JP2009527735A patent/JP5455627B2/ja active Active
- 2007-09-11 NZ NZ574665A patent/NZ574665A/en not_active IP Right Cessation
- 2007-09-11 PT PT78181088T patent/PT2066618E/pt unknown
- 2007-09-11 CN CN2007800341413A patent/CN101516831B/zh active Active
- 2007-09-11 RU RU2009113666/04A patent/RU2469019C2/ru active
- 2007-09-11 PL PL07818108T patent/PL2066618T3/pl unknown
- 2007-09-11 US US12/438,798 patent/US20090326066A1/en not_active Abandoned
- 2007-09-11 ES ES07818108.8T patent/ES2519446T3/es active Active
- 2007-09-11 EP EP07818108.8A patent/EP2066618B1/fr active Active
- 2007-09-11 BR BRPI0716990-6A2A patent/BRPI0716990A2/pt not_active Application Discontinuation
- 2007-09-11 MX MX2009002746A patent/MX2009002746A/es active IP Right Grant
2009
- 2009-02-02 ZA ZA2009/00779A patent/ZA200900779B/en unknown
- 2009-02-05 IL IL196925A patent/IL196925A/en active IP Right Grant
- 2009-03-06 TN TN2009000077A patent/TN2009000077A1/fr unknown
- 2009-03-12 GT GT200900058A patent/GT200900058A/es unknown
- 2009-03-25 NO NO20091242A patent/NO341967B1/no unknown
- 2009-03-30 MA MA31739A patent/MA30724B1/fr unknown
- 2009-04-07 CO CO09035919A patent/CO6190550A2/es not_active Application Discontinuation
2012
- 2012-10-26 US US13/661,991 patent/US8946481B2/en active Active
2014
- 2014-10-15 CY CY20141100841T patent/CY1115696T1/el unknown

Also Published As

Publication number	Publication date
US8946481B2 (en)	2015-02-03
DK2066618T3 (da)	2014-09-22
EP2066618B1 (fr)	2014-07-23
RU2469019C2 (ru)	2012-12-10
JP2010503628A (ja)	2010-02-04
RU2009113666A (ru)	2010-10-20
EP1903027A1 (fr)	2008-03-26
KR101401118B1 (ko)	2014-05-29
MX2009002746A (es)	2009-03-26
ZA200900779B (en)	2009-12-30
IL196925A0 (en)	2009-11-18
AU2007296889A1 (en)	2008-03-20
EP2066618A1 (fr)	2009-06-10
CO6190550A2 (es)	2010-08-19
HK1131381A1 (en)	2010-01-22
NO20091242L (no)	2009-03-25
CN101516831A (zh)	2009-08-26
ES2519446T3 (es)	2014-11-07
CA2662393A1 (fr)	2008-03-20
US20130066101A1 (en)	2013-03-14
US20090326066A1 (en)	2009-12-31
BRPI0716990A2 (pt)	2014-02-04
CN101516831B (zh)	2013-12-25
CY1115696T1 (el)	2017-01-25
PL2066618T3 (pl)	2015-01-30
MY146660A (en)	2012-09-14
KR20090076910A (ko)	2009-07-13
GT200900058A (es)	2010-03-11
IL196925A (en)	2013-10-31
SG177205A1 (en)	2012-01-30
HRP20140984T1 (hr)	2014-12-05
NO341967B1 (no)	2018-03-05
MA30724B1 (fr)	2009-09-01
NZ574665A (en)	2012-03-30
JP5455627B2 (ja)	2014-03-26
AU2007296889B2 (en)	2012-03-01
WO2008031567A1 (fr)	2008-03-20
SI2066618T1 (sl)	2014-11-28
CA2662393C (fr)	2015-11-03
PT2066618E (pt)	2014-09-10
WO2008031567B1 (fr)	2008-05-08

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