TN2016000029A1 - Bioconjugates of synthetic apelin polypeptides - Google Patents
Bioconjugates of synthetic apelin polypeptidesInfo
- Publication number
- TN2016000029A1 TN2016000029A1 TN2016000029A TN2016000029A TN2016000029A1 TN 2016000029 A1 TN2016000029 A1 TN 2016000029A1 TN 2016000029 A TN2016000029 A TN 2016000029A TN 2016000029 A TN2016000029 A TN 2016000029A TN 2016000029 A1 TN2016000029 A1 TN 2016000029A1
- Authority
- TN
- Tunisia
- Prior art keywords
- bioconjugates
- heart failure
- life extending
- extending moiety
- diabetes
- Prior art date
Links
- 102000018746 Apelin Human genes 0.000 title 1
- 108010052412 Apelin Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 206010007556 Cardiac failure acute Diseases 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108091008803 APLNR Proteins 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 206010059027 Brugada syndrome Diseases 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- 208000032109 Transient ischaemic attack Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 230000009787 cardiac fibrosis Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000004104 gestational diabetes Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000011461 pre-eclampsia Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 201000010875 transient cerebral ischemia Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
- 206010047302 ventricular tachycardia Diseases 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I': I' or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858303P | 2013-07-25 | 2013-07-25 | |
| PCT/US2014/047378 WO2015013169A2 (en) | 2013-07-25 | 2014-07-21 | Bioconjugates of synthetic apelin polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2016000029A1 true TN2016000029A1 (en) | 2017-07-05 |
Family
ID=62816239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2016000029A TN2016000029A1 (en) | 2013-07-25 | 2014-07-21 | Bioconjugates of synthetic apelin polypeptides |
Country Status (2)
| Country | Link |
|---|---|
| MA (1) | MA38866A3 (en) |
| TN (1) | TN2016000029A1 (en) |
-
2014
- 2014-07-21 TN TN2016000029A patent/TN2016000029A1/en unknown
- 2014-07-21 MA MA38866A patent/MA38866A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA38866A2 (en) | 2018-10-31 |
| MA38866A3 (en) | 2018-11-30 |
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