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TWI883026B - 抗ｄｌｌ３嵌合抗原受體及其用途 - Google Patents

抗ｄｌｌ３嵌合抗原受體及其用途 Download PDF

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TWI883026B
TWI883026B TW109124309A TW109124309A TWI883026B TW I883026 B TWI883026 B TW I883026B TW 109124309 A TW109124309 A TW 109124309A TW 109124309 A TW109124309 A TW 109124309A TW I883026 B TWI883026 B TW I883026B
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趙濤
彭園園
唐安
王素娟
楊帥
張望
武術
郝瑞棟
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大陸商南京傳奇生物科技有限公司
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Abstract

本文提供抗DLL3嵌合抗原受體(CAR)、DLL3結合蛋白及此類CAR或DLL3結合蛋白在治療諸如小細胞肺癌之DLL3相關病症中的用途。

Description

抗DLL3嵌合抗原受體及其用途
本發明係關於靶向DLL3之嵌合抗原受體(CAR)及對DLL3具有特異性之結合蛋白。本發明亦關於編碼該等CAR或該等結合蛋白之核酸序列、表現該等CAR之經修飾之免疫細胞以及其用於治療DLL3相關病症之用途。
細胞免疫療法之發展已提供一種有前景之治療多種腫瘤之方法。一種此類治療涉及免疫細胞、特別是T細胞之基因工程，以在細胞表面上表現嵌合抗原受體(CAR)。嵌合抗原受體係在通常格式下將單株抗體(mAb)之特異性與T細胞之效應功能相結合的蛋白質。一旦CAR在T細胞中表現，經CAR修飾之T細胞(CAR-T或CAR-T細胞)即可獲得一些特性，諸如抗原特異性識別、抗腫瘤反應性及增殖，因此可充當「活藥物」來根除所靶向之腫瘤細胞。原則上，此等CAR-T細胞可靶向任何抗原(例如細胞表面分子)。CAR-T細胞療法可克服對自體抗原之耐受性，且提供一種不依賴於患者MHC狀態之治療。近來之試驗使用經工程改造以表現靶向CD19之嵌合抗原受體的T細胞，已證明在白血病及淋巴瘤患者中之顯著臨床反應。
CAR表現為跨膜蛋白，包括抗原特異性結合位點、跨膜區及信號傳導胞質域(例如CD3ζ鏈)。抗原特異性結合位點通常為源自單株抗體之單鏈可變片段(scFv)，由經可撓性連接子接合之重鏈及輕鏈組成。近來CAR構築體已合併來自如CD28或4-1 BB之共刺激分子的另外的胞質域以增強活體內T細胞存活率。亦對CAR進行其他遺傳修飾，例如添加細胞介素基因或避免腫瘤部位免 疫抑制機制之基因。
已發現DLL3(δ樣配位體3)蛋白在臨床上與多種增生性病症相關，該等增生性病症包括展現神經內分泌特徵之腫瘤，諸如小細胞肺癌(SCLC)。起源於神經內分泌祖細胞之SCLC大約占所有肺癌之15%，且具有最低5年存活率之一，6%(Alvarado-Luna等人，2016,Transi Lung Cancer Res 5：26-38；Siegel等人，2017,CA Cancer J Clin 67：7-30)。此係因為其具有高度侵襲性，約三分之二的患者在診斷時患有轉移性疾病，且為習知治療(例如基於鉑之化學療法)極難醫治的。
需要改良之治療SCLC及其他表現DLL3之癌症的治療方法。
在一個態樣中，本揭示案提供一種嵌合抗原受體(CAR)，該嵌合抗原受體靶向DLL3(抗DLL3 CAR)。抗DLL3 CAR包含DLL3結合域，其中該DLL3結合域包含或源自單域抗體(sdAb)或單鏈可變片段(scFv)。
在一些實施例中，sdAb包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3，或多肽在CDR1、CDR2及CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：87之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：168之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：102之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：183之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：105之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：186之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：108之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：189之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：115之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：196之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：120之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：201之胺基酸序列之CDR3，或 其包含至多約3個胺基酸取代之變異體；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：88之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：169之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：89之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：170之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：90之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：171之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1；包含SEQ ID NO：87之胺基酸序列之CDR2；以及包含SEQ ID NO：168之胺基酸序列之CDR3；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1；包含SEQ ID NO：102之胺基酸序列之CDR2；以及包含SEQ ID NO：183之胺基酸序列之CDR3；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1；包含SEQ ID NO：105之胺基酸序列之CDR2；以及包含SEQ ID NO：186之胺基酸序列之CDR3；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1；包含SEQ ID NO：108之胺基酸序列之CDR2；以及包含SEQ ID NO：189之胺基酸序列之CDR3；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1；包含SEQ ID NO：115之胺基酸序列之CDR 2；以及包含SEQ ID NO：196之胺基酸序列之CDR 3；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1；包含SEQ ID NO：120之胺基酸序列之CDR2；以及包含SEQ ID NO：201之胺基酸序列之CDR 3；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1；包含SEQ ID NO：88之胺基酸序列之CDR2；以及包含SEQ ID NO：169之胺基酸序列之CDR 3；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1；包含SEQ ID NO：89之胺基酸序列之CDR2；以及包含SEQ ID NO：170之胺基酸序列之CDR 3；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1；包含SEQ ID NO：90之胺基酸序列之CDR 2；以及包含SEQ ID NO：171之胺基酸序列之CDR 3。
在一些實施例中，sdAb為針對人類或恆河猴DLL3產生之駱駝sdAb。
在一些實施例中，sdAb包含與SEQ ID NO：274-354中之任一者之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，sdAb藉由CDR移植進行人類化。
在一些實施例中，人類化sdAb包含與SEQ ID NO：355-367中之任一者之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，scFv包含重鏈可變區(VH)及輕鏈可變區(VL)，其中該scFv之VH結構域包含SEQ ID NO：498或504中所示之CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體、SEQ ID NO：499或505中所示之CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體以及SEQ ID NO：500或506中所示之CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體，且該scFv之VL結構域包含SEQ ID NO：495或501中所示之CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體、SEQ ID NO：496或502中所示之CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體以及SEQ ID NO：497或503中所示之CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，該scFv之VH結構域包含SEQ ID NO：498中所示之CDR1、SEQ ID NO：499中所示之CDR2及SEQ ID NO：500中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：495中所示之CDR1、SEQ ID NO：496中所示之CDR2及SEQ ID NO：497中所示之CDR3；或該scFv之VH結構域包含SEQ ID NO：504中所示之CDR1、SEQ ID NO：505中所示之CDR2及SEQ ID NO：506中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：501中所示之CDR1、SEQ ID NO：502中所示之CDR2及SEQ ID NO：503中所示之CDR3。
在一些實施例中，該scFv之VH結構域包含與SEQ ID NO：508中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列，且該scFv之VL結構域包含與SEQ ID NO：507中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列；或該scFv之VH結構域包含與SEQ ID NO：510中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列，且該scFv之VL結構域包含與SEQ ID NO：509中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，scFv係自合成人類Fab噬菌體文庫獲得。
在一些實施例中，DLL3為人類或恆河猴DLL3。
在一些實施例中，抗DLL3 CAR自N末端至C末端包含信號肽、該DLL3結合域、鉸鏈域、跨膜域及細胞內信號傳導域。
在一些實施例中，細胞內信號傳導域源自CD3ζ、FcRγ、FcRβ、CD3γ、CD3δ、CD3ε、CD5、CD22、CD79a、CD79b或CD66d。
在一些實施例中，細胞內信號傳導域進一步包含細胞內共刺激序列。
在一些實施例中，細胞內共刺激序列源自選自由以下組成之群的共，刺激分子：CD27、CD28、4-1BB、OX40、CD40、PD-1、LFA-1、ICOS、CD2、CD7、LIGHT、NKG2C、B7-H3、TNFRSF9、TNFRSF4、TNFRSF8、CD40LG、ITGB2、KLRC2、TNFRSF18、TNFRSF14、HAVCR1、LGALS9、DAP10、DAP12、 CD83、CD83配位體及其組合。
在一些實施例中，CAR包含與選自由SEQ ID NO：476-484、SEQ ID NO：485-494或SEQ ID NO：515-516組成之群之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，DLL3結合域包含彼此連接之兩個sdAb。
在一些實施例中，sdAb中之每一者獨立地包含與SEQ ID NO：356或SEQ ID NO：366具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，CAR包含與選自由SEQ ID NO：518-520組成之群之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，CAR包含SEQ ID NO：520之胺基酸序列。
在另一方面，本揭示案提供DLL3結合蛋白，該DLL3結合蛋白包含特異性地結合於DLL3之單域抗體(sdAb)部分，其中該sdAb部分包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb部分包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3，或多肽在CDR1、CDR2及CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb部分包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代 之變異體；包含SEQ ID NO：87之胺基酸序列之CDR 2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：168之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：102之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：183之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：105之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：186之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：108之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：189之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：115之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：196之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：120之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：201之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代 之變異體；包含SEQ ID NO：88之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：169之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：89之胺基酸序列之CDR 2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：170之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：90之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：171之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb部分包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1；包含SEQ ID NO：87之胺基酸序列之CDR2；以及包含SEQ ID NO：168之胺基酸序列之CDR 3；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1；包含SEQ ID NO：102之胺基酸序列之CDR 2；以及包含SEQ ID NO：183之胺基酸序列之CDR 3；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1；包含SEQ ID NO：105之胺基酸序列之CDR2；以及包含SEQ ID NO：186之胺基酸序列之CDR 3；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1；包含SEQ ID NO：108之胺基酸序列之CDR 2；以及包含SEQ ID NO：189之胺基酸序列之CDR3；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1；包含SEQ ID NO：115之胺基酸序列之CDR2；以及包含SEQ ID NO：196之胺基酸序列之CDR3；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1；包含SEQ ID NO：120之胺基酸序列之CDR2；以及包含SEQ ID NO：201之胺基酸序列之CDR3；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1；包含SEQ ID NO：88之胺基酸序列之CDR2；以及包含SEQ ID NO：169之胺基酸序列之CDR3；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1；包含SEQ ID NO：89之胺基酸序列之CDR2；以及包含SEQ ID NO：170之胺基酸序列之CDR3；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1；包含SEQ ID NO：90之胺基酸序列之CDR2；以及包含SEQ ID NO：171之胺基酸序列之CDR3。
在一些實施例中，sdAb部分為針對人類或恆河猴DLL3產生之駱駝sdAb。
在一些實施例中，sdAb部分包含與SEQ ID NO：274-354中之任一者之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，sdAb部分藉由CDR移植進行人類化。
在一些實施例中，人類化sdAb包含與SEQ ID NO：355-367中之任一者之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，DLL3為人類或恆河猴DLL3。
在另一方面，本揭示案提供一種DLL3結合蛋白，該DLL3結合蛋白包含特異性地結合於DLL3之單鏈可變片段(scFv)部分，其中該scFv部分包含重鏈可變區(VH)及輕鏈可變區(VL)，其中該scFv部分之VH結構域包含SEQ ID NO：498或504中所示之CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體、SEQ ID NO：499或505中所示之CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體以及SEQ ID NO：500或506中所示之CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體，且該scFv部分之VL結構域包含SEQ ID NO：495或501中所示之CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體、SEQ ID NO：496或502中所示之CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體以及SEQ ID NO：497或503中所示之CDR3 或其在該CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，scFv部分包含重鏈可變區(VH)及輕鏈可變區(VL)，其中該scFv部分之VH結構域包含SEQ ID NO：498中所示之CDR1、SEQ ID NO：499中所示之CDR2及SEQ ID NO：500中所示之CDR3，且該scFv部分之VL結構域包含SEQ ID NO：495中所示之CDR1、SEQ ID NO：496中所示之CDR2及SEQ ID NO：497中所示之CDR3；或該scFv部分之VH結構域包含SEQ ID NO：504中所示之CDR1、SEQ ID NO：505中所示之CDR2及SEQ ID NO：506中所示之CDR3，且該scFv部分之VL結構域包含SEQ ID NO：501中所示之CDR1、SEQ ID NO：502中所示之CDR2及SEQ ID NO：503中所示之CDR3。
在一些實施例中，該scFv部分之VH結構域包含與SEQ ID NO：508中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列，且該scFv部分之VL結構域包含與SEQ ID NO：507中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列；或該scFv部分之VH結構域包含與SEQ ID NO：510中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列，且該scFv部分之VL結構域包含與SEQ ID NO：509中所示之胺基酸序列具有至少約95%序列一致性的胺基酸序列。
在一些實施例中，scFv部分係自合成人類Fab噬菌體文庫獲得。
在一些實施例中，LL3為人類或恆河猴DLL3。
在另一方面，本揭示案提供一種經分離之核酸分子，該經分離之核酸分子編碼如上所述之抗DLL3 CAR或DLL3結合蛋白。
在一些實施例中，該經分離之核酸分子包含選自由SEQ ID NO：368-448組成之群的多核苷酸序列，該多核苷酸序列編碼駱駝單域抗體(sdAb)。
在一些實施例中，該經分離之核酸分子包含選自由SEQ ID NO：449-461組成之群的多核苷酸序列，該多核苷酸序列編碼人類化駱駝sdAb。
在一些實施例中，該核酸分子包含選自由SEQ ID NO：511-514組成之群的多核苷酸序列，該多核苷酸序列編碼人類scFv之VL或VH結構域。
在一些實施例中，該核酸分子進一步包含編碼嵌合轉換受體(CSR)或顯性負性受體(DNR)之多核苷酸序列。
在一些實施例中，該核酸分子進一步包含編碼PD-1顯性負性受體(PD-1 DNR)、PD-1嵌合轉換受體(PD-1 CSR)或TGF-β顯性負性受體(TGF-β DNR)的多核苷酸序列。
在一些實施例中，PD-1 DNR包含與SEQ ID NO：523具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，PD-1 CSR包含與SEQ ID NO：524具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，TGF-β DNR包含與SEQ ID NO：529具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，編碼PD-1 DNR、PD-1 CSR或TGF-β DNR之多核苷酸序列藉由編碼2A自裂解肽之多核苷酸序列連接至編碼CAR之多核苷酸序列。
在一些實施例中，2A自裂解肽為T2A或P2A肽。
在一些實施例中，核酸分子在5'至3'方向上包含編碼CAR之多核苷酸序列、編碼2A自裂解肽之多核苷酸序列以及編碼PD-1 DNR、PD-1 CSR或TGF-β DNR之多核苷酸序列。
在一些實施例中，該核酸分子編碼與SEQ ID NO：521或522具有至少約95%序列一致性之肽，或該核酸分子編碼與選自由SEQ ID NO：525-528組成之群之胺基酸序列具有至少約95%序列一致性的肽。
在另一方面，本揭示案提供一種表現載體，該表現載體包含如上所 述之經分離之核酸分子。
在另一方面，本揭示案提供一種經工程改造之免疫細胞，該經工程改造之免疫細胞包含如上所述之經分離之核酸分子。
在一些實施例中，該經工程改造之免疫細胞係選自由以下組成之群：細胞毒性T細胞、輔助T細胞、自然殺手T細胞、γδ T細胞、NKT細胞及自然殺手細胞。
在另一方面，本揭示案提供一種經工程改造之免疫細胞，該經工程改造之免疫細胞表現如上所述之抗DLL3 CAR。
在一些實施例中，該經工程改造之免疫細胞亦表現CSR或DNR。
在一些實施例中，該CSR為PD-1 CSR，該DNR為PD-1 DNR或TGF-β DNR。
在一些實施例中，PD-1 DNR包含與SEQ ID NO：523具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，PD-1 CSR包含與SEQ ID NO：524具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，TGF-β DNR包含與SEQ ID NO：529具有至少約95%序列一致性之胺基酸序列。
在一些實施例中，該CAR及該CSR、或該CAR及該DNR藉由2A自裂解肽共表現。
在一些實施例中，2A自裂解肽為T2A或P2A肽。
在一些實施例中，該經工程改造之免疫細胞表現CAR及PD-1 DNR，且經表現DLL3及PD-L1之細胞刺激。
在一些實施例中，該經工程改造之免疫細胞表現CAR及PD-1 CSR，且經表現DLL3及PD-L1之細胞刺激。
在一些實施例中，該經工程改造之免疫細胞表現CAR及TGF-β DNR，且在TGF-β存在下經表現DLL3之細胞刺激。
在一些實施例中，該經工程改造之免疫細胞係選自由以下組成之群：細胞毒性T細胞、輔助T細胞、自然殺手T細胞、γδ T細胞、NKT細胞及自然殺手細胞。
在另一方面，本揭示案提供一種醫藥組合物，該醫藥組合物包含如上所述之抗DLL3 CAR、經分離之DLL3結合蛋白、表現載體或經工程改造之免疫細胞以及生理學上可接受之賦形劑。
在另一方面，本揭示案提供一種用於治療個體之DLL3相關病症的方法，該方法包括向該個體投與治療有效量的如上所述之經工程改造之免疫細胞或治療有效量的如上所述之醫藥組合物。
在另一方面，本揭示案提供如上所述之抗DLL3 CAR、經分離之DLL3結合蛋白、表現載體或經工程改造之免疫細胞用於製備用以治療DLL3相關病症之藥物的用途。
在另一方面，本揭示案提供一種用於治療DLL3相關病症之藥物，該藥物包含如上所述之抗DLL3 CAR、DLL3結合蛋白、表現載體或經工程改造之免疫細胞。
在一些實施例中，DLL3相關病症為選自由以下組成之群的癌症：肺癌、黑素瘤、乳腺癌、前列腺癌、結腸癌、腎細胞癌、卵巢癌、神經母細胞瘤、橫紋肌肉瘤、白血病及淋巴瘤。
在一些實施例中，癌症表現DLL3及PD-L1。
在一些實施例中，癌症與對應正常組織相比具有較高TGF-β表現水準。
在一些實施例中，DLL3相關病症為小細胞肺癌。
圖1示出基於VHH之CAR構築體的示意圖。可用於構築體中之序列在SEQ ID NO：462-472、474及475中列出。
圖2示出表現包含多種駱駝抗DLL3 sdAb之示例性單特異性CAR之T細胞針對小細胞肺癌細胞株SHP-77的活體外細胞毒性分析的結果，E：T為2：1或5：1。該CAR之結果以右側所示之圖例中的次序描繪。
圖3示出在與表現DLL3之腫瘤細胞株SHP-77共同培育之後表現包含多種駱駝抗DLL3 sdAb之示例性單特異性CAR之T細胞的細胞介素釋放水準的結果。IFN-γ釋放水準及TNF-α釋放水準(E：T為2：1或5：1)分別示於圖3A及圖3B中。各圖中，該CAR之結果以右側所示之圖例中的次序描繪。
圖4示出在用小細胞肺癌細胞株SHP-77長期刺激之後，表現包含多種駱駝抗DLL3 sdAb之示例性單特異性CAR之T細胞的擴增倍數。
圖5示出在SHP-77腫瘤模型中表現具有駱駝抗DLL3 sdAb之CAR之CAR-T細胞的活體內抗腫瘤功效的結果。此模型中，各小鼠輸注100萬CAR-T細胞之劑量。
圖6示出表現包含多種人類化駱駝抗DLL3 sdAb之示例性單特異性CAR之T細胞針對小細胞肺癌細胞株SHP-77(圖6A、6B)及NCI-H82(圖6C、6D)的活體外細胞毒性分析的結果。
圖7示出在經SHP-77刺激之後表現包含多種人類化駱駝抗DLL3 sdAb之示例性單特異性CAR之T細胞的細胞介素釋放水準的結果。IFN-γ釋放水準及TNF-α釋放水準(E：T為3：1或10：1)分別示於圖7A及圖7B中。各圖中，該CAR之結果以右側所示之圖例中的次序描繪。
圖8示出在用小細胞肺癌細胞株SHP-77長期刺激之後，表現包含多種人類化駱 駝抗DLL3 sdAb之示例性單特異性CAR之T細胞的擴增倍數。
圖9示出在SHP-77腫瘤模型中表現具有人類化駱駝抗DLL3 sdAb之CAR之CAR-T細胞的活體內抗腫瘤功效的結果。此模型中，各小鼠輸注20萬CAR-T細胞之劑量。圖9A中比較9組之結果。各組中各小鼠之結果分別示於圖9B-9J中。
圖10示出串聯CAR(圖10A)及經武裝之CAR構築體的示意圖(圖10B、C)。
圖11示出通過量測短期細胞毒性(圖11A-E、V)及細胞介素釋放(圖11F-K、W-X)以及通過長期刺激分析(圖11L-U、Y-Z)對串聯CAR-T細胞及單特異性CAR-T細胞活體外功能活性比較的結果。
圖12分別示出靶向PD-1 DNR或PD-1 CSR武裝之CAR-T細胞及T3的SHP-77細胞(圖12A、B)及SHP-77/PD-L1(圖12C、D)的活體外功能比較結果。
圖13示出TGF-β-DNR增強DLL3 CAR-T細胞之活體外及活體內抗腫瘤功效。
圖13A示出TGF-β-DNR武裝之CAR的示意圖。圖13B示出相應CAR-T細胞上CAR及TGF-β-DNR之陽性比率。在短期(圖13C、D)及長期刺激分析(圖13E-G)中評估活體外抗腫瘤功效。圖13H示出活體內抗腫瘤功效。圖13I示出在治療之後SHP77異種移植模型之外周血中CAR-T細胞的藥物動力學。
除非另外定義，否則本文中使用之技術及科學術語具有與所屬領域之普通技術人員通常所瞭解之含義相同的含義。與本文所述之方法、裝置及材料類似或等效的任何方法、裝置及材料可用於實施本發明。提供以下定義以幫助瞭解本文中常用之某些術語，且不意欲限制本揭示案之範疇。
冠詞「一(a及an)」在本文中用以指一種或超過一種(即至少一種)該冠詞之語法賓語。例如，「一要素」意謂一種要素或超過一種要素。
如本文所用，術語「結合蛋白」係指結合靶分子(例如DLL3)之分子 或分子之一部分。在一些實施例中，結合蛋白包含抗體。在一些實施例中，結合蛋白包含抗體之抗原結合片段。在一些實施例中，結合蛋白可進一步包含小分子量組分，諸如小分子藥物或毒素。結合蛋白亦可為抗體或其抗原結合片段。在一些實施例中，結合蛋白包含受體之配位體結合域。在一些實施例中，結合蛋白包含跨膜受體之胞外域。結合蛋白亦可為受體之配位體結合域，或跨膜受體之胞外域。在一些實施例中，結合蛋白包含單域抗體(sdAb)或單鏈可變片段(scFv)。在一些實施例中，結合蛋白可為sdAb或scFv。DLL3結合蛋白可為DLL3結合域。在一些實施例中，DLL3結合蛋白包含結合DLL3之抗體或抗體之抗原結合片段。在一些實施例中，DLL3結合蛋白可為抗體或抗體之抗原結合片段。在一些實施例中，DLL3結合蛋白包含結合DLL3之單域抗體(sdAb)或單鏈可變片段(scFv)。在一些實施例中，DLL3結合蛋白可為sdAb或scFv。
術語「抗體」泛指由四條多肽鏈-兩條重(H)鏈及兩條輕(L)鏈構成之任何免疫球蛋白(Ig)分子或其保持Ig分子之基本抗原表位結合特徵的任何功能片段。在全長抗體中，每條重鏈由重鏈可變區(本文中縮寫為HCVR或VH)及重鏈恆定區構成。重鏈恆定區由三個結構域CH1、CH2及CH3構成。每條輕鏈由輕鏈可變區(本文中縮寫為LCVR或VL)及輕鏈恆定區構成。輕鏈恆定區由一個結構域CL構成。VH及VL區可進一步再分成高變區，稱為互補決定區(CDR)，中間散佈更保守之區域，稱為構架區(FR)。每個VH及VL由三個CDR及四個FR構成，從胺基端至羧基端按以下次序排列：FR1、CDR1、FR2、CDR2、FR3、CDR3、FR4。免疫球蛋白分子可具有任何類型(例如IgG、IgE、IgM、IgD、IgA及IgY)、類別(例如IgG 1、lgG2、IgG 3、lgG4、IgA1及lgA2)或子類。在廣泛意義上，術語「抗體」進一步指不源自具有四條多肽鏈之免疫球蛋白分子的scFv或sdAb。
抗體片段為抗體之一部分，例如F(ab')2、Fab、Fv、scFv、sdAb及其 類似物。全長抗體之功能片段保持全長抗體之靶特異性。因此諸如scFv(單鏈可變鏈片段)之重組功能抗體片段已用於研發作為基於mAb之治療劑之替代物的治療劑。scFv片段(約25kDa)由兩個可變域VH及VL組成。天然地，VH及VL結構域經由疏水性相互作用非共價締合，且往往解離。然而，穩定片段可藉由用親水性可撓性連接子將該等結構域連接，建立scFv來工程改造。
如本文所用，術語「單域抗體」(sdAb)具有其在所屬領域中之通用含義，且係指在駱駝科哺乳動物中可發現之類型之抗體的單個重鏈可變域，且天然缺乏輕鏈。這種單域抗體亦稱為VHH或「奈米單抗」。可認為單域抗體之胺基酸序列及結構由四個構架區(FR1、FR2、FR3及FR4)及三個互補決定區(CDR1、CDR2及CDR3)構成。因此，單域抗體可定義為具有以下通用結構之胺基酸序列：FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4，其類似於可變域VH或VL。sdAb用作單抗原結合蛋白或用作較大蛋白質或多肽中之抗原結合域提供許多顯著優於使用習知抗體或抗體片段(例如scFv)。sdAb之優點包括：僅僅要求單個結構域以高親和力及高選擇性結合抗原；面對變性劑或包括熱、pH值及蛋白酶在內之條件，sdAb高度穩定；且sdAb可接近習知抗體無法接近之標靶及抗原表位。雖然典型地在諸如美洲駝之駱駝科中產生sdAb，但亦可使用所屬領域中熟知之技術以合成方式產生。
如本文所用，術語「人類化sdAb」意謂在天然存在之VHH序列之胺基酸序列中的一或多個胺基酸殘基經在來自人類之習知4鏈抗體之VH結構域中的對應位置處存在之一或多個胺基酸殘基置換的sdAb。此可藉由所屬領域中熟知之方法進行。舉例而言，sdAb之FR可經人類可變FR置換。因此人類化sdAb在投與人體時具有較小抗原性。
如本文所用，術語「僅重鏈抗體」或「HCAb」係指包含重鏈，但缺乏通常在4鏈抗體中發現之輕鏈的功能抗體。已知駱駝科動物(諸如駱駝、美洲 駝或羊駝)產生HCAb。
「DLL3」又名「δ樣配位體3」，為與Notch信號傳導路徑相關之跨膜蛋白。Notch信號傳導路徑首次係在秀麗隱桿線蟲(C.elegans)及果蠅(Drosophila)中鑑別，隨後證明自無脊椎動物至脊椎動物間進化保守，參與一系列基本生物過程，包括正常胚胎發育、成人組織活體內平衡及幹細胞維持。在果蠅中，Notch信號傳導主要由一種Notch受體基因及被稱為Serrate及Delta的兩種配位體基因介導(Wharton等人，1985；Rebay等人，1991)。人類中，存在四種已知之Notch受體及五種DSL(Delta-Serrate LAG2)配位體，即Serrate之兩種同源物，稱為Jagged1及Jagged 2，以及Delta之三種同源物，稱為δ樣配位體或DLL1、DLL3及DLL4。人類中，DLL3基因位於染色體19q13上，且由跨越9.5kb之8個外顯子組成。在最後一個外顯子內之選擇性剪接產生兩種蛋白質同功型。兩者在其胞外域及其跨膜域上共享整體100%一致性，不同之處在於較長同功型含有延長之細胞質尾。
如本文所用，術語「特異性地結合」或「特異性結合」或其任何同義詞係指如藉由標準活體外分析所分析，諸如單域抗體(sdAb)之多肽能夠特異性地識別及可偵測地結合於DLL3分子。舉例而言，如本文所用，結合係使用充分描述之抗原-抗體結合分析、流式細胞術及所屬領域之技術人員已知的其他分析藉由本發明之抗DLL3多肽識別細胞表面上之DLL3分子的能力來量測。
如本文所用，術語「表現載體」為重組或合成產生之核酸構築體或序列，具有允許另一核酸在宿主細胞中轉錄及/或表現之特定核酸元件。表現載體可為質體、病毒或核酸片段之一部分。在一個實例中，表現載體為包含至少一個啟動子序列及至少一個終止序列(例如多腺苷酸化序列)以及視情況複製起點(ori)序列及視情況選擇或可選擇標記物序列的DNA載體，例如質體。視情況，表現載體可進一步包含至少一個所關注之核苷酸編碼序列，該核苷酸編碼序列 編碼至少一種多肽，其中至少一個啟動子序列與該至少一個編碼序列可操作地連接。術語「表現」包括多肽產生中所涉及之任何步驟，包括(但不限於)轉錄、轉錄後修飾、轉譯、轉譯後修飾及/或分泌。
術語「分離」係指物質實質上或基本上不含在其天然狀態下通常伴隨其之組分。物質可為細胞或大分子，例如蛋白質或核酸。舉例而言，如本文所用，「經分離之核酸」係指已自在天然存在狀態下位於側面之序列純化的多核苷酸，例如已自通常相鄰之序列移除的DNA片段。可替代地，如本文所用，「經分離之抗體」或「經分離之多肽」及其類似物係指抗體或多肽分子自其天然細胞環境及與細胞之其他組分的締合中進行活體外分離及/或純化。
非人類(例如駱駝科)抗體之「人類化」形式為含有來源於非人類免疫球蛋白之最小序列的嵌合抗體。在一些實施例中，人類化抗體為來自接受者高變區(HVR)之殘基經來自諸如小鼠、大鼠、兔或非人類靈長類動物之非人類物種(供體抗體)HVR之殘基置換的人類免疫球蛋白(接受者抗體)，具有期望之特異性、親和力及/或能力。在一些情況下，人類免疫球蛋白之構架區(「FR」)殘基經對應之非人類殘基置換。此外，人類化抗體可包含未在接受者抗體中或供體抗體中發現之殘基。可進行此等修飾以進一步改進抗體效能，例如結合親和力。一般而言，人類化抗體將包含至少一個及典型地兩種可變域之基本上全部，其中高變環之全部或基本上全部與非人類免疫球蛋白序列之高變環對應，且FR區之全部或基本上全部為人類免疫球蛋白序列之FR區，不過FR區可包括一或多個提高例如結合親和力、異構化、免疫原性等抗體效能的單獨FR殘基取代。FR中此等胺基酸取代之數目典型地在H鏈中至多6個，且在L鏈中至多3個。人類化抗體視情況亦將包含免疫球蛋白恆定區(Fc)，典型地人類免疫球蛋白之恆定區的至少一部分。關於進一步細節，參見例如Jones等人，Nature 321：522-525(1986)；Riechmann等人，Nature 332：323-329(1988)；以及Presta,Curr.Op.Struct. Biol.2：593-596(1992)。亦參見例如Vaswani及Hamilton,Ann.Allergy,Asthma & Immunol.1：105-115(1998)；Harris,Biochem.Soc.Transactions 23：1035-1038(1995)；Hurle及Gross,Curr.Op.Biotech.5：428-433(1994)；以及美國專利第6,982,321號及第7,087,409號。
關於肽、多肽或抗體序列之「序列一致性」及「同源性」定義為在比對序列及必要時引入間隙以實現最大序列一致性百分比後且不考慮任何保守取代作為序列一致性之一部分下，候選序列中與特定肽或多肽序列中之胺基酸殘基相同之胺基酸殘基的百分比。可根據所屬領域技能內之多種方式，使用公眾可獲得之計算機軟體，諸如BLAST、BLAST-2、ALIGN或MEGALIGNTM(DNASTAR)軟體，實現比對，以確定胺基酸序列一致性百分比。所屬領域技術人員可確定用於量測比對之適當參數，包括實現所比較之全長序列上之最大比對所需的任何演算法。
解離常數(KD或Kd)用作展示抗體對抗原之親和力的指標。舉例而言，藉由Scatchard方法使用用多種標記試劑標記之抗體，以及藉由使用非處方量測套組BiacoreX(Amersham Biosciences製造)或類似套組，根據與套組連接之使用者手冊及實驗操作方法容易分析。可使用此等方法獲得之KD值以單位M(Mol)表示。
如本文所用，「嵌合轉換受體(CSR)」係指一種受體，建立所述受體以逆轉其原始信號傳導路徑之結果，以賦予免疫細胞(例如CAR T細胞)所期望之活性，諸如能夠克服免疫抑制腫瘤微環境及允許其具有更大活體內持久性。在一些實施例中，CSR可利用由癌細胞表現之抑制分子來進一步刺激CAR T細胞。在一非限制性實例中，CAR T細胞可經工程改造以表現由人類抑制受體程式化細胞死亡蛋白1(PD-1)之胞外配位體結合域與CD28之跨膜及胞質共刺激信號傳導域融合所構成的CSR。當CAR T細胞投與患有表現DLL3及程式化細胞 死亡配位體1(PD-L1)之癌症的個體時，所表現之CAR可結合於DLL3且所表現之轉換受體可結合於PD-L1。PD-1/CD28嵌合轉換受體融合蛋白之性質阻止正常PD1/PD-L1介導之T細胞抑制，代之以促進經由CD28域之信號傳導，此引起對CAR T細胞之刺激。因此，PD-1之跨膜及胞內域用CD28之跨膜及胞內域替換將PD-L1轉化成CAR T細胞之共刺激配位體。此將誘發增強的針對表現PD-L1之癌細胞的毒性。在其他實施例中，CSR亦可用於抑制CAR T細胞對非預期靶細胞之作用。
如本文所用，「顯性負性受體(DNR)」係指能夠結合配位體但不會誘發細胞內之信號傳導級聯的受體。DNR通常具有完整配位體結合區，但缺少胞內酶催化區。其可為全長受體之突變形式或受體之截短形式。在CAR T細胞免疫療法後，一些癌症、尤其是實體癌可能使結合於CAR T細胞上之抑制受體的抑制配位體上調。此適應性抗性使嵌合CAR T細胞療法之功效打折。已知一些癌症、特別是實體癌分泌轉型生長因子β(TGF-β)，建立免疫抑制環境。已知TGF-β誘發或促進轉移且有效抑制免疫系統。因此，在一些實施例中，使用TGF-β受體TGFBRII之截短型式作為TGF-β DNR以提高本文揭示案之CAR T細胞的抗腫瘤效能。在一些實施例中，藉由使用2A自裂解肽使CAR及TGF-β DNR在T細胞表面上共表現。在一些實施例中，藉由使用兩種表現載體使CAR及TGF-β DNR在T細胞表面上分開表現。發現TGF-β DNR在引入本文揭示案之抗DLL3 CAR T細胞中時，能夠增強CAR T細胞針對一些DLL3陽性癌細胞、例如SCLC細胞之細胞毒性。類似地，在一些實施例中，使用PD-1受體之截短型式作為PD-1 DNR以提高本文揭示案之CAR T細胞的抗腫瘤效能。
如本文所用，「治療(treatment或treating)」包括對疾病或病理性疾患之症狀或病理的任何有益或合乎需要的作用，且可包括甚至例如癌症、自體免疫性疾病、免疫病症等所治療之疾病或疾患之一或多個可量測標記物最低程 度的減少。治療可視情況涉及延遲疾病或疾患之進展。「治療」不一定指示完全根除或醫治疾病或疾患或其相關症狀。
本發明之一些態樣係指一種DLL3結合蛋白，該DLL3結合蛋白對人類或恆河猴DLL3蛋白具有結合特異性。
在一些實施例中，DLL3結合蛋白包含特異性地結合於DLL3之單域抗體(「sdAb」)部分，其中該sdAb部分包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb包含多肽，該多肽包含：包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3，或該多肽的在CDR區中包含至多約3個胺基酸取代之變異體。在一些實施例中，抗DLL3抗體為或包含單域抗體(sdAb)，該抗體係在用人類或恆河猴DLL3蛋白免疫接種後自駱駝產生。在一些實施例中，sdAb包含如表1之每行中所列出的CDR組(即CDR1、CDR2及CDR3之組合)。
在一些實施例中，sdAb包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：87之胺基酸序列之CDR 2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：168之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1，或其包含至多約3個胺基酸取 代之變異體；包含SEQ ID NO：102之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：183之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：105之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：186之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：108之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：189之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：115之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：196之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：120之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：201之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：88之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：169之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代 之變異體；包含SEQ ID NO：89之胺基酸序列之CDR 2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：170之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：90之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：171之胺基酸序列之CDR 3，或其包含至多約3個胺基酸取代之變異體。
在一些實施例中，sdAb包含多肽，該多肽包含以下中之任一種：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1；包含SEQ ID NO：87之胺基酸序列之CDR2；以及包含SEQ ID NO：168之胺基酸序列之CDR 3；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1；包含SEQ ID NO：102之胺基酸序列之CDR 2；以及包含SEQ ID NO：183之胺基酸序列之CDR 3；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1；包含SEQ ID NO：105之胺基酸序列之CDR2；以及包含SEQ ID NO：186之胺基酸序列之CDR 3；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1；包含SEQ ID NO：108之胺基酸序列之CDR 2；以及包含SEQ ID NO：189之胺基酸序列之CDR3；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1；包含SEQ ID NO：115之胺基酸序列之CDR2；以及包含SEQ ID NO：196之胺基酸序列之CDR3；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1；包含SEQ ID NO：120之胺基酸序列之CDR2；以及包含SEQ ID NO：201之胺基酸序列之CDR3；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1；包含SEQ ID NO：88之胺基酸序列之CDR2；以及包含SEQ ID NO：169之胺基酸序列之CDR3；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1；包含SEQ ID NO：89之胺基酸序列之CDR2；以及包含SEQ ID NO：170之胺基酸序列之CDR3；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1；包含SEQ ID NO：90之胺基酸序列之CDR2；以及包含SEQ ID NO：171之胺基酸序列之CDR3。
在一些實施例中，sdAb包含與SEQ ID NO：274-354中之任一者之胺基酸序列具有至少約95%(例如約96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，sdAb包含SEQ ID NO：274-354中之任一者之胺基酸序列。在其他實施例中，sdAb進行人類化，且包含與SEQ ID NO：355-367中之任一者之胺基酸序列具有至少約95%(例如約96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，sdAb包含SEQ ID NO：355-367中之任一者之胺基酸序列。可使用所屬領域中已知之多種技術產生，該等技術包括但不限於CDR移植(參見例如美國專利第5,225,539號、第5,530,101號及第5,585,089號)、飾面(veneering)或者表面重構(resurfacing)(參見例如歐洲專利第EP 592,106號及第P 519,596號)及鏈改組(參見例如美國專利第5,565,332號)。一般地，在人類化期間，受體抗體(例如人類抗體)之CDR殘基替換為供體抗體(例如囓齒動物抗體)之CDR殘基，以保持抗原結合特異性，同時將活體內免疫原性減至最少。經常，構架區中之構架殘基亦用來自供體抗體之對應殘基取代，以改變，例如提高抗原結合。藉由所屬領域熟知之方法，例如藉由模擬CDR與構架殘基之相互作用鑑別對於抗原結合而言重要之構架殘基且進行序列比較以鑑別具有位置處之不尋常構架殘基，來鑑別此等構架取代，例如保守取代。(參見例如Queen等人，美國專利第5,585,089號；及Riechmann等人，1988,Nature,332：323)。
在一些情況下，sdAb可與人類IgG鉸鏈片段及Fc片段融合，形成重鏈抗體(HCAb)。在一些情況下，sdAb可與對除DLL3以外之抗原具有特異性的另一sdAb或scFv融合，形成雙特異性抗體。在一些情況下，sdAb可與對除DLL3以外之抗原具有特異性的兩種或更多種sdAb或scFv融合，形成多特異性抗體。 在其他情況下，sdAb可進行化學修飾以攜帶藥物分子。因此，抗DLL3 sdAb可在活體內用於將藥物分子引導至表現DLL3之細胞。
在一些實施例中，DLL3結合蛋白為或包含特異性地結合DLL3之單鏈可變片段(scFv)。在一些情況下，藉由重複數輪之噬菌體淘選自合成的人類Fab或scFv噬菌體文庫分離scFv，其中每輪淘選涉及結合、移除非特異性噬菌體以及溶離及擴增所結合之噬菌體以進行下一輪過程。在一些實施例中，DLL3結合蛋白包含特異性地結合於DLL3之scFv部分，其中該scFv包含重鏈可變區(VH)及輕鏈可變區(VL)，其中該scFv之VH結構域包含SEQ ID NO：498或504中所示之CDR1、SEQ ID NO：499或505中所示之CDR2以及SEQ ID NO：500或506中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：495或501中所示之CDR1、SEQ ID NO：496或502中所示之CDR2以及SEQ ID NO：497或503中所示之CDR3。在一些實施例中，DLL3結合蛋白包含特異性地結合於DLL3之scFv部分，其中該scFv包含重鏈可變區(VH)及輕鏈可變區(VL)，其中該scFv之VH結構域包含SEQ ID NO：498中所示之CDR1、SEQ ID NO：499中所示之CDR2以及SEQ ID NO：500中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：495中所示之CDR1、SEQ ID NO：496中所示之CDR2以及SEQ ID NO：497中所示之CDR3；或該scFv之VH結構域包含SEQ ID NO：504中所示之CDR1、SEQ ID NO：505中所示之CDR2以及SEQ ID NO：506中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：501中所示之CDR1、SEQ ID NO：502中所示之CDR2以及SEQ ID NO：503中所示之CDR3。
在一些情況下，scFv可與對除DLL3以外之抗原具有特異性的另一sdAb或scFv融合，形成雙特異性抗體。在一些情況下，scFv可與對除DLL3以外之抗原具有特異性的兩種或更多種sdAb或scFv融合，形成多特異性抗體。在其他情況下，scFv可進行化學修飾以攜帶藥物分子。因此，抗DLL3 scFv可在 活體內用於將藥物分子引導至表現DLL3之細胞。
本發明之一些態樣係關於包含DLL3結合域之CAR或CAR-T細胞(抗DLL3 CAR或抗DLL3 CAR-T細胞)。
本發明之CAR包含胞外域、跨膜域及胞內域。在一些實施例中，CAR亦包括在N末端之信號肽及介於胞外域與跨膜域之間的鉸鏈區。胞外域包括靶特異性結合元件(亦稱為抗原識別域或抗原結合域)。胞內域或胞質域經常包括一或多個共刺激信號傳導域及CD3 ζ鏈部分。共刺激信號傳導域係指包括共刺激分子之胞內域在內的CAR的一部分。
藉由CAR分子識別抗原或靶向抗原最常涉及抗體或抗體片段之使用。根據本發明，抗原結合域為特異性地結合於DLL3之抗體或抗體片段。較佳地，本發明之CAR的抗原結合域為如上所提及之抗DLL3 scFv或sdAb。
跨膜域可源自天然或合成來源。在來源為天然的情況下，結構域可源自任何膜結合或跨膜蛋白。本發明中具體使用之跨膜區可源自(即至少包含跨膜區)例如T細胞受體之α、β或ξ鏈、CD8α鏈。
本發明之CAR的細胞內信號傳導域引起免疫細胞之至少一種正常效應功能的活化。術語「效應功能」係指細胞之專門功能。T細胞之效應功能例如可為細胞溶解活性，或輔助活性，包括分泌細胞介素。因此，術語「胞內域」係指轉導效應功能信號且指導細胞進行專門功能之蛋白質部分。雖然通常可採用整個胞質域，但多數情況下不需要使用整條鏈。在使用胞質域之截短部分的程度上，此類截短部分可代替完整鏈使用，只要其轉導效應功能信號即可。因此術語胞內域意欲包括足夠轉導效應功能信號之胞質域之任何截短部分。用於本發明CAR中之胞質域的較佳實例包括協調一致以在抗原受體接合後開始信號轉導之T細胞受體(TCR)及共受體的胞質序列，以及此等序列之任何衍生物或變異體及具有相同功能能力之任何合成序列。在一些實施例中，細胞內信號傳導 域源自CD3ζ、FcRγ、FcRβ、CD3γ、CD3δ、CD3ε、CD5、CD22、CD79a、CD79b或CD66d。
常常，單單藉由TCR產生之信號不足以完全活化T細胞。因此，使用第二或共刺激信號。因此，據說T細胞活化由兩類不同胞質信號傳導序列介導：藉由TCR開始抗原依賴性初級活化之信號傳導序列(初級胞質信號傳導序列)及以非抗原相關性方式作用以提供第二或共刺激信號之信號傳導序列(第二胞質信號傳導序列)。共刺激信號傳導序列係指包括共刺激分子之胞內域在內的CAR之一部分。共刺激分子為淋巴細胞對抗原之高效反應所需的除抗原受體或其配位體以外的細胞表面分子。此類分子之實例包括CD27、CD28、4-1BB、OX40、CD40、PD-1、LFA-1、ICOS、CD2、CD7、LIGHT、NKG2C、B7-H3、TNFRSF9、TNFRSF4、TNFRSF8、CD40LG、ITGB2、KLRC2、TNFRSF18、TNFRSF14、HAVCR1、LGALS9、DAP10、DAP12、CD83、CD83配位體及其組合。
介於CAR之胞外域與跨膜域之間的鉸鏈區一般意謂多肽鏈中用於將跨膜域連接至胞外域之任何寡肽或多肽。鉸鏈區可為至多300個胺基酸，較佳2至100個胺基酸且最佳2至10個胺基酸。
除抗原結合域、跨膜域、胞質域及鉸鏈區外，本發明之CAR亦可包括連接至CAR之N末端的信號肽序列。信號肽序列存在於許多分泌蛋白及膜蛋白之N末端，且典型地具有15至30個胺基酸之長度。因為許多以上提及之蛋白質分子具有信號肽序列，所以此等信號肽可以用作本發明CAR之信號肽。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含或源自單域抗體(sdAb)或單鏈可變片段(scFv)。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含或源自單域抗體(sdAb)，其中該sdAb包括包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1或其在該CDR1中包含至多約3個胺基酸取代之變異體； 包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2或其在該CDR2中包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3或其在該CDR3中包含至多約3個胺基酸取代之變異體。在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含或源自單域抗體(sdAb)，其中該sdAb包括包含SEQ ID NO：1-81中之任一者之胺基酸序列的CDR1；包含SEQ ID NO：82-162中之任一者之胺基酸序列的CDR2；以及包含SEQ ID NO：163-243中之任一者之胺基酸序列的CDR3。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包括包含以下中之任一種的sdAb：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：87之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：168之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：102之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：183之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：105之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：186之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：108之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：189之胺基酸序列之CDR3，或 其包含至多約3個胺基酸取代之變異體；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：115之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：196之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：120之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：201之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：88之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：169之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：89之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：170之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1，或其包含至多約3個胺基酸取代之變異體；包含SEQ ID NO：90之胺基酸序列之CDR2，或其包含至多約3個胺基酸取代之變異體；以及包含SEQ ID NO：171之胺基酸序列之CDR3，或其包含至多約3個胺基酸取代之變異體。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包括包含以下中之任一種的sdAb：
(1)包含SEQ ID NO：6之胺基酸序列之CDR1；包含SEQ ID NO：87之胺基酸序 列之CDR2；以及包含SEQ ID NO：168之胺基酸序列之CDR3；
(2)包含SEQ ID NO：21之胺基酸序列之CDR1；包含SEQ ID NO：102之胺基酸序列之CDR2；以及包含SEQ ID NO：183之胺基酸序列之CDR3；
(3)包含SEQ ID NO：24之胺基酸序列之CDR1；包含SEQ ID NO：105之胺基酸序列之CDR2；以及包含SEQ ID NO：186之胺基酸序列之CDR3；
(4)包含SEQ ID NO：27之胺基酸序列之CDR1；包含SEQ ID NO：108之胺基酸序列之CDR2；以及包含SEQ ID NO：189之胺基酸序列之CDR3；
(5)包含SEQ ID NO：34之胺基酸序列之CDR1；包含SEQ ID NO：115之胺基酸序列之CDR 2；以及包含SEQ ID NO：196之胺基酸序列之CDR 3；
(6)包含SEQ ID NO：39之胺基酸序列之CDR1；包含SEQ ID NO：120之胺基酸序列之CDR2；以及包含SEQ ID NO：201之胺基酸序列之CDR 3；
(7)包含SEQ ID NO：7之胺基酸序列之CDR1；包含SEQ ID NO：88之胺基酸序列之CDR2；以及包含SEQ ID NO：169之胺基酸序列之CDR 3；
(8)包含SEQ ID NO：8之胺基酸序列之CDR1；包含SEQ ID NO：89之胺基酸序列之CDR2；以及包含SEQ ID NO：170之胺基酸序列之CDR 3；或
(9)包含SEQ ID NO：9之胺基酸序列之CDR1；包含SEQ ID NO：90之胺基酸序列之CDR 2；以及包含SEQ ID NO：171之胺基酸序列之CDR 3。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含駱駝sdAb，其中該sdAb包含與SEQ ID NO：274-354中之任一者之胺基酸序列具有至少約95%(例如96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包括包含SEQ ID NO：274-354中的任一個的胺基酸的駱駝sdAb。在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含人類化sdAb，其中該sdAb包含與SEQ ID NO：355-367中之任一者之胺基酸序列具有至少約95%(例如96%、 97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含人類化sdAb，該人類化sdAb包含SEQ ID NO：355-367中之任一者之胺基酸序列。
在一些實施例中，CAR包含DLL3結合域，其中該DLL3結合域包含或源自單鏈可變片段(scFv)，其中該scFv之VH結構域包含SEQ ID NO：498中所示之CDR1、SEQ ID NO：499中所示之CDR2以及SEQ ID NO：500中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：495中所示之CDR1、SEQ ID NO：496中所示之CDR2以及SEQ ID NO：497中所示之CDR3；或該scFv之VH結構域包含SEQ ID NO：504中所示之CDR1、SEQ ID NO：505中所示之CDR2以及SEQ ID NO：506中所示之CDR3，且該scFv之VL結構域包含SEQ ID NO：501中所示之CDR1、SEQ ID NO：502中所示之CDR2以及SEQ ID NO：503中所示之CDR3。在一些實施例中，該scFv之VH結構域包含SEQ ID NO：508中所示之胺基酸序列，且該scFv之VL結構域包含SEQ ID NO：507中所示之胺基酸序列；或該scFv之VH結構域包含SEQ ID NO：510中所示之胺基酸序列，且該scFv之VL結構域包含SEQ ID NO：509中所示之胺基酸序列。
在一些實施例中，本發明之CAR包含本文中提供為DLL3結合域的駱駝sdAb且包含與SEQ ID NO：476-484中之任一者之胺基酸序列具有至少約95%(例如96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，本發明之CAR包含本文中提供為DLL3結合域的駱駝sdAb且具有選自由SEQ ID NO：476-484組成之群之胺基酸序列。在一些實施例中，本發明之CAR包含本文中提供為DLL3結合域的人類化sdAb且包含與SEQ ID NO：485-494中之任一者之胺基酸序列具有至少約95%(例如96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在其他實施例中，本發明之CAR包含本文中提供為DLL3結合域的人類化sdAb且具有選自由SEQ ID NO：485-494組成之 群之胺基酸序列。
在一些實施例中，本發明之CAR包含本文中提供為DLL3結合域的人類scFv且包含與SEQ ID NO：515-516中之任一者之胺基酸序列具有至少約95%(例如96%、97%、98%、99%或100%)序列一致性的胺基酸序列。在一些實施例中，本發明之CAR包含本文中提供為DLL3結合域的人類scFv且具有選自由SEQ ID NO：515-516組成之群之胺基酸序列。
在一些實施例中，本發明之CAR自N末端至C末端包含信號肽、DLL3結合域、鉸鏈區、跨膜域以及細胞質信號傳導域。在具體實施例中，本發明之CAR自N末端至C末端包含如SEQ ID NO：465中所示之CD8α信號肽、DLL3結合域、如SEQ ID NO：466中所示之CD8α鉸鏈域、如SEQ ID NO：467中所示之CD8α跨膜域、如SEQ ID NO：468中所示之CD137胞質域、如SEQ ID NO：469中所示之CD28胞質域及如SEQ ID NO：470中所示之CD3ζ胞質域。
本發明之一些態樣係關於一種經分離之核酸分子，該經分離之核酸分子編碼本發明之sdAb、scFv或CAR。在一些實施例中，核酸分子編碼駱駝sdAb且包含選自由SEQ ID NO：368-448組成之群的多核苷酸序列。在一些實施例中，核酸分子編碼人類化sdAb且包含選自由SEQ ID NO：449-461組成之群的多核苷酸序列。在一些實施例中，核酸分子編碼scFv之VH及VL結構域，其中VH結構域編碼包含SEQ ID NO：512或514之多核苷酸序列的序列，VL結構域編碼包含SEQ ID NO：511或513之多核苷酸序列的序列。
本發明之一些態樣係關於一種經工程改造之免疫細胞，該經工程改造之免疫細胞包含以上提供之任一種CAR、上述任一種經分離之核酸或上述任一種載體。在一些實施例中，經工程改造之免疫細胞為細胞毒性T細胞、輔助T細胞、自然殺手T細胞、γδ T細胞、NKT細胞及自然殺手細胞。在一些實施例中，細胞包含攜帶本發明之經分離之核酸分子的表現載體。用表現載體對細胞 進行基因修飾以表現由核酸分子之一部分編碼的多肽為所屬領域中熟知之一項遺傳技術。
本發明之一些態樣係關於本發明之DLL3結合蛋白、抗DLL3 CAR、核酸分子或CAR-T細胞。在一些實施例中，本發明之CAR-T細胞用生理學上可接受之賦形劑調配成醫藥組合物。如本文所用，「生理學上可接受之賦形劑」包括不限於對於在人類或家畜中使用可接受之任何助劑、載體、稀釋劑、防腐劑、分散劑、懸浮劑、穩定劑、等張劑、溶劑、界面活性劑或乳化劑。在一些實施例中，本發明之CAR-T細胞或包含該CAR-T細胞之醫藥組合物用於治療個體之DLL3相關病症。因此，提供一種用於治療DLL3相關病症之方法，該方法包括向罹患DLL3相關病症之個體投與治療有效量的本發明之CAR-T細胞或醫藥組合物。抗體、CAR-T細胞或醫藥組合物之「治療有效量」可根據例如個體之疾病狀況、年齡、性別及重量(例如患者)的因素變化。術語「治療有效量」可包括有效「治療」個體之量。當指示治療劑量時，在具體實施例中涵蓋的待投與之精確量可由醫師考慮個體之狀況確定。在一些實施例中，DLL3相關病症為表現DLL3作為細胞表面蛋白之癌症，例如黑素瘤、乳腺癌、前列腺癌、結腸癌、腎細胞癌、卵巢癌、神經母細胞瘤、橫紋肌肉瘤、白血病及淋巴瘤。較佳地，DLL3相關病症為肺癌，尤其是小細胞肺癌(SCLC)。
實例
本文所述之實例不意欲表示以下實驗均進行或只進行該等實驗。努力確保關於所用數字(例如量、溫度等)之準確性，但應考慮一些實驗誤差及偏差。除非另外指示，否則份為重量份，分子量為重量平均分子量，溫度為攝氏度，且壓力為大氣壓或接近大氣壓。
實例1.動物免疫及抗體文庫構築
本實例證明，免疫駱駝顯示對人類或恆河猴DLL3蛋白很好之免疫 反應且所獲得之免疫文庫顯示優良品質。
動物免疫
將包含具有N末端FLAG標籤之人類DLL3蛋白(AdipoGen，AG-40B-0151)的胞外域(aa27-466)或/及表現DLL3之質體或表現DLL3之細胞(CHO-K1/DLL3或/及CHO-K1/EGF4)的免疫原與助劑或PBS混合且注入駱駝中。典型地，駱駝進行免疫2-4次，時間間隔為1週至2週。在多輪免疫後，通過用酶聯免疫吸附劑分析(ELISA)及流式細胞術分析進行血清滴定來評定針對靶抗原DLL3之免疫反應。
噬菌體展示文庫構築
使用TRIZOL®試劑，根據製造商之方案，自免疫駱駝之淋巴細胞提取全部RNA。cDNA係基於RNA模板，利用寡(dT)20引子，使用PRIMESCRIPTTM第一鏈cDNA合成套組，根據製造商之方案來合成。自駱駝cDNA擴增VHH，以產生VHH噬菌體文庫。
實例2.抗DLL3抗體之產生
本文提供之抗DLL3抗體包括自免疫駱駝或自合成人類Fab文庫分離之人類Fab產生的單域抗體(sdAb)。
噬菌體展示
噬菌體展示文庫係用藉由免疫接種(包含具有N末端FLAG標籤之人類DLL3蛋白(AdipoGen，AG-40B-0151)的胞外域(aa27-466)或/及表現DLL3之質體或表現DLL3之細胞(CHO-K1/DLL3或/及CHO-K1/EGF4)的免疫原)獲得的sdAb構築。合成另一人類Fab噬菌體展示文庫。拯救兩個噬菌體文庫且在過濾殺菌後儲存在4℃下以供進一步使用。使用基於蛋白質之淘選以及基於細胞之淘選，利用以上提及之兩種噬菌體文庫分離結合之噬菌體。使用兩個文庫，針對基於蛋白質及基於細胞之淘選方法進行至少一輪淘選，直至DLL3特異性噬菌體 純系之百分比達到30%。評定每輪輸出噬菌體之總輸出純系的數目，藉由ELISA評定DLL3陽性純系之百分比，及DLL3特異性純系之序列多樣性。基於此等結果，選擇最佳之淘選輸出，以供高通量篩選。
高通量篩選
使用所選擇之輸出噬菌體感染呈指數生長之大腸桿菌細胞。提取輸出噬菌體之雙鏈DNA。自噬菌粒載體上切割sdAb/Fab插入物，且插入抗體片段表現載體中以供高通量篩選。所得質體用於轉化呈指數生長之大腸桿菌細胞，隨後塗鋪細胞且在37℃下生長隔夜。逐一挑選數千個菌落且在含有1mL 2×YT培養基之96深孔盤中生長。藉由加入1mM IPTG誘導抗體片段之表現。
藉由ELISA，分析上清液中之sdAb/Fab蛋白結合DLL3 ECD蛋白的能力，以及藉由FACS，分析結合表現DLL3之SHP-77細胞株(美國典型菌種保藏(ATCC)® CRL-2195TM)及CHO-K1/人類DLL3(內部產生)的能力。所有結合劑均定序。移除冗餘序列。總共獲得結合人類及恆河猴DLL3蛋白及細胞株的81個駱駝sdAb及2個人類Fab結合劑。所有此等結合劑具有獨特之胺基酸序列。
藉由BIAcore T200儀器(GE Healthcare)上之表面電漿子共振(SPR)對此等獨特結合劑中之一些結合劑進行進一步表徵。實驗如下進行：藉由親和力標籤將粗sdAb/Fab蛋白質捕捉至感測器晶片上。高濃度(100nM)人類DLL3流過感測器晶片表面，且使其結合抗體片段300秒，接著注射操作緩衝液，以使所形成之複合物解離。基於一個締合及解離曲線大致計算締合速率(ka)及解離速率(kd)，且用於估計平衡解離常數(KD)。表7中示出此等獨特結合劑中之一些結合劑的結合親和力。
表1中列出抗DLL3駱駝sdAb之CDR序列且表2中列出抗DLL3人類scFv之CDR序列。
表1.抗DLL3駱駝sdAb CDR序列
Figure 109124309-A0202-12-0038-1
Figure 109124309-A0202-12-0039-2
Figure 109124309-A0202-12-0040-3
Figure 109124309-A0202-12-0041-4
Figure 109124309-A0202-12-0041-264
Figure 109124309-A0202-12-0042-6
表3中列出抗DLL3 sdAb胺基酸序列。sdAb之CDR加下劃線。編碼抗DLL3 sdAb之核酸序列示於SEQ ID NO：368-448中。
Figure 109124309-A0202-12-0042-9
Figure 109124309-A0202-12-0043-15
Figure 109124309-A0202-12-0044-16
Figure 109124309-A0202-12-0045-17
Figure 109124309-A0202-12-0046-18
Figure 109124309-A0202-12-0047-19
Figure 109124309-A0202-12-0048-20
Figure 109124309-A0202-12-0049-21
表4中列出抗DLL3人類scFv之VH及VL結構域的胺基酸序列。編碼抗DLL3人類scFv之VH或VL結構域的核酸序列示於SEQ ID NO：511-514中。
Figure 109124309-A0202-12-0049-10
Figure 109124309-A0202-12-0050-22
實例3.單特異性駱駝CAR之產生
以上表3中提供抗DLL3駱駝sdAb片段之胺基酸序列，且在SEQ ID NO：368-448中提供抗DLL3駱駝sdAb片段之核酸序列。表3之sdAb片段及另外的序列用於產生CAR構築體(SEQ ID NO：476-484)。CAR3 scFv(SEQ ID NO：473)為一種人類抗DLL3 scFv，亦用於產生作為參考之CAR構築體(CAR3)。全長CAR自N末端至C末端含有：CD8α信號肽(SEQ ID NO：465)、表3中提供之DLL3結合域sdAb、CD8α鉸鏈域(SEQ ID NO：466)、CD8α跨膜域(SEQ ID NO：467)、CD137胞內域(SEQ ID NO：468)或CD28胞內域(SEQ ID NO：469)及CD3ζ胞內域(SEQ ID NO：470)。圖1中示出CAR構築體之示意圖。接著將編碼CAR片段之核酸選殖至慢病毒載體中以在單個編碼框中建立全長CAR構築體，使用人EF1α啟動子進行表現。所得CAR主鏈載體命名為「PLLV-hEF1α-DLL3」。
實例4.駱駝抗DLL3 CAR-T細胞之產生
慢病毒之製備
將包括pCMV-△R-8.47及pMD2.G之慢病毒包裝質體混合物(Addgene，目錄號12259)與PLLV-hEF1α-DLL3載體以預先優化比率(1：1：1：2)在聚乙烯亞胺存在下預先混合，接著添加至HEK293細胞中。在培育隔夜後收集 上清液。含病毒之上清液經0.45μm PES過濾器過濾，且進行超離心以濃縮慢病毒。將病毒糰粒用預先冷卻之DPBS沖洗。將病毒適當等分，然後立即儲存在-80℃下。藉由用流式細胞術測定量測轉導至supT1細胞株之效率來確定病毒效價。
T淋巴細胞之收集及轉導
藉由單採血液成分術自健康供體收集白細胞。使用Ficoll-PaqueTM PLUS培養基，根據製造商方案，分離外周血單核細胞(PBMC)。使用Pan T細胞分離套組(Miltenyi，目錄號130-096-535)，根據製造商方案，自PBMC純化人類T細胞。經純化之T細胞隨後用人T細胞活化/擴增套組(Miltenyi，目錄號130-091-441)，根據製造商方案預先活化48小時，其中抗CD3/CD28 MACSiBead顆粒以1：2之珠粒與細胞比率添加。在7μg/mL聚凝胺存在下將預先活化之T細胞用慢病毒原液轉導。接著轉導細胞轉移至細胞培育箱中，以在合適條件下表現轉殖基因。
實例5.駱駝抗DLL3 CAR-T細胞之活體外活性的評估
活體外細胞毒性分析
在轉導後第6天，收穫轉導T細胞，且與表現DLL3之腫瘤細胞株SHP-77以2：1及5：1之效應細胞(CAR-T)與靶細胞比率共同培育20小時。在所有分析中CAR3 CAR-T細胞用作參考以比較分析變化，及/或充當對照。未轉導T細胞(UnT)用作陰性對照。
藉由乳酸去氫酶(LDH)分析來測定轉導T細胞之細胞毒性。結果表明CAR3 CAR-T及一些抗DLL3 CAR-T在活體外展現強烈的針對SHP-77細胞之抗腫瘤活性，而UnT無靶細胞殺死作用(圖2)。
IFN-γ及TNF-α釋放之偵測
另外，自活體外細胞毒性分析收集上清液，以評定CAR誘發之細胞 介素釋放，例如干擾素γ(IFN-γ)及TNF-α釋放。如圖3A及圖3B所示，CAR3 CAR-T及一些抗DLL3 CAR-T經SHP-77刺激，產生IFN-γ及TNF-α，而UnT幾乎不產生IFN-γ及TNF-α。偵測IFN-γ及TNF-α釋放之方案可涉及CISBIO之人類TNF-α套組及IFN-γ套組。
藉由長期刺激分析確定CAR-T擴增
在第0天，將1×105個SHP-77細胞塗鋪在24孔盤中以建立單層。在第1天，計數轉導T細胞且在新鮮培養基中在缺乏細胞介素下將2×105個活CAR+ T細胞塗鋪在SHP-77細胞上面。在第3天，將新的1×105個SHP-77細胞單層塗鋪在CAR-T細胞上面。在第4天，計數每個孔之活CAR-T細胞。在同一天，將來自擴增孔之2×105個CAR+ T細胞(具有至少這個量的細胞)再塗鋪以建立新的單層，如第1天。重複該過程以提供3-4輪刺激。每次刺激後之擴增倍數計算為[第4天之活CAR+ T細胞]/2×105，每次刺激第1天塗鋪之CAR T細胞的量。為針對每次新刺激下丟棄之細胞歸一化，藉由[(擴增倍數)×(擴增倍數+1)...]確定累積擴增倍數。
在3輪刺激後，計算不同CAR-T構築體之擴增倍數。如圖4所示，在SHP-77腫瘤細胞之3輪刺激下，大部分CAR-T構築體擴增超過CAR3 CAR-T。
實例6.藉由CAR-T細胞介導之腫瘤生長抑制對駱駝CAR進行活體內功效評估
在SHP-77腫瘤模型中評估駱駝CAR之抗腫瘤活性。將SHP-77細胞皮下植入NOD/SCID小鼠中且隨機化成7組(每組4隻小鼠，第0天)。第1組：媒劑(僅僅PBS)；第2組：UnT(陰性對照)；第3組：CAR3；第4組：CAS64380；第5組：CAS64511；第6組：CAS63931；第7組：CAS63997。當腫瘤可觸知(100mm3)時開始用CAR-T細胞、UnT細胞或媒劑(僅僅PBS)治療，且當腫瘤體積達約3000mm3時對小鼠施以安樂死。每週量測腫瘤體積2次。靜脈內投與CAR-T細胞，各小鼠1×106個CAR陽性T細胞。在腫瘤細胞植入後監測小鼠及 腫瘤約21天。
如圖5所示，所有選擇之駱駝CAR證明在此動物腫瘤模型中之抗腫瘤活性。
實例7.駱駝sdAb之人類化
使用CDR移植技術(參見例如美國專利第5,225,539號)將所選擇之駱駝sdAbs(SEQ ID NO：279、294、297、312)人類化。簡言之，將駱駝sdAb序列與在結構生物信息學合作研究組織(Research Collaboratory for Structural Bioinformatics，RCSB)蛋白質資料庫中可得之序列相比。每種駱駝sdAb之同源性模型係基於最接近之VH結構產生。自模型結構鑑別在CDR附近或埋在分子內(即側鏈溶劑可及表面積小於15%)之殘基。
隨後，針對NCBI人類生殖系V基因資料庫，將各駱駝sdAb序列BLAST化，以鑑別與sdAb具有最高一致性之人類VH生殖系序列(亦即人接受體)(參見例如Foote及Winter,J.Mol.Biol.224：487-499(1992)；Morea V.等人，Methods 20：267-279(2000)；Chothia C.等人，J.Mol.Biol.186：651-663(1985))。在CDR移植方法中，人類接受體之CDR經駱駝sdAb之CDR置換，產生直移植序列。直移植抗體通常喪失結合活性，需要藉由用非人類殘基置換對於抗體活性來說關鍵之構架殘基來恢復。在CDR附近或埋在分子內之胺基酸殘基通常對於抗體之活性及結構而言係重要的，因此應該為潛在回復突變位點。使用此方法，設計出一系列人類化變異體。表5中示出該等人類化變異體之CDR胺基酸序列。表6中示出人類化變異體之全長胺基酸序列。CDR加下劃線。
Figure 109124309-A0202-12-0053-11
Figure 109124309-A0202-12-0054-12
Figure 109124309-A0202-12-0054-13
Figure 109124309-A0202-12-0055-14
將駱駝及人類化sdAb序列與人類IgG1鉸鏈及Fc融合，產生嵌合及人類化HCAb序列。合成編碼此等HCAb之DNA且插入pTT5載體中。使用HCAb表現質體轉染HEK293細胞。分泌至培養基中之粗HCAb蛋白如下進行SPR親和力量測：簡言之，使用EDC活化之胺偶合化學，將捕捉抗體抗人類FcpAb(GE healthcare)固定在BiacoreTM CM5晶片上，至大約6,000RU。所關注HCAb經300秒捕捉至感測器晶片表面上。人類DLL3(AdipoGen，AG-40B-0151)以一系列遞增濃度流過感測器晶片表面。監測締合及解離階段。使用10mM甘胺酸-HCl之pH 2.0緩衝液在各循環之間移除所捕捉之抗體及抗原，以確保抗原之結合表面 新鮮。使用1：1結合模型，總體上擬合所得感測圖，以計算締合及解離速率(分別ka及kd)以及親和力(KD)。
量測一些人類化sdAb之結合親和力且比較原始駱駝sdAb之結合親和力(表7)。大部分人類化抗體保持駱駝sdAb之結合親和力。本實例證明使用標準方案之sdAb人類化係成功的。大部分sdAb在人類化後保持其結合親和力。
當用與上述相同之程序分析時scFv具有可比KD值(表7中之AS56788及AS56704)。
Figure 109124309-A0202-12-0056-23
實例8.單特異性人類化CAR之產生
以上表6中列出抗DLL3人類化sdAb之胺基酸序列，且在SEQ ID NO：449-461中列出抗DLL3人類化sdAb之核酸序列。表6中之人類化sdAb及另外的序列用於產生完全CAR構築體(SEQ ID NO：485-494)。全長CAR自N末 端至C末端含有：CD8α信號肽(SEQ ID NO：465)、表6中提供之DLL3結合域(人類化sdAb)、CD8α鉸鏈域(SEQ ID NO：466)、CD8α跨膜域(SEQ ID NO：467)、CD137胞內域(SEQ ID NO：468)或CD28胞內域(SEQ ID NO：469)及CD3ζ胞內域(SEQ ID NO：470)。圖1中示出CAR構築體之示意圖。接著將編碼CAR片段之核酸選殖至慢病毒載體中以在單個編碼框中建立全長CAR構築體，使用人EF1α啟動子進行表現。所得CAR主鏈載體命名為「PLLV-hEF1α-DLL3」。
實例9.人類化抗DLL3 CAR-T細胞之活體外活性的評估
類似於實例4中所述之程序，提供CAR-T細胞介導之腫瘤細胞殺死、細胞介素釋放及長期刺激分析評估人類化CAR的效力。
活體外細胞毒性分析
結果示於圖6A-6D中。人類化CAR-T展示在活體外優良之抗腫瘤功效。
IFN-γ釋放分析
另外，自活體外細胞毒性分析收集上清液，以評定CAR誘發之細胞介素釋放，例如干擾素γ(IFN-γ)及腫瘤壞死因子α(TNF-α)釋放。如圖7A及圖7B所示，CAR3 CAR-T及一些抗DLL3 CAR-T經SHP-77刺激，產生IFN-γ及TNF-α，而UnT幾乎不產生IFN-γ或TNF-α。
通過長期刺激分析確定CART擴增
在第0天，將1×105個SHP-77細胞塗鋪在24孔盤中以建立單層。在第1天，計數CAR-T細胞且在新鮮培養基中在缺乏細胞介素下將2×105個活CAR+ T細胞塗鋪在SHP-77細胞上面。在第3天，將新的1×105個NCI-H82細胞單層塗鋪在CAR-T細胞上面。在第4天，計數每個孔之活CAR-T細胞。在同一天，將來自擴增孔之2×105個CAR+ T細胞(具有至少這個量的細胞)再塗鋪以建立新的單層，如第1天。重複所述過程以提供3-4輪刺激。每次刺激後之擴增 倍數計算為[第4天的活CAR+ T細胞]/2×105，每次刺激第1天塗鋪之CAR T細胞的量。為針對每次新刺激下丟棄之細胞歸一化，藉由[(擴增倍數)×(擴增倍數+1)...]確定累積擴增倍數。
在3輪刺激後，計算不同CAR-T構築體之擴增倍數。如圖8所示，在SHP-77腫瘤細胞之3輪刺激下，大部分CAR-T構築體擴增超過CAR3 CAR-T。
實例10.藉由CAR-T細胞介導之腫瘤生長抑制對人類化CAR進行活體內功效評估
在SHP-77腫瘤模型中評估人類化CAR之抗腫瘤活性。SHP-77細胞皮下植入物NOD/SCID小鼠中且隨機化成9組(每組4隻小鼠，第0天)：媒劑(僅僅PBS)、UnT(陰性對照)、CAR3、CAS64380、CAS64380VH5、CAS64511、CAS64511VH5、CAS63997及CAS63997VH5。當腫瘤可觸知(100mm3)時開始用CAR-T細胞、UnT細胞或媒劑(僅僅PBS)治療，且當腫瘤體積達約3000mm3時對小鼠施以安樂死。每週量測腫瘤體積2次。靜脈內投與CAR-T細胞，各小鼠0.2×106個CAR陽性T細胞。在腫瘤細胞植入後監測小鼠及腫瘤約21天。
如圖9A-9J所示，在這個動物模型中，與基準CAR3相比，CAS64380VH5及CAS63997VH5展示優良抗腫瘤活性。
未觀察到此等人類化CAR之抗腫瘤活性與其在活體外之細胞殺死效力相關。
以下列出本文中提到之一些胺基酸序列及核酸序列。
駱駝sdAb核酸序列
SEQ ID NO：368(駱駝sdAb AS63930核酸序列)
Figure 109124309-A0202-12-0058-24
Figure 109124309-A0202-12-0059-25
SEQ ID NO：369(駱駝sdAb AS63932核酸序列)
Figure 109124309-A0202-12-0059-26
SEQ ID NO：370(駱駝sdAb AS63951核酸序列)
Figure 109124309-A0202-12-0059-27
SEQ ID NO：371(駱駝sdAb AS63984核酸序列)
Figure 109124309-A0202-12-0060-98
SEQ ID NO：372(駱駝sdAb AS63987核酸序列)
Figure 109124309-A0202-12-0060-99
SEQ ID NO：373(駱駝sdAb AS63997核酸序列)
Figure 109124309-A0202-12-0060-100
Figure 109124309-A0202-12-0061-101
SEQ ID NO：374(駱駝sdAb AS64047核酸序列)
Figure 109124309-A0202-12-0061-102
SEQ ID NO：375(駱駝sdAb AS64052核酸序列)
Figure 109124309-A0202-12-0061-103
SEQ ID NO：376(駱駝sdAb AS64062核酸序列)
Figure 109124309-A0202-12-0061-104
Figure 109124309-A0202-12-0062-105
SEQ ID NO：377(駱駝sdAb AS64072核酸序列)
Figure 109124309-A0202-12-0062-106
SEQ ID NO：378(駱駝sdAb AS64097核酸序列)
Figure 109124309-A0202-12-0062-107
SEQ ID NO：379(駱駝sdAb AS64114核酸序列)
Figure 109124309-A0202-12-0063-108
SEQ ID NO：380(駱駝sdAb AS64123核酸序列)
Figure 109124309-A0202-12-0063-109
SEQ ID NO：381(駱駝sdAb AS64130核酸序列)
Figure 109124309-A0202-12-0063-110
Figure 109124309-A0202-12-0064-111
SEQ ID NO：382(駱駝sdAb AS64137核酸序列)
Figure 109124309-A0202-12-0064-112
SEQ ID NO：383(駱駝sdAb AS64142核酸序列)
Figure 109124309-A0202-12-0064-113
SEQ ID NO：384(駱駝sdAb AS64154核酸序列)
Figure 109124309-A0202-12-0064-114
Figure 109124309-A0202-12-0065-115
SEQ ID NO：385(駱駝sdAb AS64160核酸序列)
Figure 109124309-A0202-12-0065-116
SEQ ID NO：386(駱駝sdAb AS64228核酸序列)
Figure 109124309-A0202-12-0065-117
SEQ ID NO：387(駱駝sdAb AS64300核酸序列)
Figure 109124309-A0202-12-0065-118
Figure 109124309-A0202-12-0066-119
SEQ ID NO：388(駱駝sdAb AS64380核酸序列)
Figure 109124309-A0202-12-0066-120
SEQ ID NO：389(駱駝sdAb AS64395核酸序列)
Figure 109124309-A0202-12-0066-121
Figure 109124309-A0202-12-0067-122
SEQ ID NO：390(駱駝sdAb AS64443核酸序列)
Figure 109124309-A0202-12-0067-123
SEQ ID NO：391(駱駝sdAb AS64511核酸序列)
Figure 109124309-A0202-12-0067-124
SEQ ID NO：392(駱駝sdAb AS64536核酸序列)
Figure 109124309-A0202-12-0067-125
Figure 109124309-A0202-12-0068-126
SEQ ID NO：393(駱駝sdAb AS64597核酸序列)
Figure 109124309-A0202-12-0068-127
SEQ ID NO：394(駱駝sdAb AS64617核酸序列)
Figure 109124309-A0202-12-0068-128
SEQ ID NO：395(駱駝sdAb AS64634核酸序列)
Figure 109124309-A0202-12-0068-129
Figure 109124309-A0202-12-0069-130
SEQ ID NO：396(駱駝sdAb AS69498核酸序列)
Figure 109124309-A0202-12-0069-131
SEQ ID NO：397(駱駝sdAb AS69500核酸序列)
Figure 109124309-A0202-12-0069-132
SEQ ID NO：398(駱駝sdAb AS69527核酸序列)
Figure 109124309-A0202-12-0070-133
SEQ ID NO：399(駱駝sdAb AS68280核酸序列)
Figure 109124309-A0202-12-0070-134
SEQ ID NO：400(駱駝sdAb AS68355核酸序列)
Figure 109124309-A0202-12-0070-135
Figure 109124309-A0202-12-0071-136
SEQ ID NO：401(駱駝sdAb AS69443核酸序列)
Figure 109124309-A0202-12-0071-137
SEQ ID NO：402(駱駝sdAb AS75376核酸序列)
Figure 109124309-A0202-12-0071-138
SEQ ID NO：403(駱駝sdAb AS75387核酸序列)
Figure 109124309-A0202-12-0071-139
Figure 109124309-A0202-12-0072-140
SEQ ID NO：404(駱駝sdAb AS75695核酸序列)
Figure 109124309-A0202-12-0072-141
SEQ ID NO：405(駱駝sdAb AS76169核酸序列)
Figure 109124309-A0202-12-0072-142
SEQ ID NO：406(駱駝sdAb AS63931核酸序列)
Figure 109124309-A0202-12-0073-143
SEQ ID NO：407(駱駝sdAb AS63937核酸序列)
Figure 109124309-A0202-12-0073-144
SEQ ID NO：408(駱駝sdAb AS63948核酸序列)
Figure 109124309-A0202-12-0073-145
Figure 109124309-A0202-12-0074-146
SEQ ID NO：409(駱駝sdAb AS63956核酸序列)
Figure 109124309-A0202-12-0074-147
SEQ ID NO：410(駱駝sdAb AS63965核酸序列)
Figure 109124309-A0202-12-0074-148
SEQ ID NO：411(駱駝sdAb AS63993核酸序列)
Figure 109124309-A0202-12-0074-149
Figure 109124309-A0202-12-0075-150
SEQ ID NO：412(駱駝sdAb AS63999核酸序列)
Figure 109124309-A0202-12-0075-151
SEQ ID NO：413(駱駝sdAb AS64006核酸序列)
Figure 109124309-A0202-12-0075-152
SEQ ID NO：414(駱駝sdAb AS64057核酸序列)
Figure 109124309-A0202-12-0076-153
SEQ ID NO：415(駱駝sdAb AS64060核酸序列)
Figure 109124309-A0202-12-0076-154
SEQ ID NO：416(駱駝sdAb AS64071核酸序列)
Figure 109124309-A0202-12-0076-155
Figure 109124309-A0202-12-0077-156
SEQ ID NO：417(駱駝sdAb AS64093核酸序列)
Figure 109124309-A0202-12-0077-157
SEQ ID NO：418(駱駝sdAb AS64118核酸序列)
Figure 109124309-A0202-12-0077-158
SEQ ID NO：419(駱駝sdAb AS64120核酸序列)
Figure 109124309-A0202-12-0077-159
Figure 109124309-A0202-12-0078-160
SEQ ID NO：420(駱駝sdAb AS64124核酸序列)
Figure 109124309-A0202-12-0078-161
SEQ ID NO：421(駱駝sdAb AS64135核酸序列)
Figure 109124309-A0202-12-0078-162
SEQ ID NO：422(駱駝sdAb AS64163核酸序列)
Figure 109124309-A0202-12-0079-163
SEQ ID NO：423(駱駝sdAb AS64182核酸序列)
Figure 109124309-A0202-12-0079-164
SEQ ID NO：424(駱駝sdAb AS64183核酸序列)
Figure 109124309-A0202-12-0079-165
Figure 109124309-A0202-12-0080-166
SEQ ID NO：425(駱駝sdAb AS64207核酸序列)
Figure 109124309-A0202-12-0080-167
SEQ ID NO：426(駱駝sdAb AS64276核酸序列)
Figure 109124309-A0202-12-0080-168
SEQ ID NO：427(駱駝sdAb AS64336核酸序列)
Figure 109124309-A0202-12-0080-169
Figure 109124309-A0202-12-0081-170
SEQ ID NO：428(駱駝sdAb AS64346核酸序列)
Figure 109124309-A0202-12-0081-171
SEQ ID NO：429(駱駝sdAb AS64420核酸序列)
Figure 109124309-A0202-12-0081-172
SEQ ID NO：430(駱駝sdAb AS64473核酸序列)
Figure 109124309-A0202-12-0082-174
SEQ ID NO：431(駱駝sdAb AS64475核酸序列)
Figure 109124309-A0202-12-0082-175
SEQ ID NO：432(駱駝sdAb AS64513核酸序列)
Figure 109124309-A0202-12-0082-176
Figure 109124309-A0202-12-0083-177
SEQ ID NO：433(駱駝sdAb AS64562核酸序列)
Figure 109124309-A0202-12-0083-178
SEQ ID NO：434(駱駝sdAb AS64583核酸序列)
Figure 109124309-A0202-12-0083-179
SEQ ID NO：435(駱駝sdAb AS64594核酸序列)
Figure 109124309-A0202-12-0083-180
Figure 109124309-A0202-12-0084-181
SEQ ID NO：436(駱駝sdAb AS64605核酸序列)
Figure 109124309-A0202-12-0084-182
SEQ ID NO：437(駱駝sdAb AS64606核酸序列)
Figure 109124309-A0202-12-0084-183
SEQ ID NO：438(駱駝sdAb AS68121核酸序列)
Figure 109124309-A0202-12-0084-184
Figure 109124309-A0202-12-0085-185
SEQ ID NO：439(駱駝sdAb AS68170核酸序列)
Figure 109124309-A0202-12-0085-186
SEQ ID NO：440(駱駝sdAb AS63964核酸序列)
Figure 109124309-A0202-12-0085-187
SEQ ID NO：441(駱駝sdAb AS64116核酸序列)
Figure 109124309-A0202-12-0086-188
SEQ ID NO：442(駱駝sdAb AS68270核酸序列)
Figure 109124309-A0202-12-0086-189
SEQ ID NO：443(駱駝sdAb AS68320核酸序列)
Figure 109124309-A0202-12-0086-190
Figure 109124309-A0202-12-0087-191
SEQ ID NO：444(駱駝sdAb AS68351核酸序列)
Figure 109124309-A0202-12-0087-192
SEQ ID NO：445(駱駝sdAb AS75378核酸序列)
Figure 109124309-A0202-12-0087-193
SEQ ID NO：446(駱駝sdAb AS75383核酸序列)
Figure 109124309-A0202-12-0087-194
Figure 109124309-A0202-12-0088-195
SEQ ID NO：447(駱駝sdAb AS75751核酸序列)
Figure 109124309-A0202-12-0088-196
SEQ ID NO：448(駱駝sdAb AS76422核酸序列)
Figure 109124309-A0202-12-0088-197
人類化駱駝sdAb核酸序列
SEQ ID NO：449(人類化sdAb AS64380VH4核酸序列)
Figure 109124309-A0202-12-0089-198
SEQ ID NO：450(人類化sdAb AS64380VH5核酸序列)
Figure 109124309-A0202-12-0089-199
SEQ ID NO：451(人類化sdAb AS64380VH6核酸序列)
Figure 109124309-A0202-12-0089-200
Figure 109124309-A0202-12-0090-201
SEQ ID NO：452(人類化sdAb AS64380VH7核酸序列)
Figure 109124309-A0202-12-0090-202
SEQ ID NO：453(人類化sdAb AS64511VH4核酸序列)
Figure 109124309-A0202-12-0090-203
SEQ ID NO：454(人類化sdAb AS64511VH5核酸序列)
Figure 109124309-A0202-12-0090-204
Figure 109124309-A0202-12-0091-205
SEQ ID NO：455(人類化sdAb AS64511VH6核酸序列)
Figure 109124309-A0202-12-0091-206
SEQ ID NO：456(人類化sdAb AS63931VH4核酸序列)
Figure 109124309-A0202-12-0091-207
SEQ ID NO：457(人類化sdAb AS63931VH5核酸序列)
Figure 109124309-A0202-12-0092-208
SEQ ID NO：458(人類化sdAb AS63931VH6核酸序列)
Figure 109124309-A0202-12-0092-209
SEQ ID NO：459(人類化sdAb AS63997VH4核酸序列)
Figure 109124309-A0202-12-0092-210
Figure 109124309-A0202-12-0093-211
SEQ ID NO：460(人類化sdAb AS63997VH5核酸序列)
Figure 109124309-A0202-12-0093-212
SEQ ID NO：461(人類化sdAb AS63997VH6核酸序列)
Figure 109124309-A0202-12-0093-213
SEQ ID NO：462(連接子胺基酸序列)GGGGSGGGGSGGGGS
SEQ ID NO：463(連接子胺基酸序列) GGGGSGGGGS
SEQ ID NO：464(連接子胺基酸序列)GGGGS
SEQ ID NO：465(CD8α信號肽胺基酸序列)MALPVTALLLPLALLLHAARP
SEQ ID NO：466(CD8α鉸鏈胺基酸序列)TTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYC
SEQ ID NO：467(CD8α跨膜域胺基酸序列)IYIWAPLAGTCGVLLLSLVITLYC
SEQ ID NO：468(4-1BB胞內域胺基酸序列)KRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
SEQ ID NO：469(CD28胞內域胺基酸序列)RSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
SEQ ID NO：470(CD3ζ胞內域胺基酸序列)
Figure 109124309-A0202-12-0094-28
SEQ ID NO：471(F2A元件胺基酸序列)GSGVKQTLNFDLLKLAGDVESNPGP
SEQ ID NO：472(P2A元件胺基酸序列)GSGATNFSLLKQAGDVEENPGP
SEQ ID NO：473(CAR3抗DLL3 scFv胺基酸序列)
Figure 109124309-A0202-12-0094-29
Figure 109124309-A0202-12-0095-30
SEQ ID NO：474(CD28跨膜域胺基酸序列)FWVLVVVGGVLACYSLLVTVAFIIFWV
SEQ ID NO：475(CD28鉸鏈)IEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKP
駱駝抗DLL3 CAR序列
SEQ ID NO：476(CAS63997)
Figure 109124309-A0202-12-0095-214
SEQ ID NO：477(CAS64380)
Figure 109124309-A0202-12-0095-215
Figure 109124309-A0202-12-0096-216
SEQ ID NO：478(CAS64511)
Figure 109124309-A0202-12-0096-217
SEQ ID NO：479(CAS64617)
Figure 109124309-A0202-12-0096-218
SEQ ID NO：480(CAS69443)
Figure 109124309-A0202-12-0096-219
Figure 109124309-A0202-12-0097-220
SEQ ID NO：481(CAS63931)
Figure 109124309-A0202-12-0097-221
SEQ ID NO：482(CAS64047)
Figure 109124309-A0202-12-0097-222
SEQ ID NO：483(CAS64052)
Figure 109124309-A0202-12-0098-223
SEQ ID NO：484(CAS64062)
Figure 109124309-A0202-12-0098-224
人類化抗DLL3 CAR序列
SEQ ID NO：485(CAS64380VH4)
Figure 109124309-A0202-12-0098-225
Figure 109124309-A0202-12-0099-226
SEQ ID NO：486(CAS64380VH5)
Figure 109124309-A0202-12-0099-227
SEQ ID NO：487(CAS64380VH6)
Figure 109124309-A0202-12-0099-228
SEQ ID NO：488(CAS64380VH7)
Figure 109124309-A0202-12-0099-229
Figure 109124309-A0202-12-0100-230
SEQ ID NO：489(CAS64511VH4)
Figure 109124309-A0202-12-0100-231
SEQ ID NO：490(CAS64511VH5)
Figure 109124309-A0202-12-0100-232
SEQ ID NO：491(CAS64511VH6)
Figure 109124309-A0202-12-0101-233
SEQ ID NO：492(CAS63997VH4)
Figure 109124309-A0202-12-0101-234
SEQ ID NO：493(CAS63997VH5)
Figure 109124309-A0202-12-0101-235
Figure 109124309-A0202-12-0102-236
SEQ ID NO：494(CAS63997VH6)
Figure 109124309-A0202-12-0102-237
抗DLL3人類scFv VL及VH結構域核酸序列
SEQ ID NO：511(抗DLL3人類scFv AS56704之VL結構域的核酸序列)
Figure 109124309-A0202-12-0102-238
SEQ ID NO：512(抗DLL3人類scFv AS56704之VH結構域的核酸序列)
Figure 109124309-A0202-12-0102-239
Figure 109124309-A0202-12-0103-240
SEQ ID NO：513(抗DLL3人類scFv AS56788之VL結構域的核酸序列)
Figure 109124309-A0202-12-0103-241
SEQ ID NO：514(抗DLL3人類scFv AS56788之VH結構域的核酸序列)
Figure 109124309-A0202-12-0103-242
人類抗DLL3 scFv CAR序列
SEQ ID NO：515(CAS56704)
Figure 109124309-A0202-12-0104-243
SEQ ID NO：516(CAS56788)
Figure 109124309-A0202-12-0104-244
抗DLL3基準CAR
SEQ ID NO：517(1H2.1胺基酸序列)
Figure 109124309-A0202-12-0105-245
實例11.人類化抗DLL3串聯CAR-T細胞之活體外活性的評估
為提高CAR-T之抗腫瘤功效，構築三個串聯CAR(T1、T2及T3)。串聯CAR之胺基酸序列提供於SEQ ID：518-520中。抗DLL3人類化sdAb片段之胺基酸序列提供於SEQ ID NO：356(AS64380VH5)及SEQ ID NO：366(AS63997VH5)中。1H2.1(SEQ ID NO：517，例如參見WO2019200007)為一種抗DLL3 CAR，亦用於產生作為參考之CAR構築體。全長CAR自N末端至C末端含有：CD8α信號肽(SEQ ID NO：465)、SEQ ID NO：356(AS64380VH5)及SEQ ID NO：366(AS63997VH5)中提供之DLL3結合域sdAb、CD8α鉸鏈域(SEQ ID NO：466)、CD8α跨膜域(SEQ ID NO：467)、CD137胞內域(SEQ ID NO：468)或CD28胞內域(SEQ ID NO：469)及CD3ζ胞內域(SEQ ID NO：470)。圖10A中示出CAR構築體之示意圖。對於T1，sdAb 1及sdAb 2均為AS64380VH5。對於T2，sdAb 1及sdAb 2均為AS63997VH5。對於T3，sdAb 1及sdAb 2分別為AS63997VH5及AS64380VH5。接著將編碼CAR片段之核酸選殖至慢病毒載體中以在單個編碼框中建立全長CAR構築體，使用人EF1α啟動子進行表現。
SEQ ID NO：518(T1胺基酸序列)
Figure 109124309-A0202-12-0106-246
SEQ ID NO：519(T2胺基酸序列)
Figure 109124309-A0202-12-0106-247
SEQ ID NO：520(T3胺基酸序列)
Figure 109124309-A0202-12-0106-248
Figure 109124309-A0202-12-0107-249
活體外細胞毒性分析
在轉導後第9天，收穫轉導T細胞，且與表現DLL3之腫瘤細胞株(具有DLL3高表現之SHP-77、具有DLL3中等表現之NCI-H82及具有DLL3低表現之NCI-H2171)及DLL3陰性表現之細胞株(NCI-H460及HEK293)以0.5：1及2：1之效應細胞(CAR-T)與靶細胞比率共同培育22小時。在所有分析中CAR3 CAR-T細胞用作參考以比較分析變化，及/或充當對照。未轉導之T細胞(UnT)用作陰性對照。
通過乳酸去氫酶(LDH)分析來測定轉導T細胞之細胞毒性。結果表明，CAR3 CAR-T及一些抗DLL3串聯CAR-T在活體外展現強烈的針對SHP-77細胞之抗腫瘤活性，而UnT無靶細胞殺死作用(圖11A-C)且DLL3陰性表現細胞(NCI-H460及HEK293)不誘發細胞毒性(圖11D-E)。除CAR3之外，亦比較T3及1H2.1對SHP-77細胞之活體外細胞毒性。結果顯示在短期刺激中T3具有可比或不太有效之細胞殺死活性(圖11V)。
IFN-γ及TNF-α釋放之偵測
另外，自活體外細胞毒性分析收集上清液，以評定CAR誘發之細胞 介素釋放，例如干擾素γ(IFN-γ)及TNF-α釋放。如圖11F-K所示，CAR3 CAR-T及一些抗DLL3串聯CAR-T經表現DLL3之細胞株刺激，產生IFN-γ及TNF-α，而UnT幾乎不產生IFN-γ及TNF-α。DLL3陰性表現之細胞株不減少IFN-γ及TNF-α之特異性釋放(數據未示)。偵測IFN-γ及TNF-α釋放之方案可涉及CISBIO之人類TNF-α套組及IFN-γ套組。
與1H2.1相比，T3釋放更多IFN-γ及TNF-α(在共同培育22小時後)(圖11W-X)。
藉由長期刺激分析確定串聯CAR-T細胞毒性及擴增
藉由反復抗原刺激分析評估DLL3 CAR-T細胞。在經SCLC細胞株及對照細胞株反復刺激後，串聯CAR-T細胞T3顯示對SCLC細胞、尤其對SHP-77及NCI-H82細胞更有效之細胞毒性(圖11L-P)。除細胞毒活性外，串聯CAR-T細胞T3亦顯示比其他CART高之增殖能力，尤其在經SHP-77及NCI-H82細胞刺激時(圖11Q-U)。
除CAR3之外，亦比較T3及1H2.1對SHP-77細胞之活體外細胞毒性。結果表明，在長期刺激中T3具有優良細胞毒性及擴增(圖11Y-Z)。
如下進行反復刺激。
第1輪：將CAR-T細胞及3×105個靶細胞(例如SHP-77)以1：5之效應細胞與靶細胞比率添加至24孔盤中，且在二氧化碳培育箱中在37℃、5% CO2中共同培育3天。移取200μL細胞培養上清液偵測細胞介素，且收穫共同培育之細胞以藉由流式細胞術評定% CD3及CAR陽性率；
第2輪：基於第1輪中收穫之細胞之CAR-T陽性率，將收穫之細胞繼續與相同體積之新靶細胞(SHP-77)在1：2之效應細胞與靶細胞比率下又共同培育3天。移取200μL細胞培養上清液偵測細胞介素，且收穫共同培育之細胞以藉由流式細胞術評定% CD3及CAR陽性率； 基於先前每輪CAR-T陽性率，按與第2輪類似之方式進行第3輪及下一輪。
實例12.人類化抗DLL3 PD-1 DNR或CSR武裝之CAR-T細胞的活體內活性的評估
為提高CAR-T之持久性，構築PD-1顯性負性受體(PD-1DNR)或PD-1嵌合轉換受體(PD-1CSR)武裝之DLL3 CAR。兩種CAR之胺基酸序列提供於SEQ ID：521-522中。PD-1DNR及PD-1CSR序列經由P2A連接至T3 C末端。PD-1DNR及PD-1CRS之胺基酸序列提供於SEQ ID：523-524中。圖10B中示出CAR構築體的示意圖。
SEQ ID NO：521(T3-PD-1DNR胺基酸序列)
Figure 109124309-A0202-12-0109-250
Figure 109124309-A0202-12-0110-251
SEQ ID NO：522(T3-PD-1CSR胺基酸序列)
Figure 109124309-A0202-12-0110-252
SEQ ID NO：523(PD-1DNR胺基酸序列)
Figure 109124309-A0202-12-0110-253
SEQ ID NO：524(PD-1CSR胺基酸序列)
Figure 109124309-A0202-12-0111-254
藉由反復抗原刺激分析來評估PD-1DNR或PD-1CSR武裝之DLL3 CAR-T細胞。在經SHP-77細胞反復刺激後，與習知CART相比，武裝之CAR-T細胞未增加細胞毒性效力，且未提高擴增能力(圖12A-B)。在經SHP-77/PD-L1細胞(SHP-77細胞中過度表現人PD-L1)反復刺激後，PD-1 CSR武裝之CAR-T細胞顯示優良細胞毒性效力及擴增能力(圖12C-D)。
實例13.TGF-β-DNR增強DLL3 CAR-T細胞之抗腫瘤功效
TGF-β-DNR武裝之DLL3 CAR-T細胞的構築
為提高DLL3 CAR-T細胞在腫瘤微環境中之抗腫瘤效能，將TGF-β-DNR序列合併至DLL3 CAR中，如圖13A所示。TGF-β-DNR為TGFBRII之截短型式，其由TGFBRII之胞外域及跨膜域組成。構築體T3-P2A-TGF-β-DNR、T3-T2A-TGF-β-DNR包含N末端之T3-BBZ序列、如所指示之P2A或T2A肽、C末端之TGF-β-DNR；構築體TGF-β-DNR-P2A-T3及TGF-β-DNR-T2A-T3包含N末端之TGF-β-DNR序列、如所指示之P2A或T2A肽及C末端之T3-BBZ序列。TGF-β-DNR及武裝之DLL3 CAR的詳細序列提供於SEQ ID：525-529中。
SEQ ID NO：525(T3-P2A-TGF-β-DNR胺基酸序列)
Figure 109124309-A0202-12-0111-255
Figure 109124309-A0202-12-0112-256
SEQ ID NO：526(TGF-β-DNR-P2A-T3胺基酸序列)
Figure 109124309-A0202-12-0112-257
Figure 109124309-A0202-12-0113-258
SEQ ID NO：527(T3-T2A-TGF-β-DNR胺基酸序列)
Figure 109124309-A0202-12-0113-259
SEQ ID NO：528(TGF-β-DNR-T2A-T3胺基酸序列)
Figure 109124309-A0202-12-0113-261
Figure 109124309-A0202-12-0114-262
SEQ ID NO：529(TGF-β-DNR胺基酸序列)
Figure 109124309-A0202-12-0114-263
所有構築體包裝至基於第二代慢病毒系統之慢病毒中。然後將自健康供體之PBMC分離的初級T細胞用慢病毒轉導。轉導4天後，藉由FACS偵測sdAb及TGF-β-DNR之陽性率(圖13B)。結果顯示，T3-P2A-TGF-β-DNR、T3-T2A-TGF-β-DNR、TGF-β-DNR-P2A-T3及TGF-β-DNR-T2A-T3 CAR-T細胞之sdAb陽性率相當。然而，構築體T3-P2A-TGF-β-DNR及T3-T2A-TGF-β-DNR中TGF-β-DNR之陽性率高於TGF-β-DNR-P2A-T3及TGF-β-DNR-T2A-T3中。此等結果表明TGF-β-DNR在結合於CAR之C末端時表現較高。
活體外細胞毒性分析
接著藉由LDH或IFN-γ釋放分析評估此等CAR-T細胞之細胞毒性。轉導5天後，將CAR-T細胞調至未轉導T細胞(UnT)之相同sdAb陽性率。接著將CAR-T細胞或UnT細胞與SHP77在5ng/mL TGF-β存在下共同培育48小時，且量測LDH及IFN-γ釋放(圖13C-D)。結果顯示，TGF-β-DNR武裝之CAR-T細胞誘發比未武裝之CAR-T細胞更多的靶細胞特異性溶解。因此，TGF-β-DNR武裝之CAR-T細胞展示在抗原活化後較高的IFN-γ釋放能力。與不同CAR-T細胞之TGF-β-DNR表現水平一致，T3-P2A-TGF-β-DNR、T3-T2A-TGF-β-DNR顯示IFN-γ分泌水平高於TGF-β-DNR-P2A-T3及TGF-β-DNR-T2A-T3 CAR-T細胞。總言之，此等結果證明TGF-β-DNR能夠增強DLL3 CAR-T細胞針對DLL3陽性SCLC細胞之細胞毒性。
長期刺激分析
為確定TGF-β-DNR是否能抵抗TGF-β對CAR-T細胞之抑制作用，進行長期刺激分析。簡言之，在5ng/mL TGF-β存在或缺乏下將T3-P2A-TGF-β-DNR及T3 CAR-T細胞用SHP77細胞每3天反復激發。在每輪刺激結束時，藉由FACS分析全部活細胞之T細胞百分比，且計算CAR-T細胞之擴增。如圖13E及圖13F所示，TGF-β抑制T3 CAR-T細胞之持久性及擴增。相比之下，甚至在TGF-β存在下，T3-P2A-TGF-β-DNR之持久性及擴增亦維持得很好。在用SHP77細胞進行2輪刺激之後藉由FACS分析T細胞耗盡標記物。如圖13G所示，用TGF-β處理上調T3細胞中耗盡標記物之表現，但在T3-P2A-TGF-β-DNR CAR-T細胞中未上調。總之，此等結果證明TGF-β-DNR保護DLL3 CAR-T細胞避免被TGF-β抑制。因為在實體腫瘤之微環境中TGF-β之表現水平通常升高，所以結果表明TGF-β-DNR之添加提高DLL3 CAR-T細胞在實體腫瘤中之抗腫瘤功效。
活體內抗腫瘤功效研究
為進一步研究TGF-β-DNR是否可增強DLL3 CAR-T細胞在活體內之抗腫瘤功效，在異種移植模型中評估T3-T2A-TGF-β-DNR CAR-T細胞或親本CAR-T細胞。簡言之，將1×107個SHP77細胞皮下植入NCG小鼠中。在7-10天後，當腫瘤體積達到100-200mm3時，將2.5×105個CAR-T細胞靜脈內注入小鼠中。接著每週量測腫瘤體積兩次，且每週量測外周血中CAR-T之百分比一次。如圖13H所示，在次最佳劑量下，T3-T2A-TGF-β-DNR CAR-T細胞可有效抑制腫瘤生長，而親本T3 CAR-T不能。如圖13I所示，外周血白細胞中T3-T2A-TGF-β-DNR CAR-T之百分比高於T3。總之，此等結果證明TGF-β-DNR可增強DLL3 CAR-T細胞在活體內之抗腫瘤功效。 
				                         序列表
				<![CDATA[<110>  大陸商南京傳奇生物科技有限公司(NANJING LEGEND BIOTECH CO., LTD.)]]>
				<![CDATA[<120>  抗DLL3嵌合抗原受體及其用途]]>
				<![CDATA[<130>  P10444-PCT]]>
				<![CDATA[<140>  TW 109124309]]>
				<![CDATA[<141>  2020-07-17]]>
				<![CDATA[<150>  PCT/CN2020/090587]]>
				<![CDATA[<151>  2020-05-15]]>
				<![CDATA[<150>  PCT/CN2019/096360]]>
				<![CDATA[<151>  2019-07-17]]>
				<![CDATA[<160>  529   ]]>
				<![CDATA[<170>  PatentIn version 3.3]]>
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				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS64123 CDR1]]>
				<![CDATA[<400>  13]]>
				Gly Tyr Thr Tyr Thr Ser Asn Trp Leu Gly 
				1               5                   10  
				<![CDATA[<210>  14]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64130 CDR1]]>
				<![CDATA[<400>  14]]>
				Gly Tyr Thr Tyr Arg Ser Asn Phe Met Gly 
				1               5                   10  
				<![CDATA[<210>  15]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64137 CDR1]]>
				<![CDATA[<400>  15]]>
				Gly Ser Thr Tyr Ser Thr Asn Phe Met Gly 
				1               5                   10  
				<![CDATA[<210>  16]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64142 CDR1]]>
				<![CDATA[<400>  16]]>
				Gly Phe Thr Phe Asp Arg Asn Ala Met Arg 
				1               5                   10  
				<![CDATA[<210>  17]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64154 CDR1]]>
				<![CDATA[<400>  17]]>
				Gly Tyr Thr Tyr Arg Tyr Leu Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  18]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64160 CDR1]]>
				<![CDATA[<400>  18]]>
				Val Tyr Thr Ser Ser Ser Tyr Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  19]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64228 CDR1]]>
				<![CDATA[<400>  19]]>
				Gly Val Ser Tyr Asn Arg Cys Ser Met Gly 
				1               5                   10  
				<![CDATA[<210>  20]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64300 CDR1]]>
				<![CDATA[<400>  20]]>
				Gly Asp Ile Tyr Asn Leu Met Ser Met Ala 
				1               5                   10  
				<![CDATA[<210>  21]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380 CDR1]]>
				<![CDATA[<400>  21]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  22]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64395 CDR1]]>
				<![CDATA[<400>  22]]>
				Gly Ser Thr Tyr Ser Thr Asn Phe Met Gly 
				1               5                   10  
				<![CDATA[<210>  23]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64443 CDR1]]>
				<![CDATA[<400>  23]]>
				Gly Tyr Thr Asp Ser Ser Val Tyr Ile Gly 
				1               5                   10  
				<![CDATA[<210>  24]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511 CDR1]]>
				<![CDATA[<400>  24]]>
				Arg Ala Thr Tyr Ser Thr Asn Tyr Ile Ser 
				1               5                   10  
				<![CDATA[<210>  25]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64536 CDR1]]>
				<![CDATA[<400>  25]]>
				Arg Tyr Thr Asp Asn Phe Val Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  26]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64597 CDR1]]>
				<![CDATA[<400>  26]]>
				Gly Tyr Thr Tyr Arg Val Asn Phe Met Gly 
				1               5                   10  
				<![CDATA[<210>  27]]>
				<![CDATA[<211>  9]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64617 CDR1]]>
				<![CDATA[<400>  27]]>
				Gly Tyr Thr Asp Arg Cys Ser Met Ala 
				1               5                   
				<![CDATA[<210>  28]]>
				<![CDATA[<211>  12]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64634 CDR1]]>
				<![CDATA[<400>  28]]>
				Gly Tyr Ser Phe Arg Gly Asp Phe Met Cys Met Gly 
				1               5                   10          
				<![CDATA[<210>  29]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS69498 CDR1]]>
				<![CDATA[<400>  29]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Ala 
				1               5                   10  
				<![CDATA[<210>  30]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69500 CDR1]]>
				<![CDATA[<400>  30]]>
				Arg Tyr Thr Tyr Ser Ser Ala Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  31]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69527 CDR1]]>
				<![CDATA[<400>  31]]>
				Arg Tyr Thr Phe Ser Ser Thr Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  32]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS68280 CDR1]]>
				<![CDATA[<400>  32]]>
				Gly Ser Thr Tyr Ser Ser Asn Tyr Leu Gly 
				1               5                   10  
				<![CDATA[<210>  33]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68355 CDR1]]>
				<![CDATA[<400>  33]]>
				Gly Tyr Thr Tyr Ser Gly Val Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  34]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69443 CDR1]]>
				<![CDATA[<400>  34]]>
				Gly Phe Thr Phe Asp Asp Ser Asp Met Ala 
				1               5                   10  
				<![CDATA[<210>  35]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75376 CDR1]]>
				<![CDATA[<400>  35]]>
				Gly Tyr Thr Tyr Ser Ser His Ser Met Gly 
				1               5                   10  
				<![CDATA[<210>  36]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75387 CDR1]]>
				<![CDATA[<400>  36]]>
				Gly Tyr Pro Tyr Ser Ser Pro Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  37]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75695 CDR1]]>
				<![CDATA[<400>  37]]>
				Gly Tyr Thr Val Ser Ala Tyr Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  38]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76169 CDR1]]>
				<![CDATA[<400>  38]]>
				Gly Tyr Ile Tyr Ser Ser Phe Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  39]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63931 CDR1]]>
				<![CDATA[<400>  39]]>
				Phe Ser Gly Tyr Gly Val Ser Thr Met Ala 
				1               5                   10  
				<![CDATA[<210>  40]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63937 CDR1]]>
				<![CDATA[<400>  40]]>
				Gly Ser Thr Ile Ser Ser Arg Pro Met Ala 
				1               5                   10  
				<![CDATA[<210>  41]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63948 CDR1]]>
				<![CDATA[<400>  41]]>
				Gly Tyr Thr Tyr Arg Tyr Leu Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  42]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63956 CDR1]]>
				<![CDATA[<400>  42]]>
				Gly Phe Thr Tyr Ser Asn Cys Cys Met Arg 
				1               5                   10  
				<![CDATA[<210>  43]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63965 CDR1]]>
				<![CDATA[<400>  43]]>
				Gly Tyr Ser Ser Gly Ser Cys Arg Met Gly 
				1               5                   10  
				<![CDATA[<210>  44]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63993 CDR1]]>
				<![CDATA[<400>  44]]>
				Gly Phe Thr Phe Asp Asp Leu Val Met Ala 
				1               5                   10  
				<![CDATA[<210>  45]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63999 CDR1]]>
				<![CDATA[<400>  45]]>
				Gly Tyr Thr Tyr Ser Ser Asn Trp Met Gly 
				1               5                   10  
				<![CDATA[<210>  46]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64006 CDR1]]>
				<![CDATA[<400>  46]]>
				Gly Tyr Thr Gly Asp Thr Thr Tyr Ile Gly 
				1               5                   10  
				<![CDATA[<210>  47]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64057 CDR1]]>
				<![CDATA[<400>  47]]>
				Gly Phe Thr Phe Asp Arg Asn Ala Met Arg 
				1               5                   10  
				<![CDATA[<210>  48]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64060 CDR1]]>
				<![CDATA[<400>  48]]>
				Gly Ser Thr Tyr Cys Thr Tyr Arg Met Ser 
				1               5                   10  
				<![CDATA[<210>  49]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64071 CDR1]]>
				<![CDATA[<400>  49]]>
				Gly Asn Thr Tyr Arg Leu Asn Ser Met Gly 
				1               5                   10  
				<![CDATA[<210>  50]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64093 CDR1]]>
				<![CDATA[<400>  50]]>
				Arg Tyr Ile Tyr Gly Asn Asn Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  51]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64118 CDR1]]>
				<![CDATA[<400>  51]]>
				Gly Tyr Thr Tyr Ser Ala Cys Arg Met Ala 
				1               5                   10  
				<![CDATA[<210>  52]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64120 CDR1]]>
				<![CDATA[<400>  52]]>
				Arg Tyr Ile Tyr Gly Asn Asn Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  53]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64124 CDR1]]>
				<![CDATA[<400>  53]]>
				Thr Tyr Thr Pro Ser Asn Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  54]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64135 CDR1]]>
				<![CDATA[<400>  54]]>
				Thr Ser Thr Tyr Cys Arg Tyr Tyr Met Arg 
				1               5                   10  
				<![CDATA[<210>  55]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64163 CDR1]]>
				<![CDATA[<400>  55]]>
				Gly Tyr Arg Tyr Arg Trp Asn Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  56]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64182 CDR1]]>
				<![CDATA[<400>  56]]>
				Gly Gln Thr Ser Arg Tyr Leu Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  57]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64183 CDR1]]>
				<![CDATA[<400>  57]]>
				Gly His Thr Tyr Ser Ala Asn Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  58]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64207 CDR1]]>
				<![CDATA[<400>  58]]>
				Gly Tyr Thr Tyr Ser Ser Asn Phe Met Gly 
				1               5                   10  
				<![CDATA[<210>  59]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64276 CDR1]]>
				<![CDATA[<400>  59]]>
				Gly Tyr Thr Gly Ser Ser Arg Cys Met Ala 
				1               5                   10  
				<![CDATA[<210>  60]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64336 CDR1]]>
				<![CDATA[<400>  60]]>
				Gly Arg Thr Tyr Ser Ser Cys Ser Met Gly 
				1               5                   10  
				<![CDATA[<210>  61]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64346 CDR1]]>
				<![CDATA[<400>  61]]>
				Gly Tyr Thr Tyr Phe Met Gly 
				1               5           
				<![CDATA[<210>  62]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64420 CDR1]]>
				<![CDATA[<400>  62]]>
				Gly Asp Thr Ser Arg Ser Val Trp Met Gly 
				1               5                   10  
				<![CDATA[<210>  63]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64473 CDR1]]>
				<![CDATA[<400>  63]]>
				Gly Tyr Thr Tyr Arg Tyr Leu Tyr Met Ala 
				1               5                   10  
				<![CDATA[<210>  64]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64475 CDR1]]>
				<![CDATA[<400>  64]]>
				Gly Tyr Thr Trp Ser Arg Asn Trp Met Gly 
				1               5                   10  
				<![CDATA[<210>  65]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64513 CDR1]]>
				<![CDATA[<400>  65]]>
				Asp Tyr Pro Tyr Ile Asp Asn Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  66]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64562 CDR1]]>
				<![CDATA[<400>  66]]>
				Gly Tyr Thr Ala Arg Arg Asp Phe Met Ala 
				1               5                   10  
				<![CDATA[<210>  67]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64583 CDR1]]>
				<![CDATA[<400>  67]]>
				Gly Phe Thr Ile Ala Val Tyr Thr Met Gly 
				1               5                   10  
				<![CDATA[<210>  68]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64594 CDR1]]>
				<![CDATA[<400>  68]]>
				Gly Tyr Thr Tyr Asn Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  69]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64605 CDR1]]>
				<![CDATA[<400>  69]]>
				Arg Tyr Pro Tyr Ser Ser Ile Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  70]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64606 CDR1]]>
				<![CDATA[<400>  70]]>
				Gly Tyr Thr Ser Arg Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  71]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68121 CDR1]]>
				<![CDATA[<400>  71]]>
				Gly Tyr Thr Tyr Ser Arg Asn Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  72]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68170 CDR1]]>
				<![CDATA[<400>  72]]>
				Gly Tyr Thr Tyr Arg Ser Asn Cys Met Gly 
				1               5                   10  
				<![CDATA[<210>  73]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63964 CDR1]]>
				<![CDATA[<400>  73]]>
				Gly Tyr Thr Tyr Ser Tyr Asn Asn Met Gly 
				1               5                   10  
				<![CDATA[<210>  74]]>
				<![CDATA[<211>  8]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64116 CDR1]]>
				<![CDATA[<400>  74]]>
				Gly Tyr Ile Tyr Ser Cys Val Gly 
				1               5               
				<![CDATA[<210>  75]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68270 CDR1]]>
				<![CDATA[<400>  75]]>
				Gly Tyr Pro Ser Ser Thr Tyr Tyr Met Leu Ser Met Ala 
				1               5                   10              
				<![CDATA[<210>  76]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68320 CDR1]]>
				<![CDATA[<400>  76]]>
				Gly Tyr Thr Tyr Asn Thr Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  77]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68351 CDR1]]>
				<![CDATA[<400>  77]]>
				Gly Asp Thr Phe Arg Ala Tyr Tyr Met Asn 
				1               5                   10  
				<![CDATA[<210>  78]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75378 CDR1]]>
				<![CDATA[<400>  78]]>
				Gly Asn Thr Arg Ser Thr Thr Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  79]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75383 CDR1]]>
				<![CDATA[<400>  79]]>
				Gly Tyr Thr Phe Ser Ser Tyr Cys Leu Gly 
				1               5                   10  
				<![CDATA[<210>  80]]>
				<![CDATA[<211>  11]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75751 CDR1]]>
				<![CDATA[<400>  80]]>
				Gly Tyr Phe Tyr Asn Thr Tyr Tyr Phe Met Gly 
				1               5                   10      
				<![CDATA[<210>  81]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76422 CDR1]]>
				<![CDATA[<400>  81]]>
				Gly Tyr Thr Phe Ala Gly Asn Cys Leu Gly 
				1               5                   10  
				<![CDATA[<210>  82]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63930 CDR2]]>
				<![CDATA[<400>  82]]>
				Val Val Tyr Asn Ile Asp Gly Gly Gly Arg Phe Thr Thr Tyr Ala Asp 
				1               5                   10                  15      
				Ser Val Lys Gly 
				            20  
				<![CDATA[<210>  83]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63932 CDR2]]>
				<![CDATA[<400>  83]]>
				Val Ile Tyr Thr Gly Gly Gly Ser Thr Trp Tyr Ala Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  84]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63951 CDR2]]>
				<![CDATA[<400>  84]]>
				Ser Ile Tyr Pro Ala Gly Gly Arg Pro Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  85]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63984 CDR2]]>
				<![CDATA[<400>  85]]>
				Thr Ile Val Ser Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  86]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63987 CDR2]]>
				<![CDATA[<400>  86]]>
				Val Ile Tyr Thr Pro Ser Gly Ile Thr Asp Tyr Ala Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  87]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997 CDR2]]>
				<![CDATA[<400>  87]]>
				Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  88]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64047 CDR2]]>
				<![CDATA[<400>  88]]>
				Ala Val Tyr Thr Gly Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  89]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64052 CDR2]]>
				<![CDATA[<400>  89]]>
				Thr Ile His Ser Gly Val Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  90]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64062 CDR2]]>
				<![CDATA[<400>  90]]>
				Ala Leu Tyr Thr Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  91]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64072 CDR2]]>
				<![CDATA[<400>  91]]>
				Ala His Gly Pro Val Ser Gly Thr Ala Tyr Tyr Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  92]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64097 CDR2]]>
				<![CDATA[<400>  92]]>
				Ala Ile Asn Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Leu Glu 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  93]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64114 CDR2]]>
				<![CDATA[<400>  93]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  94]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64123 CDR2]]>
				<![CDATA[<400>  94]]>
				Ile Ile Tyr Thr Gly Ser Gly Ser Thr His Tyr Arg Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  95]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64130 CDR2]]>
				<![CDATA[<400>  95]]>
				Thr Ile Asp Ser Arg Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  96]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64137 CDR2]]>
				<![CDATA[<400>  96]]>
				Thr Leu Val Thr Trp Val Glu Arg Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  97]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64142 CDR2]]>
				<![CDATA[<400>  97]]>
				Cys Ile Asp Trp Thr Gly Ala Asn Ile Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  98]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64154 CDR2]]>
				<![CDATA[<400>  98]]>
				Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  99]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64160 CDR2]]>
				<![CDATA[<400>  99]]>
				Ala Met Cys Phe Gly Gly Leu Val Thr His Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  100]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64228 CDR2]]>
				<![CDATA[<400>  100]]>
				Arg Ile Gln Pro Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  101]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64300 CDR2]]>
				<![CDATA[<400>  101]]>
				Tyr Ile Asn Thr Ile Ile Gly Asn Thr Tyr Tyr Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  102]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380 CDR2]]>
				<![CDATA[<400>  102]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  103]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64395 CDR2]]>
				<![CDATA[<400>  103]]>
				Thr Leu Val Thr Trp Ala Glu Arg Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  104]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64443 CDR2]]>
				<![CDATA[<400>  104]]>
				Ile Ile Tyr Thr Gly Gly Glu Ser Thr His Tyr Arg Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  105]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511 CDR2]]>
				<![CDATA[<400>  105]]>
				Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  106]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64536 CDR2]]>
				<![CDATA[<400>  106]]>
				Leu Ile Tyr Pro Gly Gly Gly Ser Thr Tyr Tyr Ala Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  107]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64597 CDR2]]>
				<![CDATA[<400>  107]]>
				Thr Ile Asp Ser Gly Val Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  108]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS64617 CDR2]]>
				<![CDATA[<400>  108]]>
				Arg Ile Ser Thr Ser Gly Phe Thr Asn Tyr Ala Ala Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  109]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64634 CDR2]]>
				<![CDATA[<400>  109]]>
				Val Phe Tyr Pro Gly Gly Gly Ser Thr Asn Tyr Ala Asp Ser Ala Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  110]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69498 CDR2]]>
				<![CDATA[<400>  110]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Ile Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  111]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69500 CDR2]]>
				<![CDATA[<400>  111]]>
				Ser Ile Phe Thr Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
				1               5                   10                  15      
				Lys Gly 
				<![CDATA[<210>  112]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69527 CDR2]]>
				<![CDATA[<400>  112]]>
				Ala Ile Tyr Thr Asp Asp Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  113]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68280 CDR2]]>
				<![CDATA[<400>  113]]>
				Ala Ile Ser Thr Gly Asp Gly Ala Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  114]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68355 CDR2]]>
				<![CDATA[<400>  114]]>
				Ala Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  115]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69443 CDR2]]>
				<![CDATA[<400>  115]]>
				Thr Ile Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  116]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75376 CDR2]]>
				<![CDATA[<400>  116]]>
				Val Ile Tyr Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  117]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75387 CDR2]]>
				<![CDATA[<400>  117]]>
				Val Ala Tyr Thr Gly Gly Asp Ile Gln Tyr Leu Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  118]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75695 CDR2]]>
				<![CDATA[<400>  118]]>
				Phe Ile Asp Ala Gly Gly Ala Thr Ile Tyr Ala Asp Pro Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  119]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76169 CDR2]]>
				<![CDATA[<400>  119]]>
				Tyr Ile Arg Asp Asn Ile Met Thr Ser Tyr Thr Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  120]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63931 CDR2]]>
				<![CDATA[<400>  120]]>
				Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Thr 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  121]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63937 CDR2]]>
				<![CDATA[<400>  121]]>
				Cys Ile His Thr Gly Leu Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  122]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63948 CDR2]]>
				<![CDATA[<400>  122]]>
				Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  123]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63956 CDR2]]>
				<![CDATA[<400>  123]]>
				Leu Ile Asn Ser Ser Gly Gly Thr Tyr Tyr Ala Asp Ser Val Arg Gly 
				1               5                   10                  15      
				<![CDATA[<210>  124]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63965 CDR2]]>
				<![CDATA[<400>  124]]>
				Lys Val Ile Ser Asp Gly Thr Thr Val Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  125]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63993 CDR2]]>
				<![CDATA[<400>  125]]>
				Leu Val Ala Thr Ala Gly Asn Ser Val Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  126]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63999 CDR2]]>
				<![CDATA[<400>  126]]>
				Ile Ile Tyr Thr Gly Gly Ile Ser Thr His Tyr Arg Ser Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  127]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64006 CDR2]]>
				<![CDATA[<400>  127]]>
				Leu Ile Tyr Thr Ser Gly Thr Ser Glu Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  128]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64057 CDR2]]>
				<![CDATA[<400>  128]]>
				Cys Ile Ser Trp Thr Gly Ala Asn Ile Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  129]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64060 CDR2]]>
				<![CDATA[<400>  129]]>
				Val Ile Asp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  130]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64071 CDR2]]>
				<![CDATA[<400>  130]]>
				Phe Ile Val Met Ile Arg Gly Thr Thr Tyr Tyr Gly Ala Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  131]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64093 CDR2]]>
				<![CDATA[<400>  131]]>
				Ser Ile Tyr Pro Ala Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  132]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64118 CDR2]]>
				<![CDATA[<400>  132]]>
				Phe Ile Asn Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  133]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64120 CDR2]]>
				<![CDATA[<400>  133]]>
				Ser Ile Tyr Pro Ala Gly Gly Arg Pro Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  134]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64124 CDR2]]>
				<![CDATA[<400>  134]]>
				Ala Ile Ala Thr Ile Gly Gly Thr Thr Arg Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  135]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64135 CDR2]]>
				<![CDATA[<400>  135]]>
				Ala Met Gln Pro Asp Gly Thr Thr Ser Tyr Ser Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  136]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64163 CDR2]]>
				<![CDATA[<400>  136]]>
				Ala Ile Ser Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Gly Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  137]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64182 CDR2]]>
				<![CDATA[<400>  137]]>
				Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  138]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS64183 CDR2]]>
				<![CDATA[<400>  138]]>
				Ser Val Tyr Thr Asp Asp Asp Ser Thr Met Tyr Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  139]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64207 CDR2]]>
				<![CDATA[<400>  139]]>
				Thr Ile Val Ser Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  140]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64276 CDR2]]>
				<![CDATA[<400>  140]]>
				Gln Ile Phe Thr Gly Arg Gly Thr Thr Gly Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  141]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64336 CDR2]]>
				<![CDATA[<400>  141]]>
				His Ile Phe Ser Asp Gly Ser Arg Tyr Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  142]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64346 CDR2]]>
				<![CDATA[<400>  142]]>
				Thr Ile Gly Thr Gly Asp Ile Phe Asn Gly Ala Ala Tyr Tyr Val Asp 
				1               5                   10                  15      
				Ser Val Lys Gly 
				            20  
				<![CDATA[<210>  143]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64420 CDR2]]>
				<![CDATA[<400>  143]]>
				Thr Ile Ser Thr Ala Gly Gly Ser Thr Trp Tyr Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  144]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64473 CDR2]]>
				<![CDATA[<400>  144]]>
				Cys Ile Tyr Thr Gly Ser Gly Thr Thr Gly Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  145]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64475 CDR2]]>
				<![CDATA[<400>  145]]>
				Thr Ile Thr Ile Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  146]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64513 CDR2]]>
				<![CDATA[<400>  146]]>
				Ala Ala Cys Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  147]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64562 CDR2]]>
				<![CDATA[<400>  147]]>
				Val Ile His Thr Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  148]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64583 CDR2]]>
				<![CDATA[<400>  148]]>
				Cys Thr Ser Trp Ala Gly Gly Arg Thr Tyr Thr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  149]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64594 CDR2]]>
				<![CDATA[<400>  149]]>
				Leu Ile Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  150]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64605 CDR2]]>
				<![CDATA[<400>  150]]>
				Arg Ile Tyr Thr Gly Thr Gly Ser Thr Trp Tyr Thr Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  151]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64606 CDR2]]>
				<![CDATA[<400>  151]]>
				Ala Phe Tyr Leu Ile Tyr Thr Arg Gly Gly Ser Thr Tyr Tyr Ala Ser 
				1               5                   10                  15      
				Ser Val Lys Gly 
				            20  
				<![CDATA[<210>  152]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68121 CDR2]]>
				<![CDATA[<400>  152]]>
				Thr Asp Tyr Ile Arg Phe Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  153]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68170 CDR2]]>
				<![CDATA[<400>  153]]>
				Thr Ile Tyr Thr Gly Gly Gly Arg Asn Leu Tyr Tyr Ala Asp Ser Val 
				1               5                   10                  15      
				Lys Gly 
				<![CDATA[<210>  154]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63964 CDR2]]>
				<![CDATA[<400>  154]]>
				Ala Ile Ser Gly Gly Arg Phe Thr Ala Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  155]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64116 CDR2]]>
				<![CDATA[<400>  155]]>
				Gly Ile Ser Thr Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  156]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68270 CDR2]]>
				<![CDATA[<400>  156]]>
				Ala Ile Thr Ser Gly Thr Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Asp 
				<![CDATA[<210>  157]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68320 CDR2]]>
				<![CDATA[<400>  157]]>
				Ala Ile Tyr Arg His Ser Gly Asn Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  158]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68351 CDR2]]>
				<![CDATA[<400>  158]]>
				Gly Ile Ser Ala Ser Gly Gly Arg Thr Ser Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  159]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75378 CDR2]]>
				<![CDATA[<400>  159]]>
				Ile Val Tyr Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Ala Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  160]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75383 CDR2]]>
				<![CDATA[<400>  160]]>
				Thr Phe Asn Asn Arg Gly Val Ala Asn Tyr His Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  161]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75751 CDR2]]>
				<![CDATA[<400>  161]]>
				Ala Ile Asp Thr Asp Gly Arg Thr Ser Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  162]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76422 CDR2]]>
				<![CDATA[<400>  162]]>
				Thr Tyr Asn Asn Phe Gly Val Ala Asn Tyr Ala Asp Ser Val Lys Gly 
				1               5                   10                  15      
				<![CDATA[<210>  163]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63930 CDR3]]>
				<![CDATA[<400>  163]]>
				Glu Val Ala Asp Pro Thr Trp Gly Ser Arg Asp Gln Arg Arg Tyr Lys 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  164]]>
				<![CDATA[<211>  9]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63932  CDR3]]>
				<![CDATA[<400>  164]]>
				Arg Tyr Gly Ser Gly Asn Val Asn Tyr 
				1               5                   
				<![CDATA[<210>  165]]>
				<![CDATA[<211>  21]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63951  CDR3]]>
				<![CDATA[<400>  165]]>
				Arg Ser Phe Ser Ile Ala Val Cys Ala Thr Arg Ser Gly Ile Thr Arg 
				1               5                   10                  15      
				Ser Asn Phe Ala Tyr 
				            20      
				<![CDATA[<210>  166]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63984  CDR3]]>
				<![CDATA[<400>  166]]>
				Gly Gly Pro Val Thr Asn Ala Pro Arg Trp Tyr Pro Leu Arg Pro Pro 
				1               5                   10                  15      
				Gly Tyr Asn Tyr 
				            20  
				<![CDATA[<210>  167]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63987  CDR3]]>
				<![CDATA[<400>  167]]>
				Asp Arg Pro Phe Val Cys Asn Ile Ala Asn Met Arg Arg Ser Ser Asn 
				1               5                   10                  15      
				<![CDATA[<210>  168]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997  CDR3]]>
				<![CDATA[<400>  168]]>
				Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr Asn Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  169]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64047  CDR3]]>
				<![CDATA[<400>  169]]>
				Gly Phe Val Ser Gly Gly Arg Trp Asn Gln Ser Tyr Arg Tyr Lys Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  170]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64052  CDR3]]>
				<![CDATA[<400>  170]]>
				Gly Gly Pro Pro Ala Asn Ala Asp Arg Trp Tyr Pro Leu Arg Pro Pro 
				1               5                   10                  15      
				Gly Tyr Asn Tyr 
				            20  
				<![CDATA[<210>  171]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64062  CDR3]]>
				<![CDATA[<400>  171]]>
				Val Val Pro Arg Gly Gly Ser Cys Arg Leu Asp Glu Arg Gly Tyr Tyr 
				1               5                   10                  15      
				His 
				<![CDATA[<210>  172]]>
				<![CDATA[<211>  14]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64072  CDR3]]>
				<![CDATA[<400>  172]]>
				Glu Thr Thr Met Gly Trp Ala His Glu Arg Gly Tyr Arg Tyr 
				1               5                   10                  
				<![CDATA[<210>  173]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64097  CDR3]]>
				<![CDATA[<400>  173]]>
				Gly Pro Asp Leu Gly Gly Ser Trp Cys Arg Pro Val Glu Arg Ala Phe 
				1               5                   10                  15      
				Thr Tyr 
				<![CDATA[<210>  174]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64114  CDR3]]>
				<![CDATA[<400>  174]]>
				Ala Ser Arg His Arg Leu Arg Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  175]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64123  CDR3]]>
				<![CDATA[<400>  175]]>
				Arg Phe Ser Glu Tyr Asn Tyr 
				1               5           
				<![CDATA[<210>  176]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64130  CDR3]]>
				<![CDATA[<400>  176]]>
				Gly Gly Pro Arg Thr Asn Asp Asp Arg Trp Tyr Pro Leu Arg Pro Pro 
				1               5                   10                  15      
				Gly Tyr Asn Tyr 
				            20  
				<![CDATA[<210>  177]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64137  CDR3]]>
				<![CDATA[<400>  177]]>
				Ala Ala Ala Ser Thr Asp Val Arg Leu Leu Asp Pro Gly Asp Phe Ala 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  178]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64142  CDR3]]>
				<![CDATA[<400>  178]]>
				Asp Thr Thr Ser Gly Tyr Cys Ser Gly Phe Trp Ser Thr Ser Arg Tyr 
				1               5                   10                  15      
				Ser 
				<![CDATA[<210>  179]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64154  CDR3]]>
				<![CDATA[<400>  179]]>
				Ser Ser Pro Arg Trp Gly Gly Thr Cys Arg Arg Trp Ser Gln Tyr Asn 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  180]]>
				<![CDATA[<211>  19]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64160  CDR3]]>
				<![CDATA[<400>  180]]>
				Asp Phe Gly Arg Asp Lys Asn Tyr Leu Arg Pro Leu Leu Pro His Ala 
				1               5                   10                  15      
				Tyr Asn Tyr 
				<![CDATA[<210>  181]]>
				<![CDATA[<211>  9]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64228 CDR3]]>
				<![CDATA[<400>  181]]>
				Leu Cys Trp Arg Glu Asn Val Asn Tyr 
				1               5                   
				<![CDATA[<210>  182]]>
				<![CDATA[<211>  15]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64300 CDR3]]>
				<![CDATA[<400>  182]]>
				Phe Asn Tyr Gly Gly Ala Trp Tyr Glu Glu Arg Ser Tyr Lys Tyr 
				1               5                   10                  15  
				<![CDATA[<210>  183]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380 CDR3]]>
				<![CDATA[<400>  183]]>
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  184]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64395 CDR3]]>
				<![CDATA[<400>  184]]>
				Ala Ala Ser Thr Ala Val Arg Leu Leu Asp Pro Gly Asp Phe Ala Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  185]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64443 CDR3]]>
				<![CDATA[<400>  185]]>
				Arg Phe Pro Ala Val Thr Tyr 
				1               5           
				<![CDATA[<210>  186]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511 CDR3]]>
				<![CDATA[<400>  186]]>
				Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe Arg Ala 
				1               5                   10                  15      
				<![CDATA[<210>  187]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64536 CDR3]]>
				<![CDATA[<400>  187]]>
				Lys Trp Gly Leu Gly Gly Gly Gly Leu Lys Ser Asp Thr Tyr Met Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  188]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64597 CDR3]]>
				<![CDATA[<400>  188]]>
				Gly Gly Pro Pro Thr Asp Gly Asp Arg Trp Tyr Pro Leu Arg Pro Pro 
				1               5                   10                  15      
				Gly Tyr Asn Tyr 
				            20  
				<![CDATA[<210>  189]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64617 CDR3]]>
				<![CDATA[<400>  189]]>
				Ile Val Gly Arg Thr Cys Ser Leu Asn Tyr 
				1               5                   10  
				<![CDATA[<210>  190]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64634 CDR3]]>
				<![CDATA[<400>  190]]>
				Arg Arg Trp Val Ser Gly Thr Cys Tyr Trp Asp Ser Asp Phe His Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  191]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69498 CDR3]]>
				<![CDATA[<400>  191]]>
				Ser Ser Arg His Arg Leu Arg Leu Ser Asp Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  192]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69500 CDR3]]>
				<![CDATA[<400>  192]]>
				Arg Ala Phe Gln Val Gly Tyr Cys Tyr Leu Arg Thr Asp Val Tyr Asn 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  193]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69527 CDR3]]>
				<![CDATA[<400>  193]]>
				Arg Arg Trp Ala Cys Pro Arg Val Gly Ser Trp His Glu Phe Ala Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  194]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68280 CDR3]]>
				<![CDATA[<400>  194]]>
				Ala Arg Gly Arg Phe Ile Asp Trp Thr Lys Ala Thr Gln Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  195]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68355 CDR3]]>
				<![CDATA[<400>  195]]>
				Ala Ile Val Gly Gly Phe Asn Ala Tyr Cys Ser Gly Gly Tyr Val Leu 
				1               5                   10                  15      
				Asp Phe Gly Ala 
				            20  
				<![CDATA[<210>  196]]>
				<![CDATA[<211>  24]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS69443 CDR3]]>
				<![CDATA[<400>  196]]>
				Asp Phe Leu Thr Gly Phe Tyr Tyr Ser Asp Ser Pro His Pro Ala Pro 
				1               5                   10                  15      
				Cys Ser Ala Ser Asp Phe Gly Tyr 
				            20                  
				<![CDATA[<210>  197]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75376 CDR3]]>
				<![CDATA[<400>  197]]>
				Asp Pro Asn Pro Asp Tyr Met Leu Pro Phe Arg Pro Ser Arg Arg Ser 
				1               5                   10                  15      
				Trp 
				<![CDATA[<210>  198]]>
				<![CDATA[<211>  14]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75387 CDR3]]>
				<![CDATA[<400>  198]]>
				Asp Leu Arg Leu Pro Arg Ala Gly Gly Cys Ala Tyr Ser Tyr 
				1               5                   10                  
				<![CDATA[<210>  199]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75695 CDR3]]>
				<![CDATA[<400>  199]]>
				Asp Arg Arg Gly Arg Val Arg Arg Cys Glu Tyr Asn Ala 
				1               5                   10              
				<![CDATA[<210>  200]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76169 CDR3]]>
				<![CDATA[<400>  200]]>
				Asp Arg Gly Gly Tyr Ala Asn Ser Cys Ala Val Ala Ala Arg Tyr Asp 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  201]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63931 CDR3]]>
				<![CDATA[<400>  201]]>
				Gly Trp Leu Ser Gly Gly Ser Trp His Val Pro Gly Arg Tyr Asn Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  202]]>
				<![CDATA[<211>  14]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63937 CDR3]]>
				<![CDATA[<400>  202]]>
				Asp Ser Arg Arg Pro Cys Met Val Ala Ala Gly Tyr Thr Tyr 
				1               5                   10                  
				<![CDATA[<210>  203]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63948 CDR3]]>
				<![CDATA[<400>  203]]>
				Ala Ser Pro Arg Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu Tyr Asn 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  204]]>
				<![CDATA[<211>  15]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63956 CDR3]]>
				<![CDATA[<400>  204]]>
				Tyr Gln Ala Lys Tyr Cys Ser Gly Pro Cys Ala Pro Pro Thr Asp 
				1               5                   10                  15  
				<![CDATA[<210>  205]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63965 CDR3]]>
				<![CDATA[<400>  205]]>
				Trp Cys Arg Glu Tyr Pro Gly Gly Ile Leu Asn Asn Gly 
				1               5                   10              
				<![CDATA[<210>  206]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63993 CDR3]]>
				<![CDATA[<400>  206]]>
				Arg Thr Asp Ser Glu His Ala Phe Lys Phe 
				1               5                   10  
				<![CDATA[<210>  207]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63999 CDR3]]>
				<![CDATA[<400>  207]]>
				Arg Tyr Thr Asp Tyr Asn Tyr 
				1               5           
				<![CDATA[<210>  208]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS64006 CDR3]]>
				<![CDATA[<400>  208]]>
				Arg Ser Arg Thr Met Met Tyr 
				1               5           
				<![CDATA[<210>  209]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64057 CDR3]]>
				<![CDATA[<400>  209]]>
				Asp Thr Thr Ser Gly Ser Cys Ser Gly Phe Trp Ser Thr Ser Arg Tyr 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  210]]>
				<![CDATA[<211>  14]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64060 CDR3]]>
				<![CDATA[<400>  210]]>
				Asp Pro Thr Ile Gly Cys Pro Gln Thr Tyr Arg Tyr Asn Tyr 
				1               5                   10                  
				<![CDATA[<210>  211]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64071 CDR3]]>
				<![CDATA[<400>  211]]>
				Ser Thr Lys Asp Gln Phe Tyr Val Phe Asn Pro Ile Gly Tyr Asp Ser 
				1               5                   10                  15      
				<![CDATA[<210>  212]]>
				<![CDATA[<211>  21]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64093 CDR3]]>
				<![CDATA[<400>  212]]>
				Arg Ser Phe Ser Ile Gly Val Cys Ala Thr Gln Ser Gly Ile Thr Trp 
				1               5                   10                  15      
				Ser Asn Phe Ala Tyr 
				            20      
				<![CDATA[<210>  213]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64118 CDR3]]>
				<![CDATA[<400>  213]]>
				Thr Trp Asp Ser Ser Cys Arg Phe Gln Tyr 
				1               5                   10  
				<![CDATA[<210>  214]]>
				<![CDATA[<211>  21]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64120 CDR3]]>
				<![CDATA[<400>  214]]>
				Arg Ser Phe Ser Ile Ala Asp Cys Ala Thr Gln Ser Gly Ile Thr Arg 
				1               5                   10                  15      
				Ser Asn Phe Ala Tyr 
				            20      
				<![CDATA[<210>  215]]>
				<![CDATA[<211>  19]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64124 CDR3]]>
				<![CDATA[<400>  215]]>
				Gly Arg Pro Tyr Ser Leu Pro Leu Pro Leu Pro Leu Glu Ser Gly Ala 
				1               5                   10                  15      
				Tyr Arg Tyr 
				<![CDATA[<210>  216]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64135 CDR3]]>
				<![CDATA[<400>  216]]>
				Asp Pro Met Gly Gly Ser Arg Thr Pro Cys Thr Ser Ala 
				1               5                   10              
				<![CDATA[<210>  217]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64163 CDR3]]>
				<![CDATA[<400>  217]]>
				Asp Pro Ser Val Cys Pro Gly Gly Met Trp Tyr Ser Lys Glu Tyr Arg 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  218]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64182 CDR3]]>
				<![CDATA[<400>  218]]>
				Ser Ser Pro His Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu Tyr Lys 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  219]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64183 CDR3]]>
				<![CDATA[<400>  219]]>
				Asp Leu Ser Gly Gly Pro Ala Gly Cys Gly Tyr Thr His 
				1               5                   10              
				<![CDATA[<210>  220]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64207 CDR3]]>
				<![CDATA[<400>  220]]>
				Gly Gly Pro Pro Thr Asn Gly Ala Lys Trp Tyr Pro Leu Arg Pro Pro 
				1               5                   10                  15      
				Gly Tyr Asn Tyr 
				            20  
				<![CDATA[<210>  221]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64276 CDR3]]>
				<![CDATA[<400>  221]]>
				Ser Leu Gly Pro Gly Arg Gly Ala Cys Gly Tyr Asn Tyr 
				1               5                   10              
				<![CDATA[<210>  222]]>
				<![CDATA[<211>  13]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64336 CDR3]]>
				<![CDATA[<400>  222]]>
				Arg Thr Gly Trp Ala Pro Arg Cys Ala Val Pro Gly Tyr 
				1               5                   10              
				<![CDATA[<210>  223]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64346 CDR3]]>
				<![CDATA[<400>  223]]>
				Val Gln Ser Lys Ser Ser Asn Tyr Val Leu Arg Asp Ala Ser Thr Tyr 
				1               5                   10                  15      
				Asn Tyr 
				<![CDATA[<210>  224]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64420 CDR3]]>
				<![CDATA[<400>  224]]>
				Arg Ser Arg Tyr Ala Thr Tyr 
				1               5           
				<![CDATA[<210>  225]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64473 CDR3]]>
				<![CDATA[<400>  225]]>
				Ser Ser Pro Gln Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu Tyr Asn 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  226]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64475 CDR3]]>
				<![CDATA[<400>  226]]>
				Arg Asp Thr Ala Arg Thr Tyr 
				1               5           
				<![CDATA[<210>  227]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64513 CDR3]]>
				<![CDATA[<400>  227]]>
				Gly Tyr Tyr Ser Gly Ser Gly Pro Gly Tyr Leu Leu Pro Trp Arg Tyr 
				1               5                   10                  15      
				Asn Tyr 
				<![CDATA[<210>  228]]>
				<![CDATA[<211>  22]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220> ]]>
				<![CDATA[<223>  AS64562 CDR3]]>
				<![CDATA[<400>  228]]>
				Gly Phe Arg Pro Arg Gly Gly Gly Tyr Thr Gly Asp Val Leu Ala Gln 
				1               5                   10                  15      
				Ala Ala Ala Tyr Asn Tyr 
				            20          
				<![CDATA[<210>  229]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64583 CDR3]]>
				<![CDATA[<400>  229]]>
				Lys Ala His Pro Asp Cys Ser Gly Asp Trp Ser Pro Ser Gly Tyr Glu 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  230]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64594 CDR3]]>
				<![CDATA[<400>  230]]>
				Arg Thr Gln Thr Arg Asn Tyr 
				1               5           
				<![CDATA[<210>  231]]>
				<![CDATA[<211>  22]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64605 CDR3]]>
				<![CDATA[<400>  231]]>
				Arg Ser Asn Ser Tyr Ser Tyr Ser Ser Cys Asp Tyr Gly Pro Leu Thr 
				1               5                   10                  15      
				Arg Gly Gly Tyr Asn Phe 
				            20          
				<![CDATA[<210>  232]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64606 CDR3]]>
				<![CDATA[<400>  232]]>
				Arg Leu Asp Glu Lys Met Tyr 
				1               5           
				<![CDATA[<210>  233]]>
				<![CDATA[<211>  21]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68121 CDR3]]>
				<![CDATA[<400>  233]]>
				Asp Pro Gly Ser Arg Thr Asp Asp Ser Cys Gly Thr Ser Tyr Asn Lys 
				1               5                   10                  15      
				Gly Asn Phe Gly Tyr 
				            20      
				<![CDATA[<210>  234]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68170 CDR3]]>
				<![CDATA[<400>  234]]>
				Ala Ser Asp Val Ala Val Gly Val Asn Ser Cys Gly Gly Arg Thr Ala 
				1               5                   10                  15      
				Gly Phe Asp Ala 
				            20  
				<![CDATA[<210>  235]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63964 CDR3]]>
				<![CDATA[<400>  235]]>
				Glu Val Val Asp Pro Thr Trp Gly Ser Arg Asp Gln Arg Arg Tyr Lys 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  236]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64116 CDR3]]>
				<![CDATA[<400>  236]]>
				Asp Arg Trp Asn Ser Phe Ala Asn Cys Gly Ala Trp Gly Arg Tyr Thr 
				1               5                   10                  15      
				Tyr 
				<![CDATA[<210>  237]]>
				<![CDATA[<211>  18]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68270 CDR3]]>
				<![CDATA[<400>  237]]>
				Ala Ser Gly Trp Ile Val Pro Ser Arg Ser Leu Thr Ala Asn Leu Tyr 
				1               5                   10                  15      
				Arg Tyr 
				<![CDATA[<210>  238]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68320 CDR3]]>
				<![CDATA[<400>  238]]>
				Gly Arg Ala Gly Pro Trp Ala Leu Met Arg Pro Thr Glu Phe Gly Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  239]]>
				<![CDATA[<211>  14]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS68351 CDR3]]>
				<![CDATA[<400>  239]]>
				Gly Ala Val Arg Leu Ser Thr Ser Ser Val Arg Asp Ser Ser 
				1               5                   10                  
				<![CDATA[<210>  240]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75378 CDR3]]>
				<![CDATA[<400>  240]]>
				Arg Ser Tyr Glu Tyr Thr Tyr 
				1               5           
				<![CDATA[<210>  241]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75383 CDR3]]>
				<![CDATA[<400>  241]]>
				Asp Arg Arg Tyr Gly Arg Gln Trp Tyr Gln Pro Cys Glu Trp Asn Thr 
				1               5                   10                  15      
				<![CDATA[<210>  242]]>
				<![CDATA[<211>  20]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS75751 CDR3]]>
				<![CDATA[<400>  242]]>
				Gly Phe Gly Tyr Met Asn Val Ile Gln Ala Leu Asn Gly Met Arg Gln 
				1               5                   10                  15      
				Asn Pro Asp Tyr 
				            20  
				<![CDATA[<210>  243]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS76422 CDR3]]>
				<![CDATA[<400>  243]]>
				Asp Arg Arg Asp Gly Arg Arg Trp Ser Gln Pro Cys Glu Trp Asn Thr 
				1               5                   10                  15      
				<![CDATA[<210>  244]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH4 CDR1]]>
				<![CDATA[<400>  244]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  245]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH5 CDR1]]>
				<![CDATA[<400>  245]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  246]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH6 CDR1]]>
				<![CDATA[<400>  246]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  247]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH7 CDR1]]>
				<![CDATA[<400>  247]]>
				Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				1               5                   10  
				<![CDATA[<210>  248]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH4 CDR1]]>
				<![CDATA[<400>  248]]>
				Arg Ala Thr Tyr Ser Thr Asn Tyr Ile Ser 
				1               5                   10  
				<![CDATA[<210>  249]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH5 CDR1]]>
				<![CDATA[<400>  249]]>
				Arg Ala Thr Tyr Ser Thr Asn Tyr Ile Ser 
				1               5                   10  
				<![CDATA[<210>  250]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH6 CDR1]]>
				<![CDATA[<400>  250]]>
				Arg Ala Thr Tyr Ser Thr Asn Tyr Ile Ser 
				1               5                   10  
				<![CDATA[<210>  251]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH4 CDR1]]>
				<![CDATA[<400>  251]]>
				Phe Ser Gly Tyr Gly Val Ser Thr Met Ala 
				1               5                   10  
				<![CDATA[<210>  252]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH5 CDR1]]>
				<![CDATA[<400>  252]]>
				Phe Ser Gly Tyr Gly Val Ser Thr Met Ala 
				1               5                   10  
				<![CDATA[<210>  253]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH6 CDR1]]>
				<![CDATA[<400>  253]]>
				Phe Ser Gly Tyr Gly Val Ser Thr Met Ala 
				1               5                   10  
				<![CDATA[<210>  254]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH4 CDR2]]>
				<![CDATA[<400>  254]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  255]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH5 CDR2]]>
				<![CDATA[<400>  255]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  256]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH6 CDR2]]>
				<![CDATA[<400>  256]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  257]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH7 CDR2]]>
				<![CDATA[<400>  257]]>
				Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  258]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH4 CDR2]]>
				<![CDATA[<400>  258]]>
				Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  259]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH5 CDR2]]>
				<![CDATA[<400>  259]]>
				Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  260]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH6 CDR2]]>
				<![CDATA[<400>  260]]>
				Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  261]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH4 CDR2]]>
				<![CDATA[<400>  261]]>
				Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  262]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH5 CDR2]]>
				<![CDATA[<400>  262]]>
				Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  263]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH6 CDR2]]>
				<![CDATA[<400>  263]]>
				Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  264]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH4 CDR3]]>
				<![CDATA[<400>  264]]>
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  265]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH5 CDR3]]>
				<![CDATA[<400>  265]]>
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  266]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH6 CDR3]]>
				<![CDATA[<400>  266]]>
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  267]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64380VH7 CDR3]]>
				<![CDATA[<400>  267]]>
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  268]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH4 CDR3]]>
				<![CDATA[<400>  268]]>
				Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe Arg Ala 
				1               5                   10                  15      
				<![CDATA[<210>  269]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH5 CDR3]]>
				<![CDATA[<400>  269]]>
				Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe Arg Ala 
				1               5                   10                  15      
				<![CDATA[<210>  270]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS64511VH6 CDR3]]>
				<![CDATA[<400>  270]]>
				Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe Arg Ala 
				1               5                   10                  15      
				<![CDATA[<210>  271]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH4 CDR3]]>
				<![CDATA[<400>  271]]>
				Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr Asn Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  272]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH5 CDR3]]>
				<![CDATA[<400>  272]]>
				Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr Asn Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  273]]>
				<![CDATA[<211>  16]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  AS63997VH6 CDR3]]>
				<![CDATA[<400>  273]]>
				Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr Asn Tyr 
				1               5                   10                  15      
				<![CDATA[<210>  274]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63930]]>
				<![CDATA[<400>  274]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Gly Asn 
				            20                  25                  30          
				Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Val Val Tyr Asn Ile Asp Gly Gly Gly Arg Phe Thr Thr Tyr Ala 
				    50                  55                  60                  
				Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Gly Asn Asp Lys Asn 
				65                  70                  75                  80  
				Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Gly Met 
				                85                  90                  95      
				Tyr Tyr Cys Ala Ala Glu Val Ala Asp Pro Thr Trp Gly Ser Arg Asp 
				            100                 105                 110         
				Gln Arg Arg Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  275]]>
				<![CDATA[<211>  118]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63932]]>
				<![CDATA[<400>  275]]>
				Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Tyr Gly Ser Thr 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Asn Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Gly Gly Gly Ser Thr Trp Tyr Ala Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Tyr Gly Ser Gly Asn Val Asn Tyr Trp Gly Gln Gly Thr 
				            100                 105                 110         
				Gln Val Thr Val Ser Ser 
				        115             
				<![CDATA[<210>  276]]>
				<![CDATA[<211>  130]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63951]]>
				<![CDATA[<400>  276]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ala Cys Glu Thr Ser Arg Asp Ile Tyr Gly Asn Asn 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ser Ile Tyr Pro Ala Gly Gly Arg Pro Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Phe Ser Ile Ala Val Cys Ala Thr Arg Ser Gly Ile 
				            100                 105                 110         
				Thr Arg Ser Asn Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				        115                 120                 125             
				Ser Ser 
				    130 
				<![CDATA[<210>  277]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63984]]>
				<![CDATA[<400>  277]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Ile Val Ser Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Gly Pro Val Thr Asn Ala Pro Arg Trp Tyr Pro Leu Arg 
				            100                 105                 110         
				Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  278]]>
				<![CDATA[<211>  122]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63987]]>
				<![CDATA[<400>  278]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Glu Ala Thr Gly Tyr Arg Asn Cys Met Ala 
				            20                  25                  30          
				Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Val Ile 
				        35                  40                  45              
				Tyr Thr Pro Ser Gly Ile Thr Asp Tyr Ala Ser Ser Val Lys Gly Arg 
				    50                  55                  60                  
				Phe Thr Ile Ser Gln Asn Asn Ala Arg Asn Thr Gln Tyr Leu Gln Met 
				65                  70                  75                  80  
				Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Asp 
				                85                  90                  95      
				Arg Pro Phe Val Cys Asn Ile Ala Asn Met Arg Arg Ser Ser Asn Trp 
				            100                 105                 110         
				Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120         
				<![CDATA[<210>  279]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63997]]>
				<![CDATA[<400>  279]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Phe 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  280]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64047]]>
				<![CDATA[<400>  280]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Tyr Val Tyr Arg Trp Asp 
				            20                  25                  30          
				Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
				        35                  40                  45              
				Ala Ala Val Tyr Thr Gly Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Ser Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Phe Cys 
				                85                  90                  95      
				Ala Ala Gly Phe Val Ser Gly Gly Arg Trp Asn Gln Ser Tyr Arg Tyr 
				            100                 105                 110         
				Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  281]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64052]]>
				<![CDATA[<400>  281]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Arg Ser Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
				        35                  40                  45              
				Ala Thr Ile His Ser Gly Val Ala Thr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Gly Pro Pro Ala Asn Ala Asp Arg Trp Tyr Pro Leu Arg 
				            100                 105                 110         
				Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  282]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64062]]>
				<![CDATA[<400>  282]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Pro Tyr Ser Ser Ser 
				            20                  25                  30          
				Arg Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
				        35                  40                  45              
				Val Ala Ala Leu Tyr Thr Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser 
				    50                  55                  60                  
				Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val 
				65                  70                  75                  80  
				Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
				                85                  90                  95      
				Cys Ala Ala Val Val Pro Arg Gly Gly Ser Cys Arg Leu Asp Glu Arg 
				            100                 105                 110         
				Gly Tyr Tyr His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  283]]>
				<![CDATA[<211>  123]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64072]]>
				<![CDATA[<400>  283]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Phe Leu Arg Leu Ser Cys Ala Leu Ser Gly Tyr Ser Tyr Tyr Ile Asn 
				            20                  25                  30          
				Leu Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
				        35                  40                  45              
				Ala Ala His Gly Pro Val Ser Gly Thr Ala Tyr Tyr Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Pro Gly Lys Asn Thr Met Tyr 
				65                  70                  75                  80  
				Leu Gln Met Phe Ser Leu Gln Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Glu Thr Thr Met Gly Trp Ala His Glu Arg Gly Tyr Arg Tyr 
				            100                 105                 110         
				Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120             
				<![CDATA[<210>  284]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64097]]>
				<![CDATA[<400>  284]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Tyr Thr Tyr Ser Arg Asn 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Asn Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Leu 
				    50                  55                  60                  
				Glu Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Met Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Pro Asp Leu Gly Gly Ser Trp Cys Arg Pro Val Glu Arg 
				            100                 105                 110         
				Ala Phe Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  285]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64114]]>
				<![CDATA[<400>  285]]>
				Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Thr Leu Ser Cys Glu Ala Ser Gly Asn Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ala Ser Arg His Arg Leu Arg Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  286]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64123]]>
				<![CDATA[<400>  286]]>
				Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Thr Ser Asn 
				            20                  25                  30          
				Trp Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Ile Ile Tyr Thr Gly Ser Gly Ser Thr His Tyr Arg Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Phe Ser Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  287]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64130]]>
				<![CDATA[<400>  287]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Arg Ser Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Ala Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Ile Asp Ser Arg Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Glu Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Gly Pro Arg Thr Asn Asp Asp Arg Trp Tyr Pro Leu Arg 
				            100                 105                 110         
				Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  288]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64137]]>
				<![CDATA[<400>  288]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Leu Val Thr Trp Val Glu Arg Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Arg Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ala Ala Ala Ser Thr Asp Val Arg Leu Leu Asp Pro Gly Asp 
				            100                 105                 110         
				Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  289]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64142]]>
				<![CDATA[<400>  289]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Arg Asn 
				            20                  25                  30          
				Ala Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ser Cys Ile Asp Trp Thr Gly Ala Asn Ile Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Thr Thr Ser Gly Tyr Cys Ser Gly Phe Trp Ser Thr Ser 
				            100                 105                 110         
				Arg Tyr Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  290]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64154]]>
				<![CDATA[<400>  290]]>
				Gln Val Gln Leu Lys Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Tyr Arg Tyr Leu 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Pro Arg Trp Gly Gly Thr Cys Arg Arg Trp Ser Gln 
				            100                 105                 110         
				Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  291]]>
				<![CDATA[<211>  128]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64160]]>
				<![CDATA[<400>  291]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Ser Ser Ser Tyr 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Met Cys Phe Gly Gly Leu Val Thr His Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Phe Gly Arg Asp Lys Asn Tyr Leu Arg Pro Leu Leu Pro 
				            100                 105                 110         
				His Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125             
				<![CDATA[<210>  292]]>
				<![CDATA[<211>  117]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64228]]>
				<![CDATA[<400>  292]]>
				Gln Val Gln Leu Lys Glu Ser Gly Gly Gly Ser Ile Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Tyr Asn Arg Cys 
				            20                  25                  30          
				Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
				        35                  40                  45              
				Ser Arg Ile Gln Pro Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Val Ser Gln Asp Asn Ala Lys Asn Thr Val Ser Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Asn 
				                85                  90                  95      
				Ala Leu Cys Trp Arg Glu Asn Val Asn Tyr Trp Gly Gln Gly Thr Gln 
				            100                 105                 110         
				Val Thr Val Ser Ser 
				        115         
				<![CDATA[<210>  293]]>
				<![CDATA[<211>  124]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64300]]>
				<![CDATA[<400>  293]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Asp Ile Tyr Asn Leu Met 
				            20                  25                  30          
				Ser Met Ala Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Tyr Ile Asn Thr Ile Ile Gly Asn Thr Tyr Tyr Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Phe Asn Tyr Gly Gly Ala Trp Tyr Glu Glu Arg Ser Tyr Lys 
				            100                 105                 110         
				Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 
				<![CDATA[<210>  294]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64380]]>
				<![CDATA[<400>  294]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Thr Leu Ser Cys Glu Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  295]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64395]]>
				<![CDATA[<400>  295]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Leu Val Thr Trp Ala Glu Arg Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Arg Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ala Ala Ser Thr Ala Val Arg Leu Leu Asp Pro Gly Asp Phe 
				            100                 105                 110         
				Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  296]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64443]]>
				<![CDATA[<400>  296]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Asp Ser Ser Val 
				            20                  25                  30          
				Tyr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Ile Ile Tyr Thr Gly Gly Glu Ser Thr His Tyr Arg Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Val Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Phe Pro Ala Val Thr Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  297]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64511]]>
				<![CDATA[<400>  297]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
				        35                  40                  45              
				Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe 
				            100                 105                 110         
				Arg Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  298]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64536]]>
				<![CDATA[<400>  298]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Tyr Thr Asp Asn Phe Val 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Leu Ile Tyr Pro Gly Gly Gly Ser Thr Tyr Tyr Ala Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Gly Thr Val His 
				65                  70                  75                  80  
				Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Lys Trp Gly Leu Gly Gly Gly Gly Leu Lys Ser Asp Thr Tyr 
				            100                 105                 110         
				Met Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  299]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64597]]>
				<![CDATA[<400>  299]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Arg Val Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Ile Asp Ser Gly Val Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser His Asn Asn Ala Lys Asn Thr Ile Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Gly Pro Pro Thr Asp Gly Asp Arg Trp Tyr Pro Leu Arg 
				            100                 105                 110         
				Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  300]]>
				<![CDATA[<211>  117]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64617]]>
				<![CDATA[<400>  300]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Asp Arg Cys Ser 
				            20                  25                  30          
				Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ser 
				        35                  40                  45              
				Arg Ile Ser Thr Ser Gly Phe Thr Asn Tyr Ala Ala Ser Val Lys Gly 
				    50                  55                  60                  
				Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
				65                  70                  75                  80  
				Met Asn Ser Leu Asn Pro Gly Asp Thr Gly Met Tyr Tyr Cys Ala Ile 
				                85                  90                  95      
				Ile Val Gly Arg Thr Cys Ser Leu Asn Tyr Trp Gly Asn Gly Ile Leu 
				            100                 105                 110         
				Val Thr Val Ser Ser 
				        115         
				<![CDATA[<210>  301]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64634]]>
				<![CDATA[<400>  301]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Arg Gly Asp 
				            20                  25                  30          
				Phe Met Cys Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Gly Arg Glu 
				        35                  40                  45              
				Gly Val Ala Val Phe Tyr Pro Gly Gly Gly Ser Thr Asn Tyr Ala Asp 
				    50                  55                  60                  
				Ser Ala Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr 
				65                  70                  75                  80  
				Met Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr 
				                85                  90                  95      
				Tyr Cys Ala Ala Arg Arg Trp Val Ser Gly Thr Cys Tyr Trp Asp Ser 
				            100                 105                 110         
				Asp Phe His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  302]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS69498]]>
				<![CDATA[<400>  302]]>
				Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Ile Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Arg Leu Ser Asp Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  303]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS69500]]>
				<![CDATA[<400>  303]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Asp Arg Tyr Thr Tyr Ser Ser Ala 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ser Ile Phe Thr Gly Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
				    50                  55                  60                  
				Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val 
				65                  70                  75                  80  
				Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
				                85                  90                  95      
				Cys Ala Ala Arg Ala Phe Gln Val Gly Tyr Cys Tyr Leu Arg Thr Asp 
				            100                 105                 110         
				Val Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  304]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS69527]]>
				<![CDATA[<400>  304]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Arg Tyr Thr Phe Ser Ser Thr 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Ala Ile Tyr Thr Asp Asp Gly Ser Thr Trp Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Arg Trp Ala Cys Pro Arg Val Gly Ser Trp His Glu Phe 
				            100                 105                 110         
				Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  305]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68280]]>
				<![CDATA[<400>  305]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val His Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Asp Trp Val 
				        35                  40                  45              
				Ala Ala Ile Ser Thr Gly Asp Gly Ala Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Ser Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ala Arg Gly Arg Phe Ile Asp Trp Thr Lys Ala Thr Gln Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  306]]>
				<![CDATA[<211>  128]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68355]]>
				<![CDATA[<400>  306]]>
				Gln Met Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Gly Val 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Ala Ile Val Gly Gly Phe Asn Ala Tyr Cys Ser Gly Gly Tyr Val 
				            100                 105                 110         
				Leu Asp Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125             
				<![CDATA[<210>  307]]>
				<![CDATA[<211>  132]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS69443]]>
				<![CDATA[<400>  307]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asp Asp Ser 
				            20                  25                  30          
				Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asp Gly Cys Asp Leu Val 
				        35                  40                  45              
				Ser Thr Ile Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
				65                  70                  75                  80  
				Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Asp Phe Leu Thr Gly Phe Tyr Tyr Ser Asp Ser Pro His Pro Ala 
				            100                 105                 110         
				Pro Cys Ser Ala Ser Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val 
				        115                 120                 125             
				Thr Val Ser Ser 
				    130         
				<![CDATA[<210>  308]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75376]]>
				<![CDATA[<400>  308]]>
				Gln Val Gln Leu Lys Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser His 
				            20                  25                  30          
				Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Pro Asn Pro Asp Tyr Met Leu Pro Phe Arg Pro Ser Arg 
				            100                 105                 110         
				Arg Ser Trp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  309]]>
				<![CDATA[<211>  123]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75387]]>
				<![CDATA[<400>  309]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Pro Tyr Ser Ser Pro 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Leu Val Ala Tyr Thr Gly Gly Asp Ile Gln Tyr Leu Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Leu Arg Leu Pro Arg Ala Gly Gly Cys Ala Tyr Ser Tyr 
				            100                 105                 110         
				Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120             
				<![CDATA[<210>  310]]>
				<![CDATA[<211>  121]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75695]]>
				<![CDATA[<400>  310]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Val Ser Ala Tyr 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Val Leu Gly Lys Gly Arg Glu Arg Ile 
				        35                  40                  45              
				Ala Phe Ile Asp Ala Gly Gly Ala Thr Ile Tyr Ala Asp Pro Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Val 
				                85                  90                  95      
				Ala Asp Arg Arg Gly Arg Val Arg Arg Cys Glu Tyr Asn Ala Trp Gly 
				            100                 105                 110         
				Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120     
				<![CDATA[<210>  311]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS76169]]>
				<![CDATA[<400>  311]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Phe 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
				        35                  40                  45              
				Ala Tyr Ile Arg Asp Asn Ile Met Thr Ser Tyr Thr Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Arg Thr Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Gly Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Val Asp Arg Gly Gly Tyr Ala Asn Ser Cys Ala Val Ala Ala Arg Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  312]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63931]]>
				<![CDATA[<400>  312]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Trp Leu Ser Gly Gly Ser Trp His Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  313]]>
				<![CDATA[<211>  123]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63937]]>
				<![CDATA[<400>  313]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Ser Ser Arg 
				            20                  25                  30          
				Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Cys Ile His Thr Gly Leu Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Val Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Ser Arg Arg Pro Cys Met Val Ala Ala Gly Tyr Thr Tyr 
				            100                 105                 110         
				Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120             
				<![CDATA[<210>  314]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63948]]>
				<![CDATA[<400>  314]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Tyr Arg Tyr Leu 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Glu Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ala Ser Pro Arg Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu 
				            100                 105                 110         
				Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  315]]>
				<![CDATA[<211>  123]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63956]]>
				<![CDATA[<400>  315]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser Asn Cys 
				            20                  25                  30          
				Cys Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Ala Arg Glu Leu Val 
				        35                  40                  45              
				Ser Leu Ile Asn Ser Ser Gly Gly Thr Tyr Tyr Ala Asp Ser Val Arg 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Tyr Gln Ala Lys Tyr Cys Ser Gly Pro Cys Ala Pro Pro Thr Asp 
				            100                 105                 110         
				Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120             
				<![CDATA[<210>  316]]>
				<![CDATA[<211>  121]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63965]]>
				<![CDATA[<400>  316]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Ser Ser Gly Ser Cys 
				            20                  25                  30          
				Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
				        35                  40                  45              
				Ser Lys Val Ile Ser Asp Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Leu Ser Gln Gly Asn Ala Lys Asn Thr Val Tyr Leu 
				65                  70                  75                  80  
				Gln Met Ser Ser Leu Leu Pro Glu Asp Thr Ala Met Tyr Tyr Cys Asn 
				                85                  90                  95      
				Ala Trp Cys Arg Glu Tyr Pro Gly Gly Ile Leu Asn Asn Gly Trp Gly 
				            100                 105                 110         
				Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120     
				<![CDATA[<210>  317]]>
				<![CDATA[<211>  118]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63993]]>
				<![CDATA[<400>  317]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Thr Phe Asp Asp Leu 
				            20                  25                  30          
				Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Leu Val 
				        35                  40                  45              
				Ser Leu Val Ala Thr Ala Gly Asn Ser Val Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala His Ser Thr Ala Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Arg Thr Asp Ser Glu His Ala Phe Lys Phe Trp Gly Gln Gly Thr 
				            100                 105                 110         
				Gln Val Thr Val Ser Ser 
				        115             
				<![CDATA[<210>  318]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63999]]>
				<![CDATA[<400>  318]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
				        35                  40                  45              
				Ala Ile Ile Tyr Thr Gly Gly Ile Ser Thr His Tyr Arg Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Tyr Thr Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  319]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64006]]>
				<![CDATA[<400>  319]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Tyr Thr Gly Asp Thr Thr 
				            20                  25                  30          
				Tyr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Leu Ile Tyr Thr Ser Gly Thr Ser Glu Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Gly Ala Arg Ser Arg Thr Met Met Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  320]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64057]]>
				<![CDATA[<400>  320]]>
				Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Arg Asn 
				            20                  25                  30          
				Ala Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ser Cys Ile Ser Trp Thr Gly Ala Asn Ile Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asp Thr Thr Ser Gly Ser Cys Ser Gly Phe Trp Ser Thr Ser 
				            100                 105                 110         
				Arg Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  321]]>
				<![CDATA[<211>  122]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64060]]>
				<![CDATA[<400>  321]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Tyr Cys Thr Tyr 
				            20                  25                  30          
				Arg Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
				        35                  40                  45              
				Ala Val Ile Asp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
				                85                  90                  95      
				Thr Asp Pro Thr Ile Gly Cys Pro Gln Thr Tyr Arg Tyr Asn Tyr Trp 
				            100                 105                 110         
				Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120         
				<![CDATA[<210>  322]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64071]]>
				<![CDATA[<400>  322]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asn Thr Tyr Arg Leu Asn 
				            20                  25                  30          
				Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Phe Ile Val Met Ile Arg Gly Thr Thr Tyr Tyr Gly Ala Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Gln Thr Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Thr Lys Asp Gln Phe Tyr Val Phe Asn Pro Ile Gly Tyr 
				            100                 105                 110         
				Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  323]]>
				<![CDATA[<211>  130]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64093]]>
				<![CDATA[<400>  323]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Thr Ser Arg Tyr Ile Tyr Gly Asn Asn 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ser Ile Tyr Pro Ala Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Ile Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Phe Ser Ile Gly Val Cys Ala Thr Gln Ser Gly Ile 
				            100                 105                 110         
				Thr Trp Ser Asn Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				        115                 120                 125             
				Ser Ser 
				    130 
				<![CDATA[<210>  324]]>
				<![CDATA[<211>  117]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64118]]>
				<![CDATA[<400>  324]]>
				Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ala Cys 
				            20                  25                  30          
				Arg Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
				        35                  40                  45              
				Ser Phe Ile Asn Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ala Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Asn 
				                85                  90                  95      
				Thr Trp Asp Ser Ser Cys Arg Phe Gln Tyr Trp Gly Gln Gly Thr Gln 
				            100                 105                 110         
				Val Thr Val Ser Ser 
				        115         
				<![CDATA[<210>  325]]>
				<![CDATA[<211>  130]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64120]]>
				<![CDATA[<400>  325]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Glu Thr Ser Arg Tyr Ile Tyr Gly Asn Asn 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ser Ile Tyr Pro Ala Gly Gly Arg Pro Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Phe Ser Ile Ala Asp Cys Ala Thr Gln Ser Gly Ile 
				            100                 105                 110         
				Thr Arg Ser Asn Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				        115                 120                 125             
				Ser Ser 
				    130 
				<![CDATA[<210>  326]]>
				<![CDATA[<211>  128]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64124]]>
				<![CDATA[<400>  326]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Val Ser Thr Tyr Thr Pro Ser Asn Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Ala Thr Ile Gly Gly Thr Thr Arg Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Gly Ala Lys Asn Thr Ile Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Arg Pro Tyr Ser Leu Pro Leu Pro Leu Pro Leu Glu Ser 
				            100                 105                 110         
				Gly Ala Tyr Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125             
				<![CDATA[<210>  327]]>
				<![CDATA[<211>  121]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64135]]>
				<![CDATA[<400>  327]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Thr Ser Thr Tyr Cys Arg Tyr 
				            20                  25                  30          
				Tyr Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
				        35                  40                  45              
				Ser Ala Met Gln Pro Asp Gly Thr Thr Ser Tyr Ser Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Met Ser Gln Asp Arg Ala Asn Asn Met Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
				                85                  90                  95      
				Arg Asp Pro Met Gly Gly Ser Arg Thr Pro Cys Thr Ser Ala Trp Gly 
				            100                 105                 110         
				Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120     
				<![CDATA[<210>  328]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64163]]>
				<![CDATA[<400>  328]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Arg Tyr Arg Trp Asn 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Ser Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Gly Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Met Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Asp Pro Ser Val Cys Pro Gly Gly Met Trp Tyr Ser Lys Glu Tyr 
				            100                 105                 110         
				Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  329]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64182]]>
				<![CDATA[<400>  329]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Gln Thr Ser Arg Tyr Leu 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Cys Ile Tyr Thr Gly Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Thr Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Pro His Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu 
				            100                 105                 110         
				Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  330]]>
				<![CDATA[<211>  122]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64183]]>
				<![CDATA[<400>  330]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Tyr Ser Ala Asn 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Trp Val 
				        35                  40                  45              
				Ala Ser Val Tyr Thr Asp Asp Asp Ser Thr Met Tyr Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Phe Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Met Tyr Ile Cys 
				                85                  90                  95      
				Ala Ala Asp Leu Ser Gly Gly Pro Ala Gly Cys Gly Tyr Thr His Trp 
				            100                 105                 110         
				Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120         
				<![CDATA[<210>  331]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64207]]>
				<![CDATA[<400>  331]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Ile Val Ser Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Gly Pro Pro Thr Asn Gly Ala Lys Trp Tyr Pro Leu Arg 
				            100                 105                 110         
				Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  332]]>
				<![CDATA[<211>  122]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64276]]>
				<![CDATA[<400>  332]]>
				Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Ser Leu Ser Cys Val Val Ser Gly Tyr Thr Gly Ser Ser Arg 
				            20                  25                  30          
				Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
				        35                  40                  45              
				Ala Gln Ile Phe Thr Gly Arg Gly Thr Thr Gly Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Arg Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Leu Gly Pro Gly Arg Gly Ala Cys Gly Tyr Asn Tyr Trp 
				            100                 105                 110         
				Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120         
				<![CDATA[<210>  333]]>
				<![CDATA[<211>  121]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64336]]>
				<![CDATA[<400>  333]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Thr Tyr Ser Ser Cys 
				            20                  25                  30          
				Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
				        35                  40                  45              
				Ser His Ile Phe Ser Asp Gly Ser Arg Tyr Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Asn 
				                85                  90                  95      
				Arg Arg Thr Gly Trp Ala Pro Arg Cys Ala Val Pro Gly Tyr Trp Gly 
				            100                 105                 110         
				Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120     
				<![CDATA[<210>  334]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64346]]>
				<![CDATA[<400>  334]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Phe Met Gly 
				            20                  25                  30          
				Trp Phe Arg Gln Ala Pro Gln Lys Glu Arg Glu Trp Val Ala Thr Ile 
				        35                  40                  45              
				Gly Thr Gly Asp Ile Phe Asn Gly Ala Ala Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Ala Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
				                85                  90                  95      
				Ala Ala Val Gln Ser Lys Ser Ser Asn Tyr Val Leu Arg Asp Ala Ser 
				            100                 105                 110         
				Thr Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  335]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64420]]>
				<![CDATA[<400>  335]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Glu Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Ser Arg Ser Val 
				            20                  25                  30          
				Trp Met Gly Trp Ala Arg Gln Val Pro Gly Lys Glu Arg Glu Val Val 
				        35                  40                  45              
				Ala Thr Ile Ser Thr Ala Gly Gly Ser Thr Trp Tyr Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Arg Tyr Ala Thr Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  336]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64473]]>
				<![CDATA[<400>  336]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Tyr Arg Tyr Leu 
				            20                  25                  30          
				Tyr Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Cys Ile Tyr Thr Gly Ser Gly Thr Thr Gly Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Asn Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Pro Gln Trp Gly Gly Thr Cys Arg Arg Trp Ser Glu 
				            100                 105                 110         
				Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  337]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64475]]>
				<![CDATA[<400>  337]]>
				Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Trp Ser Arg Asn 
				            20                  25                  30          
				Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Phe 
				        35                  40                  45              
				Ala Thr Ile Thr Ile Ser Gly Gly Ser Thr Trp Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Gly Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Asp Thr Ala Arg Thr Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  338]]>
				<![CDATA[<211>  127]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64513]]>
				<![CDATA[<400>  338]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Asp Tyr Pro Tyr Ile Asp Asn 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ala Cys Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Thr Gly Tyr Tyr Ser Gly Ser Gly Pro Gly Tyr Leu Leu Pro Trp 
				            100                 105                 110         
				Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125         
				<![CDATA[<210>  339]]>
				<![CDATA[<211>  131]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64562]]>
				<![CDATA[<400>  339]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Arg Arg Asp 
				            20                  25                  30          
				Phe Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Val Ile His Thr Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ile Met Asn 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Phe Arg Pro Arg Gly Gly Gly Tyr Thr Gly Asp Val Leu 
				            100                 105                 110         
				Ala Gln Ala Ala Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
				        115                 120                 125             
				Val Ser Ser 
				    130     
				<![CDATA[<210>  340]]>
				<![CDATA[<211>  126]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64583]]>
				<![CDATA[<400>  340]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ala Val Tyr 
				            20                  25                  30          
				Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
				        35                  40                  45              
				Ser Cys Thr Ser Trp Ala Gly Gly Arg Thr Tyr Thr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Lys Ala His Pro Asp Cys Ser Gly Asp Trp Ser Pro Ser Gly 
				            100                 105                 110         
				Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125     
				<![CDATA[<210>  341]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64594]]>
				<![CDATA[<400>  341]]>
				Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Asn Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Leu Ile Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ser Val Arg Thr Gln Thr Arg Asn Tyr Trp Gly Gln Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  342]]>
				<![CDATA[<211>  131]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64605]]>
				<![CDATA[<400>  342]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Val Ser Arg Tyr Pro Tyr Ser Ser Ile 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Ser Glu Gly Val 
				        35                  40                  45              
				Ala Arg Ile Tyr Thr Gly Thr Gly Ser Thr Trp Tyr Thr Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Gln Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Asn Ser Tyr Ser Tyr Ser Ser Cys Asp Tyr Gly Pro 
				            100                 105                 110         
				Leu Thr Arg Gly Gly Tyr Asn Phe Trp Gly Gln Gly Thr Gln Val Thr 
				        115                 120                 125             
				Val Ser Ser 
				    130     
				<![CDATA[<210>  343]]>
				<![CDATA[<211>  115]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64606]]>
				<![CDATA[<400>  343]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Tyr Thr Ser Arg Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Leu Ile Tyr Thr Arg Gly Gly Ser Thr Tyr Tyr Ala Ser Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Lys Lys Thr Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Val Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Leu Arg Leu Asp Glu Lys Met Tyr Trp Gly Gln Gly Thr Gln Val Thr 
				            100                 105                 110         
				Val Ser Ser 
				        115 
				<![CDATA[<210>  344]]>
				<![CDATA[<211>  133]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68121]]>
				<![CDATA[<400>  344]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Asp Ala Ser Gly Tyr Thr Tyr Ser Arg Asn 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Phe Tyr Thr Asp Tyr Ile Arg Phe Gly Arg Thr Tyr Tyr Ala 
				    50                  55                  60                  
				Asp Ser Val Lys Gly Arg Phe Thr Ile Phe Gln Asp Asn Ala Lys Asn 
				65                  70                  75                  80  
				Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
				                85                  90                  95      
				Tyr Tyr Cys Ala Ala Asp Pro Gly Ser Arg Thr Asp Asp Ser Cys Gly 
				            100                 105                 110         
				Thr Ser Tyr Asn Lys Gly Asn Phe Gly Tyr Trp Gly Gln Gly Thr Gln 
				        115                 120                 125             
				Val Thr Val Ser Ser 
				    130             
				<![CDATA[<210>  345]]>
				<![CDATA[<211>  130]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68170]]>
				<![CDATA[<400>  345]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Tyr Arg Ser Asn 
				            20                  25                  30          
				Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Thr Ile Tyr Thr Gly Gly Gly Arg Asn Leu Tyr Tyr Ala Asp Ser 
				    50                  55                  60                  
				Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
				65                  70                  75                  80  
				Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Arg Tyr Tyr 
				                85                  90                  95      
				Cys Ala Ala Ala Ser Asp Val Ala Val Gly Val Asn Ser Cys Gly Gly 
				            100                 105                 110         
				Arg Thr Ala Gly Phe Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
				        115                 120                 125             
				Ser Ser 
				    130 
				<![CDATA[<210>  346]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS63964]]>
				<![CDATA[<400>  346]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Tyr Thr Tyr Ser Tyr Asn 
				            20                  25                  30          
				Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Ser Gly Gly Arg Phe Thr Ala Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr Leu 
				65                  70                  75                  80  
				Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Gly Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Glu Val Val Asp Pro Thr Trp Gly Ser Arg Asp Gln Arg Arg Tyr 
				            100                 105                 110         
				Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  347]]>
				<![CDATA[<211>  124]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS64116]]>
				<![CDATA[<400>  347]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Cys Val 
				            20                  25                  30          
				Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Gly 
				        35                  40                  45              
				Ile Ser Thr Gly Gly Gly Gly Thr Val Tyr Ala Asp Ser Val Lys Gly 
				    50                  55                  60                  
				Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
				65                  70                  75                  80  
				Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
				                85                  90                  95      
				Asp Arg Trp Asn Ser Phe Ala Asn Cys Gly Ala Trp Gly Arg Tyr Thr 
				            100                 105                 110         
				Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 
				<![CDATA[<210>  348]]>
				<![CDATA[<211>  130]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68270]]>
				<![CDATA[<400>  348]]>
				Gln Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Pro Ser Ser Thr Tyr 
				            20                  25                  30          
				Tyr Met Leu Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
				        35                  40                  45              
				Glu Gly Val Ala Ala Ile Thr Ser Gly Thr Gly Ser Thr Ser Tyr Ala 
				    50                  55                  60                  
				Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Lys Asp Tyr Ala Asn Asn 
				65                  70                  75                  80  
				Thr Leu Tyr Leu His Ile Asn Asn Leu Lys Pro Glu Asp Thr Ala Met 
				                85                  90                  95      
				Tyr Tyr Cys Ala Ala Ala Ser Gly Trp Ile Val Pro Ser Arg Ser Leu 
				            100                 105                 110         
				Thr Ala Asn Leu Tyr Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				        115                 120                 125             
				Ser Ser 
				    130 
				<![CDATA[<210>  349]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68320]]>
				<![CDATA[<400>  349]]>
				Gln Val His Leu Val Glu Ser Gly Gly Asp Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Asn Thr Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Tyr Arg His Ser Gly Asn Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Tyr Ala Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Arg Ala Gly Pro Trp Ala Leu Met Arg Pro Thr Glu Phe 
				            100                 105                 110         
				Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  350]]>
				<![CDATA[<211>  123]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS68351]]>
				<![CDATA[<400>  350]]>
				Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Phe Arg Ala Tyr 
				            20                  25                  30          
				Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
				        35                  40                  45              
				Ser Gly Ile Ser Ala Ser Gly Gly Arg Thr Ser Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Leu Asn Ser Leu Ser Thr Glu Asp Thr Gly Met Tyr Tyr Cys 
				                85                  90                  95      
				Val Lys Gly Ala Val Arg Leu Ser Thr Ser Ser Val Arg Asp Ser Ser 
				            100                 105                 110         
				Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120             
				<![CDATA[<210>  351]]>
				<![CDATA[<211>  116]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75378]]>
				<![CDATA[<400>  351]]>
				Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Val Ser Gly Asn Thr Arg Ser Thr Thr 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ile Val Tyr Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Ala Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Thr Thr Ile Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Arg Ser Tyr Glu Tyr Thr Tyr Trp Gly Arg Gly Thr Gln Val 
				            100                 105                 110         
				Thr Val Ser Ser 
				        115     
				<![CDATA[<210>  352]]>
				<![CDATA[<211>  124]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75383]]>
				<![CDATA[<400>  352]]>
				Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
				            20                  25                  30          
				Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Gln Gly Val 
				        35                  40                  45              
				Ala Thr Phe Asn Asn Arg Gly Val Ala Asn Tyr His Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Ala Ser Val Asp Asn Ala Lys Asn Thr Leu Leu Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Glu Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Asp Arg Arg Tyr Gly Arg Gln Trp Tyr Gln Pro Cys Glu Trp Asn 
				            100                 105                 110         
				Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 
				<![CDATA[<210>  353]]>
				<![CDATA[<211>  129]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS75751]]>
				<![CDATA[<400>  353]]>
				Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Phe Tyr Asn Thr Tyr 
				            20                  25                  30          
				Tyr Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
				        35                  40                  45              
				Val Ala Ala Ile Asp Thr Asp Gly Arg Thr Ser Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Phe Gly Tyr Met Asn Val Ile Gln Ala Leu Asn Gly Met 
				            100                 105                 110         
				Arg Gln Asn Pro Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
				        115                 120                 125             
				Ser 
				<![CDATA[<210>  354]]>
				<![CDATA[<211>  124]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3駱駝sdAb胺基酸序列AS76422]]>
				<![CDATA[<400>  354]]>
				Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ala Gly Asn 
				            20                  25                  30          
				Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
				        35                  40                  45              
				Val Thr Tyr Asn Asn Phe Gly Val Ala Asn Tyr Ala Asp Ser Val Lys 
				    50                  55                  60                  
				Gly Arg Phe Thr Val Ser Gln Asp Asn Ala Lys Asn Thr Leu Leu Leu 
				65                  70                  75                  80  
				Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
				                85                  90                  95      
				Ala Asp Arg Arg Asp Gly Arg Arg Trp Ser Gln Pro Cys Glu Trp Asn 
				            100                 105                 110         
				Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
				        115                 120                 
				<![CDATA[<210>  355]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64380VH4]]>
				<![CDATA[<400>  355]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  356]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64380VH5]]>
				<![CDATA[<400>  356]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  357]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64380VH6]]>
				<![CDATA[<400>  357]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  358]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64380VH7]]>
				<![CDATA[<400>  358]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn 
				            20                  25                  30          
				Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Glu Val 
				        35                  40                  45              
				Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val 
				    50                  55                  60                  
				Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr 
				            100                 105                 110         
				Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  359]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64511VH4]]>
				<![CDATA[<400>  359]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ala Val 
				        35                  40                  45              
				Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe 
				            100                 105                 110         
				Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  360]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64511VH5]]>
				<![CDATA[<400>  360]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Ala Val 
				        35                  40                  45              
				Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe 
				            100                 105                 110         
				Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  361]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS64511VH6]]>
				<![CDATA[<400>  361]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala Thr Tyr Ser Thr Asn 
				            20                  25                  30          
				Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
				        35                  40                  45              
				Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe Asp Gly Arg Asp Phe 
				            100                 105                 110         
				Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  362]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63931VH4]]>
				<![CDATA[<400>  362]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Trp Leu Ser Gly Gly Ser Trp His Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  363]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63931VH5]]>
				<![CDATA[<400>  363]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Trp Leu Ser Gly Gly Ser Trp His Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  364]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63931VH6]]>
				<![CDATA[<400>  364]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Ala Gly Trp Leu Ser Gly Gly Ser Trp His Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  365]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63997VH4]]>
				<![CDATA[<400>  365]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  366]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63997VH5]]>
				<![CDATA[<400>  366]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  367]]>
				<![CDATA[<211>  125]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類化sdAb胺基酸序列AS63997VH6]]>
				<![CDATA[<400>  367]]>
				Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val Ser 
				            20                  25                  30          
				Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
				        35                  40                  45              
				Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
				                85                  90                  95      
				Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
				            100                 105                 110         
				Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
				        115                 120                 125 
				<![CDATA[<210>  368]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63930核酸序列]]>
				<![CDATA[<400>  368]]>
				gaggtgcaac tggcggagtc tgggggagga tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagt ggcaactata tggcctggtt ccgccaggct    120
				ccagggaacg agcgcgaggg ggtcgcagtt gtttataata ttgacggtgg cggtcgtttc    180
				actacctatg ccgactccgt gaagggccga ttcaccatct cccgaggcaa cgacaagaac    240
				acggtgtatc tgcaaatgaa cagcctgaaa cctgaggata gtggcatgta ctactgtgcg    300
				gcagaggtag ctgatccgac ctgggggtcg cgtgaccaaa gacgatataa gtactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  369]]>
				<![CDATA[<211>  354]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63932核酸序列]]>
				<![CDATA[<400>  369]]>
				caggtgcaat tggaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata cacctacggt agcaccttca tgggctggtt ccgccagaat    120
				ccagggaagg agcgcgaggg ggtcgcagtt atttatactg gtggtggtag tacatggtat    180
				gccagctccg tgaagggccg attcaccatc tcccaggaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgcgttac    300
				gggtcgggaa acgttaacta ctggggccag gggacccagg tcaccgtctc ctca          354
				<![CDATA[<210>  370]]>
				<![CDATA[<211>  390]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63951核酸序列]]>
				<![CDATA[<400>  370]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				gcctgtgaaa cctctagaga catctacggt aacaactgca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg agtcgcgtct atttatcctg ctggtggtcg cccgtactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatgg acagcctgaa acctgaggac acggccatgt actactgcgc ggcacgctct    300
				ttttcgatag cagtttgcgc gacgcgctct ggtattacca ggtctaattt tgcttactgg    360
				ggccagggga cccaggtcac cgtctcctca                                     390
				<![CDATA[<210>  371]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63984核酸序列]]>
				<![CDATA[<400>  371]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagt agcaacttca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaact attgtttctg gtggtggtac cacatactat    180
				gccgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggggc    300
				cccgttacga acgcacctag atggtacccc ctccgacctc ctggttataa ctactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  372]]>
				<![CDATA[<211>  366]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63987核酸序列]]>
				<![CDATA[<400>  372]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgaag ccactggata tagaaactgc atggcctggt tccgccaagc tccagggaag    120
				gaacgcgagg gggtcgcagt tatttatact cctagtggta tcacggacta tgcaagctcc    180
				gtgaagggcc gattcaccat ctcccaaaac aacgccagga acacgcagta tctgcaaatg    240
				aacagcctga aacctgagga cactgccatg tactactgtg cggcagatcg accctttgtt    300
				tgtaatatag cgaatatgag aaggtcctcc aactggggcc gggggaccca ggtcaccgtc    360
				tcctca                                                               366
				<![CDATA[<210>  373]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63997核酸序列]]>
				<![CDATA[<400>  373]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag gctctttctc tggatacggc gtcagtacca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct attacagttg gtagtggaaa cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccgagaca acgccaagag gacggtgttt    240
				ttgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggtcggatac    300
				ttgtcgggtg gtagttggga cgttcccgga aggtataact actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  374]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64047核酸序列]]>
				<![CDATA[<400>  374]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctcagta cgtttacagg tgggacctca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggc ggtcgctgct gtttatactg gtgatggtat tacatactat    180
				gccgactccg tgaagggccg attcagcatt tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actggcatgt acttctgtgc ggcaggcttc    300
				gtctctggtg gtagatggaa ccagtcatat cgttataaat actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  375]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64052核酸序列]]>
				<![CDATA[<400>  375]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctaccgc agcaacttca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg gatcgcaact attcattctg gtgtggctac cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggggc    300
				ccccctgcga acgctgatag atggtacccc ctccgacctc ctggttataa ctactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  376]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64062核酸序列]]>
				<![CDATA[<400>  376]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ttggagggtc tctgagactc     60
				tcctgtgcag cctctagatc tccctacagt agcagtaggt gcatggggtg gttccgccag    120
				gctccaggga aggagcgcga gggggtcgca gctctttata ctggtggtgg tagcacatcc    180
				tatgccgact ccgtgaaggg ccgattcacc atctcccaag acaacgccaa gaatacggtg    240
				tatctgcaaa tgaacagcct gaaacctgag gacactgcca tgtactactg tgcggcagtt    300
				gtccctaggg gtggtagctg ccgtcttgat gaaagagggt attaccactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  377]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64072核酸序列]]>
				<![CDATA[<400>  377]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ccggagggtt tctgagactc     60
				tcctgtgcac tctctggata cagctactat attaacttga tggcgtggtt ccgtcaggct    120
				ccagggaagg agcgcgaggc agtcgcagct catggtcctg tgagtgggac agcatactat    180
				accgactccg tgaagggccg attcaccatc tcccgagacc ccggcaagaa cacgatgtat    240
				cttcaaatgt ttagcctgca accggaggac actgccctct actactgtgc ggcggaaacg    300
				actatgggtt gggcccacga acgcgggtat aggtactggg gccaggggac ccaggtcacc    360
				gtctcctca                                                            369
				<![CDATA[<210>  378]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64097核酸序列]]>
				<![CDATA[<400>  378]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgaag cctctggata cacctacagt cgcaactgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct attaacactg gtggtggtag cacatattat    180
				gccgactccc ttgagggccg attcaccatc tcccaagaca acgccaagaa tactatgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcaggtccc    300
				gatctcggtg gtagctggtg tcggcccgtt gagcgggctt ttacgtactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  379]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64114核酸序列]]>
				<![CDATA[<400>  379]]>
				caggtgcaac tgcaggagtc tggggggggc tcggtgcagg ctggagggtc tctgacactc     60
				tcctgtgaag cctctggaaa cacctacagt actaattaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaaga ggtcgcggtt atttacactc gtggtggtca cacatactat    180
				gtcgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagcttca    300
				cgacatagac tccgtttaaa taacccacgg gactatgact actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  380]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64123核酸序列]]>
				<![CDATA[<400>  380]]>
				caggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacttatacg agcaactggc tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcaatt atttatactg gtagtggtag tacacactat    180
				cgcagctccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgcgtttc    300
				tcagagtata attactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  381]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64130核酸序列]]>
				<![CDATA[<400>  381]]>
				gaggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctaccgt agcaacttca tgggctggtt ccgccaggct    120
				ccggcgaagg agcgcgaggg ggtcgcaact attgattctc gtggtactat cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgagaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggggc    300
				ccccgcacga acgatgatag atggtacccc ctccgacctc ctggttataa ctactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  382]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64137核酸序列]]>
				<![CDATA[<400>  382]]>
				caggtgaggt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgctg cctctggatc cacctacagt acaaacttca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaacg ctggttactt gggttgaacg cacagcctat    180
				gccgactccg tgaagggccg attcaccatc tcccaagacc gcgccaagaa cacggtgtat    240
				ctacaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagccgcc    300
				gcttccactg atgtacgtct cctcgacccg ggggactttg cttactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  383]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64142核酸序列]]>
				<![CDATA[<400>  383]]>
				caggtgcacc tgatggagtc tgggggaggc ttggtgcaga caggggggtc tctgagactc     60
				tcctgtacag cctctggatt cacttttgat cgtaatgcca tgcgctggta ccgccaggct    120
				ccagggaagg agcgcgaggg ggtctcatgt attgattgga cgggtgcaaa tattgcctat    180
				gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat    240
				ctgcaaatga acagcctgaa acctgaggac acgggcatgt attactgtgc ggcagatacg    300
				acgtcggggt attgttcagg cttttggtct acgagccggt actcatgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  384]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64154核酸序列]]>
				<![CDATA[<400>  384]]>
				caggtgcaat tgaaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtacag cctctggata cacctacaga tacctctaca tgggctggtt ccgccagact    120
				ccagggaagg agcgcgaggg ggtcgcatgt atttatactg gtagtggtag cacagggtat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acaacctgaa acctgaggac actgccatgt actactgtgc ggcaagttcg    300
				ccccggtggg gcggtacctg tcgacgctgg tctcagtata actactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  385]]>
				<![CDATA[<211>  384]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64160核酸序列]]>
				<![CDATA[<400>  385]]>
				gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcgg cctctgtata caccagcagt agctactgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct atgtgttttg gtggtcttgt cacacactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca atgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagatttc    300
				ggcagggata aaaactattt acgaccgtta ctgccccatg catataacta ctggggccaa    360
				gggacccagg tcaccgtctc ctca                                           384
				<![CDATA[<210>  386]]>
				<![CDATA[<211>  351]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64228核酸序列]]>
				<![CDATA[<400>  386]]>
				caggtgcaat tgaaggagtc tgggggaggt tcgatccagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggagt ctcctacaat aggtgcagta tgggctggta ccgccaggct    120
				ccagggaagg ggcgcgagtt ggtctcacgt attcagccgg gtggtaatac atactatgca    180
				gactccgtga agggccgatt caccgtctcc caagacaacg ccaagaacac agtatctcta    240
				caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaacgc actgtgctgg    300
				cgggagaatg ttaactactg gggccagggg acccaggtca ccgtctcctc a             351
				<![CDATA[<210>  387]]>
				<![CDATA[<211>  372]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64300核酸序列]]>
				<![CDATA[<400>  387]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcaga ctggaggatc tctgagactc     60
				tcctgtgcag tctctggaga catctataac ctcatgtcga tggcctggtt ccgccgggct    120
				ccagggaagg agcgcgaggg ggtcgcatat attaatacta ttattggtaa cacatactat    180
				actgactccg tgaagggccg attcaccatc tcccgcgata actccaagaa cactttgtat    240
				ctgcaaatga acaacctgaa acctgaggac acagccatgt actactgtgc ggcgttcaat    300
				tacggaggtg cctggtacga ggaacgcagc tataaatact ggggccaggg gacccaggtc    360
				accgtctcct ca                                                        372
				<![CDATA[<210>  388]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64380核酸序列]]>
				<![CDATA[<400>  388]]>
				gaggtgcagc tggtggagtc tggggggggc tcggtgcagg ctggagggtc tctgacactc     60
				tcctgtgaag cctctggaaa cacctacagt agtaattaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcggtt atttacactc gtggtggtca cacatactat    180
				gtcgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgtcttca    300
				cgacatagac tcggtttaaa taacccacgg gactatgact actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  389]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64395核酸序列]]>
				<![CDATA[<400>  389]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgctg cctctggatc cacctacagt acaaacttca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaacg cttgttactt gggctgaacg cacagcctat    180
				gccgactccg tgaagggccg attcaccatc tcccaagacc gcgccaagaa cacggtgtat    240
				ctacaaatga acggcctgaa acctgaggac actgccatgt actactgtgc ggcagccgct    300
				tccactgctg tacgtctcct cgacccgggg gactttgctt actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  390]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64443核酸序列]]>
				<![CDATA[<400>  390]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata taccgacagt agcgtctaca taggctggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcgatt atttatactg gtggtgaaag cacacactat    180
				cgcagctccg tgaagggccg attcaccgtc tcccaagaca acgccaagaa cacgctgtat    240
				ctgcaaatga acagcctgaa acctgaggac acggccatgt attactgtgc agcacgattc    300
				ccagctgtta cctactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  391]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64511核酸序列]]>
				<![CDATA[<400>  391]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctagagc cacctacagt accaactaca taagctggtt ccgccaggct    120
				ccagggaagg agcgcgaggc ggtcgcaaca attactactg gtgatggtga gacagcgtat    180
				gccgactccg tgaagggccg attcaccatc tcccgagaca acgccaagaa cacggtctat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgaacttg    300
				cgaatcggtg gcgactggtt cgacggacgc gattttcgtg cctggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  392]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64536核酸序列]]>
				<![CDATA[<400>  392]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctagata caccgacaat ttcgtgtaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcactg atttatcctg gtggtggtag cacctactat    180
				gcctcctccg tgaagggccg attcaccatc tcccaagaca acgccaaggg cacggtgcat    240
				ctgcaaatga acaacctgaa acctgaggac actgccatgt actactgtgc ggcaaaatgg    300
				gggctgggcg gggggggcct gaaatcagat acgtatatgt actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  393]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64597核酸序列]]>
				<![CDATA[<400>  393]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctaccgt gtcaacttca tgggctggtt ccgccagact    120
				ccagggaagg agcgcgaggg ggtcgcaact attgattctg gtgtgggtac cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccataaca acgccaagaa cacgatttat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggggc    300
				ccccctacgg acggtgatag atggtacccc ctccgacctc ctggttataa ctattggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  394]]>
				<![CDATA[<211>  351]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64617核酸序列]]>
				<![CDATA[<400>  394]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cactgataga tgcagcatgg cctggtaccg ccaggctcca    120
				gggaaggagc gcgagttggt ctcgcgtatt agcacgagcg gtttcacaaa ctacgcagcc    180
				tccgtgaagg gccgattcac catctcccaa gacaacgcca agaacacggt gtatctgcaa    240
				atgaacagcc tgaaccccgg ggacacgggc atgtattact gtgccataat cgtaggacgt    300
				acttgtagtt tgaactactg gggcaacggc atcctggtca ccgtctcctc a             351
				<![CDATA[<210>  395]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64634核酸序列]]>
				<![CDATA[<400>  395]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctccggata cagttttaga ggcgacttta tgtgtatggg ctggttccgc    120
				cagactccag ggaaggggcg cgagggggtc gcagtttttt atcctggtgg cggcagcaca    180
				aactatgccg actccgcgaa gggccgattc accatctccc aagacaacgc caagaacacg    240
				atgtatctgc aaatgaacac cctgaaacct gaggacactg ccatgtacta ctgtgcggct    300
				cgacggtggg tcagtggtac ctgctactgg gatagtgact ttcattactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  396]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS69498核酸序列]]>
				<![CDATA[<400>  396]]>
				cagatgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggaaa cacctacagt accaattaca tggcgtggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcggtt atttacactc gtggtggtca cacctactat    180
				atcgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaataa acagcctgaa acctgaggac actgccatgt actactgtgc ggcgtcttca    300
				cgaattagac tccattgaat cgacccacgg gactatcacg actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  397]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS69500核酸序列]]>
				<![CDATA[<400>  397]]>
				caggtgaggt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag ccgacagata cacctacagt agcgcctgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcctct atttttactg gtactggtgg tagcacatac    180
				tatgccgact ccgtgaaggg ccgattcacc atctcccaag acaacgccaa gaacacggtg    240
				tatctgcaaa tgaacagcct gaaacctgag gacactgcca tatactactg tgcggcaagg    300
				gccttccagg tcggttactg ctacctgcga accgatgtgt ataactactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  398]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS69527核酸序列]]>
				<![CDATA[<400>  398]]>
				gaggtgcagc tggcggagtc tgggggaggc tcggtccagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctagata caccttcagt agcacctgca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcagct atttatactg atgatggtag cacatggtat    180
				gccgactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgctatgt actactgtgc ggcacgtagg    300
				tgggcgtgcc ccagggttgg tagctggcat gagttcgcct actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  399]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68280核酸序列]]>
				<![CDATA[<400>  399]]>
				caggtgcaac tggtggagtc tgggggaggc tcggtgcacc ctggagggtc tctgagactc     60
				tcctgtgcag cctctggatc cacctacagt tccaactacc tcggctggtt ccgccaggct    120
				ccaggaaagg ggcgcgactg ggttgcggct attagcactg gtgacggtgc cacagcctat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcttgaa acttgaggac agtgccatgt actactgtgc ggcggctcgc    300
				ggcagattta tcgattggac aaaggcaacc cagtatgact actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  400]]>
				<![CDATA[<211>  384]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68355核酸序列]]>
				<![CDATA[<400>  400]]>
				cagatgcagc tggtggagtc tgggggagac tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagc ggcgtctgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct attgatagtg atggtagcac aagctacgca    180
				gactccgtga agggccgatt caccatctcc aaagacaacg ccaagaacac tctgtatctg    240
				caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcggc agccattgtc    300
				gggggtttta atgcatattg tagtggtggt tatgttctgg actttggtgc ctggggccag    360
				gggacccagg tcaccgtctc ctca                                           384
				<![CDATA[<210>  401]]>
				<![CDATA[<211>  396]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS69443核酸序列]]>
				<![CDATA[<400>  401]]>
				gaggtgcagc tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgttcag cctctggttt cacttttgat gattctgaca tggcctggta ccgccaggct    120
				ccaggggatg ggtgcgactt ggtctcaact attagtagtg atggtagcac atactatgca    180
				gactccgtga agggccgatt caccatctcc caagacaacg ccaagaacac ggtgtatctg    240
				caaatgcaca gcctgaaacc tgaggacacg gccgtgtatt actgtgcggc agatttcctc    300
				accggctttt actatagcga ctccccccat ccggcccctt gttctgcatc cgactttggt    360
				tactggggcc aggggaccca ggtcaccgtc tcctca                              396
				<![CDATA[<210>  402]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75376核酸序列]]>
				<![CDATA[<400>  402]]>
				caggtgcaat tgaaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagt agccactcca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagtt atttatactg gtgatggtag cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagatccg    300
				aaccccgatt atatgcttcc gtttcggccg tcccgtaggt cgtggtgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  403]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75387核酸序列]]>
				<![CDATA[<400>  403]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cccctacagt agcccctgca tggcctggtt tcgccaggct    120
				ccagggaagg agcgcgaggg ggttttagtt gcttatactg gtggggacat tcaatacctt    180
				accgactccg tgaagggccg attcaccatc tcccgagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcggatctg    300
				cgattacctc gtgccggcgg ttgtgcgtat agctactggg gccaggggac ccaggtcacc    360
				gtctcctca                                                            369
				<![CDATA[<210>  404]]>
				<![CDATA[<211>  363]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75695核酸序列]]>
				<![CDATA[<400>  404]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata caccgtcagt gcctactgta tgggctggtt ccgccaggtt    120
				ctagggaagg ggcgcgagag gatcgcattt atcgatgccg ggggtgctac gatttacgca    180
				gaccccgtga agggccgatt caccatctcc aaagacaacg ccaagaacac tctgtatctg    240
				caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgttgc agatcgccgg    300
				gggcgggtac gtcggtgcga gtataacgcc tggggccagg ggacccaggt caccgtctcc    360
				tca                                                                  363
				<![CDATA[<210>  405]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS76169核酸序列]]>
				<![CDATA[<400>  405]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata catttacagt agcttctgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggt ggtcgcgtat attcgcgata atattatgac aagttacaca    180
				gactccgtga agggccgatt caccatctcc aaagacaacg ccaagagaac tctgtatcta    240
				caaatgaacg gcctgaaacc tgaagatact ggcatgtact actgtgcggt agaccggggg    300
				ggatacgcta atagttgcgc ggtagcggcc cggtatgatt actggggccg ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  406]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63931核酸序列]]>
				<![CDATA[<400>  406]]>
				gaggtgcagc tggcggagtc tgggggaggc tcggtgcagg ctggggggtc tctgagactc     60
				tcctgtgcag gctctttctc tggatacggc gtcagtacca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct attactgttg gtagtggaaa cacatactat    180
				gccgactccg tgacgggccg attcaccatc tcccgagaca acgccaagag gacggtgtat    240
				ttgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggccggatgg    300
				ttgtcgggtg gtagttggca cgttcccggc aggtataact actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  407]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63937核酸序列]]>
				<![CDATA[<400>  407]]>
				caggtgaagt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggatc caccatcagt agtcgcccga tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcgtgt atacatactg gtcttggtag aacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaagtga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagactcg    300
				cggcggccgt gtatggtagc cgcagggtat acctactggg gccaggggac ccaggtcacc    360
				gtctcctca                                                            369
				<![CDATA[<210>  408]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63948核酸序列]]>
				<![CDATA[<400>  408]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtacag cctctggata cacctataga tacctctaca tgggctggtt ccgccagact    120
				ccagggaagg agcgcgaggg ggtcgcatgt atttatactg gtagtggtag cacagggtat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccgagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagcttcg    300
				ccccggtggg gtggtacctg tcgacggtgg tccgagtata actactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  409]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63956核酸序列]]>
				<![CDATA[<400>  409]]>
				caggtgcacc tggtggagtc tgggggaggc ttggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctccggatt cacctacagt aactgctgca tgaggtggta ccgccaggct    120
				ccagggaagg cgcgcgagtt ggtctcatta attaatagta gtggtggcac atactatgca    180
				gactctgtga ggggccgatt caccatctcc aaagacaacg ccaagaacac gctgtatctg    240
				caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtgcggc ttaccaagcc    300
				aagtactgtt caggcccttg cgccccccca actgactggg gccaggggac ccaggtcacc    360
				gtctcctca                                                            369
				<![CDATA[<210>  410]]>
				<![CDATA[<211>  363]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63965核酸序列]]>
				<![CDATA[<400>  410]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata cagcagcggt agttgtcgca tgggctggta ccgccaggct    120
				ccagggaagg agcgcgagtt ggtttcaaag gttattagtg atggtactac agtctatgca    180
				gactccgtga agggccgatt caccctctcc caaggaaacg ccaagaacac ggtgtatctg    240
				caaatgagta gcctgttacc tgaggacacg gccatgtatt actgtaatgc atggtgtagg    300
				gagtatcccg gggggatcct gaataacggc tggggccagg ggacccaggt caccgtctcc    360
				tca                                                                  363
				<![CDATA[<210>  411]]>
				<![CDATA[<211>  354]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63993核酸序列]]>
				<![CDATA[<400>  411]]>
				caggtgaagt tggtggagtc tggggggggc ttggtgcagg caggggggtc tctgagactc     60
				tcctgtacag tttctggatt cactttcgat gacctcgtca tggcctggtt ccgccaggct    120
				ccagggaagg agcgccaact tgtctcgttg gttgcgactg ctggtaatag cgtctatgca    180
				gactccgtga agggccgatt cacactctcc agagacaacg cccacagcac ggcgtatctg    240
				caaatgaacg gcctgaaacc tgaggacacg gccatgtatt actgtgcggc acgtaccgat    300
				tctgagcatg cgtttaagtt ctggggtcag gggacccagg tcaccgtctc ctca          354
				<![CDATA[<210>  412]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63999核酸序列]]>
				<![CDATA[<400>  412]]>
				gaggtgcaac tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacttacagt agcaactgga tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgagga ggtcgcaatt atttatactg gtggtattag tacacactat    180
				cgcagctccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgcgttat    300
				acagactata actactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  413]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64006核酸序列]]>
				<![CDATA[<400>  413]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgaag tctctggata caccggcgat acgacttaca taggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcactt atttatacta gtggtactag cgagtactac    180
				gccgactccg tgaagggccg attcatcatc tcccgagaca acgccaagaa cacggtgtat    240
				ttacaaatga acagcctgaa acctgaggac actgccatgt actactgtgg cgcacggagc    300
				cgcacgatga tgtactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  414]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64057核酸序列]]>
				<![CDATA[<400>  414]]>
				caggtgcaat tggaggagtc tgggggaggc ttggtgcaga caggggggtc tctgagactc     60
				tcctgtacag cctctggatt cacttttgat cgtaatgcca tgcgctggta ccgccaggct    120
				ccagggaagg agcgcgaggg ggtctcatgt attagttgga cgggtgcaaa tattgcctat    180
				gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat    240
				ctgcaaatga acagcctgaa acctgaggac acgggcatgt attactgtgc ggcagatacg    300
				acgtcggggt cttgttcagg cttttggtct acgagccggt actactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  415]]>
				<![CDATA[<211>  366]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64060核酸序列]]>
				<![CDATA[<400>  415]]>
				caggtgaagt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggatc cacctactgt acctaccgta tgagctggtt ccgccaggct    120
				ccagggaagg agcgcgagtt cgtcgcagtt attgatagtg gcggtagcac aagctacgca    180
				gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacac ggtgtatctg    240
				caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaaac agatccaacc    300
				atcggctgcc cccagacata taggtataac tactggggcc aggggaccca ggtcaccgtc    360
				tcctca                                                               366
				<![CDATA[<210>  416]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64071核酸序列]]>
				<![CDATA[<400>  416]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggaaa cacttacagg ctcaactcta tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcattt attgttatga ttagaggtac cacatactat    180
				ggcgcctccg taaagggccg attcaccatc tcccaagaca acgcccagac cacggtgtat    240
				ctgcaaatga gcagcctgaa accggaggac actgccatgt actactgtgc ggcatccact    300
				aaggaccagt tttatgtatt taatcctatt gggtatgact cttggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  417]]>
				<![CDATA[<211>  390]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64093核酸序列]]>
				<![CDATA[<400>  417]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcaa cctctagata catctacggt aacaactgca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg agtcgcgtct atttatcctg ctggtggtcg cacgtactat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaattg acagcctgaa acctgaggac acggccatgt actactgcgc ggcacgctct    300
				ttttcgatag gagtttgcgc gacgcagtct ggtattacct ggtctaattt tgcttactgg    360
				ggccagggga cccaggtcac cgtctcctca                                     390
				<![CDATA[<210>  418]]>
				<![CDATA[<211>  351]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64118核酸序列]]>
				<![CDATA[<400>  418]]>
				caggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagt gcctgtagaa tggcctggta ccgccaggct    120
				cccgggaagg agcgcgagtt ggtttcattt attaatagtg ctggtagcac atactatgcc    180
				gactccgtga agggccgatt cgccatctcc cgagacaacg ccaagacaac ggtgtatcta    240
				caaatgaacg ccctgaaagc tgaggacacg gccatatatt actgtaacac atgggatagt    300
				agctgccgct ttcagtactg gggccagggg acccaggtca ccgtctcctc a             351
				<![CDATA[<210>  419]]>
				<![CDATA[<211>  404]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64120核酸序列]]>
				<![CDATA[<400>  419]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgaaa cctctagata catctacggt aacaactgca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg agtcgcgtct atttatcctg ctggtggtcg cccgtactat    180
				gccgactccg tgaagggccg attcaccatc tcccaaagac aacgccaaga acacggtgta    240
				tctgcaaaat ggacagccct gaaaacctga ggacacggcc catgtactac tgcgcgggca    300
				cgcttctttt ttcgatagca aattgcgcca acgcaatcct ggtattaacc agggccaaat    360
				tttggcttac gggggccagg ggacccaggt cacccttctc ctca                     404
				<![CDATA[<210>  420]]>
				<![CDATA[<211>  384]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64124核酸序列]]>
				<![CDATA[<400>  420]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcaga ctggagggtc tctgagactc     60
				tcctgtgcag tctctacgta cacccccagt aacaactaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg cgtcgcggct atcgctacta ttggtggtac cacacgttat    180
				gccgactccg tgaagggccg attcaccatc tcccaagacg gcgccaagaa cacgatatat    240
				ctgcaaatga acggcctgaa accggaggac actgccatgt actactgtgc ggccgggcgg    300
				ccatactcat tacccttacc cttacccttg gaaagcggtg cgtatcgcta ctggggccag    360
				gggacccagg tcaccgtctc ctca                                           384
				<![CDATA[<210>  421]]>
				<![CDATA[<211>  363]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64135核酸序列]]>
				<![CDATA[<400>  421]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctacatc aacctactgt aggtactaca tgcgctggta ccggcaggct    120
				ccagggaaag agcgcgagtt cgtctcagcg atgcaacccg atggtacgac aagctactca    180
				gactccgtga agggccgatt caccatgtcc caagacagag ccaacaatat gttgtatctg    240
				caaatgaaca gcctgaggcc tgaggacacg gccatgtatt actgtaaaag agatccaatg    300
				gggggttcaa ggaccccgtg cacctccgcc tggggccagg ggacccaggt caccgtctcc    360
				tca                                                                  363
				<![CDATA[<210>  422]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64163核酸序列]]>
				<![CDATA[<400>  422]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag tctctggata cagatataga tggaactgca tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct atttctactg gaagcggaag cacatactat    180
				gccggctccg tgaagggccg attcaccatc tcccaagaca acgccaagaa catgtatctg    240
				caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcggc agatccttcg    300
				gtttgccccg gtggtatgtg gtactccaaa gagtataggt actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  423]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64182核酸序列]]>
				<![CDATA[<400>  423]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgcacag cctctggaca gacctccaga tacctctaca tgggctggtt tcgccagact    120
				ccagggaagg agcgcgaggg ggtcgcatgt atttatactg gtagtggtag cacagggtat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaacga atagcctgaa acctgaggac actgccatgt actactgtgc ggcaagttcg    300
				ccccattggg gcggtacctg tcgacgctgg tccgagtata agtactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  424]]>
				<![CDATA[<211>  366]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64183核酸序列]]>
				<![CDATA[<400>  424]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggaca cacctacagt gccaactgca tggcctggtt ccgccgggcc    120
				ccagggaagg agcgcgagtg ggtcgcgtcg gtttatactg atgatgatag cacaatgtat    180
				accgactccg tgaagggccg attcaccatc ttccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actggcatgt acatctgtgc ggcagattta    300
				agcggaggac cggccggttg tgggtatacc cactggggcc aggggaccca ggtcaccgtc    360
				tcctca                                                               366
				<![CDATA[<210>  425]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64207核酸序列]]>
				<![CDATA[<400>  425]]>
				gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacagt agcaacttca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaact attgtttctg gtggtggtac cacatactat    180
				gccgactccg tgaggggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggggc    300
				ccccctacga acggtgctaa gtggtacccc ctccgacctc ctggttataa ctactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  426]]>
				<![CDATA[<211>  366]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64276核酸序列]]>
				<![CDATA[<400>  426]]>
				caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagcctc     60
				tcctgtgtag tctctggata caccggcagt agccgctgta tggcctggtt ccgccaggct    120
				ccagggaagg agcgcgaggc ggtcgcacaa atttttactg gtcgtggtac cacaggctat    180
				gccgactccg tgaagggccg attcactatt tcccaagaca acgccaagaa cacggtgtat    240
				ctgcgaatga acagtctgag acctgaggac actgccattt actactgtgc ggcgagtctc    300
				ggcccgggac gcggagcctg tgggtataac tactggggcc aggggaccca ggtcaccgtc    360
				tcctca                                                               366
				<![CDATA[<210>  427]]>
				<![CDATA[<211>  363]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64336核酸序列]]>
				<![CDATA[<400>  427]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctaagactc     60
				tcctgtacaa cctctggacg cacctacagt agctgcagca tgggctggta ccgccaggct    120
				ccagggaagg agcgcgagtt ggtctcacat atttttagtg atggtagcag atactatgca    180
				gactccgtga agggccgatt caccatctcc caagacaacg ccaagaacac ggtgtatctg    240
				caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaccg ccgtacgggt    300
				tgggcaccaa ggtgcgctgt tcccggttac tggggccagg ggacccaggt caccgtctcc    360
				tca                                                                  363
				<![CDATA[<210>  428]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64346核酸序列]]>
				<![CDATA[<400>  428]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctatttc atgggctggt tccgccaggc tccacagaag    120
				gagcgcgaat gggtcgcgac tattggtact ggtgatattt tcaatggcgc tgcttactat    180
				gtcgactccg tgaagggccg attcgccatc tcccaagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaagac actgccgtgt acgtctgtgc ggcagttcaa    300
				tcgaaatcct caaactacgt gttgagagac gcatctacct acaactactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  429]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64420核酸序列]]>
				<![CDATA[<400>  429]]>
				gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctgaagggtc tctgagactc     60
				tcctgtgcag cctctggaga caccagtaga agcgtctgga tgggctgggc ccgccaggtt    120
				ccagggaaag agcgcgaggt ggtcgcaacc attagtactg ccggtggtag tacatggtat    180
				accgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtac    240
				ctgcaaatga acagcctgaa acctgaggac actgccatat actattgtgc ggccagaagc    300
				agatatgcta cctactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  430]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64473核酸序列]]>
				<![CDATA[<400>  430]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtacag cctctggata cacctacaga tacctctaca tggcctggtt ccgccagact    120
				ccagggaagg agcgcgaggg ggtcgcatgt atttatactg gtagtggtac cacagggtat    180
				gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa tacggtgtat    240
				ctgcaaatga acagcctgaa cgctgaggac actgccatgt actactgtgc ggcaagttcg    300
				ccccagtggg gcggtacctg tcgacgctgg tccgagtata actactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  431]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64475核酸序列]]>
				<![CDATA[<400>  431]]>
				caggtgcaac tgcaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctggagt cgcaactgga tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg gttcgcaact attacaatta gtggtggtag cacatggtat    180
				gccgactccg tgaagggccg attcaccatc tccctagaca acgccgggaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgcgggat    300
				accgcgcgga cctactgggg ccagggtacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  432]]>
				<![CDATA[<211>  381]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64513核酸序列]]>
				<![CDATA[<400>  432]]>
				gaggtgcagc tggtggaatc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctgacta cccctacata gacaactgca tgggctggtt ccgccagggt    120
				ccagggaagg agcgcgaggg ggtcgcagct gcgtgtactg gtggtggtag cacatattat    180
				gccgactccg tgaagggccg attcaccatc tcccgagaca acgccaagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgacgtgt actactgtgc gacaggctac    300
				tatagcggct ctggtccggg gtatttactc ccatggaggt ataactactg gggccagggg    360
				acccaggtca ccgtctcctc a                                              381
				<![CDATA[<210>  433]]>
				<![CDATA[<211>  393]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64562核酸序列]]>
				<![CDATA[<400>  433]]>
				gaggtgcaac tggtggaatc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata caccgctagg cgcgacttca tggcctggtt ccgccaggtt    120
				ccagggaagg agcgcgaggg ggtcgcagtc attcatactg gtggtgacac cacatactat    180
				gccgactccg tgaagggccg attcaccatc tcccgcgaca acgcccagaa cataatgaat    240
				ctgcaaatga acagccttaa acctgaggac actgccatgt actactgtgc ggcaggtttc    300
				cgtccgcgtg gtggaggata cacgggtgac gtcttggccc aggctgcggc atacaactac    360
				tggggccagg ggacccaggt caccgtctcc tca                                 393
				<![CDATA[<210>  434]]>
				<![CDATA[<211>  378]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64583核酸序列]]>
				<![CDATA[<400>  434]]>
				gaggtgcagc tggcggagtc tgggggaggc ttggtgcagg caggggggtc tctgagactc     60
				tcctgtacag cctctggatt cactattgct gtttatacca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg aatctcatgt actagctggg ctggtggtcg cacatacact    180
				gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat    240
				ctgcaaatga acagcctgaa acctgaggac acggccatgt attactgtgc ggcaaaggca    300
				catcccgact gttcagggga ttggtcccca tctgggtatg aatactgggg ccaggggacc    360
				caggtcaccg tctcctca                                                  378
				<![CDATA[<210>  435]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64594核酸序列]]>
				<![CDATA[<400>  435]]>
				caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata cacctacaat agcaactaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcactt atttatactg gtggtggtag cacatattat    180
				gccgactccg tgaagggccg attcaccatc tcccgagaca acgccaaaaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgttc ggtaagaacg    300
				cagacgcgta actactgggg ccaggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  436]]>
				<![CDATA[<211>  393]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64605核酸序列]]>
				<![CDATA[<400>  436]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag tttctagata tccctacagc agcatctgca tgggctggtt ccgccaggct    120
				ccagggaagg agagcgaggg tgtcgcacgt atttatactg gtactggtag tacatggtat    180
				accgactccg tgaagggccg attcaccatc gcccgagaca acgcccagaa cacggtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcgcgtagc    300
				aattcatatt catattcaag ttgtgattac ggccccctca cgaggggggg gtataacttc    360
				tggggccagg ggacccaggt caccgtctcc tca                                 393
				<![CDATA[<210>  437]]>
				<![CDATA[<211>  345]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64606核酸序列]]>
				<![CDATA[<400>  437]]>
				gaggtgcagc tggcggagtc tgggggagga tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag tctctggata caccagccgt agcaattaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcgcta atttatactc gtggtggtag cacatactat    180
				gcctcctccg tgaagggccg gttcaccatc tcccaagaca gtgccaagaa aacgtatctg    240
				caaatgaaca gtgtgaaacc ggaggacact gccatgtact actgtgcttt gcgccttgat    300
				gagaagatgt actggggcca ggggacccag gtcaccgtct cctca                    345
				<![CDATA[<210>  438]]>
				<![CDATA[<211>  399]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68121核酸序列]]>
				<![CDATA[<400>  438]]>
				gaggtgcagc tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgatg cctctggata cacctacagc cgcaactgca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagcg ttctatactg attatattcg ttttgggcgc    180
				acatattatg ccgactccgt gaagggccga ttcaccatct tccaagacaa cgccaagaac    240
				acggtgtatc tgcaaatgaa cagcctgaaa cctgaggaca ctgccatgta ctactgtgcg    300
				gcagatcctg ggagtcgtac agacgatagt tgtggtacct catacaacaa agggaatttt    360
				ggttactggg gccaggggac ccaggtcacc gtctcctca                           399
				<![CDATA[<210>  439]]>
				<![CDATA[<211>  390]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68170核酸序列]]>
				<![CDATA[<400>  439]]>
				caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc gctgagactc     60
				tcctgtacag cctctggata cacctacaga agcaactgta tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaaca atctatactg gtggtggtcg taatctatac    180
				tatgccgact ccgtgaaggg ccgattcacc atctcccgag acaacgccaa gaacaccctg    240
				tacctgcaaa tgaacagcct gaagcctgag gactctgcca ggtactactg tgcggccgcg    300
				agtgacgtgg cagttggtgt taattcctgc gggggaagga ctgcggggtt tgacgcctgg    360
				ggccagggga cccaggtcac cgtctcctca                                     390
				<![CDATA[<210>  440]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS63964核酸序列]]>
				<![CDATA[<400>  440]]>
				caggtgaggt tagtggagtc tgggggagga tcggtacagg ctggagggtc tctgagactc     60
				tcctgctcag cctctggata cacctacagt tacaacaata tgggctggtt ccgccaggct    120
				ccagggaacg agcgcgaggg ggtcgcagct attagtggtg gtcgtttcac cgcctatgcc    180
				gactccgtga agggccgatt caccatctcc cgagacaacg ccgagaacac gctgtatctg    240
				caaatgaaca acctgaaacc tgaggacact gggatgtact actgtgcggc agaggtagtt    300
				gatccgacct gggggtcgcg tgaccaaaga cgatataagt actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  441]]>
				<![CDATA[<211>  372]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS64116核酸序列]]>
				<![CDATA[<400>  441]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcgtgtgcag cctctggata catctacagt tgcgtgggct ggttccgcca ggctccaggg    120
				aaggagcgcg agggggtcgc aggtattagt actggtggtg gtggcacagt ctatgccgac    180
				tccgtgaagg gccaattcac catctcccga gacaacgcca agaacacggt gtacctgcaa    240
				atggacagcc tgaaacctga ggacactgcc atgtactact gtgcggcaga tcgatggaat    300
				tcattcgcta attgcggtgc ctggggaagg tatacctact ggggccaggg gacccaggtc    360
				accgtctcct ca                                                        372
				<![CDATA[<210>  442]]>
				<![CDATA[<211>  390]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68270核酸序列]]>
				<![CDATA[<400>  442]]>
				caggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata cccctcttcc acctactaca tgctcagcat ggcgtggttc    120
				cgccaggctc cagggaagga gcgcgagggg gtcgccgcta ttactagcgg tactgggagc    180
				acaagctacg cagactccgt gaaggaccga ttcaccatct ccaaagacta cgccaacaac    240
				actctgtatc tgcacataaa caacctgaaa cctgaggaca ctgccatgta ctactgtgcg    300
				gcagcctcag gttggatcgt tcctagtagg tccctgaccg ccaacctata taggtattgg    360
				ggccagggga cccaggtcac cgtctcctca                                     390
				<![CDATA[<210>  443]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68320核酸序列]]>
				<![CDATA[<400>  443]]>
				caggtgcacc tggtggagtc tgggggagac tcggtgcagg ctggagggtc cctgagactc     60
				tcctgtgcag cctctggata cacctacaat accaactaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcagct atttatagac atagtggtaa cacagcctat    180
				gccgactccg tgaagggccg attcaccatc tcccaagact acgccaagaa caccgtgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagggcgc    300
				gctggtccct gggccctgat gcgcccgact gagtttggtt actggggcca ggggacccag    360
				gtcaccgtct cctca                                                     375
				<![CDATA[<210>  444]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS68351核酸序列]]>
				<![CDATA[<400>  444]]>
				caggtgcaat tggaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc     60
				tcctgtgcgg cctctggaga cacatttcgt gcctattaca tgaactgggt ccgccaggct    120
				ccagggaagg gattcgagtg ggtctcaggt attagcgcca gtggcggccg tacgtcatac    180
				gcagactccg tgaagggccg attcaccatc tccagagaca acgccaaaaa cacgctgtat    240
				ctgcaattga acagcctgag cactgaggac acgggcatgt attattgtgt aaagggagct    300
				gtccgtctct cgacatcgtc agtacgggat tcgtcctggg gccaggggac ccaggtcacc    360
				gtctcctca                                                            369
				<![CDATA[<210>  445]]>
				<![CDATA[<211>  348]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75378核酸序列]]>
				<![CDATA[<400>  445]]>
				caggtgcaat tggaggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag tctctggaaa cacccgcagt accacgtaca tgggctggtt ccgccaggct    120
				ccagggaagg agcgcgaggg ggtcgcaata gtttatactg gtggtcgtga cacatactat    180
				gccgcctccg tgaagggccg attcaccatc tcccaagaca acgccaagac aacgatctat    240
				ctgcaaatga acagtctgga acctgaggac actgccatgt actactgtgc ggcacgctca    300
				tatgagtata cctactgggg tcgggggacc caggtcaccg tctcctca                 348
				<![CDATA[<210>  446]]>
				<![CDATA[<211>  372]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75383核酸序列]]>
				<![CDATA[<400>  446]]>
				gaggtgcaac tggcggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata caccttcagt agctactgct tgggctggtt ccgccaggct    120
				ccagggaagc agcgccaggg ggtcgcaacg tttaataata gaggtgtcgc aaactaccac    180
				gattccgtga agggccgatt caccgcctcc gtagacaacg ccaagaacac tctgcttctg    240
				caaatgaaca gcctggaacc tgacgacacg gccatgtact actgtgcggc ggatcgccgg    300
				tacggtcgtc agtggtatca gccttgcgag tggaacacct ggggccaggg gacccaggtc    360
				accgtctcct ca                                                        372
				<![CDATA[<210>  447]]>
				<![CDATA[<211>  387]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS75751核酸序列]]>
				<![CDATA[<400>  447]]>
				caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgtag cctctggata cttctacaat acctactact ttatgggctg gttccgccag    120
				gctccaggga aggagcgcga gggggtcgca gctattgata ctgatggtag aacaagttac    180
				gcagactccg tgaagggccg attcaccatc tccaaagaca acgccaagaa cactctgtat    240
				ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcaggtttt    300
				ggctatatga atgttattca ggctcttaat ggcatgagac agaatcccga ctactggggc    360
				caggggaccc aggtcaccgt ctcctca                                        387
				<![CDATA[<210>  448]]>
				<![CDATA[<211>  372]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝sdAb AS76422核酸序列]]>
				<![CDATA[<400>  448]]>
				caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc     60
				tcctgtgcag cctctggata caccttcgct ggcaactgct tgggctggtt tcgccaggct    120
				ccagggaagg ggcgcgaggg ggtcgtaacg tacaataact tcggtgtcgc caactacgcc    180
				gattccgtga agggccgatt caccgtctcc caagacaacg ccaagaacac tctgcttctg    240
				caaatgaaca gcctggaacc tgaggacact gccatgtact actgtgcggc ggaccgccgg    300
				gacggtcgtc gctggtctca gccttgcgag tggaatacct ggggccaggg gacccaggtc    360
				accgtctcct ca                                                        372
				<![CDATA[<210>  449]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64380VH4核酸序列]]>
				<![CDATA[<400>  449]]>
				gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag catctggaaa cacctacagc tccaattata tgggatggtt caggcaggca    120
				cctggcaagg gactggagga ggtggccgtg atctacacca ggggaggaca cacatactat    180
				gtggactccg tgcggggacg gttcaccatc agcagggata acgccaagaa cagcctgtat    240
				ctgcagatga actctctgag agccgaggac acagccgtgt actattgtgc agcatctagc    300
				aggcacaggc tgggcctgaa caatccaagg gactacgatt attggggcca gggcaccctg    360
				gtgacagtgt cctct                                                     375
				<![CDATA[<210>  450]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64380VH5核酸序列]]>
				<![CDATA[<400>  450]]>
				gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag catctggaaa cacctacagc tccaattata tgggatggtt caggcaggca    120
				cctggcaagg gcctggagga ggtggccgtg atctacacca gaggcggcca cacatactat    180
				gtggactccg tgcggggacg gttcaccatc agccaggata acgccaagaa cagcctgtat    240
				ctgcagatga actctctgag ggccgaggac acagccgtgt actattgtgc agcatctagc    300
				aggcacaggc tgggcctgaa caatccaagg gactacgatt attggggcca gggcaccctg    360
				gtgacagtgt cctct                                                     375
				<![CDATA[<210>  451]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64380VH6核酸序列]]>
				<![CDATA[<400>  451]]>
				gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag catctggaaa cacctacagc tccaattata tgggatggtt caggcaggca    120
				cctggcaagg gcctggagga ggtggccgtg atctacacca gaggcggcca cacatactat    180
				gtggactccg tgcggggacg gttcaccatc agccaggata acgccaagaa cagcgtgtat    240
				ctgcagatga actctctgag ggccgaggac acagccatgt actattgtgc agcatctagc    300
				aggcacaggc tgggcctgaa caatccaagg gactacgatt attggggcca gggcaccctg    360
				gtgacagtgt cctct                                                     375
				<![CDATA[<210>  452]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64380VH7核酸序列]]>
				<![CDATA[<400>  452]]>
				gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag catctggaaa cacctacagc tccaattata tgggatggtt caggcaggca    120
				cctggcaagg gaagagagga ggtggccgtg atctacacca ggggaggaca cacatactat    180
				gtggactccg tgcggggacg gttcaccatc agccaggata acgccaagaa cagcgtgtat    240
				ctgcagatga actctctgag ggccgaggac acagccatgt actattgtgc agcatctagc    300
				aggcacaggc tgggcctgaa caatccaagg gactacgatt attggggcca gggcaccctg    360
				gtgacagtgt cctct                                                     375
				<![CDATA[<210>  453]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64511VH4核酸序列]]>
				<![CDATA[<400>  453]]>
				gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggctc tctgaggctg     60
				agctgcgcag catccagagc aacctactct acaaactata tcagctggtt caggcaggca    120
				cctggcaagg gactggaggc agtggcaacc atcaccacag gcgatggcga gacagcctac    180
				gccgactctg tgaagggcag gtttaccatc tcccgcgata acgccaagaa cagcctgtat    240
				ctgcagatga acagcctgag ggccgaggac acagccgtgt actattgtgc agcaaatctg    300
				aggatcggag gcgactggtt cgatggaagg gactttagag catggggaca gggaaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  454]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64511VH5核酸序列]]>
				<![CDATA[<400>  454]]>
				gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggctc tctgaggctg     60
				agctgcgcag catccagagc aacctactct acaaactata tcagctggtt caggcaggca    120
				cctggcaagg gactggaggc agtggcaacc atcaccacag gcgatggcga gacagcctac    180
				gccgactctg tgaagggcag gtttaccatc tcccgcgata acgccaagaa cagcgtgtat    240
				ctgcagatga acagcctgag ggccgaggac acagccatgt actattgtgc agcaaatctg    300
				aggatcggag gcgactggtt cgatggaagg gactttagag catggggaca gggaaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  455]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS64511VH6核酸序列]]>
				<![CDATA[<400>  455]]>
				gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggctc tctgaggctg     60
				agctgcgcag catccagagc aacctactct acaaactata tcagctggtt caggcaggca    120
				cctggcaagg gaagggaggc agtggccacc atcaccacag gcgatggcga gacagcctac    180
				gccgactctg tgaagggcag gtttaccatc tcccgcgata acgccaagaa cagcgtgtat    240
				ctgcagatga acagcctgcg ggccgaggac acagccatgt actattgtgc agcaaatctg    300
				aggatcggag gcgactggtt cgatggaagg gactttagag catggggaca gggaaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  456]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63931VH4核酸序列]]>
				<![CDATA[<400>  456]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag gctctttcag cggatacggc gtgtccacca tggcatggtt taggcaggca    120
				cctggcaagg gactggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaccggccg gttcacaatc tctagagata acagcaagaa taccctgtat    240
				ctgcagatga acagcctgcg ggccgaggac acagccgtgt actattgtgc agcaggatgg    300
				ctgtccggag gatcttggca cgtgcccggc aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  457]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63931VH5核酸序列]]>
				<![CDATA[<400>  457]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag gctctttcag cggatacggc gtgtccacca tggcatggtt taggcaggca    120
				cctggcaagg gactggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaccggccg gttcacaatc tctagagata acagcaagaa taccgtgtat    240
				ctgcagatga acagcctgcg ggccgaggac acagccatgt actattgtgc agcaggatgg    300
				ctgtccggag gatcttggca cgtgcccggc aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  458]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63931VH6核酸序列]]>
				<![CDATA[<400>  458]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag gctctttcag cggatacggc gtgtccacca tggcctggtt taggcaggca    120
				cctggcaagg gaagggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaccggccg gttcacaatc tctagagata acagcaagaa taccgtgtat    240
				ctgcagatga acagcctgcg ggccgaggac acagccatgt actattgtgc agcaggatgg    300
				ctgtccggag gatcttggca cgtgcccggc aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  459]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63997VH4核酸序列]]>
				<![CDATA[<400>  459]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag cctctttcag cggatacggc gtgtccacca tggcatggtt taggcaggca    120
				cctggcaagg gactggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaagggccg gttcaccatc tctagagata acagcaagaa tacactgtac    240
				ctgcagatga acagcctgcg ggccgaggac acagccgtgt actattgtgc cgtgggctat    300
				ctgtccggag gatcttggga tgtgccagga aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  460]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63997VH5核酸序列]]>
				<![CDATA[<400>  460]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag cctctttcag cggatacggc gtgtccacca tggcatggtt taggcaggca    120
				cctggcaagg gactggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaagggccg gttcaccatc tctagagata acagcaagaa tacagtgtac    240
				ctgcagatga acagcctgcg ggccgaggac acagccatgt actattgtgc cgtgggctat    300
				ctgtccggag gatcttggga tgtgccagga aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  461]]>
				<![CDATA[<211>  375]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化sdAb AS63997VH6核酸序列]]>
				<![CDATA[<400>  461]]>
				caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggcag cctgaggctg     60
				tcctgcgcag cctctttcag cggatacggc gtgtccacca tggcctggtt taggcaggca    120
				cctggcaagg gaagggaggg agtggcagca atcaccgtgg gatccggaaa cacatactat    180
				gccgactctg tgaagggccg gttcaccatc tctagagata acagcaagaa tacagtgtac    240
				ctgcagatga acagcctgcg ggccgaggac acagccatgt actattgtgc cgtgggctat    300
				ctgtccggag gatcttggga tgtgccagga aggtacaact attggggcca gggcaccctg    360
				gtgacagtga gctcc                                                     375
				<![CDATA[<210>  462]]>
				<![CDATA[<211>  15]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  連接子胺基酸序列]]>
				<![CDATA[<400>  462]]>
				Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
				1               5                   10                  15  
				<![CDATA[<210>  463]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  連接子胺基酸序列]]>
				<![CDATA[<400>  463]]>
				Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
				1               5                   10  
				<![CDATA[<210>  464]]>
				<![CDATA[<211>  5]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  連接子胺基酸序列]]>
				<![CDATA[<400>  464]]>
				Gly Gly Gly Gly Ser 
				1               5   
				<![CDATA[<210>  465]]>
				<![CDATA[<211>  21]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD8α信號肽胺基酸序列]]>
				<![CDATA[<400>  465]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro 
				            20      
				<![CDATA[<210>  466]]>
				<![CDATA[<211>  69]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD8α鉸鏈胺基酸序列]]>
				<![CDATA[<400>  466]]>
				Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
				1               5                   10                  15      
				Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
				            20                  25                  30          
				Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
				        35                  40                  45              
				Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
				    50                  55                  60                  
				Ile Thr Leu Tyr Cys 
				65                  
				<![CDATA[<210>  467]]>
				<![CDATA[<211>  24]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD8α跨膜域胺基酸序列]]>
				<![CDATA[<400>  467]]>
				Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
				1               5                   10                  15      
				Ser Leu Val Ile Thr Leu Tyr Cys 
				            20                  
				<![CDATA[<210>  468]]>
				<![CDATA[<211>  42]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  4-1BB胞內域胺基酸序列]]>
				<![CDATA[<400>  468]]>
				Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
				1               5                   10                  15      
				Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
				            20                  25                  30          
				Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
				        35                  40          
				<![CDATA[<210>  469]]>
				<![CDATA[<211>  41]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD28胞內域胺基酸序列]]>
				<![CDATA[<400>  469]]>
				Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
				1               5                   10                  15      
				Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
				            20                  25                  30          
				Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
				        35                  40      
				<![CDATA[<210>  470]]>
				<![CDATA[<211>  112]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD3ζ胞內域胺基酸序列]]>
				<![CDATA[<400>  470]]>
				Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
				1               5                   10                  15      
				Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
				            20                  25                  30          
				Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
				        35                  40                  45              
				Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
				    50                  55                  60                  
				Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
				65                  70                  75                  80  
				Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
				                85                  90                  95      
				Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				            100                 105                 110         
				<![CDATA[<210>  471]]>
				<![CDATA[<211>  25]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  F2A元件胺基酸序列]]>
				<![CDATA[<400>  471]]>
				Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
				1               5                   10                  15      
				Gly Asp Val Glu Ser Asn Pro Gly Pro 
				            20                  25  
				<![CDATA[<210>  472]]>
				<![CDATA[<211>  22]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  P2A元件胺基酸序列]]>
				<![CDATA[<400>  472]]>
				Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
				1               5                   10                  15      
				Glu Glu Asn Pro Gly Pro 
				            20          
				<![CDATA[<210>  473]]>
				<![CDATA[<211>  257]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CAR3抗DLL3 scFv胺基酸序列]]>
				<![CDATA[<400>  473]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
				            20                  25                  30          
				Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
				        35                  40                  45              
				Asn Ile Tyr Tyr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
				    50                  55                  60                  
				Pro Lys Leu Leu Ile Tyr Thr Ala Asn Ser Leu Glu Asp Val Pro Ser 
				65                  70                  75                  80  
				Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
				                85                  90                  95      
				Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Lys Gln Ala Tyr 
				            100                 105                 110         
				Asp Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
				        115                 120                 125             
				Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
				    130                 135                 140                 
				Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
				145                 150                 155                 160 
				Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Trp Ile 
				                165                 170                 175     
				His Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr 
				            180                 185                 190         
				Ile Asn Pro Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe Lys Asp Arg 
				        195                 200                 205             
				Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu 
				    210                 215                 220                 
				Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
				225                 230                 235                 240 
				Gly Ser Asn Phe Phe Asp Tyr Trp Gln Gly Thr Thr Val Thr Val Ser 
				                245                 250                 255     
				Ser 
				<![CDATA[<210>  474]]>
				<![CDATA[<211>  27]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD28跨膜域胺基酸序列]]>
				<![CDATA[<400>  474]]>
				Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
				1               5                   10                  15      
				Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
				            20                  25          
				<![CDATA[<210>  475]]>
				<![CDATA[<211>  39]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  CD28鉸鏈]]>
				<![CDATA[<400>  475]]>
				Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
				1               5                   10                  15      
				Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
				            20                  25                  30          
				Phe Pro Gly Pro Ser Lys Pro 
				        35                  
				<![CDATA[<210>  476]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS63997]]>
				<![CDATA[<400>  476]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Arg Thr Val Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  477]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64380]]>
				<![CDATA[<400>  477]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Glu Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  478]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64511]]>
				<![CDATA[<400>  478]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala 
				        35                  40                  45              
				Thr Tyr Ser Thr Asn Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Ala Val Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe 
				        115                 120                 125             
				Asp Gly Arg Asp Phe Arg Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  479]]>
				<![CDATA[<211>  361]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64617]]>
				<![CDATA[<400>  479]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
				        35                  40                  45              
				Thr Asp Arg Cys Ser Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
				    50                  55                  60                  
				Arg Glu Leu Val Ser Arg Ile Ser Thr Ser Gly Phe Thr Asn Tyr Ala 
				65                  70                  75                  80  
				Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
				                85                  90                  95      
				Thr Val Tyr Leu Gln Met Asn Ser Leu Asn Pro Gly Asp Thr Gly Met 
				            100                 105                 110         
				Tyr Tyr Cys Ala Ile Ile Val Gly Arg Thr Cys Ser Leu Asn Tyr Trp 
				        115                 120                 125             
				Gly Asn Gly Ile Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
				    130                 135                 140                 
				Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
				145                 150                 155                 160 
				Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
				                165                 170                 175     
				Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
				            180                 185                 190         
				Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
				        195                 200                 205             
				Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
				    210                 215                 220                 
				Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
				225                 230                 235                 240 
				Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
				                245                 250                 255     
				Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
				            260                 265                 270         
				Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
				        275                 280                 285             
				Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
				    290                 295                 300                 
				Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
				305                 310                 315                 320 
				Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
				                325                 330                 335     
				Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
				            340                 345                 350         
				Leu His Met Gln Ala Leu Pro Pro Arg 
				        355                 360     
				<![CDATA[<210>  480]]>
				<![CDATA[<211>  376]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS69443]]>
				<![CDATA[<400>  480]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe 
				        35                  40                  45              
				Thr Phe Asp Asp Ser Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asp 
				    50                  55                  60                  
				Gly Cys Asp Leu Val Ser Thr Ile Ser Ser Asp Gly Ser Thr Tyr Tyr 
				65                  70                  75                  80  
				Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys 
				                85                  90                  95      
				Asn Thr Val Tyr Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala 
				            100                 105                 110         
				Val Tyr Tyr Cys Ala Ala Asp Phe Leu Thr Gly Phe Tyr Tyr Ser Asp 
				        115                 120                 125             
				Ser Pro His Pro Ala Pro Cys Ser Ala Ser Asp Phe Gly Tyr Trp Gly 
				    130                 135                 140                 
				Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
				145                 150                 155                 160 
				Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
				                165                 170                 175     
				Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
				            180                 185                 190         
				Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
				        195                 200                 205             
				Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
				    210                 215                 220                 
				Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
				225                 230                 235                 240 
				Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
				                245                 250                 255     
				Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
				            260                 265                 270         
				Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
				        275                 280                 285             
				Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
				    290                 295                 300                 
				Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
				305                 310                 315                 320 
				Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
				                325                 330                 335     
				Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
				            340                 345                 350         
				Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
				        355                 360                 365             
				His Met Gln Ala Leu Pro Pro Arg 
				    370                 375     
				<![CDATA[<210>  481]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS63931]]>
				<![CDATA[<400>  481]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Arg Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Gly Trp Leu Ser Gly Gly Ser Trp His 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  482]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64047]]>
				<![CDATA[<400>  482]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val His Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gln Tyr 
				        35                  40                  45              
				Val Tyr Arg Trp Asp Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Ala Val Ala Ala Val Tyr Thr Gly Asp Gly Ile Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Gly Met Tyr Phe Cys Ala Ala Gly Phe Val Ser Gly Gly Arg Trp Asn 
				        115                 120                 125             
				Gln Ser Tyr Arg Tyr Lys Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  483]]>
				<![CDATA[<211>  373]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64052]]>
				<![CDATA[<400>  483]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val His Leu Met Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
				        35                  40                  45              
				Thr Tyr Arg Ser Asn Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Glu Arg Glu Gly Ile Ala Thr Ile His Ser Gly Val Ala Thr Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Gly Gly Pro Pro Ala Asn Ala Asp Arg 
				        115                 120                 125             
				Trp Tyr Pro Leu Arg Pro Pro Gly Tyr Asn Tyr Trp Gly Gln Gly Thr 
				    130                 135                 140                 
				Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
				145                 150                 155                 160 
				Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
				                165                 170                 175     
				Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
				            180                 185                 190         
				Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
				        195                 200                 205             
				Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
				    210                 215                 220                 
				Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
				225                 230                 235                 240 
				Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
				                245                 250                 255     
				Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
				            260                 265                 270         
				Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
				        275                 280                 285             
				Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
				    290                 295                 300                 
				Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
				305                 310                 315                 320 
				Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
				                325                 330                 335     
				Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
				            340                 345                 350         
				Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
				        355                 360                 365             
				Ala Leu Pro Pro Arg 
				    370             
				<![CDATA[<210>  484]]>
				<![CDATA[<211>  371]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 駱駝抗DLL3 CAR序列CAS64062]]>
				<![CDATA[<400>  484]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser 
				            20                  25                  30          
				Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser 
				        35                  40                  45              
				Pro Tyr Ser Ser Ser Arg Cys Met Gly Trp Phe Arg Gln Ala Pro Gly 
				    50                  55                  60                  
				Lys Glu Arg Glu Gly Val Ala Ala Leu Tyr Thr Gly Gly Gly Ser Thr 
				65                  70                  75                  80  
				Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn 
				                85                  90                  95      
				Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
				            100                 105                 110         
				Thr Ala Met Tyr Tyr Cys Ala Ala Val Val Pro Arg Gly Gly Ser Cys 
				        115                 120                 125             
				Arg Leu Asp Glu Arg Gly Tyr Tyr His Trp Gly Gln Gly Thr Gln Val 
				    130                 135                 140                 
				Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
				145                 150                 155                 160 
				Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
				                165                 170                 175     
				Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
				            180                 185                 190         
				Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
				        195                 200                 205             
				Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
				    210                 215                 220                 
				Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
				225                 230                 235                 240 
				Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
				                245                 250                 255     
				Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
				            260                 265                 270         
				Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
				        275                 280                 285             
				Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
				    290                 295                 300                 
				Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
				305                 310                 315                 320 
				Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
				                325                 330                 335     
				Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
				            340                 345                 350         
				Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
				        355                 360                 365             
				Pro Pro Arg 
				    370     
				<![CDATA[<210>  485]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64380VH4]]>
				<![CDATA[<400>  485]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  486]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64380VH5]]>
				<![CDATA[<400>  486]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  487]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64380VH6]]>
				<![CDATA[<400>  487]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  488]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64380VH7]]>
				<![CDATA[<400>  488]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Arg Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  489]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64511VH4]]>
				<![CDATA[<400>  489]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala 
				        35                  40                  45              
				Thr Tyr Ser Thr Asn Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Ala Val Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Val Tyr Tyr Cys Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe 
				        115                 120                 125             
				Asp Gly Arg Asp Phe Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  490]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64511VH5]]>
				<![CDATA[<400>  490]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala 
				        35                  40                  45              
				Thr Tyr Ser Thr Asn Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Ala Val Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe 
				        115                 120                 125             
				Asp Gly Arg Asp Phe Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  491]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS64511VH6]]>
				<![CDATA[<400>  491]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ala 
				        35                  40                  45              
				Thr Tyr Ser Thr Asn Tyr Ile Ser Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Arg Glu Ala Val Ala Thr Ile Thr Thr Gly Asp Gly Glu Thr Ala 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Ala Asn Leu Arg Ile Gly Gly Asp Trp Phe 
				        115                 120                 125             
				Asp Gly Arg Asp Phe Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  492]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS63997VH4]]>
				<![CDATA[<400>  492]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Val Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  493]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS63997VH5]]>
				<![CDATA[<400>  493]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  494]]>
				<![CDATA[<211>  369]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類化抗DLL3 CAR序列CAS63997VH6]]>
				<![CDATA[<400>  494]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Arg Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
				145                 150                 155                 160 
				Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
				                165                 170                 175     
				Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
				            180                 185                 190         
				Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
				        195                 200                 205             
				Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
				    210                 215                 220                 
				Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
				225                 230                 235                 240 
				Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
				                245                 250                 255     
				Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
				            260                 265                 270         
				Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
				        275                 280                 285             
				Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
				    290                 295                 300                 
				Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
				305                 310                 315                 320 
				Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
				                325                 330                 335     
				Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
				            340                 345                 350         
				Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
				        355                 360                 365             
				Arg 
				<![CDATA[<210>  495]]>
				<![CDATA[<211>  11]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv CDR1序列AS56704]]>
				<![CDATA[<400>  495]]>
				Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
				1               5                   10      
				<![CDATA[<210>  496]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv CDR2序列AS56704]]>
				<![CDATA[<400>  496]]>
				Ser Ala Ser Ser Leu Tyr Ser 
				1               5           
				<![CDATA[<210>  497]]>
				<![CDATA[<211>  9]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv CDR3序列AS56704]]>
				<![CDATA[<400>  497]]>
				Gln Gln Ala Ser Trp Ser Pro Ile Thr 
				1               5                   
				<![CDATA[<210>  498]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR1序列AS56704]]>
				<![CDATA[<400>  498]]>
				Gly Phe Asn Ile Ser Ser Ser Tyr Met His 
				1               5                   10  
				<![CDATA[<210>  499]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR2序列AS56704]]>
				<![CDATA[<400>  499]]>
				Tyr Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  500]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR3序列AS56704]]>
				<![CDATA[<400>  500]]>
				Gly Gly Tyr Tyr Tyr His Gly Met Asp Tyr 
				1               5                   10  
				<![CDATA[<210>  501]]>
				<![CDATA[<211>  11]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VL CDR1序列AS56788]]>
				<![CDATA[<400>  501]]>
				Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
				1               5                   10      
				<![CDATA[<210>  502]]>
				<![CDATA[<211>  7]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VL CDR2序列AS56788]]>
				<![CDATA[<400>  502]]>
				Ser Ala Ser Ser Leu Tyr Ser 
				1               5           
				<![CDATA[<210>  503]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VL CDR3序列AS56788]]>
				<![CDATA[<400>  503]]>
				Gln Gln His Tyr Ala Pro Ser Leu Ile Thr 
				1               5                   10  
				<![CDATA[<210>  504]]>
				<![CDATA[<211>  10]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR1序列AS56788]]>
				<![CDATA[<400>  504]]>
				Gly Phe Asn Ile Ser Ser Tyr Ser Met His 
				1               5                   10  
				<![CDATA[<210>  505]]>
				<![CDATA[<211>  17]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR2序列AS56788]]>
				<![CDATA[<400>  505]]>
				Tyr Ile Ser Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
				1               5                   10                  15      
				Gly 
				<![CDATA[<210>  506]]>
				<![CDATA[<211>  9]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH CDR3序列AS56788]]>
				<![CDATA[<400>  506]]>
				Tyr Ser Tyr Tyr Tyr Gly Met Asp Tyr 
				1               5                   
				<![CDATA[<210>  507]]>
				<![CDATA[<211>  107]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VL胺基酸序列AS56704]]>
				<![CDATA[<400>  507]]>
				Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
				1               5                   10                  15      
				Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
				            20                  25                  30          
				Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
				        35                  40                  45              
				Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
				    50                  55                  60                  
				Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
				65                  70                  75                  80  
				Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Trp Ser Pro Ile 
				                85                  90                  95      
				Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
				            100                 105         
				<![CDATA[<210>  508]]>
				<![CDATA[<211>  119]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH胺基酸序列AS56704]]>
				<![CDATA[<400>  508]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Ser 
				            20                  25                  30          
				Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
				        35                  40                  45              
				Ala Tyr Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Arg Gly Gly Tyr Tyr Tyr His Gly Met Asp Tyr Trp Gly Gln Gly 
				            100                 105                 110         
				Thr Leu Val Thr Val Ser Ser 
				        115                 
				<![CDATA[<210>  509]]>
				<![CDATA[<211>  108]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VL胺基酸序列AS56788]]>
				<![CDATA[<400>  509]]>
				Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
				1               5                   10                  15      
				Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
				            20                  25                  30          
				Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
				        35                  40                  45              
				Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
				    50                  55                  60                  
				Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
				65                  70                  75                  80  
				Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ala Pro Ser Leu 
				                85                  90                  95      
				Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
				            100                 105             
				<![CDATA[<210>  510]]>
				<![CDATA[<211>  118]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  抗DLL3人類scFv VH胺基酸序列AS56788]]>
				<![CDATA[<400>  510]]>
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				1               5                   10                  15      
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Tyr 
				            20                  25                  30          
				Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
				        35                  40                  45              
				Ala Tyr Ile Ser Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
				    50                  55                  60                  
				Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
				65                  70                  75                  80  
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				                85                  90                  95      
				Ala Arg Tyr Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
				            100                 105                 110         
				Leu Val Thr Val Ser Ser 
				        115             
				<![CDATA[<210>  511]]>
				<![CDATA[<211>  321]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 抗DLL3人類scFv AS56704之VL結構域之核酸序列]]>
				<![CDATA[<400>  511]]>
				gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc     60
				attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg    120
				ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc    180
				cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg    240
				gaagatttcg caacttatta ctgtcagcaa gcttcttggt ctccgatcac gttcggacag    300
				ggcaccaaag ttgagattaa a                                              321
				<![CDATA[<210>  512]]>
				<![CDATA[<211>  357]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 抗DLL3人類scFv AS56704之VH結構域之核酸序列]]>
				<![CDATA[<400>  512]]>
				gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg     60
				agctgcgcag cttctggctt caacatctct tcttcttata tgcactgggt gcgtcaggcg    120
				ccgggtaaag gcctggaatg ggttgcatat atttatcctt cttatggcta tacttcttat    180
				gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac    240
				ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgcggtggt    300
				tactactacc atggtatgga ctactggggt caaggcaccc tggttaccgt gagcagc       357
				<![CDATA[<210>  513]]>
				<![CDATA[<211>  324]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 抗DLL3人類scFv AS56788之VL結構域之核酸序列]]>
				<![CDATA[<400>  513]]>
				gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc     60
				attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg    120
				ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc    180
				cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg    240
				gaagatttcg caacttatta ctgtcagcaa cattacgctc cgtctctgat cacgttcgga    300
				cagggcacca aagttgagat taaa                                           324
				<![CDATA[<210>  514]]>
				<![CDATA[<211>  354]]>
				<![CDATA[<212>  DNA]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 抗DLL3人類scFv AS56788之VH結構域之核酸序列]]>
				<![CDATA[<400>  514]]>
				gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg     60
				agctgcgcag cttctggctt caacatctct tcttattcta tgcactgggt gcgtcaggcg    120
				ccgggtaaag gcctggaatg ggttgcatat atttcttctt attatggcta tacttattat    180
				gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac    240
				ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgctactct    300
				tactactacg gtatggacta ctggggtcaa ggcaccctgg ttaccgtgag cagc          354
				<![CDATA[<210>  515]]>
				<![CDATA[<211>  485]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類抗DLL3 scFv CAR序列CAS56704]]>
				<![CDATA[<400>  515]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
				            20                  25                  30          
				Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
				        35                  40                  45              
				Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
				    50                  55                  60                  
				Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
				65                  70                  75                  80  
				Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
				                85                  90                  95      
				Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
				            100                 105                 110         
				Ser Trp Ser Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
				        115                 120                 125             
				Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
				    130                 135                 140                 
				Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
				145                 150                 155                 160 
				Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Ser Tyr 
				                165                 170                 175     
				Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
				            180                 185                 190         
				Tyr Ile Tyr Pro Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
				        195                 200                 205             
				Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
				    210                 215                 220                 
				Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
				225                 230                 235                 240 
				Arg Gly Gly Tyr Tyr Tyr His Gly Met Asp Tyr Trp Gly Gln Gly Thr 
				                245                 250                 255     
				Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
				            260                 265                 270         
				Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
				        275                 280                 285             
				Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
				    290                 295                 300                 
				Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
				305                 310                 315                 320 
				Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
				                325                 330                 335     
				Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
				            340                 345                 350         
				Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
				        355                 360                 365             
				Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
				    370                 375                 380                 
				Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
				385                 390                 395                 400 
				Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
				                405                 410                 415     
				Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
				            420                 425                 430         
				Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
				        435                 440                 445             
				Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
				    450                 455                 460                 
				Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
				465                 470                 475                 480 
				Ala Leu Pro Pro Arg 
				                485 
				<![CDATA[<210>  516]]>
				<![CDATA[<211>  485]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223> 人類抗DLL3 scFv CAR序列CAS56788]]>
				<![CDATA[<400>  516]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
				            20                  25                  30          
				Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
				        35                  40                  45              
				Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
				    50                  55                  60                  
				Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
				65                  70                  75                  80  
				Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
				                85                  90                  95      
				Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
				            100                 105                 110         
				Tyr Ala Pro Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
				        115                 120                 125             
				Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
				    130                 135                 140                 
				Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
				145                 150                 155                 160 
				Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Tyr 
				                165                 170                 175     
				Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
				            180                 185                 190         
				Ala Tyr Ile Ser Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
				        195                 200                 205             
				Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
				    210                 215                 220                 
				Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
				225                 230                 235                 240 
				Ala Arg Tyr Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
				                245                 250                 255     
				Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
				            260                 265                 270         
				Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
				        275                 280                 285             
				Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
				    290                 295                 300                 
				Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
				305                 310                 315                 320 
				Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
				                325                 330                 335     
				Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
				            340                 345                 350         
				Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
				        355                 360                 365             
				Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
				    370                 375                 380                 
				Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
				385                 390                 395                 400 
				Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
				                405                 410                 415     
				Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
				            420                 425                 430         
				Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
				        435                 440                 445             
				Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
				    450                 455                 460                 
				Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
				465                 470                 475                 480 
				Ala Leu Pro Pro Arg 
				                485 
				<![CDATA[<210>  517]]>
				<![CDATA[<211>  476]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  1H2.1胺基酸序列]]>
				<![CDATA[<400>  517]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
				            20                  25                  30          
				Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp 
				        35                  40                  45              
				Ser Ile Ser Ser Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr 
				65                  70                  75                  80  
				Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
				                85                  90                  95      
				Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
				            100                 105                 110         
				Val Tyr Tyr Cys Ala Ser Ile Ala Val Arg Gly Phe Phe Phe Asp Tyr 
				        115                 120                 125             
				Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
				    130                 135                 140                 
				Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
				145                 150                 155                 160 
				Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
				                165                 170                 175     
				Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
				            180                 185                 190         
				Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr 
				        195                 200                 205             
				Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
				    210                 215                 220                 
				Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
				225                 230                 235                 240 
				Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Leu Thr Phe Gly Gly Gly 
				                245                 250                 255     
				Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Leu Asp Asn Glu Lys Ser 
				            260                 265                 270         
				Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
				        275                 280                 285             
				Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
				    290                 295                 300                 
				Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
				305                 310                 315                 320 
				Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
				                325                 330                 335     
				Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
				            340                 345                 350         
				Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
				        355                 360                 365             
				Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
				    370                 375                 380                 
				Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
				385                 390                 395                 400 
				Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
				                405                 410                 415     
				Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
				            420                 425                 430         
				Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
				        435                 440                 445             
				Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
				    450                 455                 460                 
				Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				465                 470                 475     
				<![CDATA[<210>  518]]>
				<![CDATA[<211>  509]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T1胺基酸序列]]>
				<![CDATA[<400>  518]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
				        35                  40                  45              
				Thr Tyr Ser Ser Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Glu Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr 
				65                  70                  75                  80  
				Tyr Val Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
				                85                  90                  95      
				Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Val Tyr Tyr Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn 
				        115                 120                 125             
				Asn Pro Arg Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				            500                 505                 
				<![CDATA[<210>  519]]>
				<![CDATA[<211>  509]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T2胺基酸序列]]>
				<![CDATA[<400>  519]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val 
				            180                 185                 190         
				Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly 
				        195                 200                 205             
				Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser 
				    210                 215                 220                 
				Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr 
				                245                 250                 255     
				Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg 
				            260                 265                 270         
				Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				            500                 505                 
				<![CDATA[<210>  520]]>
				<![CDATA[<211>  509]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T3胺基酸序列]]>
				<![CDATA[<400>  520]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				            500                 505                 
				<![CDATA[<210>  521]]>
				<![CDATA[<211>  775]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T3-PD-1DNR胺基酸序列]]>
				<![CDATA[<400>  521]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
				            500                 505                 510         
				Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
				        515                 520                 525             
				Pro Gly Pro Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala 
				    530                 535                 540                 
				Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp 
				545                 550                 555                 560 
				Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr 
				                565                 570                 575     
				Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu 
				            580                 585                 590         
				Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
				        595                 600                 605             
				Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys 
				    610                 615                 620                 
				Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
				625                 630                 635                 640 
				Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala 
				                645                 650                 655     
				Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu 
				            660                 665                 670         
				Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser 
				        675                 680                 685             
				Pro Ser Pro Arg Pro Ala Gly Gln Ala Ala Ala Pro Thr Thr Thr Pro 
				    690                 695                 700                 
				Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
				705                 710                 715                 720 
				Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
				                725                 730                 735     
				Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
				            740                 745                 750         
				Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
				        755                 760                 765             
				Cys Asn His Arg Arg Ile Gln 
				    770                 775 
				<![CDATA[<210>  522]]>
				<![CDATA[<211>  766]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T3-PD-1CSR胺基酸序列]]>
				<![CDATA[<400>  522]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
				            500                 505                 510         
				Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
				        515                 520                 525             
				Pro Gly Pro Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala 
				    530                 535                 540                 
				Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp 
				545                 550                 555                 560 
				Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr 
				                565                 570                 575     
				Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu 
				            580                 585                 590         
				Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
				        595                 600                 605             
				Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys 
				    610                 615                 620                 
				Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
				625                 630                 635                 640 
				Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala 
				                645                 650                 655     
				Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu 
				            660                 665                 670         
				Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro 
				        675                 680                 685             
				Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
				    690                 695                 700                 
				Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
				705                 710                 715                 720 
				Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
				                725                 730                 735     
				Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
				            740                 745                 750         
				Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
				        755                 760                 765     
				<![CDATA[<210>  523]]>
				<![CDATA[<211>  244]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  PD-1DNR胺基酸序列]]>
				<![CDATA[<400>  523]]>
				Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
				1               5                   10                  15      
				Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
				            20                  25                  30          
				Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
				        35                  40                  45              
				Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
				    50                  55                  60                  
				Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
				65                  70                  75                  80  
				Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
				                85                  90                  95      
				Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
				            100                 105                 110         
				Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
				        115                 120                 125             
				Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
				    130                 135                 140                 
				Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
				145                 150                 155                 160 
				Arg Pro Ala Gly Gln Ala Ala Ala Pro Thr Thr Thr Pro Ala Pro Arg 
				                165                 170                 175     
				Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
				            180                 185                 190         
				Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
				        195                 200                 205             
				Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
				    210                 215                 220                 
				Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
				225                 230                 235                 240 
				Arg Arg Ile Gln 
				<![CDATA[<210>  524]]>
				<![CDATA[<211>  235]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  PD-1CSR胺基酸序列]]>
				<![CDATA[<400>  524]]>
				Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
				1               5                   10                  15      
				Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
				            20                  25                  30          
				Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
				        35                  40                  45              
				Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
				    50                  55                  60                  
				Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
				65                  70                  75                  80  
				Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
				                85                  90                  95      
				Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
				            100                 105                 110         
				Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
				        115                 120                 125             
				Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
				    130                 135                 140                 
				Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro Leu 
				145                 150                 155                 160 
				Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
				                165                 170                 175     
				Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
				            180                 185                 190         
				Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
				        195                 200                 205             
				Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
				    210                 215                 220                 
				Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
				225                 230                 235 
				<![CDATA[<210>  525]]>
				<![CDATA[<211>  730]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T3-P2A-TGF-β-DNR胺基酸序列]]>
				<![CDATA[<400>  525]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
				            500                 505                 510         
				Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
				        515                 520                 525             
				Pro Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His 
				    530                 535                 540                 
				Ile Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln 
				545                 550                 555                 560 
				Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
				                565                 570                 575     
				Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
				            580                 585                 590         
				Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
				        595                 600                 605             
				Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
				    610                 615                 620                 
				Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
				625                 630                 635                 640 
				Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
				                645                 650                 655     
				Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
				            660                 665                 670         
				Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn 
				        675                 680                 685             
				Pro Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu 
				    690                 695                 700                 
				Pro Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr 
				705                 710                 715                 720 
				Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
				                725                 730 
				<![CDATA[<210>  526]]>
				<![CDATA[<211>  730]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  TGF-β-DNR-P2A-T3胺基酸序列]]>
				<![CDATA[<400>  526]]>
				Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
				1               5                   10                  15      
				Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
				            20                  25                  30          
				Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
				        35                  40                  45              
				Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
				    50                  55                  60                  
				Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
				65                  70                  75                  80  
				Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
				                85                  90                  95      
				Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
				            100                 105                 110         
				Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
				        115                 120                 125             
				Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
				    130                 135                 140                 
				Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
				145                 150                 155                 160 
				Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
				                165                 170                 175     
				Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
				            180                 185                 190         
				Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
				        195                 200                 205             
				Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
				    210                 215                 220                 
				Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
				225                 230                 235                 240 
				Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
				                245                 250                 255     
				Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly 
				            260                 265                 270         
				Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
				        275                 280                 285             
				Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp 
				    290                 295                 300                 
				Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
				305                 310                 315                 320 
				Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
				                325                 330                 335     
				Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly 
				            340                 345                 350         
				Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
				        355                 360                 365             
				Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
				    370                 375                 380                 
				Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
				385                 390                 395                 400 
				Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn Tyr Met 
				                405                 410                 415     
				Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val Ala Val 
				            420                 425                 430         
				Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg Gly 
				        435                 440                 445             
				Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
				    450                 455                 460                 
				Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
				465                 470                 475                 480 
				Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr 
				                485                 490                 495     
				Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
				            500                 505                 510         
				Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
				        515                 520                 525             
				Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
				    530                 535                 540                 
				Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
				545                 550                 555                 560 
				Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
				                565                 570                 575     
				Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
				            580                 585                 590         
				Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
				        595                 600                 605             
				Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
				    610                 615                 620                 
				Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
				625                 630                 635                 640 
				Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
				                645                 650                 655     
				Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
				            660                 665                 670         
				Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
				        675                 680                 685             
				Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
				    690                 695                 700                 
				Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
				705                 710                 715                 720 
				Ala Leu His Met Gln Ala Leu Pro Pro Arg 
				                725                 730 
				<![CDATA[<210>  527]]>
				<![CDATA[<211>  729]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  T3-T2A-TGF-β-DNR胺基酸序列]]>
				<![CDATA[<400>  527]]>
				Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
				1               5                   10                  15      
				His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
				            20                  25                  30          
				Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser 
				        35                  40                  45              
				Gly Tyr Gly Val Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
				    50                  55                  60                  
				Gly Leu Glu Gly Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr 
				65                  70                  75                  80  
				Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
				                85                  90                  95      
				Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
				            100                 105                 110         
				Ala Met Tyr Tyr Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp 
				        115                 120                 125             
				Val Pro Gly Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
				    130                 135                 140                 
				Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
				145                 150                 155                 160 
				Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
				                165                 170                 175     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser 
				            180                 185                 190         
				Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu 
				        195                 200                 205             
				Val Ala Val Ile Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser 
				    210                 215                 220                 
				Val Arg Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu 
				225                 230                 235                 240 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
				                245                 250                 255     
				Cys Ala Ala Ser Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp 
				            260                 265                 270         
				Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
				        275                 280                 285             
				Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
				    290                 295                 300                 
				Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
				305                 310                 315                 320 
				Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
				                325                 330                 335     
				Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
				            340                 345                 350         
				Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
				        355                 360                 365             
				Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
				    370                 375                 380                 
				Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
				385                 390                 395                 400 
				Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
				                405                 410                 415     
				Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
				            420                 425                 430         
				Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
				        435                 440                 445             
				Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
				    450                 455                 460                 
				Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
				465                 470                 475                 480 
				Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
				                485                 490                 495     
				Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
				            500                 505                 510         
				Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
				        515                 520                 525             
				Gly Pro Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile 
				    530                 535                 540                 
				Val Leu Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys 
				545                 550                 555                 560 
				Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
				                565                 570                 575     
				Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
				            580                 585                 590         
				Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
				        595                 600                 605             
				Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
				    610                 615                 620                 
				Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
				625                 630                 635                 640 
				Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
				                645                 650                 655     
				Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
				            660                 665                 670         
				Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
				        675                 680                 685             
				Asp Leu Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro 
				    690                 695                 700                 
				Pro Leu Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg 
				705                 710                 715                 720 
				Val Asn Arg Gln Gln Lys Leu Ser Ser 
				                725                 
				<![CDATA[<210>  528]]>
				<![CDATA[<211>  729]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  TGF-β-DNR-T2A-T3胺基酸序列]]>
				<![CDATA[<400>  528]]>
				Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
				1               5                   10                  15      
				Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
				            20                  25                  30          
				Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
				        35                  40                  45              
				Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
				    50                  55                  60                  
				Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
				65                  70                  75                  80  
				Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
				                85                  90                  95      
				Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
				            100                 105                 110         
				Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
				        115                 120                 125             
				Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
				    130                 135                 140                 
				Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
				145                 150                 155                 160 
				Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
				                165                 170                 175     
				Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
				            180                 185                 190         
				Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu 
				        195                 200                 205             
				Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro 
				    210                 215                 220                 
				Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg 
				225                 230                 235                 240 
				Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
				                245                 250                 255     
				Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val 
				            260                 265                 270         
				Ser Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly 
				        275                 280                 285             
				Val Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser 
				    290                 295                 300                 
				Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
				305                 310                 315                 320 
				Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr 
				                325                 330                 335     
				Cys Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg 
				            340                 345                 350         
				Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
				        355                 360                 365             
				Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
				    370                 375                 380                 
				Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
				385                 390                 395                 400 
				Leu Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly 
				                405                 410                 415     
				Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val Ala Val Ile 
				            420                 425                 430         
				Tyr Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg Gly Arg 
				        435                 440                 445             
				Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
				    450                 455                 460                 
				Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ser 
				465                 470                 475                 480 
				Ser Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr Trp 
				                485                 490                 495     
				Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
				            500                 505                 510         
				Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
				        515                 520                 525             
				Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
				    530                 535                 540                 
				Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
				545                 550                 555                 560 
				Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
				                565                 570                 575     
				Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
				            580                 585                 590         
				Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
				        595                 600                 605             
				Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
				    610                 615                 620                 
				Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
				625                 630                 635                 640 
				Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
				                645                 650                 655     
				Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
				            660                 665                 670         
				Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
				        675                 680                 685             
				Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
				    690                 695                 700                 
				Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
				705                 710                 715                 720 
				Leu His Met Gln Ala Leu Pro Pro Arg 
				                725                 
				<![CDATA[<210>  529]]>
				<![CDATA[<211>  199]]>
				<![CDATA[<212>  PRT]]>
				<![CDATA[<213>  人工(Artificial)]]>
				<![CDATA[<220>]]>
				<![CDATA[<223>  TGF-β-DNR胺基酸序列]]>
				<![CDATA[<400>  529]]>
				Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
				1               5                   10                  15      
				Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
				            20                  25                  30          
				Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
				        35                  40                  45              
				Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
				    50                  55                  60                  
				Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
				65                  70                  75                  80  
				Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
				                85                  90                  95      
				Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
				            100                 105                 110         
				Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
				        115                 120                 125             
				Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
				    130                 135                 140                 
				Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
				145                 150                 155                 160 
				Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
				                165                 170                 175     
				Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
				            180                 185                 190         
				Arg Gln Gln Lys Leu Ser Ser 
				        195

Claims (26)

  1. 一種嵌合抗原受體(CAR)，該嵌合抗原受體包含DLL3結合域，其中該DLL3結合域包含源自單域抗體(sdAb)部分，其中 該sdAb包含多肽，該多肽包含： 包含SEQ ID NO: 21之胺基酸序列之CDR1；包含SEQ ID NO: 102之胺基酸序列之CDR2；以及包含SEQ ID NO: 183之胺基酸序列之CDR3。
  2. 如申請專利範圍第1項之CAR，其中 (1) 該sdAb包含與SEQ ID NO: 294之胺基酸序列具有至少95%序列一致性的胺基酸序列；或 (2)  該人類化sdAb包含與SEQ ID NO: 355-358中之任一者之胺基酸序列具有至少95%序列一致性的胺基酸序列。
  3. 如申請專利範圍第1至2項中任一項之CAR，其中該CAR自N末端至C末端包含信號肽、該DLL3結合域、鉸鏈域、跨膜域及細胞內信號傳導域。
  4. 如申請專利範圍第3項之CAR，其中該細胞內信號傳導域源自CD3ζ、FcRγ、FcRβ、CD3γ、CD3δ、CD3ε、CD5、CD22、CD79a、CD79b或CD66d。
  5. 如申請專利範圍第3之CAR，其中該細胞內信號傳導域進一步包含細胞內共刺激序列。
  6. 如申請專利範圍第5項之CAR，其中該細胞內共刺激序列源自選自由以下組成之群的共刺激分子：CD27、CD28、4-1BB、OX40、CD40、PD-1、LFA-1、ICOS、CD2、CD7、LIGHT、NKG2C、B7-H3、TNFRSF9、TNFRSF4、TNFRSF8、CD40LG、ITGB2、KLRC2、TNFRSF18、TNFRSF14、HAVCR1、LGALS9、DAP10、DAP12、CD83、CD83配位體及其組合。
  7. 如申請專利範圍第1至2項中任一項之CAR，其中該CAR包含與選自由SEQ ID NO: 477、SEQ ID NO: 485-488組成之群之胺基酸序列具有至少95%序列一致性的胺基酸序列。
  8. 如申請專利範圍第1至2項中任一項之CAR，其中該DLL3結合域包含彼此連接之兩個sdAb。
  9. 如申請專利範圍第8項之CAR，其中該等sdAb中之每一者獨立地包含與SEQ ID NO:356具有至少95%序列一致性的胺基酸序列。
  10. 如申請專利範圍第8項之CAR，其中該CAR包含與選自由SEQ ID NO: 518組成之群之胺基酸序列具有至少95%序列一致性的胺基酸序列。
  11. 一種DLL3結合蛋白，該DLL3結合蛋白包含特異性地結合於DLL3之單域抗體(sdAb)部分，其中， 該sdAb部分包含多肽，該多肽包含： 包含SEQ ID NO: 21之胺基酸序列之CDR1；包含SEQ ID NO: 102之胺基酸序列之CDR 2；以及包含SEQ ID NO: 183之胺基酸序列之CDR 3。
  12. 如申請專利範圍第11項之DLL3結合蛋白，其中 (1) 該sdAb部分包含與SEQ ID NO: 294之胺基酸序列具有至少95%序列一致性的胺基酸序列；或 (2)  該人類化sdAb包含與SEQ ID NO: 355-358中之任一者之胺基酸序列具有至少95%序列一致性的胺基酸序列。
  13. 一種經分離之核酸分子，該經分離之核酸分子編碼如申請專利範圍第1至10項中任一項之CAR或如申請專利範圍第11至12項中任一項之DLL3結合蛋白。
  14. 如申請專利範圍第13項之經分離之核酸分子，其中該經分離之核酸分子包含選自由SEQ ID NO: 388、SEQ ID NO: 449-452組成之群的多核苷酸序列，該多核苷酸序列編碼駱駝單域抗體(sdAb)。
  15. 如申請專利範圍第13至14項中任一項之經分離之核酸分子，其中該核酸分子進一步包含編碼嵌合轉換受體(CSR)或顯性負性受體(DNR)之多核苷酸序列。
  16. 如申請專利範圍第13至14項中任一項之經分離之核酸分子，其中該核酸分子進一步包含編碼PD-1顯性負性受體(PD-1 DNR)、PD-1嵌合轉換受體(PD-1 CSR)或TGF-β顯性負性受體(TGF-β DNR)之多核苷酸序列。
  17. 如申請專利範圍第16項之經分離之核酸分子，其中該PD-1 DNR包含與SEQ ID NO: 523具有至少95%序列一致性之胺基酸序列；該PD-1 CSR包含與SEQ ID NO: 524具有至少95%序列一致性之胺基酸序列；該TGF-βDNR包含與SEQ ID NO: 529具有至少95%序列一致性之胺基酸序列。
  18. 一種表現載體，該表現載體包含如申請專利範圍第13至17項中任一項之經分離之核酸分子。
  19. 一種經工程改造之免疫細胞，該經工程改造之免疫細胞包含如申請專利範圍第13至17項中任一項之經分離之核酸分子或如申請專利範圍第18項之表現載體。
  20. 一種經工程改造之免疫細胞，該經工程改造之免疫細胞表現如申請專利範圍第1至10項中任一項之CAR。
  21. 如申請專利範圍第20項之經工程改造之免疫細胞，其中該經工程改造之免疫細胞亦表現CSR或DNR。
  22. 如申請專利範圍第21項之經工程改造之免疫細胞，其中該CSR為PD-1 CSR，該DNR為PD-1 DNR或TGF-β DNR。
  23. 如申請專利範圍第19至22項中任一項之經工程改造之免疫細胞，其中該經工程改造之免疫細胞係選自由以下組成之群：細胞毒性T細胞、輔助T細胞、自然殺手T細胞、γδ T細胞、NKT細胞及自然殺手細胞。
  24. 一種醫藥組合物，該醫藥組合物包含如申請專利範圍第1至10項中任一項之CAR、如申請專利範圍第11至12項中任一項之DLL3結合蛋白、如申請專利範圍第18項之表現載體或如申請專利範圍第19至23項中任一項之經工程改造之免疫細胞及生理學上可接受之賦形劑。
  25. 一種如申請專利範圍第19至23項中任一項之經工程改造之免疫細胞或治療有效量的如申請專利範圍第24項之醫藥組合物的用途，其係用於製備用於治療患有病症之個體之藥物，其中該病症為選自由以下組成之群的癌症：肺癌、黑素瘤、乳腺癌、前列腺癌、結腸癌、腎細胞癌、卵巢癌、神經母細胞瘤、橫紋肌肉瘤、白血病及淋巴瘤。
  26. 如申請專利範圍第25項所述之用途，其中該病症為小細胞肺癌。
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