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UA91007C2 - Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы - Google Patents

Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы

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Publication number
UA91007C2
UA91007C2 UAA200605781A UAA200605781A UA91007C2 UA 91007 C2 UA91007 C2 UA 91007C2 UA A200605781 A UAA200605781 A UA A200605781A UA A200605781 A UAA200605781 A UA A200605781A UA 91007 C2 UA91007 C2 UA 91007C2
Authority
UA
Ukraine
Prior art keywords
substituted
quinoxalinones
quinolinones
adp
ribose
Prior art date
Application number
UAA200605781A
Other languages
English (en)
Ukrainian (uk)
Inventor
Доминик Жан-Пьер Мабир
Дун Якобус Альфонсус Йозефус ван
Мария Викторина Франсиска Сомерс
Вальтер Будевийн Леопольд Вутерс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA91007C2 publication Critical patent/UA91007C2/ru

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    • C07ORGANIC CHEMISTRY
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    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
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    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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UAA200605781A 2003-12-10 2004-11-18 Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы UA91007C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03078918 2003-12-10

Publications (1)

Publication Number Publication Date
UA91007C2 true UA91007C2 (ru) 2010-06-25

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UAA200605781A UA91007C2 (ru) 2003-12-10 2004-11-18 Замещенные 6-циклогексилалкилом замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли-(адф-рибоза)полимеразы

Country Status (17)

Country Link
US (1) US7652014B2 (ru)
EP (1) EP1694653B1 (ru)
JP (1) JP4948178B2 (ru)
KR (1) KR101149031B1 (ru)
CN (2) CN102206180B (ru)
AU (1) AU2004299183B2 (ru)
BR (1) BRPI0417571A (ru)
CA (1) CA2548273C (ru)
EA (1) EA010592B1 (ru)
ES (1) ES2565581T3 (ru)
IL (1) IL176199A (ru)
NO (1) NO337621B1 (ru)
NZ (1) NZ547278A (ru)
SG (1) SG151250A1 (ru)
UA (1) UA91007C2 (ru)
WO (1) WO2005058843A1 (ru)
ZA (1) ZA200604774B (ru)

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BRPI0417571A (pt) 2007-03-20
NO20063129L (no) 2006-07-05
KR20060108753A (ko) 2006-10-18
NZ547278A (en) 2010-01-29
CN102206180B (zh) 2013-05-29
ES2565581T3 (es) 2016-04-05
EP1694653B1 (en) 2016-01-20
KR101149031B1 (ko) 2012-05-29
JP2007513898A (ja) 2007-05-31
CA2548273C (en) 2013-04-16
CA2548273A1 (en) 2005-06-30
JP4948178B2 (ja) 2012-06-06
AU2004299183B2 (en) 2010-09-23
NO337621B1 (no) 2016-05-09
AU2004299183A1 (en) 2005-06-30
CN102206180A (zh) 2011-10-05
WO2005058843A1 (en) 2005-06-30
US20090042881A1 (en) 2009-02-12
SG151250A1 (en) 2009-04-30
EP1694653A1 (en) 2006-08-30
CN1890225A (zh) 2007-01-03
IL176199A0 (en) 2006-10-05
IL176199A (en) 2012-03-29
ZA200604774B (en) 2007-11-28
WO2005058843A8 (en) 2006-06-15
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US7652014B2 (en) 2010-01-26
EA010592B1 (ru) 2008-10-30

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