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UA97942C2 - Твердая фармацевтическая композиция, содержащая валсартан - Google Patents

Твердая фармацевтическая композиция, содержащая валсартан

Info

Publication number
UA97942C2
UA97942C2 UAA200707163A UAA200707163A UA97942C2 UA 97942 C2 UA97942 C2 UA 97942C2 UA A200707163 A UAA200707163 A UA A200707163A UA A200707163 A UAA200707163 A UA A200707163A UA 97942 C2 UA97942 C2 UA 97942C2
Authority
UA
Ukraine
Prior art keywords
valsartan
pharmaceutical composition
solid pharmaceutical
valsartan particles
particles
Prior art date
Application number
UAA200707163A
Other languages
English (en)
Ukrainian (uk)
Inventor
Миха Врбинк
Яника Сланк
Мария Рангус
Силво Жупанчич
Франчи Бевек
Лидия Церноса
Original Assignee
КРКА, д.д., НОВО МЕСТО
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КРКА, д.д., НОВО МЕСТО filed Critical КРКА, д.д., НОВО МЕСТО
Priority claimed from PCT/EP2005/013963 external-priority patent/WO2006066961A1/en
Publication of UA97942C2 publication Critical patent/UA97942C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение касается способа приготовления твердой фармацевтической композиции, содержащей частички валсартана, который включает следующие стадии: получение частичек валсартана, имеющих максимальный диаметр 1100 мкм; грануляцию смеси валсартана и эксципиентов с использованием воды в качестве грануляционной жидкости для получения гранулята; добавление дополнительных эксципиентов к данному грануляту для получения смеси для прессования; прессование данной смеси в нужную форму, где в состав композиции входит поперечно сшитая натрийкарбоксиметилцелюлоза в качестве эксципиента.
UAA200707163A 2004-12-24 2005-12-23 Твердая фармацевтическая композиция, содержащая валсартан UA97942C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04030782A EP1674080A1 (en) 2004-12-24 2004-12-24 Solid pharmaceutical composition comprising valsartan
PCT/EP2005/013963 WO2006066961A1 (en) 2004-12-24 2005-12-23 Solid pharmaceutical composition comprising valsartan

Publications (1)

Publication Number Publication Date
UA97942C2 true UA97942C2 (ru) 2012-04-10

Family

ID=34927999

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200707163A UA97942C2 (ru) 2004-12-24 2005-12-23 Твердая фармацевтическая композиция, содержащая валсартан

Country Status (3)

Country Link
EP (1) EP1674080A1 (ru)
UA (1) UA97942C2 (ru)
ZA (1) ZA200705131B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008056375A2 (en) * 2006-11-09 2008-05-15 Lupin Limited Pharmaceutical formulations comprising valsartan
WO2008120242A1 (en) * 2007-03-29 2008-10-09 Alembic Limited Valsartan tablet formulations
EP2067470A1 (en) * 2007-12-03 2009-06-10 Laboratorios Lesvi, S.L. Pharmaceutical compositions containing valsartan and process for its preparation
DE102008051783A1 (de) * 2008-10-17 2010-04-22 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Valsartan enthaltende Tablette
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
DE102011108762A1 (de) * 2011-07-28 2013-01-31 Stada Arzneimittel Ag Verpresste feste pharmazeutische Zusammensetzung, umfassend amorphes partikuläres Valsartan als Wirkstoff
CN108553435A (zh) * 2018-06-08 2018-09-21 华益药业科技(安徽)有限公司 一种缬沙坦片及其制备方法
CN112603894A (zh) * 2020-12-31 2021-04-06 浙江华海药业股份有限公司 一种缬沙坦颗粒的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
US6211217B1 (en) * 1999-03-16 2001-04-03 Novartis Ag Method for reducing pericardial fibrosis and adhesion formation
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
MXPA02010091A (es) * 2000-04-12 2003-02-12 Novartis Ag Novedoso uso medico de inhibidores de sintasa de aldosterona solos o en combinacion con antagonistas del receptor at-1.
SK287558B6 (sk) * 2000-07-19 2011-02-04 Novartis Ag Soli valsartanu, ich použitie, spôsob ich výroby a farmaceutické prípravky obsahujúce tieto soli
EP1618097A1 (en) * 2003-04-21 2006-01-25 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
WO2004094391A2 (en) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan and intermediates thereof

Also Published As

Publication number Publication date
ZA200705131B (en) 2008-06-25
EP1674080A1 (en) 2006-06-28

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