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WO1986001209A3 - NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG - Google Patents

NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG

Info

Publication number
WO1986001209A3
WO1986001209A3 PCT/EP1985/000385 EP8500385W WO8601209A3 WO 1986001209 A3 WO1986001209 A3 WO 1986001209A3 EP 8500385 W EP8500385 W EP 8500385W WO 8601209 A3 WO8601209 A3 WO 8601209A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteases
amino acid
blood coagulation
group
coagulation system
Prior art date
Application number
PCT/EP1985/000385
Other languages
German (de)
English (en)
Other versions
WO1986001209A2 (fr
Inventor
Knut Bartl
Udo Becker
Der Eltz Herbert Von
Helmut Lill
Hans-Georg Batz
Original Assignee
Boehringer Mannheim Gmbh
Knut Bartl
Udo Becker
Der Eltz Herbert Von
Helmut Lill
Batz Hans Georg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Knut Bartl, Udo Becker, Der Eltz Herbert Von, Helmut Lill, Batz Hans Georg filed Critical Boehringer Mannheim Gmbh
Publication of WO1986001209A2 publication Critical patent/WO1986001209A2/fr
Publication of WO1986001209A3 publication Critical patent/WO1986001209A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Dans de nouvelles compositions ayant la formule générale (I), A est l'acide aminé arginine ou lysine, X est un groupe d'acides aminés de protection à terminal N ou un acide aminé D, Y est une liaison simple ou une chaîne composée de 1 à 3 acides aminés, NR1R2 est un groupe en position o ou p où R1 et R2 sont indépendants l'un de l'autre et représentent de l'hydrogène ou de l'alcoyle ayant 1 à 3 atomes C et R3 est un atome d'hydrogène, un groupe carboxyle, un atome d'halogène ou un groupe alcoyle ayant 1 à 3 atomes C. Ces compositions sont utiles comme substrats chromogènes de protéinases. Elles sont obtenues par réduction et le cas échéant par alkylation des nitroanilides correspondantes. Un réactif correspondant pour déterminer des protéïnases du système de coagulation du sang comprend une composition ayant la formule (I), un agent d'oxydation, un dérivé d'aniline ou de phénol qui forme un colorant par oxydation avec de la phénylène-diamine et une substance tampon.
PCT/EP1985/000385 1984-08-02 1985-07-31 NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG WO1986001209A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843428543 DE3428543A1 (de) 1984-08-02 1984-08-02 Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems
DEP3428543.1 1984-08-02

Publications (2)

Publication Number Publication Date
WO1986001209A2 WO1986001209A2 (fr) 1986-02-27
WO1986001209A3 true WO1986001209A3 (fr) 1986-03-27

Family

ID=6242223

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1985/000385 WO1986001209A2 (fr) 1984-08-02 1985-07-31 NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG

Country Status (6)

Country Link
EP (1) EP0190299A1 (fr)
JP (1) JPS61501635A (fr)
AU (1) AU564556B2 (fr)
DE (1) DE3428543A1 (fr)
WO (1) WO1986001209A2 (fr)
ZA (1) ZA855814B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
FI860043A7 (fi) * 1986-01-06 1987-07-07 Orion Yhtymae Oy Peptidisubstraatit sekä menetelmä endotoksiinin kvantitatiiviseksi määrittämiseksi.
SE461494B (sv) * 1986-03-21 1990-02-19 Thorsman & Co Ab Faestanordning foer en elektrisk kopplingsdosa
SE8601327D0 (sv) * 1986-03-21 1986-03-21 Kabivitrum Ab Nya peptidderivat
FR2644697B1 (fr) * 1989-03-24 1992-05-15 Poudres & Explosifs Ste Nale Composes anesthesiques a duree d'action controlee et compositions pharmaceutiques les contenant
AU4634896A (en) * 1995-01-10 1996-07-31 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
DE59912999D1 (de) 1999-02-23 2006-02-02 Pentapharm Ag Basel Oligopeptidderivate zur elektrochemischen messung der aktivität von proteasen
EP1802649B1 (fr) * 2004-10-12 2011-01-19 F. Hoffmann-La Roche AG Synthese de peptides en phase solide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056210A2 (fr) * 1981-01-09 1982-07-21 Centre National De La Recherche Scientifique (Cnrs) Procédé pour le dosage fluorimétrique des endotoxines, nouveaux peptides portant un fluorophore utilisables dans ledit procédé et leur méthode de préparation
JPS57176940A (en) * 1981-04-25 1982-10-30 Wako Pure Chem Ind Ltd Novel color-developing peptide derivative
JPS58172354A (ja) * 1982-04-05 1983-10-11 Dai Ichi Pure Chem Co Ltd ペプチド誘導体
GB2118190A (en) * 1982-04-13 1983-10-26 Erba Farmitalia Peptides with sauvagine-like activity
EP0110306A2 (fr) * 1982-11-27 1984-06-13 BEHRINGWERKE Aktiengesellschaft Composés chromogènes, leur procédé d'obtention et leur emploi
JPH08142597A (ja) * 1994-11-21 1996-06-04 Dainippon Printing Co Ltd 転写箔及びこれを用いた装飾ガラス

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056210A2 (fr) * 1981-01-09 1982-07-21 Centre National De La Recherche Scientifique (Cnrs) Procédé pour le dosage fluorimétrique des endotoxines, nouveaux peptides portant un fluorophore utilisables dans ledit procédé et leur méthode de préparation
JPS57176940A (en) * 1981-04-25 1982-10-30 Wako Pure Chem Ind Ltd Novel color-developing peptide derivative
JPS58172354A (ja) * 1982-04-05 1983-10-11 Dai Ichi Pure Chem Co Ltd ペプチド誘導体
GB2118190A (en) * 1982-04-13 1983-10-26 Erba Farmitalia Peptides with sauvagine-like activity
EP0110306A2 (fr) * 1982-11-27 1984-06-13 BEHRINGWERKE Aktiengesellschaft Composés chromogènes, leur procédé d'obtention et leur emploi
JPH08142597A (ja) * 1994-11-21 1996-06-04 Dainippon Printing Co Ltd 転写箔及びこれを用いた装飾ガラス

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 100, 1984 Columbus, Ohio (US) see page 645, Abstract 121624y & JP, A, 58172354 (Daiichi Kagaku Takuhin K.K.) 11 October 1983 *
CHEMICAL ABSTRACTS, Vol. 95, 1981 Columbus, Ohio (US) see page 201, Abstract 109987q & JP, A, 8142597 (Seikagaku Kogyo Co. Ltd.) 20 April 1981 *
CHEMICAL ABSTRACTS, Vol. 98, 1983, Columbus, Ohio (US) see page 554, Abstract 161166x & JP, A, 57176940 (Wako Pure Chemical Industries Ltd.) 30 October 1982 *
CHEMICAL ABSTRCTS, Vol. 99, 1983 Columbus, Ohio (US) see page 697, Abstract 122953c & JP, a, 5890535 (Wako Pure Chemical Industries, Ltd.) 30 May 1983 *
Journal of Medicinal Chemistry, Vol. 268 No. 5, May 1983 The American Chemical Society (US) P.K. CHAKRAVARTY et al.: "Plasmin-Activated Prodrugs for Cancer Chemotherapy, 1. Synthesis and Biological Activity of Peptidylacivicin and Peptidylphenylenediamine Mustard", pages 633-638, see the whole article *

Also Published As

Publication number Publication date
ZA855814B (en) 1986-04-30
AU564556B2 (en) 1987-08-13
DE3428543A1 (de) 1986-02-13
AU4723885A (en) 1986-03-07
JPS61501635A (ja) 1986-08-07
WO1986001209A2 (fr) 1986-02-27
EP0190299A1 (fr) 1986-08-13

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