[go: up one dir, main page]

WO1989003846A3 - Anticorps monoclonaux contre l'interleukine-4 humaine et hybridomes les produisant - Google Patents

Anticorps monoclonaux contre l'interleukine-4 humaine et hybridomes les produisant Download PDF

Info

Publication number
WO1989003846A3
WO1989003846A3 PCT/US1988/003631 US8803631W WO8903846A3 WO 1989003846 A3 WO1989003846 A3 WO 1989003846A3 US 8803631 W US8803631 W US 8803631W WO 8903846 A3 WO8903846 A3 WO 8903846A3
Authority
WO
WIPO (PCT)
Prior art keywords
human interleukin
monoclonal antibodies
same
antibodies against
against human
Prior art date
Application number
PCT/US1988/003631
Other languages
English (en)
Other versions
WO1989003846A2 (fr
Inventor
John S Abrams
Isabelle Chretien
Frank D Lee
Michael K Pearce
Original Assignee
Schering Biotech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Biotech Corp filed Critical Schering Biotech Corp
Priority to KR1019890701139A priority Critical patent/KR930008112B1/ko
Priority to DE3886760T priority patent/DE3886760T2/de
Priority to JP63509356A priority patent/JPH0698020B2/ja
Priority to AT88910302T priority patent/ATE99332T1/de
Publication of WO1989003846A2 publication Critical patent/WO1989003846A2/fr
Publication of WO1989003846A3 publication Critical patent/WO1989003846A3/fr
Priority to DK101890A priority patent/DK169627B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Les anticorps monoclonaux de la présente invention sont spécifiques contre l'interleukine-4 humaine. Des kits et des procédés sont également décrits pour détecter, mesurer et immunopurifier l'interleukine-4 humaine, et pour bloquer l'activité biologique de l'interleukine-4 humaine.
PCT/US1988/003631 1987-10-26 1988-10-21 Anticorps monoclonaux contre l'interleukine-4 humaine et hybridomes les produisant WO1989003846A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019890701139A KR930008112B1 (ko) 1987-10-26 1988-10-21 사람 인터루킨-4에 대한 모노클로날 항체 및 이를 생성하는 하이브리도마
DE3886760T DE3886760T2 (de) 1987-10-26 1988-10-21 Monoklonale antikörper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen.
JP63509356A JPH0698020B2 (ja) 1987-10-26 1988-10-21 ヒト インターロイキン４に対するモノクローナル抗体および該抗体を産生するハイブリドーマ
AT88910302T ATE99332T1 (de) 1987-10-26 1988-10-21 Monoklonale antikoerper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen.
DK101890A DK169627B1 (da) 1987-10-26 1990-04-25 Monoklonale antistoffer mod human interleukin-4, hybridomaer producerende sådanne, fremgangsmåde og sæt til påvisning af human interleukin-4 samt fremgangsmåde til immunoprensning af human interleukin-4

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US113,623 1987-10-26
US07/113,623 US5041381A (en) 1986-07-03 1987-10-26 Monoclonal antibodies against human interleukin-4 and hybridomas producing the same

Publications (2)

Publication Number Publication Date
WO1989003846A2 WO1989003846A2 (fr) 1989-05-05
WO1989003846A3 true WO1989003846A3 (fr) 1989-05-18

Family

ID=22350540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/003631 WO1989003846A2 (fr) 1987-10-26 1988-10-21 Anticorps monoclonaux contre l'interleukine-4 humaine et hybridomes les produisant

Country Status (18)

Country Link
US (1) US5041381A (fr)
EP (2) EP0375743B1 (fr)
JP (1) JPH0698020B2 (fr)
KR (1) KR930008112B1 (fr)
CN (2) CN1032816A (fr)
AU (1) AU611750B2 (fr)
CA (1) CA1335653C (fr)
DE (1) DE3886760T2 (fr)
DK (1) DK169627B1 (fr)
ES (1) ES2061736T3 (fr)
HK (1) HK105996A (fr)
IE (1) IE62491B1 (fr)
IL (1) IL88145A0 (fr)
MY (1) MY108526A (fr)
NZ (1) NZ226692A (fr)
PT (1) PT88847B (fr)
WO (1) WO1989003846A2 (fr)
ZA (1) ZA887987B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700915A (en) * 1985-11-19 1997-12-23 Schering Corporations Human interleukin immunopurification processes
HU211059B (en) * 1988-02-02 1995-10-30 Schering Biotech Corp Method for producing pharmaceutical compositions usable for reducing immunglobulin e responses, containing human il-4 antibodies
CA2071872A1 (fr) * 1989-12-15 1991-06-16 Abla A. Creasey Anticorps de type cytokine pour le traitement de la septicemie
GB8928501D0 (en) * 1989-12-18 1990-02-21 Unilever Plc Reagents
EP0506826B1 (fr) * 1989-12-20 1996-04-17 Schering Corporation Antagonistes d'anticorps de l'interleucine-4 humaine
US5132109A (en) * 1990-10-05 1992-07-21 Ludwig Institute For Cancer Research Method for inhibiting production of ige and method for enhancing production of igg using interleukin 9 and inhibitors thereof
DE4137333A1 (de) * 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
ES2121078T3 (es) * 1992-02-19 1998-11-16 Schering Corp Clonacion y expresion de anticuerpos monoclonales humanizados contra interleuquina-4 humana.
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
CN1105728C (zh) * 1993-09-07 2003-04-16 史密丝克莱恩比彻姆公司 用于治疗il4介导疾病的重组il4抗体
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US20020193575A1 (en) * 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
EP0659766A1 (fr) * 1993-11-23 1995-06-28 Schering-Plough Anticorps monoclonaux humains contre des cytokines humains et méthode de fabrication de tels anticorps
US5959085A (en) * 1993-11-23 1999-09-28 Schering Corporation Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
WO1995021942A1 (fr) * 1994-02-15 1995-08-17 T Cell Diagnostics, Inc. Trousse de dosage immunologique comprenant des reactifs universels
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
AUPN481295A0 (en) * 1995-08-16 1995-09-07 Medvet Science Pty. Ltd. Agonists of haemopoietic growth factors
US20020090682A1 (en) * 1995-10-23 2002-07-11 Tracy Willson Novel haemopoietin receptor and genetic sequences encoding same
MXPA02011682A (es) 2000-05-26 2003-05-14 Immunex Corp Uso de antagonistas de interleuquina-4 y composiciones de los mismos.
GB0210535D0 (en) * 2002-05-08 2002-06-19 Novartis Ag Organic compounds
JP2004045384A (ja) * 2002-05-22 2004-02-12 Matsushita Electric Ind Co Ltd 免疫学的測定方法、免疫学的測定装置、生体成分測定用トイレ、抗アルブミンモノクローナル抗体、それを産生する細胞株、およびアルブミン検出キット
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
PE20060560A1 (es) * 2004-08-03 2006-06-27 Novartis Ag Anticuerpos de interleucina-4 humana
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
GB0807214D0 (en) * 2008-04-21 2008-05-28 Belfast Health And Social Care Biomarkers
GB201210587D0 (en) * 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
GB201210571D0 (en) * 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
CN103421747B (zh) * 2013-09-09 2015-01-07 扬州大学 分泌牛il-4单克隆抗体的杂交瘤细胞株、其单克隆抗体及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255329A (en) 1973-10-02 1981-03-10 Syva Company Double receptor fluorescent immunoassay
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4431739A (en) * 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4423147A (en) 1980-04-11 1983-12-27 Secher David S Monoclonal antibody to interferon-α
DE3161585D1 (en) 1980-06-20 1984-01-12 Battelle Memorial Institute A method for the delignification of wood and other ligno-cellulosic products
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4355023A (en) 1980-09-30 1982-10-19 The Massachusetts General Hospital Antibody fragment compositions and process
US4599308A (en) 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
US4470925A (en) 1982-05-05 1984-09-11 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
US4474493A (en) 1982-09-09 1984-10-02 Modular Systems, Inc. Dowel fastener and joints including same
US4642234A (en) 1983-09-15 1987-02-10 University Of Bath Disinfection of contact lenses
US4731237A (en) 1983-11-07 1988-03-15 The Wistar Institute Immune response to virus induced by anti-idiotype antibodies
DE3586772T2 (de) 1984-07-24 1993-03-04 Coselco Mimotopes Pty Ltd Verfahren zur bestimmung von mimotopen.
US4562003A (en) 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
EP0190711B1 (fr) 1985-02-07 1989-04-26 Kowa Company, Ltd. Anticorps monoclonaux contre l'activateur de plasminogène tissulaire dérivé de cellules normales humaines
WO1986006487A1 (fr) 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Methode de determination de mimotopes
IL80678A (en) * 1985-11-19 1999-05-09 Schering Biotech Corp Human interleukin-4

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts/RRM, volume 29, no. Ohara et al.: "Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor-1", see the title and terms *
Proc. Natl. Acad. Sci. USA, volume 83, December 1986, F.D. Finkelman et al.: "Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1", pages 9675-9678 *
The Journal of Immunology, volume 139, no. 4, 15 August 1987, The American Association of Immunologists, (US), J. Ohara et al.: "High-efficiency purification and chemical characterization of B cell stimulatory factor-1/interleukin 4", pages 1127-1134 *

Also Published As

Publication number Publication date
DK101890D0 (da) 1990-04-25
JPH0698020B2 (ja) 1994-12-07
US5041381A (en) 1991-08-20
AU611750B2 (en) 1991-06-20
EP0375743B1 (fr) 1993-12-29
EP0375743A1 (fr) 1990-07-04
ZA887987B (en) 1990-06-27
CA1335653C (fr) 1995-05-23
IL88145A0 (en) 1989-06-30
EP0314402A3 (fr) 1989-06-07
EP0314402A2 (fr) 1989-05-03
KR890701632A (ko) 1989-12-21
CN1176391A (zh) 1998-03-18
JPH03503118A (ja) 1991-07-18
PT88847B (pt) 1993-01-29
KR930008112B1 (ko) 1993-08-26
DK169627B1 (da) 1994-12-27
NZ226692A (en) 1991-06-25
IE883213L (en) 1989-04-26
DK101890A (da) 1990-04-25
DE3886760T2 (de) 1994-09-08
AU2782789A (en) 1989-05-23
CN1032816A (zh) 1989-05-10
ES2061736T3 (es) 1994-12-16
MY108526A (en) 1996-10-31
DE3886760D1 (de) 1994-02-10
HK105996A (en) 1996-06-28
WO1989003846A2 (fr) 1989-05-05
IE62491B1 (en) 1995-02-08

Similar Documents

Publication Publication Date Title
WO1989003846A3 (fr) Anticorps monoclonaux contre l'interleukine-4 humaine et hybridomes les produisant
CA2130436A1 (fr) Clonage et expression des anticorps monoclonaux humanises diriges contre l'interleukine-4 humaine
CA2021594A1 (fr) Anticorps contre le recepteur de l'interleukine-6 humaine
NO870770L (no) FremgangsmŸte for fremstilling av monoklonale antistoffer.
WO1995024481A3 (fr) Anticorps monoclonaux humanises contre l'interleukine-4 chez l'homme
DE3689948D1 (de) Monoklonale antikörper und testverfahren.
EP0585960A3 (fr) Méthode diagnostique pour les maladies autoimmunes
FI862978L (fi) Onkofetaalisia spesifisiä monoklonaalisia vasta-aineita, menetelmä niiden valmistamiseksi ja niiden käyttö.
DE3585049D1 (de) Monoklonale antikoerper.
AU1042488A (en) Bilirubin antigen, monoclonal antibody therefor, process for their preparation, and their use
DE3587714D1 (de) Menschliches alpha 2-Plasmin spezifischer monoklonaler Antikörper.
IE860227L (en) Monoclonal anti-alpha-amylase antibody
AU3744289A (en) Immunochemical assay for human granulocyte-macrophage colony stimulating factor
NO173901C (no) Fremgangsmaate, monoklonalt antistoff og sett for maaling av vevplasminogenaktivator-aktivitet
FI873606A7 (fi) Ihmisen glykoalbumiinin määrittämiseen käyttökelpoisia vasta-aineita.
DE3886545D1 (de) Monoklonale human-antikörper, spezifisch für rh(d).
DE3785175D1 (de) A-assoziierte h-antigene, spezifische monoklonale antikoerper und methoden zu deren verwendung zur blutgruppenbestimmung.
AU6189486A (en) Monoclonal antibodies to prosomal proteins
EP0166458A3 (en) Monoclonal antibody capable of specifically distinguishing human hepato-carcinoma cells
DE3790139D2 (en) Antiparatypical antibodies, their use for detecting and treating auto-immune diseases
IE882250L (en) Monoclonal antibodies and methods for diagnosis of Phytophthora infection
EP0369797A3 (fr) Anticorps monoclonal reconnaissant la protéine Reg
AU2868489A (en) Assays for incipient diabetes, monoclonal antibodies used therein and kits for use therefor
GB2177094B (en) Diagnostic kits incorporating polyclonal antibodies.
EP0453419A3 (en) Use of the sp-2 monoclonal antibody for diagnostics and for monitoring of the hiv infection progress

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK FI HU JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE BJ CF CG CH CM DE FR GA GB IT LU ML MR NL SE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK FI HU JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE BJ CF CG CH CM DE FR GA GB IT LU ML MR NL SE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1988910302

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1988910302

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1988910302

Country of ref document: EP