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WO1990000548A3 - Alcanolamines derivees utilisees comme agents cardiovasculaires - Google Patents

Alcanolamines derivees utilisees comme agents cardiovasculaires Download PDF

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Publication number
WO1990000548A3
WO1990000548A3 PCT/EP1989/000807 EP8900807W WO9000548A3 WO 1990000548 A3 WO1990000548 A3 WO 1990000548A3 EP 8900807 W EP8900807 W EP 8900807W WO 9000548 A3 WO9000548 A3 WO 9000548A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiovascular agents
alkanolamines
derivatized
antiarrhythmic effect
class
Prior art date
Application number
PCT/EP1989/000807
Other languages
English (en)
Other versions
WO1990000548A2 (fr
Inventor
Randall Edward Lis
William Carl Lumma
Thomas Kenneth Morgan
Klaus Nickisch
Ronald Andre Wohl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to JP1507740A priority Critical patent/JPH07119193B2/ja
Publication of WO1990000548A2 publication Critical patent/WO1990000548A2/fr
Publication of WO1990000548A3 publication Critical patent/WO1990000548A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention se rapporte à de nouvelles alcanolamines dérivées représentées par la formule structurelle (I) et utiles comme agents cardiovasculaires. Est particulièrement décrite leur utilité comme agents cardiovasculaires comportant une action anti-arythmie. Le type d'action anti-arythmie décrite est une variété de combinaison de classe II/classe III. Des formules pharmaceutiques contenant de tels composés sont également décrites.
PCT/EP1989/000807 1988-07-13 1989-07-13 Alcanolamines derivees utilisees comme agents cardiovasculaires WO1990000548A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1507740A JPH07119193B2 (ja) 1988-07-13 1989-07-13 心血管系医薬としてのアルカノールアミン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/218,195 US5051423A (en) 1988-07-13 1988-07-13 Derivatized alkanolamines as cardiovascular agents
US218,195 1988-07-13

Publications (2)

Publication Number Publication Date
WO1990000548A2 WO1990000548A2 (fr) 1990-01-25
WO1990000548A3 true WO1990000548A3 (fr) 1990-05-03

Family

ID=22814120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/000807 WO1990000548A2 (fr) 1988-07-13 1989-07-13 Alcanolamines derivees utilisees comme agents cardiovasculaires

Country Status (9)

Country Link
US (1) US5051423A (fr)
EP (1) EP0358284B1 (fr)
JP (1) JPH07119193B2 (fr)
AT (1) ATE157089T1 (fr)
CA (1) CA1328105C (fr)
DE (1) DE68928262T2 (fr)
ES (1) ES2107998T3 (fr)
GR (1) GR3025151T3 (fr)
WO (1) WO1990000548A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018904A1 (fr) * 1990-05-30 1991-12-12 American Home Products Corporation Arylsulfonamides et benzamides substitues
EP0524146A1 (fr) * 1991-07-19 1993-01-20 Ciba-Geigy Ag Dérivés de pipérazine substitués par un groupe amino
US5202346A (en) * 1992-02-25 1993-04-13 American Home Products Corporation Piperidinyl and piperazinyl derivatives
US5254689A (en) * 1992-02-25 1993-10-19 American Home Products Corporation Piperdinyl and piperazinyl derivatives
US5384319A (en) * 1993-01-06 1995-01-24 Ciba-Geigy Corporation Aminoalkylphenyl compounds
US5380726A (en) * 1993-01-15 1995-01-10 Ciba-Geigy Corporation Substituted dialkylthio ethers
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
AU1617499A (en) * 1997-12-05 1999-06-28 Eli Lilly And Company Selective beta3 adrenergic agonists
US6537994B2 (en) * 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
EP1326861A1 (fr) * 2000-10-20 2003-07-16 Pfizer Products Inc. Ethanolamines alpha-aryle et utilisation de ces dernieres en tant qu'agonistes du recepteur adrenergique beta-3
EP1554572B1 (fr) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
MXPA04004980A (es) 2001-11-30 2004-08-11 Hoffmann La Roche Antagonistas del receptor ccr-3.
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
AU2003209527A1 (en) 2002-02-27 2003-09-09 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
BR0307996A (pt) 2002-02-27 2004-12-07 Pfizer Prod Inc Processos e intermediários úteis na preparação de receptores de agonistas beta3-adrenérgicos
US6982259B2 (en) * 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
US20050075323A1 (en) * 2003-03-05 2005-04-07 Pfizer Inc Beta3 adrenergic receptor agonists and uses thereof
ES2528403T3 (es) 2005-04-28 2015-02-09 Proteus Digital Health, Inc. Sistemas informáticos farmacéuticos
WO2008036682A2 (fr) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
CA2752373C (fr) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Systeme d'administration de medicament a base de glutathionne
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2100933A1 (fr) * 1970-07-18 1972-03-24 Pfizer
EP0007206A1 (fr) * 1978-07-03 1980-01-23 Eli Lilly And Company Phénéthanolamines, leurs compositions, leur utilisation et leur préparation
EP0056486A2 (fr) * 1981-01-19 1982-07-28 BASF Aktiengesellschaft Phénylpiperazinyl-propanoles de hétarylphénoles, leur préparation et leurs compositions pharmaceutiques
EP0068669A1 (fr) * 1981-06-20 1983-01-05 Beecham Group Plc Phényléthanolamines secondaires, procédés de leur préparation et leur application pharmaceutique
EP0257864A1 (fr) * 1986-08-09 1988-03-02 Pfizer Limited Agents antiarrythmiques
EP0290377A1 (fr) * 1987-05-05 1988-11-09 Schering Aktiengesellschaft [1H-Imidazolyl-1]-4 benzamides substitués en tant qu'agents antiarythmiques
EP0306440A2 (fr) * 1987-09-04 1989-03-08 Schering Aktiengesellschaft 1-Phényl-1H-imidazoles substitués en C-4 du groupe phényle comme agents cardiovasculaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
GB1521471A (en) * 1974-06-05 1978-08-16 Randall & Son Ltd J Token-deposit locks
DE3023369A1 (de) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2100933A1 (fr) * 1970-07-18 1972-03-24 Pfizer
EP0007206A1 (fr) * 1978-07-03 1980-01-23 Eli Lilly And Company Phénéthanolamines, leurs compositions, leur utilisation et leur préparation
EP0056486A2 (fr) * 1981-01-19 1982-07-28 BASF Aktiengesellschaft Phénylpiperazinyl-propanoles de hétarylphénoles, leur préparation et leurs compositions pharmaceutiques
EP0068669A1 (fr) * 1981-06-20 1983-01-05 Beecham Group Plc Phényléthanolamines secondaires, procédés de leur préparation et leur application pharmaceutique
EP0257864A1 (fr) * 1986-08-09 1988-03-02 Pfizer Limited Agents antiarrythmiques
EP0290377A1 (fr) * 1987-05-05 1988-11-09 Schering Aktiengesellschaft [1H-Imidazolyl-1]-4 benzamides substitués en tant qu'agents antiarythmiques
EP0306440A2 (fr) * 1987-09-04 1989-03-08 Schering Aktiengesellschaft 1-Phényl-1H-imidazoles substitués en C-4 du groupe phényle comme agents cardiovasculaires

Also Published As

Publication number Publication date
EP0358284B1 (fr) 1997-08-20
US5051423A (en) 1991-09-24
JPH07119193B2 (ja) 1995-12-20
ATE157089T1 (de) 1997-09-15
DE68928262D1 (de) 1997-09-25
WO1990000548A2 (fr) 1990-01-25
JPH03501617A (ja) 1991-04-11
CA1328105C (fr) 1994-03-29
ES2107998T3 (es) 1997-12-16
EP0358284A2 (fr) 1990-03-14
EP0358284A3 (fr) 1990-06-20
GR3025151T3 (en) 1998-02-27
DE68928262T2 (de) 1998-04-02

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