WO1990001353A1 - Applicateurs electrostatiques chauffant en profondeur - Google Patents
Applicateurs electrostatiques chauffant en profondeur Download PDFInfo
- Publication number
- WO1990001353A1 WO1990001353A1 PCT/US1988/002720 US8802720W WO9001353A1 WO 1990001353 A1 WO1990001353 A1 WO 1990001353A1 US 8802720 W US8802720 W US 8802720W WO 9001353 A1 WO9001353 A1 WO 9001353A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- applicator
- tissue
- energy
- resonant
- heating
- Prior art date
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 60
- 230000005684 electric field Effects 0.000 claims abstract description 10
- 230000008878 coupling Effects 0.000 claims description 18
- 238000010168 coupling process Methods 0.000 claims description 18
- 238000005859 coupling reaction Methods 0.000 claims description 18
- 239000003990 capacitor Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 238000000151 deposition Methods 0.000 claims description 5
- 230000035945 sensitivity Effects 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 abstract description 12
- 238000011282 treatment Methods 0.000 abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 206010020843 Hyperthermia Diseases 0.000 description 13
- 230000036031 hyperthermia Effects 0.000 description 13
- 210000003205 muscle Anatomy 0.000 description 12
- 238000005259 measurement Methods 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 6
- 230000035515 penetration Effects 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000013021 overheating Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
Definitions
- the resulting induced concentric electric field lines 34 are parallel to the body surface 36 and energy deposition in the deep muscle tissue 38 is not dependent upon electric field lines that must pass through the fat/skin layer 40.
- Clinical experience with over 1000 patients shows that excessive surface heating is spared and deep heating is often achieved.
- distilled water bags 64 are placed between the dipoles and the patient. This allows the dipole elements to function in a medium having a dielectric constant similar to muscle tissue (approximately 78) , thus enhancing the coupling and minimizing the discontinuity between the dipole elements and the body surface.
- a dielectric constant similar to muscle tissue approximately 78
- Prior art devices 2 through 5 are not resonant devices and a serious impedance mismatch with the 50 ohm line to the RF power source will result unless a water bolus is used as described. Moreover, the lack of a resonant structure limits the frequencies which may be employed in the devices. Additionally, in a clinical environment, it is preferable to use as simplified a device as possible and preferably a device that does not surround the patient.
- a further object of the invention is to employ structures that do not surround the patient, to eliminate the need for side coupling elements and shield plates.
- Fig. 11 is a graph showing the measured thermal pattern in an experiment employing the present invention as observed in a muscle equivalent phantom of the torso having the same cross-section as used in E-fiel measurements of Fig. 10;
- Fig. 11 shows the thermal response after applying 800 watts for 8 minutes.
- Fig. 12 shows that a similar heating pattern was obtained when the duration was increased to 15 minutes. As is shown, relatively uniform heating is obtained at any depth in the desired cross-section. The thermal increase in the center of the phantom was approximately 15% less than that obtained at the bottom surface, but it was also abou 10% greater than that at the top surface.
- the two sets of plates 82-84 are connected by the coils 95 and RF energy is coupled to one of the coils as shown at 94.
- the plates on opposite sides of the gap produce a difference of potential across the gap region 86 that is an aperture or RF coupling mechanism through which energy is transferred to the body.
- the relatively large surfaces of the plates in terms of body dimensions, provide a large distributed capacitive coupling to the body on either side of the gap region that provides an efficient aperture through which the RF energy is launched into the body. This is further verified with measurement data.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Electrotherapy Devices (AREA)
Abstract
Un applicateur électrostatique chauffant en profondeur dépose une énergie HF d'une manière relativement uniforme sur toute une section transversale donnée du torse humain, ayant ainsi pour résultat un chauffage uniforme similaire de la région. L'applicateur utilise une paire d'applicateurs rectangulaires (70), plats (82) ou cylindriques produisant un champ électrique produisant de la chaleur parallèl à l'axe principal du corps (74) de manière à réduire au minimum le chauffage en surface excessif. Ledit applicateur trouve une utilisation particulière dans le traitement de cancers profonds chez des patients. Il suffit de le placer près du torse pour un fonctionnement satisfaisant, permettant ainsi un espace d'air relativement grand entre ledit applicateur et le patient. Il nécessite un temps de montage très court, est facile à utiliser et ne présente aucun danger pour le patient.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/006,219 US4823811A (en) | 1987-01-23 | 1987-01-23 | Electrostatic deep heating applicator |
| PCT/US1988/002720 WO1990001353A1 (fr) | 1988-08-11 | 1988-08-11 | Applicateurs electrostatiques chauffant en profondeur |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1988/002720 WO1990001353A1 (fr) | 1988-08-11 | 1988-08-11 | Applicateurs electrostatiques chauffant en profondeur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1990001353A1 true WO1990001353A1 (fr) | 1990-02-22 |
Family
ID=22208832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1988/002720 WO1990001353A1 (fr) | 1987-01-23 | 1988-08-11 | Applicateurs electrostatiques chauffant en profondeur |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1990001353A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2203701C2 (ru) * | 2001-04-04 | 2003-05-10 | Казанский государственный технический университет им. А.Н. Туполева | Способ формирования распределения электромагнитного сигнала в системе излучателей для сверхвысокочастотной гипертермии (варианты) |
| WO2005110544A1 (fr) * | 2004-05-07 | 2005-11-24 | Therm Med Llc | Procede et systeme destines a produire une hyperthermie induite par radiofrequence |
| US7510555B2 (en) | 2004-05-07 | 2009-03-31 | Therm Med, Llc | Enhanced systems and methods for RF-induced hyperthermia |
| US7627381B2 (en) | 2004-05-07 | 2009-12-01 | Therm Med, Llc | Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy |
| EP4427801A1 (fr) * | 2023-03-07 | 2024-09-11 | Fluxmetrix Ltd | Appareil pour générer un champ magnétique |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB425803A (en) * | 1933-05-23 | 1935-03-21 | Robert Pierre Ernest Leroy | Improvements in apparatus for the production of artificial fever |
| US2044257A (en) * | 1930-11-18 | 1936-06-16 | Siemens Reiniger Werke Ag | Apparatus for electromedical treatment |
| FR807349A (fr) * | 1936-06-15 | 1937-01-09 | Dispositif pour le traitement thérapeutique à l'aide de champs alternatifs à haute fréquence, notamment à l'aide d'ondes courtes | |
| US2130758A (en) * | 1935-06-01 | 1938-09-20 | E J Rose Mfg Company Of Califo | Electrode for diathermy treatment and the like |
| US4028518A (en) * | 1974-06-18 | 1977-06-07 | L'oreal | Device for superficially heating an adjacent body |
| CA1177895A (fr) * | 1980-04-29 | 1984-11-13 | Larry Norton | Appareil pour accroitre l'activite in-vivo des medicaments contre le cancer |
| US4672980A (en) * | 1980-04-02 | 1987-06-16 | Bsd Medical Corporation | System and method for creating hyperthermia in tissue |
-
1988
- 1988-08-11 WO PCT/US1988/002720 patent/WO1990001353A1/fr unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2044257A (en) * | 1930-11-18 | 1936-06-16 | Siemens Reiniger Werke Ag | Apparatus for electromedical treatment |
| GB425803A (en) * | 1933-05-23 | 1935-03-21 | Robert Pierre Ernest Leroy | Improvements in apparatus for the production of artificial fever |
| US2130758A (en) * | 1935-06-01 | 1938-09-20 | E J Rose Mfg Company Of Califo | Electrode for diathermy treatment and the like |
| FR807349A (fr) * | 1936-06-15 | 1937-01-09 | Dispositif pour le traitement thérapeutique à l'aide de champs alternatifs à haute fréquence, notamment à l'aide d'ondes courtes | |
| US4028518A (en) * | 1974-06-18 | 1977-06-07 | L'oreal | Device for superficially heating an adjacent body |
| US4672980A (en) * | 1980-04-02 | 1987-06-16 | Bsd Medical Corporation | System and method for creating hyperthermia in tissue |
| CA1177895A (fr) * | 1980-04-29 | 1984-11-13 | Larry Norton | Appareil pour accroitre l'activite in-vivo des medicaments contre le cancer |
Non-Patent Citations (1)
| Title |
|---|
| IEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, Volume MTT-32, No. 8, issued August 1984, P. RASKMARK.: "Focused Electromagnetic Heating of Muscle Tissue", see pages 887-888. * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2203701C2 (ru) * | 2001-04-04 | 2003-05-10 | Казанский государственный технический университет им. А.Н. Туполева | Способ формирования распределения электромагнитного сигнала в системе излучателей для сверхвысокочастотной гипертермии (варианты) |
| WO2005110544A1 (fr) * | 2004-05-07 | 2005-11-24 | Therm Med Llc | Procede et systeme destines a produire une hyperthermie induite par radiofrequence |
| US7510555B2 (en) | 2004-05-07 | 2009-03-31 | Therm Med, Llc | Enhanced systems and methods for RF-induced hyperthermia |
| US7627381B2 (en) | 2004-05-07 | 2009-12-01 | Therm Med, Llc | Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy |
| EP2345453A3 (fr) * | 2004-05-07 | 2011-11-09 | Therm Med LLC | Systèmes d'hyperthermie induite par RF |
| EP4427801A1 (fr) * | 2023-03-07 | 2024-09-11 | Fluxmetrix Ltd | Appareil pour générer un champ magnétique |
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