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WO1990003164A3 - Formulations pharmaceutiques - Google Patents

Formulations pharmaceutiques Download PDF

Info

Publication number
WO1990003164A3
WO1990003164A3 PCT/GB1989/001161 GB8901161W WO9003164A3 WO 1990003164 A3 WO1990003164 A3 WO 1990003164A3 GB 8901161 W GB8901161 W GB 8901161W WO 9003164 A3 WO9003164 A3 WO 9003164A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active material
chylomicra
formulations
insulin
Prior art date
Application number
PCT/GB1989/001161
Other languages
English (en)
Other versions
WO1990003164A2 (fr
Inventor
Young W Cho
Michael John Flynn
Original Assignee
Patralan Ltd
Young W Cho
Michael John Flynn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patralan Ltd, Young W Cho, Michael John Flynn filed Critical Patralan Ltd
Priority to BG89877A priority Critical patent/BG60849B1/bg
Publication of WO1990003164A2 publication Critical patent/WO1990003164A2/fr
Publication of WO1990003164A3 publication Critical patent/WO1990003164A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Des formulations, administrables par voie orale ou rectale, d'une substance biologiquement active comprennent une micro-émulsion aqueuse. La phase hydrophile de cette micro-émulsion comprend la substance biologiquement active et la phase hydrophobe renferme de la chylomicra ou une substance susceptible de former de la chylomicra dans la muqueuse intestinale après administration. La substance biologiquement active peut être n'importe laquelle parmi une large gamme de substances comprenant l'insuline, la calcitonine et la somatotrophine ou hormone de croissance. Les formulations décrites conviennent particulièrement à l'administration orale d'insuline dans le traitement du diabète.
PCT/GB1989/001161 1988-09-29 1989-09-29 Formulations pharmaceutiques WO1990003164A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG89877A BG60849B1 (bg) 1988-09-29 1989-09-29 Фармацевтична форма и метод за получаването й

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888822857A GB8822857D0 (en) 1988-09-29 1988-09-29 Pharmaceutical formulations
GB8822857.2 1988-09-29

Publications (2)

Publication Number Publication Date
WO1990003164A2 WO1990003164A2 (fr) 1990-04-05
WO1990003164A3 true WO1990003164A3 (fr) 1990-06-14

Family

ID=10644447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001161 WO1990003164A2 (fr) 1988-09-29 1989-09-29 Formulations pharmaceutiques

Country Status (28)

Country Link
US (1) US5656289A (fr)
EP (1) EP0366277B1 (fr)
JP (1) JP2927835B2 (fr)
KR (1) KR0139641B1 (fr)
AR (1) AR243375A1 (fr)
AT (1) ATE98480T1 (fr)
AU (2) AU4341789A (fr)
BG (1) BG60849B1 (fr)
CA (1) CA1339814C (fr)
CZ (1) CZ285237B6 (fr)
DD (1) DD300405A5 (fr)
DE (1) DE68911473T2 (fr)
DK (1) DK481989A (fr)
ES (1) ES2060785T3 (fr)
FI (1) FI98196C (fr)
GB (1) GB8822857D0 (fr)
HK (1) HK85596A (fr)
HU (2) HUT54033A (fr)
IE (1) IE63543B1 (fr)
MX (1) MX17752A (fr)
NO (1) NO300199B1 (fr)
NZ (1) NZ230838A (fr)
PL (1) PL163635B1 (fr)
PT (1) PT91850B (fr)
RO (1) RO108219B1 (fr)
RU (1) RU2122403C1 (fr)
WO (1) WO1990003164A2 (fr)
ZA (1) ZA897437B (fr)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
GB9022788D0 (en) * 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
US5614219A (en) * 1991-12-05 1997-03-25 Alfatec-Pharma Gmbh Oral administration form for peptide pharmaceutical substances, in particular insulin
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
WO1993011799A1 (fr) * 1991-12-18 1993-06-24 Pfizer Inc. Hydrolisats ou proteines de soja utilises dans des compositions pharmaceutiques pour proteger des peptides bioactifs contre l'inactivation enzymatique
US5525519A (en) * 1992-01-07 1996-06-11 Middlesex Sciences, Inc. Method for isolating biomolecules from a biological sample with linear polymers
BR9201168A (pt) * 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6153592A (en) * 1992-11-09 2000-11-28 Port Systems, Llc Enhancing the bioavailability of proteolytically labile therapeutic agents
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
ES2182841T3 (es) * 1993-04-19 2003-03-16 Inst Advanced Skin Res Inc Preparacion en microemulsion conteniendo una substancia dificilmente absorbible.
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
EP0696208B1 (fr) 1993-04-22 2001-08-22 Emisphere Technologies, Inc. Compositions de medicaments par voie orale
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
EP0721380B1 (fr) * 1993-09-29 1999-05-26 Technobiochip Couches minces proteiniques et compositions destinees a leur preparation
DE69426570T2 (de) * 1993-11-03 2001-08-23 Isomed, Inc. Mizelleförmige feinteilige pharmazeutische zusammensetzungen
GB9325445D0 (en) * 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
GB9424902D0 (en) * 1994-12-09 1995-02-08 Cortecs Ltd Solubilisation Aids
DK0808154T3 (da) * 1995-02-06 2001-04-30 Elan Pharma Int Ltd Formuleringer af forbindelser som nanopartikel-dispersioner i fordøjelige olier eller fedtsyrer
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
WO1997036480A1 (fr) 1996-03-29 1997-10-09 Emisphere Technologies, Inc. Composes et compositions d'apport de principes actifs
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
GB2320248B (en) 1995-09-11 1999-04-14 Emisphere Tech Inc Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
AU716747B2 (en) * 1996-02-12 2000-03-02 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
CA2258264A1 (fr) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Parfums microencapsules et leur procede de production
CA2259179C (fr) * 1996-07-03 2008-09-23 University Of Pittsburgh Formulations d'emulsions pour des agents actifs hydrophiles
US6465016B2 (en) * 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6150164A (en) * 1996-09-30 2000-11-21 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
ES2130056B1 (es) * 1997-01-16 2000-02-01 Lipotec Sa Un nuevo preparado farmaceutico para mejorar la biodisponibilidad oral de drogas de dificil absorcion.
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
RU2212230C2 (ru) * 1998-03-05 2003-09-20 Ниппон Синяку Ко., Лтд. Жировая эмульсия для ингаляции
RU2222334C2 (ru) * 1998-05-25 2004-01-27 Ниппон Синяку Ко., Лтд. Способ получения композитного препарата, содержащего нуклеиновую кислоту
ATE259220T1 (de) 1998-05-29 2004-02-15 Skyepharma Canada Inc Gegen hitzeeinwirkung geschützte mikropartikel und verfahren zur terminalen dampfsterilisation derselben
US6660277B1 (en) 1998-06-19 2003-12-09 Avon Products, Inc. Gel matrix non-emulsion composition containing two clay gels
ATE462417T1 (de) * 1998-08-13 2010-04-15 Cima Labs Inc Microemulsionen als feste dosisformen zur oralen verabreichung
EP1105096B1 (fr) 1998-08-19 2003-10-29 Skyepharma Canada Inc. Dispersions aqueuses injectables de propofol
HK1042856B (zh) 1998-11-20 2007-07-27 Skyepharma Canada Inc. 可分散的磷脂稳定的微粒
DE19855819C2 (de) * 1998-12-03 2001-02-15 Roche Diagnostics Gmbh Stabilisierung von Cytokeratin enthaltenden Kalibratoren
AU769539B2 (en) 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6248354B1 (en) * 1999-03-04 2001-06-19 Allergan Sales, Inc. Capsule system
TR200103788T2 (tr) * 1999-04-09 2002-05-21 Ortho-Mcneil Pharmaceutical, Inc. Farmasötik eritropoietin bileşimleri
US6176849B1 (en) * 1999-05-21 2001-01-23 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat
US6610035B2 (en) 1999-05-21 2003-08-26 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
AU730929B2 (en) * 1999-07-06 2001-03-22 Nestec S.A. Composition and method for prolonging the useful life of enteral feeding tubes
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6417237B1 (en) * 2000-06-08 2002-07-09 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes and compositions containing the same
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
RU2197986C2 (ru) * 2001-03-23 2003-02-10 Волчек Игорь Анатольевич Иммуномодулирующее средство неинъекционного применения
US6951655B2 (en) * 2001-10-11 2005-10-04 Imi Biomed, Inc. Pro-micelle pharmaceutical compositions
DE10158447B4 (de) * 2001-11-30 2005-02-10 Aquanova German Solubilisate Technologies (Agt) Gmbh Ascorbinsäure-Solubilisat
ITMI20012694A1 (it) * 2001-12-19 2003-06-19 Remedia S R L Composizione farmaceutica comprendente una microemulsione doppia olio/acqua/olio incorporata in un supporto solido
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
SI21258A (sl) * 2002-07-17 2004-02-29 LEK farmacevtska dru�ba d.d. Stabilni farmacevtski pripravek, ki vsebuje eritropoietin in poloksamerni poliol
KR100533460B1 (ko) * 2002-07-20 2005-12-08 대화제약 주식회사 난용성 약물의 가용화용 점막흡착성 조성물, 이를 이용한난용성 약물의 가용화용 제형 및 이들의 제조 방법
WO2004024184A1 (fr) * 2002-09-11 2004-03-25 Takeda Pharmaceutical Company Limited Preparation a liberation prolongee
FR2851918B1 (fr) * 2003-03-06 2006-06-16 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
EP1537876A1 (fr) * 2003-12-01 2005-06-08 BioGeneriX AG Formulation d'une solution d'érythropoiétine
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
NZ550320A (en) 2004-04-15 2010-02-26 Chiasma Inc Compositions capable of facilitating penetration across a biological barrier
WO2005115340A1 (fr) * 2004-05-19 2005-12-08 Glatt Air Techniques, Inc. Granules contenant des microgranules et procede de preparation de ces granules
EP1652513A1 (fr) * 2004-11-02 2006-05-03 Denderah Pharm Sa Micelles inversées basés sur des stérols et des acylglycerols and leur utilisation thérapeutique
US20070071779A1 (en) * 2005-09-26 2007-03-29 Leggit Ingenuity, Llc Compositions for delivering lipophilic agents to the intestinal mucosa and method of making thereof
RU2315619C2 (ru) * 2006-02-07 2008-01-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Суппозитории с интерфероном
WO2007127787A2 (fr) * 2006-04-25 2007-11-08 Joslin Diabetes Center, Inc. Lymphocytes t cd4+ de régulation spécifique auto-antigénique de l'insuline
US9918934B2 (en) * 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
EP1985188B1 (fr) * 2007-04-24 2013-02-27 Generale Biscuit Procédé pour la pulvérisation d'une couche contenant des graisses et du sucre dans un produit comestible
EP2200613B1 (fr) 2007-09-21 2018-09-05 The Johns Hopkins University Dérivés de phénazine et leurs utilisations
JP5156458B2 (ja) * 2008-03-31 2013-03-06 理研ビタミン株式会社 ソフトカプセル充填用液状組成物
KR101503474B1 (ko) * 2007-09-27 2015-03-18 리켄 비타민 가부시키가이샤 연질 캅셀 충전용 액상 조성물
NZ591810A (en) 2008-09-17 2012-12-21 Chiasma Inc Pharmaceutical compositions and related methods of delivery the composition comprises a medium chain fatty acid
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
RU2414150C2 (ru) * 2009-02-02 2011-03-20 Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава Способ коррекции общего уровня трипсин-ингибиторной активности сыворотки крови с помощью соевого печенья, обогащенного активным соевым ингибитором
US9428630B2 (en) 2009-06-19 2016-08-30 Exacto, Inc. Water-in-oil polyacrylamide-based microemulsions and related methods
US9307758B2 (en) 2009-06-19 2016-04-12 Exacto, Inc. Polyacrylamide based agricultural compositions
US9309378B2 (en) 2009-06-19 2016-04-12 Exacto, Inc. Emulsion compositions comprising polyacrylamide copolymer and ethylene oxide—propylene oxide copolymer
CN101756900B (zh) * 2010-02-25 2012-05-30 谢恬 一种榄香烯微乳
JP5406110B2 (ja) * 2010-04-20 2014-02-05 日東電工株式会社 半導体ウエハ加工用粘着シート
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
CA2933086C (fr) * 2013-12-11 2019-04-02 Health-Ever Biotech Co. Ltd Compositions pharmaceutiques a base de carotenoide
WO2016033556A1 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Esters de (17-β)-hydroxy-4-androstène-3-one biodisponibles à l'état solide
WO2016033549A2 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Compositions de (17-ss)-3-oxoandrost-4-èn-17-yl tridécanoate et leurs procédés de préparation et d'utilisation
RS66942B1 (sr) 2015-02-03 2025-07-31 Amryt Endo Inc Lečenje akromegalije oralnim oktreotidom
WO2016205423A2 (fr) 2015-06-15 2016-12-22 Lipocine Inc. Composition et méthode pour l'administration orale de promédicaments androgènes
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
MX2018011705A (es) 2016-04-01 2019-06-10 Therapeuticsmd Inc Composicion farmaceutica de hormona esteroide.
WO2017173044A1 (fr) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Compositions d'hormones stéroïdes dans des huiles à chaîne moyenne
WO2018098501A1 (fr) 2016-11-28 2018-05-31 Lipocine Inc. Traitement oral à base d'undécanoate de testostérone
GB201808563D0 (en) 2018-05-24 2018-07-11 Univ Manchester Treatments
GB201808564D0 (en) 2018-05-24 2018-07-11 Douglas Pharmaceuticals Ltd Treatments
US11998643B2 (en) * 2018-07-10 2024-06-04 Universidade De Santiago De Compostela Nanostructure lipid system
CA3107214A1 (fr) 2018-07-20 2020-01-23 Lipocine Inc. Maladie du foie
BR112021017773A2 (pt) 2019-03-14 2021-11-23 Exacto Inc Composição que compreende uma microemulsão de poliacrilamida e método que utiliza a dita composição para o gerenciamento de pragas de cultura
GB201907305D0 (en) 2019-05-23 2019-07-10 Douglas Pharmaceuticals Ltd Treatment of conditions
DE102019211195A1 (de) * 2019-07-26 2021-01-28 Add Advanced Drug Delivery Technologies Ltd. Verfahren und Vorrichtung zur Herstellung eines im Wesentlichen im wässrigen Milieu lösbaren Cannabinoid-Granulats
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
CA3207576A1 (fr) * 2021-02-08 2022-08-11 Tyler White Vitamine c a liberation prolongee et sa fabrication
EP4351536A1 (fr) * 2021-06-06 2024-04-17 Starton Therapeutics, Inc. Systèmes d'administration transdermique de médicaments pour l'administration d'une quantité thérapeutiquement efficace de lénalidomide et d'autres agents immunomodulateurs
US20240366731A1 (en) 2021-08-12 2024-11-07 Celagenex Research (India) Pvt. Ltd. Oral algal oil based gastro-intestinal tract permeable peptide composition

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
FR2455458A1 (fr) * 1979-05-02 1980-11-28 Kureha Chemical Ind Co Ltd Liposomes contenant une substance active, notamment un principe actif de medicament
GB2085729A (en) * 1980-10-17 1982-05-06 Dainippon Pharmaceutical Co Pharmaceutical composition for oral administration containing coagulation factor VIII
EP0140085A2 (fr) * 1983-09-12 1985-05-08 Fujisawa Pharmaceutical Co., Ltd. Préparation à base de vésicules lipidiques contenant un médicament et procédé de leur fabrication
US4536324A (en) * 1982-07-19 1985-08-20 Lion Corporation Nonionic surfactant type vesicle dispersion
FR2581543A1 (fr) * 1985-05-09 1986-11-14 Tressens Dominique Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale
EP0277776A2 (fr) * 1987-02-02 1988-08-10 The University Of Tennessee Research Corporation Liposomes à noyaux solides
WO1988006881A1 (fr) * 1987-03-13 1988-09-22 Micro-Pak, Inc. Procede de production de vesicules multilamellaires a volume aqueux eleve
WO1989000812A1 (fr) * 1987-07-28 1989-02-09 Micro-Pak, Inc. Procede de fabrication de vesicules de lipides unilamellaires
JPH06172721A (ja) * 1992-09-03 1994-06-21 Hitachi Kasei Polymer Kk 研磨材固定用テープ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165385A (en) * 1973-05-29 1979-08-21 Dianis Creations, Inc. Water-in-oil emulsion for skin moisturizing
JPS5517328A (en) * 1978-07-21 1980-02-06 Tanabe Seiyaku Co Ltd Insulin-containing emulsion and its preparation
JPS5772920A (en) * 1980-10-27 1982-05-07 Toyama Chem Co Ltd Carcinostatic agent containing blood plasma or blood serumal lipoprotein
JPS5821622A (ja) * 1981-07-28 1983-02-08 Kowa Co 糖尿病治療用薬剤
JPS60155109A (ja) * 1984-01-23 1985-08-15 Terumo Corp リポソ−ム製剤
JPS6172721A (ja) * 1984-09-19 1986-04-14 Daigo Eiyou Kagaku Kk インシユリン含有リポゾ−ム
US4849227A (en) * 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
US4851220A (en) * 1986-11-26 1989-07-25 Schering Corporation Stable oleaginous gel
NZ222907A (en) * 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146499A (en) * 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
FR2455458A1 (fr) * 1979-05-02 1980-11-28 Kureha Chemical Ind Co Ltd Liposomes contenant une substance active, notamment un principe actif de medicament
GB2085729A (en) * 1980-10-17 1982-05-06 Dainippon Pharmaceutical Co Pharmaceutical composition for oral administration containing coagulation factor VIII
US4536324A (en) * 1982-07-19 1985-08-20 Lion Corporation Nonionic surfactant type vesicle dispersion
EP0140085A2 (fr) * 1983-09-12 1985-05-08 Fujisawa Pharmaceutical Co., Ltd. Préparation à base de vésicules lipidiques contenant un médicament et procédé de leur fabrication
FR2581543A1 (fr) * 1985-05-09 1986-11-14 Tressens Dominique Pharmacotechnie permettant la realisation d'une preparation insulinique active par voie orale
EP0277776A2 (fr) * 1987-02-02 1988-08-10 The University Of Tennessee Research Corporation Liposomes à noyaux solides
WO1988006881A1 (fr) * 1987-03-13 1988-09-22 Micro-Pak, Inc. Procede de production de vesicules multilamellaires a volume aqueux eleve
WO1989000812A1 (fr) * 1987-07-28 1989-02-09 Micro-Pak, Inc. Procede de fabrication de vesicules de lipides unilamellaires
JPH06172721A (ja) * 1992-09-03 1994-06-21 Hitachi Kasei Polymer Kk 研磨材固定用テープ

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, Volume 10, No. 239 (C-367) (2295), 19 August 1986; & JP-A-6172721 (Daigo Eiyou Kagaku K.K.) 14 April 1986 *
PATENT ABSTRACTS OF JAPAN, Volume 6, No. 154 (C-119) (1032), 14 August 1982; & JP-A-5772920 (Toyama Kagaku Kogyo K.K.) 7 May 1982 *
PATENT ABSTRACTS OF JAPAN, Volume 7, No. 97 (C-163) (1242), 23 April 1983; & JP-A-5821622 (Kouwa K.K.) 8 February 1983 *

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US5656289A (en) 1997-08-12
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IE893118L (en) 1990-03-29
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KR0139641B1 (ko) 1998-06-01
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ATE98480T1 (de) 1994-01-15
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FI894637A0 (fi) 1989-09-29
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