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WO1990007000A3 - Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof - Google Patents

Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof Download PDF

Info

Publication number
WO1990007000A3
WO1990007000A3 PCT/US1989/005128 US8905128W WO9007000A3 WO 1990007000 A3 WO1990007000 A3 WO 1990007000A3 US 8905128 W US8905128 W US 8905128W WO 9007000 A3 WO9007000 A3 WO 9007000A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
galactosyltransferase
provides
encodes
acid sequence
Prior art date
Application number
PCT/US1989/005128
Other languages
French (fr)
Other versions
WO1990007000A2 (en
Inventor
Michiko N Fukuda
Hubert A Appert
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of WO1990007000A2 publication Critical patent/WO1990007000A2/en
Publication of WO1990007000A3 publication Critical patent/WO1990007000A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides an isolated nucleic acid sequence which encodes purified membrane-bound human β-1,4-galactosyltransferase, or a functional equivalent thereof. This invention also provides an isolated nucleic acid sequence which encodes purified soluble human β-1,4-galactosyltransferase or a functional equivalent thereof. The invention further provides vectors comprising these nucleic acid sequences and the expression of recombinant proteins by use of a host vector system. The invention still further provides antibodies reactive with the proteins and probes reactive with the nucleic acid sequences. Finally, the invention provides a method of diagnosing congenital dyserthropoietic anemia type II in a subject.
PCT/US1989/005128 1988-12-13 1989-11-16 Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof WO1990007000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28373288A 1988-12-13 1988-12-13
US283,732 1988-12-13

Publications (2)

Publication Number Publication Date
WO1990007000A2 WO1990007000A2 (en) 1990-06-28
WO1990007000A3 true WO1990007000A3 (en) 1990-08-09

Family

ID=23087318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005128 WO1990007000A2 (en) 1988-12-13 1989-11-16 Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof

Country Status (3)

Country Link
AU (1) AU4751990A (en)
CA (1) CA2003797A1 (en)
WO (1) WO1990007000A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
GB2256197B (en) * 1991-05-31 1995-11-22 Ciba Geigy Ag Yeast as host for expression of heterologous glycosyl transferase enzymes
SE9201544L (en) * 1991-05-31 1992-12-01 Ciba Geigy Ag MAKE SUBSTANTIAL GYCOSYL TRANSFER PHASES
FI952574L (en) * 1992-11-27 1995-05-26 Ciba Geigy Ag Glycosyltransferase-active proteins
GB9603256D0 (en) * 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6558934B1 (en) * 1998-07-17 2003-05-06 Glycozm Aps UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyl-transferase, β4Gal-T2
ATE346914T1 (en) 1999-08-24 2006-12-15 Glycozym Aps UDP-N-ACETYLGLUCOSAMINE: GALACTOSE-BETA 1,3-N-ACETYLGALACTOSAMINE-ALPHA-R/(GLCNAC -GALNAC) BETA 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2GNT3
CN1331292A (en) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 Polypeptide-human beta-1,4 galactosyltransferase 13.2 and polynucleotide for coding it

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, vol. 139, no. 1, 29 August 1986, Academic Press, Inc., (Duluth, MN, US), H.E. Appert et al.: "Isolation of a cDNA coding for human galactosyl transferase", pages 163-168, see the whole article (cited in the application) *
Biochemical and Biophysical Research Communications, vol. 187, no. 2, 15 December 1988, Academic Press, Inc., (Duluth, MN, US), K.A. Masri et al.: "Identification of the full-lenght coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: betal, 4-galactosyltransferase)", see pages 657-663 *
The Journal of Biological Chemistry, vol. 263, no. 21, 25 July 1988, (Baltimore, ND, US), N.L. Shaper et al.: "Characterization of the full lenght cDNA for murine beta-1,4-Galactosyltransferase", pages 10420-10428, see "Discussion" (cited in the application) *

Also Published As

Publication number Publication date
AU4751990A (en) 1990-07-10
CA2003797A1 (en) 1990-06-13
WO1990007000A2 (en) 1990-06-28

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