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WO1990011812A1 - Filtre de degazage et son procede de fabrication - Google Patents

Filtre de degazage et son procede de fabrication Download PDF

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Publication number
WO1990011812A1
WO1990011812A1 PCT/US1990/001820 US9001820W WO9011812A1 WO 1990011812 A1 WO1990011812 A1 WO 1990011812A1 US 9001820 W US9001820 W US 9001820W WO 9011812 A1 WO9011812 A1 WO 9011812A1
Authority
WO
WIPO (PCT)
Prior art keywords
fibers
housing
interior chamber
filter
hydrophilic
Prior art date
Application number
PCT/US1990/001820
Other languages
English (en)
Inventor
William C. Schmeiser
Lee K. Kulle
Birendra K. Lal
Robin G. Pauley
Original Assignee
Baxter International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc. filed Critical Baxter International Inc.
Publication of WO1990011812A1 publication Critical patent/WO1990011812A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/38—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0233—Manufacturing thereof forming the bundle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/024—Hollow fibre modules with a single potted end
    • B01D63/0241—Hollow fibre modules with a single potted end being U-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A61M2005/1655—Filter with fibers, e.g. filtering element in form of hollow fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/16—Specific vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2319/00—Membrane assemblies within one housing
    • B01D2319/06—Use of membranes of different materials or properties within one module

Definitions

  • the present invention relates generally to fluid filters which separate gas from liquid in a fluid stream and vent the gas and to a method of making same. More particularly, the present invention relates to such filters utilizing hollow fibers for separating an venting gas and for filtering liquids.
  • Fluid filters which utilize porous membrane or other filter media for filtering liquids, which als separate gas from liquid and vent the gas have been use in a variety of situations.
  • One important use for suc filters is in filtering parenteral solution or othe fluid, as the fluid is administered to a living subject, usually human.
  • any gas suspended or entrained in the fluid also b removed so as to eliminate any hazard of embolism fro air or gas reaching the patient.
  • 4,568,366, for example, dis ⁇ closes a medical fluid filter which utilizes hydrophilic fibers, and unlike the present invention, a hydrophobic membrane positioned at the top of the filter.
  • This filter is position sensitive and must be maintained in an upright position in order for separated gas to be vented from the housing. Build-up of gas may result in partial blockage of the hydrophilic fibers and lead to reduced flow rates to the patient.
  • European Patent Application No. 0086028 discloses a filter for water purification which uses both hydrophobic and hydrophilic fibers. However, unlike the present invention, the two different fibers are not contained in the same housing.
  • the hydrophobic fibers are encased within a housing mounted on top of the liquid filtering housing, thereby making the effec ⁇ tiveness of the filter dependent upon its maintenance in an upright position. As such, this filter also requires two separate housings, thereby increasing manufacturing costs.
  • U.S. Patent No. 4,636,307 discloses a water purification filter which utilizes both hydrophilic and hydrophobic fibers. Unlike the present invention, the device disclosed in this patent does not separate and vent gas, but intentionally reentrains the gas into the liquid after it is filtered. Specifically, after the water has passed through the hydrophilic fibers and been filtered of impurities, the filtered water and the gas, which passed through the hydrophobic filters, exit the filter housing through the same outlet. This is not atypical. Water purification filters are seldom concerned with re-entrainment of the gas in the liquid after filtering. Indeed, a certain level of dissolved air enhances the taste of the water.
  • a filter for separating and venting gas from liquid is defined by a housing having an interior chamber with a fluid inlet into the interior chamber and a gas outlet from the interior chamber. Located within the housing are two sets of microporous hollow fibers. One set of hollow fibers is of a hydrophilic nature and the interiors of the fibers are in communication with the liquid outlet. The other set of hollow fibers is of a hydrophobic nature and the interiors of the fibers are in communication with the gas venting outlet.
  • Gas entrained in the fluid introduced into the housing is separated from the liquid by the hydrophilic fibers, which are impermeable to gas when wetted.
  • the gas is vented from the housing by passing through the hydrophobic fibers, which are relatively impermeable to liquid, thus preventing the collection of gas on the surfaces of the hydrophilic fibers which would reduce the fibers' filtering ability.
  • the gas passes from the hydrophobic fibers out of the housing through the gas venting outlet.
  • the hollow fibers herein may be two u-shaped bundles, one bundle hydrophilic and one hydrophobic, with the bundle of hydrophobic fibers adjacent to and in substantially side-by-side relation to the bundle of hydrophilic fibers.
  • Use of u-shaped fibers has the advantage of minimizing manufacturing time and cost.
  • One or both bundles of the fibers herein may extend sub ⁇ stantially the full length of the interior chamber, thus providing greater filtering and venting surface.
  • the bundle of hydrophilic fibers of the present invention may be substantially aligned between the fluid inlet and the liquid outlet of the filter housing, with the open ends of the fibers secured by potting compound in an aperture of a potting collar, and in communication with the liquid outlet.
  • the open ends of the hydrophobic fibers herein may be secured int another aperture of the potting collar so as to be i communication with the gas venting outlet.
  • the hydrophilic fibers of the presen invention are preferably naturally hydrophilic and non chemical secreting, and there are preferably about twic as many hydrophilic fibers as hydrophobic fibers t provide a large filtering surface area for adequat liquid flow rates.
  • the housing ma be of a generally elongated and tubular shape, definin a fluid inlet at the upper end.
  • the gas venting outle may be a lateral aperture located proximal to the lowe end of the housing.
  • the open ends of the hydrophobi fibers may be secured within the gas venting outlet wit the ends opening to the exterior of the housing an spaced from the ends of the hydrophilic fibers.
  • Th hydrophilic fibers may be positioned in a substantiall side by side relationship with the hydrophobic fiber with the open ends of the hydrophilic fibers in com munication with the open lower end of the housing.
  • a cap having a liquid outlet may be secured t the open lower end of the housing so as to seal th lower end of the housing and overlie and protect without blocking, the gas venting aperture.
  • the filter of an alternative embodiment may b manufactured from a one-piece housing having a branc arm extending from the side of the housing proximal t the open lower end of the housing.
  • the hydrophobi fibers are inserted into the interior of the housin through the branch arm and extend substantially th entire length of the interior housing.
  • the hydrophili fibers are inserted into the housing through the ope lower end of the housing and extend substantially th entire length of the interior housing. The housing i then clamped circumferentially adjacent the juncture o the branch arm and the lower end until both bundles o fibers are tightly enclosed within the housing.
  • Potting compound is then injected into the housing through the open end or branch arm, preferably the branch arm, thereby sealing the fibers together at the point above the clamp.
  • the clamp is removed and the branch arm is cut from the housing at the base of the branch arm, thereby exposing the open ends of the hydrophobic fibers to the ambient atmosphere.
  • a cap having a liquid outlet port is sealingly placed over the open lower end of the housing so that the open ends of the hydrophilic fibers are in communication with the liquid outlet tube of the cap.
  • the cap also overlies the gas venting aperture but is spaced therefrom to define an annular gas venting passageway between the interior sidewall of the cap and the exterior surface of the housing.
  • FIG. 1 is an exploded perspective view o the preferred filter of the present invention.
  • Figure 2 is a bottom plan view of the ca employed in filter of Figure 1.
  • Figure 3 is a side view of the cap employed i the filter of Figure 1.
  • Figure 4 is a top plan view of the cap o Figure 4.
  • Figure 5 is a side elevational view of th filter of Figure 1.
  • Figure 6 is a side elevational view of th filter of Figure 1 showing the fibers potted in th collar.
  • Figure 7 is an exploded perspective view partially broken away, of an alternative filter housin and cap of the present invention.
  • Figure 8 is a series of perspective views partially broken away, depicting the manufacture of th alternative embodiment of the present invention depicte in Figure 9.
  • Figure 9 is a vertical cross-sectional view o an alternative embodiment of the present invention.
  • Figure 10 is a vertical cross-sectional vie of a second alternative embodiment of this invention.
  • Figure 11 is a cross-sectional view of th second alternative embodiment taken along line 11-11 o Figure 10.
  • FIG 12 is a cross-sectional view of t second alternative embodiment of this invention tak along line 12-12 of Figure 10.
  • DETAILED DESCRIPTION OF THE DRAWINGS • Turning now to a detailed description of the present invention as shown in its preferred and alternative embodiments in the attached drawings.
  • the present invention is generally embodied in a filter unit, generally at 8, which may be an integral part of an overall medical fluid administration set for administering parenteral solutions and the like to patients or, alternatively, as an add-on to a separate administration set.
  • the present invention is embodied in a housing made of three molded plastic pieces.
  • the upper housing 10 defining a elongated interior chamber 12, a potting collar 14 and a lowe ** r end cap 16.
  • the upper housing 10 is generally elongated and oval in cross-sectional shape.
  • the housing 10 has a closed upper end 18 and an open lower end 20.
  • the upper housing 10 may be constructed from any material which is compatible with the fluid being filtered, but the material is preferably clear, so that the liquid within the filter may be observed.
  • the housing 10 is preferably made of clear, rigid, ABS, PVC, or methyl- acrylic type plastic, such as that available under the trademark PLEXIGLAS from the Rohm and Haas Company of Philadelphia, Pennsylvania, USA. This material is relatively inexpensive and easy to mold.
  • the potting collar 14 is also of one-piece, molded construction having a generally oval cross- sectional shape. It may be constructed from the same material as the upper housing and may be either clear or opaque. Disposed within the potting collar are two cylindrical ports or apertures 22 and 24 in substan ⁇ tially side-by-side relation. The collar is sealingly joined, as by solvent or sonic bonding, to the lower open end of the upper housing 10 so that the collar's apertures are in direct communication with the interior chamber 12 of the housing.
  • the cap 16 is of one-piece, molded con struction and may also be constructed of the sam material as the upper housing 10 and the potting colla 14.
  • the cap 16 has a base 26 which has a generally ova shape, a gas outlet port 28 and a generally cylindrica liquid outlet tube 30 in substantially side-by-sid relationship to the gas outlet.
  • the cap is ⁇ ealingl joined to and covers the base of the potting collar 1 so that the gas outlet port 28 and the liquid outle tube 30 are substantially aligned with the two aperture 22 and 24, respectively, of the potting collar 14.
  • the gas outlet port 28 and the liquid outlet tub 30 are in communication, through the apertures of th potting collar 14 and the interior of the hollow fibers with the interior chamber 12 of the housing 10.
  • an inlet port tube 32 is provided at the uppe end 18 of the housing 10.
  • the fluid inlet tube 32 is located to one side of th upper end 18 of the housing and is generally aligne with the liquid outlet tube 30.
  • One set of the fibers 34 i constructed of material of a hydrophilic (wate attracting) nature and the other set of fibers 36 i constructed of material of a hydrophobic nature (wate repelling) .
  • the sets of fibers are positioned generall side-by-side within the interior chamber 12.
  • the fibers are arranged in a U configuration and having their open ends positioned a the lower end 20 of the interior chamber 12.
  • the fibers may be straight havin closed ends opposite the open ends of the fibers
  • this embodiment involves the additional step o sealing closed one end of each fiber.
  • the hydrophilic fibers 34 are non-chemical secreting and constructed of a naturally hydrophilic material such as mixed esters of cellulose, or nylon, which is compatible with the housing material and aqueous parenteral solutions.
  • the hydrophilic fibers have an average pore size ranging from about 0.1 to 0.45 microns, and preferably about 0.22 microns to remove bacteria from the liquid being filtered.
  • Such fibers are wetted by water and resistant to thl transmission of gas therethrough, so long as the gas pressure is below the bubble point of the material of th ⁇ fibers.
  • the bubble point generally describes the differential pressure across the membrane at which gas will be forced through the wetted fiber membrane, and, for the preferred material described above, is about 40- 60 PSIA.
  • a surfactant may be applied to the surfaces of the hydrophilic fibers 34 to facilitate the flow of aqueous liquid therethrough.
  • a surfactant may be applied to the surfaces of the hydrophilic fibers 34 to facilitate the flow of aqueous liquid therethrough.
  • a mixture of monoesters of sorbitance with capric, lauric, myristic, palmitic, and/or oleic acids may be used.
  • the hydrophilic fibers 34 of the preferred embodiment extend the entire length of the interior chamber of the housing 10 for greater filtering capacity, and are substantially aligned between the fluid inlet tube 32 and the liquid outlet tube 30. When fluid is introduced into the housing through the fluid inlet tube 32, the liquid permeates the hydrophilic fibers and is discharged through the liquid outlet tube 30.
  • the ends of the hydrophilic fibers are open and substantially disposed and fastened within the aperture of the potting collar that is in communicatio with the liquid outlet tube.
  • the fastening substance i in the form of a potting resin, such as adhesive o urethane resin, which sealingly joins the open ends o the hydrophilic fibers together and secures them withi - li ⁇ the potting collar aperture with the open ends openin to the liquid outlet tube 30.
  • the second set of fibers 36 is made o material of a hydrophobic nature.
  • the set of hydrophobic fibers 36 is i side-by-side, substantially parallel relationship to th set of hydrophilic fibers 34 and extends substantiall the entire length of the interior chamber of th housing.
  • gas entrained within the chamber wil come into contact with at least one hydrophobic fibe and pass through the fiber and out of the chambe through the gas outlet port, thus rendering the filte substantially position insensitive.
  • the ends of th hydrophobic fibers are open and positioned at the lowe end of the interior housing and are secured by th potting resin in the second aperture of the pottin collar. As such, the ends are open to and i communication with the gas outlet port.
  • FIG. 7-9 An alternative embodiment as shown in Figur 7-9 is a filter according to the present inventio including an upper housing 38 defining an interi chamber 40, and a liquid outlet cap 42.
  • the housing and the cap of th alternative embodiment is preferably molded from material which is compatible with the fluid to filtered.
  • the upper housing 38 is of a general tubular shape having a tapered open upper end defining a fluid inlet port 46, and an open lower e 48.
  • the housing 38 constructed of one-piece molded plastic having t general shape as described above, and having an ope ended branch arm 50 extending from the side of the low end 48 of the housing 38 at an angle acute to the side of the housing.
  • the interior of the branch arm 50 opens to the interior chamber 40 of the housing 38.
  • One bundle 52 of hollow fibers is of a hydrophilic nature
  • the other bundle 54 is of a hydrophobic nature.
  • the fibers may extend substantially the entire length of the interior housing and may be either u-shaped with open ends or straight with one open end and one closed or sealed end.
  • FIG 8 shows the various stages of manufacture of this embodiment of the present invention.
  • the hydrophobic fibers 54 are positioned within the interior chamber 40 of the housing.
  • the closed ends 56 of the hydrophobic fibers are located in the region of the tapered upper end 44 of the housing 38.
  • the lower portion of the hydrophobic fibers 54 extend into the branch arm 50 of the housing with the closed ends of fibers sticking out of the housing.
  • the hydrophilic fibers are positioned in a substantially side-by-side relationship to the hydrophobic fibers also with their closed ends located in the tapered upper end of the housing.
  • the open ends of the hydrophilic fibers are located at the open lower end of the housing, and away from the open ends of the hydrophobic fibers.
  • the two sets of fibers are encased in potting compound from a point above the juncture of the branch arm and the open lower end of the housing. Preferably this occurs while pressure is being applied circumferentially at the juncture so that the fibers are circumferentially engaged by the interior surface of the housing. Potting compound is injected into the housing through the open end or the branch arm thereby sealing the fibers together above the clamp.
  • the branch arm 50 of the housing as shown in Figure 8d, i then cut off from the housing creating a latera aperture defining a gas vent 58 exposing the open end of the hydrophobic fibers to the outside of the filter
  • gas entrained within the fluid passes through the hydrophobic fibers and out of the open end of the fibers through the lateral aperture.
  • the liquid outlet cap 42 is, in thi embodiment, generally cylindrical and includes a liqui outlet port 60. As shown in Figure 8e, after the branc arm 50 has been cut away from the housing, the cap 42 i secured over the open lower end of the housing. The ca extends to the uppermost portion of the gas ventin outlet so as to overlie and protect the outlet. Th inside diameter of the cap is sufficiently larger tha the housing to define an annular venting gap or pas sageway between the outside of the housing and th inside surface of the cap. As illustrated in Figure 8f, the open ends o the hydrophilic filters are in communication with th liquid outlet port of the cap.
  • Liquid is introduce into the housing, in this illustration, through a tube and passes through the hydrophilic fibers and out of th housing through the liquid outlet port into anothe tube or the like. Gas entrained in the liquid passes through the hydrophobic fibers and out the annular ga into the atmosphere.
  • the filter o this embodiment includes a housing 62 defining an inte ior chamber 64, and a cap 66.
  • the housing and cap of this alternati embodiment may be molded from plastic or other materi which is compatible with the fluid to be filtered.
  • T housing 62 is generally cylindrical and has an upper e 68 which includes a substantial tapered fluid inlet po 70.
  • the housing 62 also includes a lower end porti 72 .
  • Two sets of hollow fibers, 74 and 76 are positioned within the interior chamber 64 of the housing 62 and run substantially the entire length of the interior chamber 64.
  • the fibers may be either U-shaped or straight; and one set of fibers is hydrophilic 74 and the other set is hydrophobic 76.
  • the hydrophobic fibers 76 are positioned generally in three bundles along the side of the interior chamber 64, and preferably positioned within axially-extending recesses 78 defined in the interior wall of the chamber 64.
  • the hydrophilic fibers 74 are positioned in a side- by-side relationship to the hydrophobic fibers.
  • the ends of the two sets of fibers 74 and 76 are disposed within the open lower end 72 of the housing and are encased in potting compound 80, with the ends of the fibers left open, as described above in connection with the preferred embodiment.
  • the cap 66 is sealingly joined to the open lower end 72 of the housing 62.
  • the cap 66 tapers 82 substantially towards a centrally located cylindrical liquid outlet port 84.
  • One or more gas venting ports 86 may be located to one side of the fluid outlet port 84, in this embodiment.
  • the cap 66 includes, in this embodiment, a cylindrical inner wall 88, which is circumscribed by the cap's outer wall 66.
  • the inner wall 88 is of sufficient height to seal against the housing 62 and/or against the potting compound 80. In this manner, the inner wall 88 defines a liquid communication passage 90 between the hydrophilic fibers 74 and the liquid outlet port 84. In addition, the inner wall 88 of the cap 66 defines an annulatr gas venting chamber 92 which provides fluid communication between the hydrophobic fibers and the gas venting port 86.

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  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

On décrit un filtre de dégazage (10) comprenant un logement (8), dont les parois (18) définissent une chambre interne (22) comportant un orifice d'entrée pour un fluide (32), un orifice de sortie pour le liquide (30) et un orifice de sortie pour le gaz (28) sortant de ladite chambre interne. Dans la chambre se trouvent plusieurs fibres microporeuses creuses, les unes de nature hydrophile (34), dont le passage intérieur communique avec l'orifice de sortie du liquide, les autres de nature hydrophobe (36), dont le passage intérieur communique avec l'orifice de sortie du gaz.
PCT/US1990/001820 1989-04-07 1990-04-04 Filtre de degazage et son procede de fabrication WO1990011812A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33496789A 1989-04-07 1989-04-07
US334,967 1989-04-07

Publications (1)

Publication Number Publication Date
WO1990011812A1 true WO1990011812A1 (fr) 1990-10-18

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AU (1) AU5433690A (fr)
WO (1) WO1990011812A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0492634A1 (fr) * 1990-12-28 1992-07-01 Terumo Kabushiki Kaisha Filtre de perfusion
WO1993012866A1 (fr) * 1991-12-20 1993-07-08 The Dow Chemical Company Module de separation de fluide souple a fibres creuses
DE4300438C1 (de) * 1993-01-09 1994-06-30 Sartorius Gmbh Verfahren und Vorrichtung zur Trennung von Öl/Wasser-Gemischen
EP1008358A3 (fr) * 1998-12-09 2000-07-05 JMS Co., Ltd. Filtre de perfusion
EP1106193A1 (fr) * 1999-12-01 2001-06-13 B. Braun Melsungen Ag Dispositif d'infusion
WO2002018037A3 (fr) * 2000-08-31 2002-06-06 Millipore Corp Structure de filtre avec event a gaz, comprenant un systeme de membrane a fibres creuses
EP1629875A4 (fr) * 2003-05-01 2007-12-05 Entegris Inc Groupe de filtration equipe d'un mecanisme de desaeration
US7517387B2 (en) 2002-06-24 2009-04-14 Gambro Lundia Ab Gas separation devices
US7559911B2 (en) 2003-09-05 2009-07-14 Gambro Lundia Ab Blood chamber for extracorporeal blood circuits and a process for manufacturing the blood chamber
DE19807769B4 (de) * 1998-02-24 2010-09-30 Paul Rauschert Gmbh & Co. Kg Halterung für keramische Mikrofilter
JP2014003910A (ja) * 2012-06-21 2014-01-16 Cowa Co Ltd 果肉入りゼリー菓子の製造方法
JP2014184377A (ja) * 2013-03-22 2014-10-02 Toray Ind Inc 中空糸膜モジュール、中空糸膜モジュールの製造方法、浄水器用カートリッジおよび浄水器
EP2455126B1 (fr) 2010-11-15 2017-02-22 F. Hoffmann-La Roche AG Conteneur pour stocker des liquides médicaux ou pharmaceutiques
EP3434348A1 (fr) * 2017-07-25 2019-01-30 Hamilton Sundstrand Corporation Dispositifs de dégazage de fluides présentant des profilés sélectionnés
US10328193B2 (en) 2012-03-21 2019-06-25 Gambro Lundia Ab Extracorporeal blood treatment apparatus with multiple treatment solution reservoirs
WO2022140604A1 (fr) * 2020-12-23 2022-06-30 Repligen Corporation Éventage ou dégazage de dispositifs de filtrage et systèmes de filtration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207379A1 (fr) * 1985-06-19 1987-01-07 Mitsubishi Rayon Co., Ltd. Module filtrant à fibres creuses et procédé de filtration l'utilisant
US4636307A (en) * 1983-09-16 1987-01-13 Mitsubishi Rayon Co., Ltd. Hollow-fiber filtering module and water purification device utilizing it
WO1987002906A1 (fr) * 1985-11-18 1987-05-21 Microgon, Inc. Tube d'alimentation et filtre de fluide combines
EP0254100A2 (fr) * 1986-07-18 1988-01-27 Akzo Nobel N.V. Dispositif pour éliminer les bulles de gaz des fluides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636307A (en) * 1983-09-16 1987-01-13 Mitsubishi Rayon Co., Ltd. Hollow-fiber filtering module and water purification device utilizing it
EP0207379A1 (fr) * 1985-06-19 1987-01-07 Mitsubishi Rayon Co., Ltd. Module filtrant à fibres creuses et procédé de filtration l'utilisant
WO1987002906A1 (fr) * 1985-11-18 1987-05-21 Microgon, Inc. Tube d'alimentation et filtre de fluide combines
EP0254100A2 (fr) * 1986-07-18 1988-01-27 Akzo Nobel N.V. Dispositif pour éliminer les bulles de gaz des fluides

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221474A (en) * 1990-12-28 1993-06-22 Terumo Kabushiki Kaisha Transfusion filtering device
AU647856B2 (en) * 1990-12-28 1994-03-31 Terumo Kabushiki Kaisha Transfusion filtering device
EP0492634A1 (fr) * 1990-12-28 1992-07-01 Terumo Kabushiki Kaisha Filtre de perfusion
WO1993012866A1 (fr) * 1991-12-20 1993-07-08 The Dow Chemical Company Module de separation de fluide souple a fibres creuses
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