WO1992008740A3 - Facteur de reconnaissance de recepteurs et procedes d'utilisation d'un tel facteur - Google Patents
Facteur de reconnaissance de recepteurs et procedes d'utilisation d'un tel facteur Download PDFInfo
- Publication number
- WO1992008740A3 WO1992008740A3 PCT/US1991/008529 US9108529W WO9208740A3 WO 1992008740 A3 WO1992008740 A3 WO 1992008740A3 US 9108529 W US9108529 W US 9108529W WO 9208740 A3 WO9208740 A3 WO 9208740A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor recognition
- factor
- recognition factor
- transcription factor
- receptor
- Prior art date
Links
- 108091023040 Transcription factor Proteins 0.000 abstract 3
- 102000040945 Transcription factor Human genes 0.000 abstract 3
- 102000014150 Interferons Human genes 0.000 abstract 2
- 108010050904 Interferons Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229940079322 interferon Drugs 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003319 supportive effect Effects 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention se rapporte à la découverte d'un facteur de reconnaissance de récepteurs qui reconnaît le récepteur cellulaire spécifique auquel un ligand spécifique a été lié et qui peut par conséquent signaler et/ou déclencher la liaison du facteur de transcription au site d'ADN. Le facteur de reconnaissance du récepteur peut lui-même faire partie d'un facteur de transcription ou il peut avoir une interaction avec un facteur de transcription pour amener celui-ci à s'activer et à se déplacer jusqu'au noyau pour permettre la liaison avec l'ADN. L'activité de ce facteur de reconnaissance de récepteurs se révèle indépendante du second messager dès lors que les perturbations manisfestes se produisant dans les concentrations du second messager sont sans effet. Le concept de la présente invention est illustré par les résultats d'études effectuées avec la transcription génique stimulée par interféron IFN et en particulier par l'activation causée par l'interféron IFNα. Des observations supplémentaires tirées d'études effectuées avec l'interféron IFNτ confortent ces résultats.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61332690A | 1990-11-14 | 1990-11-14 | |
| US613,326 | 1990-11-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1992008740A2 WO1992008740A2 (fr) | 1992-05-29 |
| WO1992008740A3 true WO1992008740A3 (fr) | 1992-08-06 |
Family
ID=24456859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1991/008529 WO1992008740A2 (fr) | 1990-11-14 | 1991-11-14 | Facteur de reconnaissance de recepteurs et procedes d'utilisation d'un tel facteur |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU9092091A (fr) |
| WO (1) | WO1992008740A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3926893A (en) * | 1992-03-19 | 1993-10-21 | Rockefeller University, The | Ifn receptors recognition factors, protein sequences and methods of use thereof |
| WO1994017180A1 (fr) * | 1993-01-19 | 1994-08-04 | University Of Massachusetts Medical Center | Kinases situees dans le noyau, qui activent des facteurs de transcription |
| US6255059B1 (en) | 1993-03-31 | 2001-07-03 | Cadus Pharmaceutical Corporation | Methods for identifying G protein coupled receptor effectors |
| US20030054402A1 (en) | 1993-03-31 | 2003-03-20 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| US7235648B1 (en) | 1993-03-31 | 2007-06-26 | Cadus Technologies, Inc. | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US6864060B1 (en) | 1993-03-31 | 2005-03-08 | Cadus Technologies, Inc. | Yeast cells expressing modified G proteins and methods of use therefor |
| US6100042A (en) | 1993-03-31 | 2000-08-08 | Cadus Pharmaceutical Corporation | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| WO1995008629A1 (fr) * | 1993-09-24 | 1995-03-30 | The Rockefeller University | Sequence de proteines ou facteurs de reconnaissance de recepteurs et leur procede d'utilisation |
| US5723300A (en) * | 1995-07-10 | 1998-03-03 | University Of Massachusetts Medical Center | Nuclear localized transcription factor kinase and diagnostic assays related thereto |
| US6716435B1 (en) | 1997-04-18 | 2004-04-06 | Ganeden Biotech, Inc. | Absorbent product containing absorbent structure and Bacillus coagulans |
| US6355473B1 (en) | 1998-05-06 | 2002-03-12 | Cadus Pharmaceutical Corp. | Yeast cells having mutations in stp22 and uses therefor |
| US7081360B2 (en) | 1998-07-28 | 2006-07-25 | Cadus Technologies, Inc. | Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties |
| US7273747B2 (en) | 1998-08-27 | 2007-09-25 | Cadus Technologies, Inc. | Cell having amplified signal transduction pathway responses and uses therefor |
| US6251605B1 (en) | 1998-10-27 | 2001-06-26 | Cadus Pharmaceutical Corporation | Yeast cells having mutations in Cav1 and uses therefor |
| AU2030000A (en) | 1998-11-25 | 2000-06-13 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| US6504008B1 (en) | 1999-02-01 | 2003-01-07 | Cadus Technologies, Inc. | Cell based signal generation |
| US6555325B1 (en) | 1999-06-14 | 2003-04-29 | Cadus Technologies, Inc. | System for detection of a functional interaction between a compound and a cellular signal transduction component |
| US7223533B2 (en) | 1999-09-10 | 2007-05-29 | Cadus Technologies, Inc. | Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways |
-
1991
- 1991-11-14 WO PCT/US1991/008529 patent/WO1992008740A2/fr active Application Filing
- 1991-11-14 AU AU90920/91A patent/AU9092091A/en not_active Abandoned
Non-Patent Citations (5)
| Title |
|---|
| Genes and Development, vol. 3, no. 9, September 1989, (Cold Spring Harbor, NY, US), D.E. LEVY et al.: "Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro", pages 1362-1371, see the abstract; figure 6; page 1368, right-hand column, lines 33-41 * |
| Genes and Development, vol. 4, no. 10, October 1990, (Cold Spring Harbor, NY, US), D.S. KESSLER et al.: "Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator", pages 1753-1765, see the abstract; figure 9 (cited in the application) * |
| Proceedings of the National Academy of Sciences of USA, vol. 87, no. 21, November 1990, (Washington, DC, US), X.-Y. FU et al.: "ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains", pages 8555-8559, see the abstract (cited in the application) * |
| The EMBO Journal, vol. 9, no. 4, April 1990, (Oxford, GB), D.E. LEVY et al.: "Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3", pages pages 1105-1111, see the abstract * |
| The New Biologist, vol. 2, no. 10, October 1990, (Philadelphia, US), D. LEVY et al.: "Interferon-dependent transcriptional activation: Signal transduction without second messenger involvement?", pages 923-928, see the abstract; figure 1; page 925, left-hand column, lines 22-27 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992008740A2 (fr) | 1992-05-29 |
| AU9092091A (en) | 1992-06-11 |
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