[go: up one dir, main page]

WO1992017200A3 - Formulations stables a base d'ion metal et d'hormone de croissance - Google Patents

Formulations stables a base d'ion metal et d'hormone de croissance Download PDF

Info

Publication number
WO1992017200A3
WO1992017200A3 PCT/US1992/002365 US9202365W WO9217200A3 WO 1992017200 A3 WO1992017200 A3 WO 1992017200A3 US 9202365 W US9202365 W US 9202365W WO 9217200 A3 WO9217200 A3 WO 9217200A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal ion
growth hormone
stable growth
hgh
formulations
Prior art date
Application number
PCT/US1992/002365
Other languages
English (en)
Other versions
WO1992017200A2 (fr
Inventor
Brian C Cunningham
Michael G Mulkerrin
James A Wells
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of WO1992017200A2 publication Critical patent/WO1992017200A2/fr
Publication of WO1992017200A3 publication Critical patent/WO1992017200A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des complexes stables d'hormone de croissance humaine (hGH) et d'ion métal bivalent permettant d'obtenir des formulations stabilisées de hGH par formation de dimères ion métal-hGH. Les dimères stables sont caractérisés et les formulations thérapeutiques de zinc et hGH sont également décrites.
PCT/US1992/002365 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance WO1992017200A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67664591A 1991-03-28 1991-03-28
US676,645 1991-03-28

Publications (2)

Publication Number Publication Date
WO1992017200A2 WO1992017200A2 (fr) 1992-10-15
WO1992017200A3 true WO1992017200A3 (fr) 1992-12-23

Family

ID=24715358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002365 WO1992017200A2 (fr) 1991-03-28 1992-03-25 Formulations stables a base d'ion metal et d'hormone de croissance

Country Status (2)

Country Link
AU (1) AU1757092A (fr)
WO (1) WO1992017200A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981485A (en) 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US6022858A (en) * 1991-12-20 2000-02-08 Novo Nordisk A/S Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
ZA965368B (en) * 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
WO1998027980A2 (fr) * 1996-12-20 1998-07-02 Takeda Chemical Industries, Ltd. Procede de production d'une preparation a liberation prolongee
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
US6191107B1 (en) * 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
AU738473B2 (en) * 1997-10-31 2001-09-20 Glaxosmithkline Llc Novel metal complexes
WO1999022734A1 (fr) * 1997-10-31 1999-05-14 Smithkline Beecham Corporation Nouveaux complexes metalliques
ES2392392T3 (es) 1999-06-28 2012-12-10 Genentech, Inc. Métodos para producir ligando Apo-2 utilizando iones metálicos divalentes
DK1274459T3 (da) * 2000-04-19 2006-02-06 Genentech Inc Præparater med vedholdende frigivelse indeholdende væksthormon
CA2418960A1 (fr) 2000-08-07 2002-02-14 Inhale Therapeutic Systems, Inc. Poudres a inhaler de proteines en faisceau a quatre helices sechees par atomisation presentant une agregation reduite au minimum
EP1372729B1 (fr) 2001-02-23 2009-04-08 Genentech, Inc. Polymeres erodables a injecter
PT1397155E (pt) 2001-06-21 2015-12-07 Genentech Inc Formulação de libertação sustentada
WO2003029420A2 (fr) 2001-10-02 2003-04-10 Genentech, Inc. Variants de ligands apo-2 et leurs utilisations
AU2003247609A1 (en) 2002-06-24 2004-01-06 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885798A (en) * 1958-12-06 1961-12-28 Organon Labor Ltd Preparations of the growth hormone
EP0343696A2 (fr) * 1984-10-04 1989-11-29 Monsanto Company Zinc-somatotropines
EP0216485A1 (fr) * 1985-08-12 1987-04-01 International Minerals And Chemical Corporation Libération prolongée d'hormones stimulantes de croissance
WO1989009614A1 (fr) * 1988-04-15 1989-10-19 Genentech, Inc. Formulation d'hormones de croissance humaine

Also Published As

Publication number Publication date
AU1757092A (en) 1992-11-02
WO1992017200A2 (fr) 1992-10-15

Similar Documents

Publication Publication Date Title
WO1992017200A3 (fr) Formulations stables a base d'ion metal et d'hormone de croissance
AU1962088A (en) Urinary follicle stimulating hormone
AU3819185A (en) Pest control in animals
HUP9802287A3 (en) A stabilized pharmaceutical formulation comprising a growth hormone pre-treated with zinc and optionally lysine or calcium ions
EP0591688A3 (en) Self-propelled combine
AU1508688A (en) Stabilised metallic oxides
AU1868595A (en) Human growth hormone
ZA914200B (en) Method for preparing interferon alpha-2 crystals
AU5010685A (en) Human tumor necrosis factor
AU4288293A (en) Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
AU579358B2 (en) Fish growth hormone
AU4628993A (en) Physiologically active peptide composition
AU5743194A (en) Treatment of dermatological malignancies with biologically active peptides
AU5271893A (en) Release-controlled implantable somatotropin composition
AU1929888A (en) Grass edger
AU1346488A (en) Arginine-depleted human tumor necrosis factor
AU1283988A (en) Phenoxyphenylthioureas, phenoxyphenylisothioureas and phenoxyphenylcarbodiimides and use thereof for controlling pests
AU1543488A (en) Fungicidal aminotriazoles and aminoimidazoles
EP0663834A4 (fr) Peptides liberant l'hormone de croissance.
AU2050688A (en) Stabilised pesticidal composition
AU587708B2 (en) Zoysia grass plant
AU633018B2 (en) Stabilized thiocarbonate solutions and the use thereof for controlling soil pests
AU7209394A (en) Gallium complexes for the treatment of free radical-induced diseases
AU4701893A (en) 2-arylhydrazono-3-ketonic acid piperidides as pest control agents
NZ268125A (en) Growth hormone pharmaceutical composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA FI HU JP NO

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA FI HU JP NO

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase