WO1993000083A1 - Composition pharmaceutique contenant de l'acide gamma-hydroxybutyrique ou sa lactone et utilisee dans le traitement de la toxicomanie et des troubles nutritionnels - Google Patents
Composition pharmaceutique contenant de l'acide gamma-hydroxybutyrique ou sa lactone et utilisee dans le traitement de la toxicomanie et des troubles nutritionnels Download PDFInfo
- Publication number
- WO1993000083A1 WO1993000083A1 PCT/EP1992/001409 EP9201409W WO9300083A1 WO 1993000083 A1 WO1993000083 A1 WO 1993000083A1 EP 9201409 W EP9201409 W EP 9201409W WO 9300083 A1 WO9300083 A1 WO 9300083A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- drugs
- hydroxybutyric acid
- lactone
- salts
- Prior art date
Links
- 208000030212 nutrition disease Diseases 0.000 title claims abstract description 8
- 150000002596 lactones Chemical class 0.000 title claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title description 14
- 206010013663 drug dependence Diseases 0.000 title description 2
- 208000011117 substance-related disease Diseases 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 13
- 239000004081 narcotic agent Substances 0.000 claims abstract description 9
- 229940001470 psychoactive drug Drugs 0.000 claims abstract description 8
- 239000004089 psychotropic agent Substances 0.000 claims abstract description 8
- 230000000506 psychotropic effect Effects 0.000 claims abstract description 8
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 7
- 229960002715 nicotine Drugs 0.000 claims abstract description 7
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019788 craving Nutrition 0.000 claims abstract description 6
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 238000001990 intravenous administration Methods 0.000 claims description 5
- 208000032841 Bulimia Diseases 0.000 claims description 4
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 4
- 208000008589 Obesity Diseases 0.000 claims description 4
- 208000022531 anorexia Diseases 0.000 claims description 4
- 150000001768 cations Chemical class 0.000 claims description 4
- 206010061428 decreased appetite Diseases 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 2
- 230000003111 delayed effect Effects 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 abstract description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 6
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 5
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 5
- 206010048010 Withdrawal syndrome Diseases 0.000 description 5
- 229960002069 diamorphine Drugs 0.000 description 5
- 229960001797 methadone Drugs 0.000 description 5
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 4
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 4
- 229960003086 naltrexone Drugs 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 3
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 3
- 229960004127 naloxone Drugs 0.000 description 3
- 229940127240 opiate Drugs 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 239000003557 cannabinoid Substances 0.000 description 2
- 229930003827 cannabinoid Natural products 0.000 description 2
- 229940065144 cannabinoids Drugs 0.000 description 2
- 229960003920 cocaine Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000003368 psychostimulant agent Substances 0.000 description 2
- 230000036642 wellbeing Effects 0.000 description 2
- YSGQGNQWBLYHPE-CFUSNLFHSA-N (7r,8r,9s,10r,13s,14s,17s)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 YSGQGNQWBLYHPE-CFUSNLFHSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- 241001535291 Analges Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 208000003698 Heroin Dependence Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- 208000026251 Opioid-Related disease Diseases 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000005040 opiate dependence Diseases 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003109 potassium Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Definitions
- the present invention relates to pharmaceutical compositions having therapeutic effects on abstinence, on craving (the intense and compulsive desire for a substance), and on dependence on drugs, drugs of abuse, psychotropics, stupefacient and/or psychoactive substances, nicotine and also on nutritional disorders (in particular bulimia, obesity and anorexia), such compositions being characterised in that they contain, as the active principle, ft-hydroxybutyric acid (GHB) , or salts thereof with pharmaceutically acceptable cations, or the corresponding lactone.
- GLB ft-hydroxybutyric acid
- the invention further relates to the use of %- hydroxybutyric acid or of its physiologically equiva ⁇ lent forms for the preparation of a medicament which is useful in the treatment of the withdrawal syndrome induced by drugs, drugs of abuse, psychotropics, stupefacient and/or psychoactive substances and nicotine.
- the relevant salts of GHB include, for example, alkali metal (e.g. sodium or potassium) salts, alkaline earth metal (e.g. calcium or magnesium) salts, ammonium salts, salts of pharmaceutically acceptable bases (ethanolamine. diethanolamine, piperidine, piperazine and the like), salts of basic amino acids (lysine, ornithine, citrulline) etc.
- alkali metal e.g. sodium or potassium
- alkaline earth metal e.g. calcium or magnesium
- ammonium salts salts of pharmaceutically acceptable bases (ethanolamine. diethanolamine, piperidine, piperazine and the like), salts of basic amino acids (lysine, ornithine, citrulline) etc.
- the acid is a normal constituent of the central nervous system (CNS) of mammals, with the highest concentration in the hypo- thalamus and in the basal ganglia (c% 1.78 nM/g and 4.1 nM/g in rats and in guinea pigs, respectively).
- CNS central nervous system
- GHB Y-aminobutyric acid
- y- hydroxybutyric acid and physiologically equivalent forms can advantageously be utilised for the treatment of the so-called withdrawal syndrome from drugs, drugs of abuse, psychotropics, stupefacient and/or psychoactive substances and from nicotine; in particular, drugs such as narcotics, opiates, cocaine, cannabinoids or psychoactive substances such as benzodiazepines, psychostimulants, amphetamines, nico ⁇ tine and their derivatives or the like.
- drugs such as narcotics, opiates, cocaine, cannabinoids or psychoactive substances such as benzodiazepines, psychostimulants, amphetamines, nico ⁇ tine and their derivatives or the like.
- ft- hydroxybutyric acid has also proved to be effective in the treatment of nutritional disorders such as bulimia, obesity and anorexia.
- ⁇ craving'* which can be defined as an intense and compulsive desire for a given substance or a given food.
- ⁇ -Hydroxybutyric acid has proved to be particu- larly active in inhibiting the onset of such symptoms, as it has been possible to demonstrate on the basis of clinical experiments on 23 subjects meeting the diagnostic criteria of opiate dependence and on 3 patients affected by nutritional disorders (one case of anorexia, one of bulimia and one of obesity).
- Table 1 shows the characteristics of the groups of subjects employed, in accordance with a "double blind" scheme, for the study of the activity of GHB in the treatment of the opiate withdrawal syndrome. Eleven subjects were treated with GHB, including six who had used heroin in the last 24 hours (5 M, I F) and 5 undergoing methadone treatment (4 M, I F).
- the control group consisted of 12 patients, 7 who used heroin (6 M, I F) and 5 undergoing therapy with methadone (3 M, 2 F) .
- the two groups were homogeneous with regard to age, sex, duration and physical condition (Table 1) .
- the patients showed the simultaneous use of benzodiazepine and/or cocaine, cannabinoids, amphetamine-type psychostimu- lants or nicotine.
- the GHB group was treated by the oral route in 6 administrations (1.5 mg/kg/weight/day) .
- the start of the treatment was decided on the basis of the onset of an abstinence symptomatology and was continued for 4 days in the case of the patients who had used heroin in the preceding 24 hours; treatment was continued for 8 days in the case of the patients who had used methadone.
- the patients were subjected to a naltrexone induction by means of the administration of 0.4 mg of naloxone by the intravenous route, and then of 10 mg of naltrexone on the first day, 20 mg on the second day, 50 mg on the third and, then, were referred for a multimode treatment.
- the GHB treated subjects showed, at 15* from the first administration, a reduction in the symptomatology, which subsequently declined so as to disappear within 30*.
- the patients reported subjective wellbeing. In one case, a report was given of a feeling of slight dizziness, which disappeared after 30' without involving departure from the trial.
- naltrexone induction was completed on the following days; subsequently, the patients were assigned to the out-patients multimode programme.
- compositions forming the subject of the invention may be prepared by employing conventional excipients and techniques, such as those described in
- the preferred administration route is the oral route using capsules, tablets, syrups or equivalent forms. It may be advantageous to employ administrations via the parenteral and/or intravenous route and delayed-release forms, for the purpose of reducing the frequency of administration imposed by the pharmacokinetics of the active principle.
- the average daily dose will depend on a number of factors, such as the seriousness of the condition to be treated, as well as the weight, sex and age of the patient but, in general, this dose will be within the range 0.5 to 10 mg/kg/day, preferably between 1 and 2.5 mg/kg/day.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'acide Sg(g)-hydroxybutyrique et ses formes physiologiquement équivalentes sont utilisés pour le traitement du syndrome de sevrage, du désir impérieux de consommation de drogues, de la toxicomanie, de la dépendance due à l'usage de drogues, de psychotropes, de substances stupéfiantes et psychoanaleptiques, et de nicotine, ainsi que des troubles de la nutrition.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT92912485T ATE204473T1 (de) | 1991-06-28 | 1992-06-23 | Pharmazeutische zusammensetzung, die gamma- hydroxybuttersäure oder das entsprechende lakton enthält, zur behandlung von drogenabhängigkeit und ernährungsstörungen |
| DE69232016T DE69232016T2 (de) | 1991-06-28 | 1992-06-23 | Pharmazeutische zusammensetzung, die gamma-hydroxybuttersäure oder das entsprechende lakton enthält, zur behandlung von drogenabhängigkeit und ernährungsstörungen |
| EP92912485A EP0563336B1 (fr) | 1991-06-28 | 1992-06-23 | Composition pharmaceutique contenant de l'acide gamma-hydroxybutyrique ou sa lactone et utilisee dans le traitement de la toxicomanie et des troubles nutritionnels |
| US08/081,388 US5426120A (en) | 1991-06-28 | 1992-06-23 | Pharmaceutical composition containing γ-hydroxybutyric acid or its lactone in the treatment of drug dependence and nutritional disorders |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI91A001791 | 1991-06-28 | ||
| ITMI911791A IT1248588B (it) | 1991-06-28 | 1991-06-28 | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993000083A1 true WO1993000083A1 (fr) | 1993-01-07 |
Family
ID=11360230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1992/001409 WO1993000083A1 (fr) | 1991-06-28 | 1992-06-23 | Composition pharmaceutique contenant de l'acide gamma-hydroxybutyrique ou sa lactone et utilisee dans le traitement de la toxicomanie et des troubles nutritionnels |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5426120A (fr) |
| EP (1) | EP0563336B1 (fr) |
| AT (1) | ATE204473T1 (fr) |
| AU (1) | AU2018792A (fr) |
| DE (1) | DE69232016T2 (fr) |
| IT (1) | IT1248588B (fr) |
| WO (1) | WO1993000083A1 (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0663824A4 (fr) * | 1991-11-07 | 1994-10-27 | Univ New York | Composes d'activation des vannes a potassium et leurs procedes d'utilisation. |
| EP0635265A1 (fr) | 1993-07-22 | 1995-01-25 | LABORATORIO FARMACEUTICO C.T. S.r.l. | Composition pharmaceutique à libération contrôlée à base d'un ou plusieurs sels de l'acide gamma hydroxybutyrique pharmaceutiquement acceptables |
| WO1998006690A1 (fr) * | 1996-08-09 | 1998-02-19 | Laboratorio Farmaceutico C.T. S.R.L. | UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME |
| WO2000044374A1 (fr) * | 1999-02-01 | 2000-08-03 | Ortho-Mcneil Pharmaceutical, Inc. | Utilisation de derives anti-convulsifs pour traiter la boulimie nerveuse |
| WO2010055260A1 (fr) * | 2008-11-14 | 2010-05-20 | Debregeas Et Associes Pharma | Nouvelle composition à base d'acide gamma-hydroxybutyrique |
| US8916202B2 (en) | 2009-08-12 | 2014-12-23 | Debregeas Et Associes Pharma | Floating microgranules |
| US8999392B2 (en) | 2009-08-12 | 2015-04-07 | Debregeas Et Associes Pharma | Pharmaceutical formulations to prevent the misuse of medicinal drugs |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472431B2 (en) | 1998-12-23 | 2002-10-29 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
| RU2210360C1 (ru) * | 2002-09-19 | 2003-08-20 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Психотропное средство |
| US8193211B2 (en) | 2004-09-30 | 2012-06-05 | Supernus Pharmaceuticals, Inc. | Controlled release compositions of gamma-hydroxybutyrate |
| HRP20131027T1 (hr) | 2009-04-23 | 2013-12-06 | Concert Pharmaceuticals Inc. | Analozi 4-hidroksimaslaäśne kiseline |
| US8759394B2 (en) * | 2011-02-14 | 2014-06-24 | Concert Pharmaceuticals, Inc. | 4-hydroxybutyric acid analogs |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11000498B2 (en) | 2016-07-22 | 2021-05-11 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| CA3127871A1 (fr) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Compositions de gamma-hydroxybutyrate presentant une pharmacocinetique amelioree a l'etat alimente |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0344704A1 (fr) * | 1988-06-03 | 1989-12-06 | LABORATORIO FARMACEUTICO C.T. S.r.l. | Utilisation des sels de l'acide gamma-hydroxybutyrique pour la fabrication des compositions pharmaceutiques pour l'utilisation dans le traitement de l'alcoolisme, et les compositions obtenues |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD139519A1 (de) * | 1978-11-10 | 1980-01-09 | Annedore Wehl | Verfahren zur herstellung analgetischer formulierungen mit verbesserten gebrauchswerteigenschaften |
-
1991
- 1991-06-28 IT ITMI911791A patent/IT1248588B/it active IP Right Grant
-
1992
- 1992-06-23 US US08/081,388 patent/US5426120A/en not_active Expired - Lifetime
- 1992-06-23 AT AT92912485T patent/ATE204473T1/de not_active IP Right Cessation
- 1992-06-23 AU AU20187/92A patent/AU2018792A/en not_active Abandoned
- 1992-06-23 WO PCT/EP1992/001409 patent/WO1993000083A1/fr active IP Right Grant
- 1992-06-23 EP EP92912485A patent/EP0563336B1/fr not_active Expired - Lifetime
- 1992-06-23 DE DE69232016T patent/DE69232016T2/de not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0344704A1 (fr) * | 1988-06-03 | 1989-12-06 | LABORATORIO FARMACEUTICO C.T. S.r.l. | Utilisation des sels de l'acide gamma-hydroxybutyrique pour la fabrication des compositions pharmaceutiques pour l'utilisation dans le traitement de l'alcoolisme, et les compositions obtenues |
Non-Patent Citations (9)
| Title |
|---|
| Alcohol and Alcoholism, vol. 24, no. 5, 1989, Pergamon Press plc, GB; F. Fadda et al.: "Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in ats", pages 447-451, see the whole article * |
| Biochemical Pharmacology, vol. 23, no. 1, 1974, Pergamon Press, GB; M. Krishna Menon et al.: "Studies on the biochemical mechanisms of the central effects of gamma-hydroxybutyric acid" pages 879-885, see the whole article * |
| Federation Proceedings, vol. 36, no. 3, abstracts 61st annual meeting, Chicago, Illinois, US; R.D. Robson et al.: "Suppression of morphine withdrawal symptoms by baclofen (Bf) (lioresal(R))", see page 1025, abstract 3969 * |
| Neuropharmacology, vol. 24, no. 5, May 1985, Pergamon Press Ltd, GB; P.L. Gray et al.: "Evidence for GABA tolerance in barbiturate-dependent and withdrawn mice", pages 437-444, see the whole article, esp. page 440 * |
| Sov. Med., no. 12, 1984, E.A. Churkin et al.: "Hemosorption in narcologic practice", see Dialog Information Services Description * |
| Soviet Inventions Illustrated, Derwent Publications, section Chem., Week 7802, abstract 78-03570A, & SU, A, 552084 (AM USSR PHARMACOLOG) 15 April 1977, see abstract * |
| Soviet Inventions Illustrated, Derwent Publications, Section Chemical, Week 8534, abstract 85-208923, & SU, A, 11318163 (DNEPRA MEDICINE INST.) 7 February 1985, see abstract * |
| The Lancet, vol. II, nr. 8666, September 1989, L. Gallimberti et al.: "Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome", pages 787-789, see the whole article (cited in the application) * |
| Zh. Nevropatol. Psikhiatr. (USSR), vol. 66, no. 5, 1966, V.M. Banstchikov et al.: "L'emploi des dérivés de l'acide gamma aminobutyrique dans la pratique psychiatrique", pages 763-767, see abstract * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0663824A4 (fr) * | 1991-11-07 | 1994-10-27 | Univ New York | Composes d'activation des vannes a potassium et leurs procedes d'utilisation. |
| EP0635265A1 (fr) | 1993-07-22 | 1995-01-25 | LABORATORIO FARMACEUTICO C.T. S.r.l. | Composition pharmaceutique à libération contrôlée à base d'un ou plusieurs sels de l'acide gamma hydroxybutyrique pharmaceutiquement acceptables |
| US5594030A (en) * | 1993-07-22 | 1997-01-14 | Laboratorio Farmaceutico C.T. S.R.L. | Controlled release pharmaceutical compositions based on one or more pharmaceutically acceptable salts of gamma hydroxy-butyric acid |
| US6770784B2 (en) * | 1996-08-09 | 2004-08-03 | Laboratorio Farmaceutico C.T. S.R.L. | Use of γ-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
| US6436998B1 (en) | 1996-08-09 | 2002-08-20 | Laboratoric Farmaceutico C.T. S.R.L. | Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
| WO1998006690A1 (fr) * | 1996-08-09 | 1998-02-19 | Laboratorio Farmaceutico C.T. S.R.L. | UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME |
| WO2000044374A1 (fr) * | 1999-02-01 | 2000-08-03 | Ortho-Mcneil Pharmaceutical, Inc. | Utilisation de derives anti-convulsifs pour traiter la boulimie nerveuse |
| WO2010055260A1 (fr) * | 2008-11-14 | 2010-05-20 | Debregeas Et Associes Pharma | Nouvelle composition à base d'acide gamma-hydroxybutyrique |
| FR2938431A1 (fr) * | 2008-11-14 | 2010-05-21 | Debregeas Et Associes Pharma | Nouvelle composition a base d'acide gamma-hydroxybutyrique |
| US8529954B2 (en) | 2008-11-14 | 2013-09-10 | Debregeas Et Associes Pharma | Composition based on gamma-hydroxybutyric acid |
| AU2009315441B2 (en) * | 2008-11-14 | 2015-02-26 | Debregeas Et Associes Pharma | Novel composition based on gamma-hydroxybutyric acid |
| EA023305B1 (ru) * | 2008-11-14 | 2016-05-31 | Дебрежа Э Ассосье Фарма | Гранулят гамма-гидроксимасляной кислоты |
| US8916202B2 (en) | 2009-08-12 | 2014-12-23 | Debregeas Et Associes Pharma | Floating microgranules |
| US8999392B2 (en) | 2009-08-12 | 2015-04-07 | Debregeas Et Associes Pharma | Pharmaceutical formulations to prevent the misuse of medicinal drugs |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE204473T1 (de) | 2001-09-15 |
| US5426120A (en) | 1995-06-20 |
| AU2018792A (en) | 1993-01-25 |
| EP0563336A1 (fr) | 1993-10-06 |
| ITMI911791A1 (it) | 1992-12-28 |
| IT1248588B (it) | 1995-01-19 |
| ITMI911791A0 (it) | 1991-06-28 |
| DE69232016T2 (de) | 2002-05-29 |
| EP0563336B1 (fr) | 2001-08-22 |
| DE69232016D1 (de) | 2001-09-27 |
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