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WO1993000427A3 - Facteurs regulateurs de la croissance des neurites - Google Patents

Facteurs regulateurs de la croissance des neurites Download PDF

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Publication number
WO1993000427A3
WO1993000427A3 PCT/EP1992/001384 EP9201384W WO9300427A3 WO 1993000427 A3 WO1993000427 A3 WO 1993000427A3 EP 9201384 W EP9201384 W EP 9201384W WO 9300427 A3 WO9300427 A3 WO 9300427A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
metalloproteases
treatment
myelin associated
malignant tumors
Prior art date
Application number
PCT/EP1992/001384
Other languages
English (en)
Other versions
WO1993000427A2 (fr
Inventor
Martin E Schwab
Pierenrico W Caroni
Paolo A Paganetti
Original Assignee
Canton Zurich Erziehungsdirekt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/719,692 external-priority patent/US5250414A/en
Application filed by Canton Zurich Erziehungsdirekt filed Critical Canton Zurich Erziehungsdirekt
Publication of WO1993000427A2 publication Critical patent/WO1993000427A2/fr
Publication of WO1993000427A3 publication Critical patent/WO1993000427A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Gènes et protéines codées de ceux-ci servant à réguler la croissance des neurites, et utilisations diagnostique et thérapeutique de ces protéines (ci-après: facteurs régulateurs de la croissance des neurites). Lesdites protéines incluent des protéines associées à la myéline du système nerveux central (CNS) et des métalloprotéases associées aux cellules de glioblastomes et aux autres tumeurs malignes aptes à métastaser dans le cerveau. Les protéines associées à la myéline du CNS inhibent l'excroissance de neurites dans les cellules nerveuses et les cellules de neuroblastomes, et peuvent également inhiber la propagation fibroblastique. Ces protéines d'inhibition incluent des protéines dont les poids moléculaires sont de 35 000 et 250 000 daltons respectivement, leurs analogues, leurs dérivés et leurs fragments. Lesdites protéines d'inhibition associées à la myéline du CNS peuvent être utilisées dans le traitement des tumeurs malignes. Lesdites métalloprotéases sont utiles dans le traitement des lésions nerveuses et des troubles dégénératifs du système nerveux. On a également prévu des inhibiteurs des métalloprotéases pouvant s'utiliser, en association avec lesdites protéines d'inhibition associées à la myéline du CNS, dans le traitement des tumeurs malignes.
PCT/EP1992/001384 1991-06-24 1992-06-19 Facteurs regulateurs de la croissance des neurites WO1993000427A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US719,692 1991-06-24
US07/719,692 US5250414A (en) 1988-11-04 1991-06-24 Diagnostic methods using neurite growth regulatory factors

Publications (2)

Publication Number Publication Date
WO1993000427A2 WO1993000427A2 (fr) 1993-01-07
WO1993000427A3 true WO1993000427A3 (fr) 1993-04-29

Family

ID=24891002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1992/001384 WO1993000427A2 (fr) 1991-06-24 1992-06-19 Facteurs regulateurs de la croissance des neurites

Country Status (2)

Country Link
AU (1) AU2152092A (fr)
WO (1) WO1993000427A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509002A (ja) * 1993-02-11 1995-10-05 エルツィーヒュングスディレクション　オブ　ザ　キャントン　チューリッヒ ニューロトロフィンとミエリン−関連の軸索成長阻害タンパク質に対する抗体との組み合わせが中枢神経系の再生を促進する
AU718508B2 (en) * 1995-04-19 2000-04-13 Acorda Therapeutics, Inc. CNS neurite outgrowth modulators, and compositions, cells and methods embodying and using same
US6576607B1 (en) 1995-04-19 2003-06-10 Acorda Therapeutics Methods using CNS neurite outgrowth modulators
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
ATE435232T1 (de) 1998-11-06 2009-07-15 Univ Zuerich Nukleotid- und proteinsequenzen von nogo-genen und darauf beruhende methoden
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
AU3464299A (en) * 1999-04-01 2000-10-23 Procter & Gamble Company, The A purification process for a calcium binding type enzyme, such as a metalloprotease, using a calcium free buffer
US7186530B1 (en) 2000-04-07 2007-03-06 Chiron Corporation Protein associated with cell stress response
AU4216200A (en) * 1999-04-08 2000-10-23 Chiron Corporation Novel protein associated with cell stress response

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046523A1 (fr) * 1980-08-26 1982-03-03 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Détergents zwittérioniques non-dénaturants pour la biochimie de membranes
WO1990005191A1 (fr) * 1988-11-04 1990-05-17 Erziehungsdirektion Of The Canton Zurich Facteurs de regulation de la croissance des neurites

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046523A1 (fr) * 1980-08-26 1982-03-03 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Détergents zwittérioniques non-dénaturants pour la biochimie de membranes
WO1990005191A1 (fr) * 1988-11-04 1990-05-17 Erziehungsdirektion Of The Canton Zurich Facteurs de regulation de la croissance des neurites

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Experientia, vol. 46, March 1990, (Basel, CH) P.A. Paganetti et al.: "Glioblastoma infiltration into CNS tissue in vitro: the role of a metalloprotease", see abstract, & 22nd Annual Meeting of the Swiss Societies for Experimental Biology, March 15/16, 1990, Z}rich *
EXPERIMENTAL NEUROLOGY vol. 115, no. 1, January 1992, NEW YORK, US pages 189 - 192 D.S. CADELLI ET AL. 'Oligodendrocyte- and Myelin-Associated Inhibitors of Neurite Outgrowth: Their Involvement in the Lack of CNS Regeneration' *
J. CELL BIOL. vol. 107, no. 6, December 1988, NEW YORK, US pages 2281 - 2291 P. A. PAGANETTI ET AL. 'Glioblastoma Infiltration into Central Nervous System Tissue in Vitro: Involvement of a Metalloprotease' cited in the application *
J. Cell Biol., vol. 107, no. 6, December 1988 (New York, US) P.A. Paganetti et al.: "Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease", pages 2281-2291, see abstract; page 2282, right-hand column, paragraphs 1-2 (cited in the application) *
J. CELL. BIOL. vol. 106, no. 4, April 1988, NEW YORK, US P. CARONI & M.E. SCHWAB 'Two Membrane Protein Fractions from Rat Central Myelin with Inhibitory Properties for Neurite Growth and Fibroblast Spreading' cited in the application *

Also Published As

Publication number Publication date
WO1993000427A2 (fr) 1993-01-07
AU2152092A (en) 1993-01-25

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