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WO1993001723A1 - Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs - Google Patents

Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs Download PDF

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Publication number
WO1993001723A1
WO1993001723A1 PCT/US1992/005757 US9205757W WO9301723A1 WO 1993001723 A1 WO1993001723 A1 WO 1993001723A1 US 9205757 W US9205757 W US 9205757W WO 9301723 A1 WO9301723 A1 WO 9301723A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
lys
amino acid
ala
seq
Prior art date
Application number
PCT/US1992/005757
Other languages
English (en)
Inventor
Barry Berkowitz
Leonard Jacob
Original Assignee
Magainin Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magainin Pharmaceuticals, Inc. filed Critical Magainin Pharmaceuticals, Inc.
Priority to JP5502858A priority Critical patent/JPH07502979A/ja
Priority to EP92915677A priority patent/EP0671930A4/fr
Priority to AU23237/92A priority patent/AU667479B2/en
Publication of WO1993001723A1 publication Critical patent/WO1993001723A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates

Definitions

  • n is at least 4.
  • An XPF peptide may also have the following structure:
  • CPF peptides as well as analogues and derivatives thereof are herein sometimes referred to collectively as CPF peptides.
  • the peptide when the peptide includes the structure X 32 , the peptide may include the following structure:
  • the peptide when the peptide includes the structure X 34 , the peptide may include the following structure:
  • the peptide when the peptide includes the structure X 34 , the peptide may include the following structure:
  • the peptide when the peptide includes the structure X 35 , the peptide may include the following structure:
  • the peptide may have the structure (Y 58 ) a -X 58 -(Z 58 ) b , wherein X 58 , Y 58 , and Z 58 are as hereinabove described, a is 0 or 1, and b is 0 or 1.
  • An ion having pharmacological properties is an ion which when introduced into a target cell inhibits and/or prevents and/or destroys the growth of a target cell.
  • NAME/KEY Magainin II peptide.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

Procédé de prévention ou de traitement d'affection(s) bucco-dentaire(s), qui consiste à administrer à un hôte au moins une protéine ou un peptide biologiquement actif. Le peptide ou la protéine est du type ionophore. Ces peptides ou protéines agissent efficacement contre les bactéries, les champignons ou les virus associés à la plaque, la gingivite, les caries dentaires, la parodontolyse, les infections d'implants dentaires et d'autres affections dentaires ou bucco-dentaires.
PCT/US1992/005757 1991-06-12 1992-07-09 Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs WO1993001723A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP5502858A JPH07502979A (ja) 1991-07-25 1992-07-09 生物活性ペプチドを利用する口腔内の有害な状態の予防と治療
EP92915677A EP0671930A4 (fr) 1991-07-25 1992-07-09 Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs.
AU23237/92A AU667479B2 (en) 1991-06-12 1992-07-09 Treating the oral cavity with ion-channel forming peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73507091A 1991-07-25 1991-07-25
US735,070 1991-07-25

Publications (1)

Publication Number Publication Date
WO1993001723A1 true WO1993001723A1 (fr) 1993-02-04

Family

ID=24954237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/005757 WO1993001723A1 (fr) 1991-06-12 1992-07-09 Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs

Country Status (5)

Country Link
EP (1) EP0671930A4 (fr)
JP (1) JPH07502979A (fr)
AU (1) AU667479B2 (fr)
CA (1) CA2074626A1 (fr)
WO (1) WO1993001723A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593866A (en) * 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
EP0671938A4 (fr) * 1992-10-26 1997-01-15 Magainin Pharma Nouveaux peptides a activite biologique et leurs applications.
WO1998006419A1 (fr) * 1996-08-15 1998-02-19 Southern Illinois University Facilitation de l'activite de peptides antimicrobiens au moyen d'ions metalliques
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
WO1999059536A1 (fr) * 1998-05-15 1999-11-25 Unilever Plc Utilisation d'un agent de prevention des gingivites
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US6191254B1 (en) 1995-08-23 2001-02-20 University Of British Columbia Antimicrobial cationic peptides
US6297215B1 (en) 1995-06-02 2001-10-02 The University Of British Columbia Antimicrobial cationic peptides
US6566334B1 (en) 1997-02-06 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Short amphipathic peptides with activity against bacteria and intracellular pathogens
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
EP1655018A1 (fr) * 2004-09-08 2006-05-10 Henkel Kommanditgesellschaft auf Aktien Composition dentaires et buccales pour le soin et le nettoyage avec un effet anti-inflammatoire

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810777A (en) * 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4962277A (en) * 1988-12-09 1990-10-09 Scripps Clinic And Research Foundation Deletion analogues of magainin peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199891A (en) * 1981-03-04 1985-07-31 Univ Melbourne Caries-inhibiting compositions containing casein or x-s-casein or phosuitin
EP0441832B1 (fr) * 1988-10-21 1994-06-15 The Children's Hospital Of Philadelphia Composition et traitement a l'aide et peptides a activite biologique et certains anions
US5045531A (en) * 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
WO1991012015A1 (fr) * 1990-02-08 1991-08-22 Magainin Sciences Inc. Peptides amphiphiles biologiquement actifs et procede pour inhiber la croissance de cellules cibles, de virus ou de cellules contaminees par virus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810777A (en) * 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4962277A (en) * 1988-12-09 1990-10-09 Scripps Clinic And Research Foundation Deletion analogues of magainin peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0671930A4 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593866A (en) * 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
EP0671938A4 (fr) * 1992-10-26 1997-01-15 Magainin Pharma Nouveaux peptides a activite biologique et leurs applications.
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
US6297215B1 (en) 1995-06-02 2001-10-02 The University Of British Columbia Antimicrobial cationic peptides
US6906035B2 (en) 1995-06-02 2005-06-14 The University Of British Columbia Antimicrobial cationic peptides
US6465429B1 (en) 1995-06-02 2002-10-15 The University Of British Columbia Antimicrobial cationic peptides
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US7390873B2 (en) 1995-08-23 2008-06-24 University Of British Columbia Antimicrobial cationic peptides
US6191254B1 (en) 1995-08-23 2001-02-20 University Of British Columbia Antimicrobial cationic peptides
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
AU725954B2 (en) * 1996-08-15 2000-10-26 Board Of Trustees Of Southern Illinois University, The Enhancement of antimicrobial peptide activity by metal ions
US6042848A (en) * 1996-08-15 2000-03-28 The Board Of Trustees Of Southern Illinois University Enhancement of antimicrobial peptide activity by metal ions
WO1998006419A1 (fr) * 1996-08-15 1998-02-19 Southern Illinois University Facilitation de l'activite de peptides antimicrobiens au moyen d'ions metalliques
US6566334B1 (en) 1997-02-06 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Short amphipathic peptides with activity against bacteria and intracellular pathogens
US7262163B2 (en) 1997-02-06 2007-08-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Short amphipathic peptides with activity against bacteria and intracellular pathogens
US6290975B1 (en) 1998-05-15 2001-09-18 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Method for the prevention of gum disease
WO1999059536A1 (fr) * 1998-05-15 1999-11-25 Unilever Plc Utilisation d'un agent de prevention des gingivites
EP1655018A1 (fr) * 2004-09-08 2006-05-10 Henkel Kommanditgesellschaft auf Aktien Composition dentaires et buccales pour le soin et le nettoyage avec un effet anti-inflammatoire

Also Published As

Publication number Publication date
AU2323792A (en) 1993-02-23
JPH07502979A (ja) 1995-03-30
EP0671930A4 (fr) 1996-02-07
CA2074626A1 (fr) 1993-01-26
AU667479B2 (en) 1996-03-28
EP0671930A1 (fr) 1995-09-20

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