WO1993002700A1 - Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales - Google Patents
Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales Download PDFInfo
- Publication number
- WO1993002700A1 WO1993002700A1 PCT/DE1992/000631 DE9200631W WO9302700A1 WO 1993002700 A1 WO1993002700 A1 WO 1993002700A1 DE 9200631 W DE9200631 W DE 9200631W WO 9302700 A1 WO9302700 A1 WO 9302700A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- collagen
- prophylaxis
- skin
- herpes labialis
- infections
- Prior art date
Links
- 108010035532 Collagen Proteins 0.000 title claims abstract description 28
- 102000008186 Collagen Human genes 0.000 title claims abstract description 28
- 229920001436 collagen Polymers 0.000 title claims abstract description 28
- 208000004898 Herpes Labialis Diseases 0.000 title claims abstract description 11
- 206010067152 Oral herpes Diseases 0.000 title claims abstract description 11
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 10
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 7
- 238000002347 injection Methods 0.000 claims abstract description 13
- 239000007924 injection Substances 0.000 claims abstract description 13
- 239000000725 suspension Substances 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 9
- 241000283690 Bos taurus Species 0.000 claims description 6
- 239000003589 local anesthetic agent Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000007704 transition Effects 0.000 abstract description 3
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 4
- 229960003150 bupivacaine Drugs 0.000 description 4
- 229960004194 lidocaine Drugs 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 206010019973 Herpes virus infection Diseases 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010077465 Tropocollagen Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 206010023424 Kidney infection Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000034493 Mucous membrane disease Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000515 collagen sponge Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 1
- 238000006253 efflorescence Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000003712 glycosamine group Chemical group 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229940107931 zovirax Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Definitions
- herpes in humans An example of this is blister lichen, herpes simplex, a virus-related, harmless skin condition in which grouped, millet-sized blisters, for example, appear on the mouth (herpes labialis), which dry up after a few days. It shows up in febrile illnesses (especially with pneumonia or kidney infections or malaria), after heavy tanning and in women during menstruation.
- Collagens are long-fiber, linear-colloidal, high-molecular Skieroproteins of the extracellular matrix, which occur in connective tissues (e.g. skin, cartilage, tendons, ligaments and blood vessels), in the protein-containing basic substance of the bone (ossein) and in dentin (dentin) together with proteoglycans. With a share of 25 to 30%, they are the most common animal proteins in terms of quantity.
- the basic structural unit of collagen, tropo-collagen (MW approx. 300,000), consists of three polypeptide chains in the form of special left-handed helices, which - in accordance with a technique also known in rope making - are in turn turned to the right (triple helix).
- the tropo-collagen molecule is a "rope" of 280 nm in length with a diameter of 1.4 nm; the fibrils measure a cross-section of 200-500 nm (see Römpps Chemielexikon, Vol. 3, p. 2297, 1990).
- Modified collagen is being tested in medicine as a temporary skin replacement, as a replacement for cornea and vitreous fluid in the eye, as a replacement for tendons, tendon sheaths, hollow organs and veins, as a blood plasma substitute and in wound healing (EP-B 52288, .TP-A-52 -076416).
- Collagen sponge is used as a hemostatic agent.
- Medicines containing collagen are used to improve expandable skin deformations, such as those associated with scars, skin loss caused by different causes, and age-related skin folds. These collagen-containing medicines are injected under the skin to be filled in and for this reason usually contain a local anesthetic.
- collagen is used for the manufacture of a medicament for the prophylaxis of herpes labialis infections.
- the collagen used is insoluble collagen, which can be obtained from calf or bovine skin, for example; however, collagen from bovine skin is preferred.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
On utilise le collagène pour préparer un médicament prophylactique d'infections herpétiques labiales. On prépare de préférence une suspension injectable qui contient du collagène et le cas échéant un anesthésique local. La suspension injectable est administrée par injection dans la zone de transition entre la peau et la muqueuse dans la région des lèvres.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19914125393 DE4125393A1 (de) | 1991-07-31 | 1991-07-31 | Verwendung von kollagen zur prophylaxe von herpes labialis-infektionen |
| DEP4125393.0 | 1991-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993002700A1 true WO1993002700A1 (fr) | 1993-02-18 |
Family
ID=6437430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/DE1992/000631 WO1993002700A1 (fr) | 1991-07-31 | 1992-07-28 | Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE4125393A1 (fr) |
| WO (1) | WO1993002700A1 (fr) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE701570A (fr) * | 1963-12-12 | 1968-01-19 |
-
1991
- 1991-07-31 DE DE19914125393 patent/DE4125393A1/de not_active Withdrawn
-
1992
- 1992-07-28 WO PCT/DE1992/000631 patent/WO1993002700A1/fr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE701570A (fr) * | 1963-12-12 | 1968-01-19 |
Non-Patent Citations (1)
| Title |
|---|
| BIOLOGICAL ABSTRACTS vol. 68, no. 9 , 1979, Philadelphia, PA, US; abstract no. 52353, TENNICAN ,PATRICK O. ET AL. 'THE DIVERSE EFFECTS OF TOPICAL AND SYSTEMIC ADMINISTRATION OF ZINC ON THE VIRULENCE OF HERPES SIMPLEX GENITALIS.' Seite 5243 ; * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE4125393A1 (de) | 1993-02-04 |
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