WO1993004063A1 - Compose de benzisoxazole et son utilisation - Google Patents

Compose de benzisoxazole et son utilisation Download PDF

Info

Publication number: WO1993004063A1
Authority: WO; WIPO (PCT)
Prior art keywords: bond; group; defined above; positions; compound
Prior art date: 1991-08-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

PCT/JP1992/001060

Other languages

English (en)

French (fr)

Inventor

Hiroyuki Sueoka

Shu Murakami

Shuzo Takehara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Tanabe Pharma Corp

Original Assignee

Yoshitomi Pharmaceutical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-22

Filing date

1992-08-21

Publication date

1993-03-04

1992-08-21 Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd

1992-08-21 Priority to EP19920918032 priority Critical patent/EP0602242A4/en

1993-03-04 Publication of WO1993004063A1 publication Critical patent/WO1993004063A1/ja

1994-02-22 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

PCT/JP1992/001060 1991-08-22 1992-08-21 Compose de benzisoxazole et son utilisation Ceased WO1993004063A1 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP19920918032 EP0602242A4 (en)	1991-08-22	1992-08-21	Benzisoxazole compound and use thereof.

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
JP3/237397		1991-08-22
JP23739791		1991-08-22
JP10036792		1992-03-25
JP4/100367		1992-03-25
JP4/101707		1992-03-26
JP4/101763		1992-03-26
JP10176392		1992-03-26
JP10170792		1992-03-26
JP4/112154		1992-04-03
JP11215492		1992-04-03

Publications (1)

Publication Number	Publication Date
WO1993004063A1 true WO1993004063A1 (fr)	1993-03-04

Family

ID=27526005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP1992/001060 Ceased WO1993004063A1 (fr)	1991-08-22	1992-08-21	Compose de benzisoxazole et son utilisation

Country Status (3)

Country	Link
EP (1)	EP0602242A4 (ja)
CA (1)	CA2116117A1 (ja)
WO (1)	WO1993004063A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5750542A (en) *	1993-09-28	1998-05-12	Pfizer	Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
US5916902A (en) *	1995-09-13	1999-06-29	Pfizer Inc.	Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
KR20040020457A (ko) *	2002-08-30	2004-03-09	주식회사 대웅	3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
WO2006090224A1 (en)	2005-02-25	2006-08-31	Pfizer Japan Inc.	Benzisoxazole derivatives
WO2007126041A1 (ja)	2006-04-28	2007-11-08	Eisai R & D Management Co., Ltd.	ベンゾイソオキサゾール化合物
EP1891954A2 (en)	1998-09-30	2008-02-27	Takeda Pharmaceutical Company Limited	Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
RU2597766C2 (ru) *	2011-03-23	2016-09-20	Раквалиа Фарма Инк.	Агонист рецептора 5-нт4 в качестве прокинетического агента

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1054885B1 (en)	1998-02-09	2007-07-18	Duphar International Research B.V	Benzisoxazole derivatives having d4-antagonistic activity
PT1209151E (pt)	1999-09-01	2007-05-31	Eisai R&D Man Co Ltd	Derivados piperidina 4-substituídos.
WO2005016276A2 (en) *	2003-08-05	2005-02-24	Samaritan Pharmaceuticals Inc.	Sigma-1 receptor ligand with acetylcholinesterase inhibition properties
US7144907B2 (en)	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en)	2003-09-03	2009-05-26	Array Biopharma Inc.	Method of treating inflammatory diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61221186A (ja) *	1985-03-27	1986-10-01	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新規１，２‐ベンズイソキサゾール‐３‐イル及び１，２‐ベンズイソチアゾール‐３‐イル誘導体
EP0449186A2 (en) *	1990-03-28	1991-10-02	The Du Pont Merck Pharmaceutical Company	N-aralkyl piperidine derivatives as psychotropic drugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2654104B1 (fr) *	1989-11-07	1992-01-03	Adir	Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
SG49055A1 (en) *	1991-03-28	1998-05-18	Eisai Co Ltd	Heterocyclic-cyclic amine derivatives

1992
- 1992-08-21 WO PCT/JP1992/001060 patent/WO1993004063A1/ja not_active Ceased
- 1992-08-21 EP EP19920918032 patent/EP0602242A4/en not_active Withdrawn
- 1992-08-21 CA CA 2116117 patent/CA2116117A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61221186A (ja) *	1985-03-27	1986-10-01	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新規１，２‐ベンズイソキサゾール‐３‐イル及び１，２‐ベンズイソチアゾール‐３‐イル誘導体
EP0449186A2 (en) *	1990-03-28	1991-10-02	The Du Pont Merck Pharmaceutical Company	N-aralkyl piperidine derivatives as psychotropic drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0602242A4 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6498255B2 (en)	1991-03-28	2002-12-24	Pfizer Inc.	Heterocyclic-cyclic amine derivatives as cholinesterase inhibitors
US6326382B1 (en)	1992-03-09	2001-12-04	Eisai Co., Ltd	Heterocyclic-cyclic amine derivatives
US5750542A (en) *	1993-09-28	1998-05-12	Pfizer	Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
US5916902A (en) *	1995-09-13	1999-06-29	Pfizer Inc.	Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
EP1891954A2 (en)	1998-09-30	2008-02-27	Takeda Pharmaceutical Company Limited	Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
KR20040020457A (ko) *	2002-08-30	2004-03-09	주식회사 대웅	3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
WO2006090224A1 (en)	2005-02-25	2006-08-31	Pfizer Japan Inc.	Benzisoxazole derivatives
US8816090B2 (en)	2005-02-25	2014-08-26	Pfizer Inc.	Benzisoxazole derivatives
WO2007126041A1 (ja)	2006-04-28	2007-11-08	Eisai R & D Management Co., Ltd.	ベンゾイソオキサゾール化合物
RU2597766C2 (ru) *	2011-03-23	2016-09-20	Раквалиа Фарма Инк.	Агонист рецептора 5-нт4 в качестве прокинетического агента
US10137113B2 (en)	2011-03-23	2018-11-27	Raqualia Pharma Inc.	5-HT4 receptor agonist as a prokinetic agent

Also Published As

Publication number	Publication date
EP0602242A4 (en)	1994-06-29
CA2116117A1 (en)	1993-03-04
EP0602242A1 (en)	1994-06-22

Publication	Publication Date	Title
TW288011B (ja)	1996-10-11
EP0602242A4 (en)	1994-06-29	Benzisoxazole compound and use thereof.
AU6866291A (en)	1991-03-14	Pharmacologically active compounds and mixtures thereof, organic compositions and metal salts
WO1987006226A3 (en)	1988-04-07	Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparations containing the absorption promoters
CA2275166A1 (en)	1998-06-18	Novel benzopyran derivatives
CA2153681A1 (en)	1994-08-04	Topical ketoconazole compositions
UA39101C2 (uk)	2001-06-15	ПОХІДНІ 11<font face="Symbol">b</font>-БЕНЗАЛЬДОКСИМ-ЕСТРА-4,9-ДІЄНУ, СПОСІБ ЇХ ОДЕРЖАННЯ І ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ З АНТИПРОГЕСТИНОВОЮ АКТИВНІСТЮ
BG62620B1 (bg)	2000-03-31	Карбоциклични съединения
GR3021789T3 (en)	1997-02-28	17-Aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
CA2172855A1 (en)	1991-01-22	Cholesterol or Neutral Fat Level Reducer
EP0990648A4 (en)	2001-11-21	DERIVATIVES OF 4-CHINOLOL AND AGRICULTURAL AND GARDENING BACTERICIDES THAT CONTAIN THEM AS AN ACTIVE COMPONENT
IE44977L (en)	1977-10-02	Chromans
EP0775487A4 (en)	1999-03-10	TRIAZINE DERIVATIVE AND MEDICINE
EP0686636A4 (en)	1997-01-22	TRICYCLIC DERIVATIVES OF BENZAZEPINE AND BENZOTHIAZEPINE
AU8156394A (en)	1995-06-29	Methods for inhibiting LDL oxidation and atheroclerosis
EP0787720A4 (en)	1999-02-03	NEW PYRIDONE CARBOXYLATE DERIVATIVES OR SALTS THEREOF AND ANTIBACTERIAL COMPOSITIONS THAT CONTAIN THEM AS ACTIVE INGREDIENTS
AU2692792A (en)	1993-05-21	Oxazolidone derivative
EP0436734A4 (en)	1992-01-02	New aminopiperazine derivatives
IE901350L (en)	1990-10-14	Diaminoethylene compounds
CA2220019A1 (en)	1996-11-07	Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
IL89734A0 (en)	1989-09-28	Polypeptide derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU6582394A (en)	1994-11-21	Novel bisoxadiazolidine derivative
AU575342B2 (en)	1988-07-28	Gamma - butyrolactone derivatives
EP1134219A4 (en)	2002-11-06	AMINOMETHYLPYRROLIDINE DERIVATIVES SUBSTITUTED BY CYCLOALKYLES
EP1142883A4 (en)	2002-08-21	HETEROCYCLIC COMPOUNDS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM

Legal Events

Date	Code	Title	Description
1993-03-04	AK	Designated states	Kind code of ref document: A1 Designated state(s): CA HU KR US
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