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WO1993010722A3 - Fetal membrane tubes for nerve and vessel grafts - Google Patents

Fetal membrane tubes for nerve and vessel grafts Download PDF

Info

Publication number
WO1993010722A3
WO1993010722A3 PCT/US1992/010165 US9210165W WO9310722A3 WO 1993010722 A3 WO1993010722 A3 WO 1993010722A3 US 9210165 W US9210165 W US 9210165W WO 9310722 A3 WO9310722 A3 WO 9310722A3
Authority
WO
WIPO (PCT)
Prior art keywords
nerve
vessel grafts
grafts
fetal membrane
membrane tubes
Prior art date
Application number
PCT/US1992/010165
Other languages
French (fr)
Other versions
WO1993010722A2 (en
Inventor
Saleh M Shenaq
Kathy Jo Gray
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Priority to FI942425A priority Critical patent/FI942425A7/en
Priority to EP19930900646 priority patent/EP0614345A4/en
Priority to AU32245/93A priority patent/AU663150B2/en
Priority to JP5510233A priority patent/JPH07501465A/en
Publication of WO1993010722A2 publication Critical patent/WO1993010722A2/en
Publication of WO1993010722A3 publication Critical patent/WO1993010722A3/en
Priority to NO941917A priority patent/NO941917D0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005Ingredients of undetermined constitution or reaction products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/044Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/043Proteins; Polypeptides; Degradation products thereof
    • A61L31/047Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/32Materials or treatment for tissue regeneration for nerve reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Disclosed are cylinders having a wall formed of at least one layer of sterilized cross-linked Types I, II, III collagen or combinations thereof from placenta for nerve and blood vessel grafts, methods of manufacture and use. The nerve grafts promote axon regeneration therethrough. The nerve and blood vessel grafts are non-immunogenic, can be constructed into tubes of various lengths and diameters, are easily accessible and are patent or open in use.
PCT/US1992/010165 1991-11-26 1992-11-25 Fetal membrane tubes for nerve and vessel grafts WO1993010722A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FI942425A FI942425A7 (en) 1991-11-26 1992-11-25 Tubes made from fetal membranes for nerve and blood vessel transplants
EP19930900646 EP0614345A4 (en) 1991-11-26 1992-11-25 FETAL MEMBRANE TUBES FOR NERVOUS AND BLOOD VESSEL TRANSPLANTS.
AU32245/93A AU663150B2 (en) 1991-11-26 1992-11-25 Fetal membrane tubes for nerve and vessel grafts
JP5510233A JPH07501465A (en) 1991-11-26 1992-11-25 Fetal membrane tube for nerve and vascular grafts
NO941917A NO941917D0 (en) 1991-11-26 1994-05-24 Fötale diaphragm tubes for nerve and vessel grafting

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79951791A 1991-11-26 1991-11-26
US07/799,517 1991-11-26

Publications (2)

Publication Number Publication Date
WO1993010722A2 WO1993010722A2 (en) 1993-06-10
WO1993010722A3 true WO1993010722A3 (en) 1993-06-24

Family

ID=25176121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/010165 WO1993010722A2 (en) 1991-11-26 1992-11-25 Fetal membrane tubes for nerve and vessel grafts

Country Status (13)

Country Link
EP (1) EP0614345A4 (en)
JP (1) JPH07501465A (en)
CN (1) CN1079912A (en)
AU (1) AU663150B2 (en)
CA (1) CA2124190A1 (en)
FI (1) FI942425A7 (en)
IL (1) IL103893A (en)
NO (1) NO941917D0 (en)
NZ (1) NZ245286A (en)
RU (1) RU94028108A (en)
TW (1) TW310273B (en)
WO (1) WO1993010722A2 (en)
ZA (1) ZA929119B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6986735B2 (en) 1998-06-05 2006-01-17 Organogenesis Inc. Method of making a bioremodelable vascular graft prosthesis
US7041131B2 (en) 1998-06-05 2006-05-09 Organogenesis, Inc. Bioengineered vascular graft support prostheses
US7060103B2 (en) 1995-04-07 2006-06-13 Organogenesis Inc. Tissue repair fabric
US7121999B2 (en) 1998-06-05 2006-10-17 Organogenesis Inc. Method of preparing layered graft prostheses
US7214242B2 (en) 1998-06-05 2007-05-08 Organogenesis, Inc. Bioengineered tubular graft prostheses
US9415074B2 (en) 2007-09-07 2016-08-16 Mimedx Group, Inc. Placental tissue grafts
US9433647B2 (en) 2006-08-17 2016-09-06 Mimedx Group, Inc. Placental tissue grafts

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9400163D0 (en) * 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
CA2173508A1 (en) * 1995-03-31 1996-10-01 Tooru Yui Medical device and method for producing the same
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
JPH09122225A (en) * 1995-10-31 1997-05-13 Bio Eng Lab:Kk Raw material film material for medical material and method for producing the same
JPH09122227A (en) * 1995-10-31 1997-05-13 Bio Eng Lab:Kk Medical material and manufacturing method thereof
JP3476631B2 (en) * 1995-12-21 2003-12-10 株式会社アムニオテック Medical material composed of human-derived natural collagen membrane
TW528600B (en) * 1996-11-20 2003-04-21 Yasuhiko Shimizu Artificial neural canal
US20050186283A1 (en) 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US9034315B2 (en) 1997-10-10 2015-05-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Cell-charged multi-layer collagen membrane
US8858981B2 (en) 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
CN1101704C (en) * 1998-05-28 2003-02-19 南京市鼓楼医院 Blood vessel graft preparing technology using human umbilical artery
WO1999063908A1 (en) * 1998-06-10 1999-12-16 Tapic International Co., Ltd. Artificial neural tube
CZ301649B6 (en) * 2000-06-28 2010-05-12 Ed. Geistlich Soehne Ag Fur Chemische Industrie Incorporated Under The Laws Of Switzerland Tube for regeneration of nerves and process for producing thereof
US6773723B1 (en) * 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US6713085B2 (en) 2001-04-27 2004-03-30 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method and membrane for mucosa regeneration
DE10141652B4 (en) * 2001-08-24 2011-04-07 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system based on polyacrylate pressure-sensitive adhesives without functional groups and its use
US20050152986A1 (en) * 2001-09-06 2005-07-14 Nicolaas Duneas Cross-linked collagenous biomaterial
CA2412012C (en) 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
CN100368534C (en) * 2003-05-01 2008-02-13 四川大学华西医院 Biologically derived amniotic membrane, composite biologically derived amniotic membrane and preparation method thereof
CN1986001B (en) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 Biological wound-protecting film
CA2723801A1 (en) * 2008-05-09 2009-11-12 The General Hospital Corporation Tissue engineered constructs
EP2675465B1 (en) 2011-02-14 2020-07-01 MIMEDX Group Inc. Tissue grafts modified with a cross-linking agent and method of making and using the same
JP5940095B2 (en) * 2011-02-14 2016-06-29 ミメドックス グループ インコーポレーティッドMimedx Group Inc. Laminated tissue graft composed of Wharton Jerry and method of making and using the same
US9585983B1 (en) 2011-10-12 2017-03-07 BioDlogics, LLC Wound covering and method of preparation
EP2793745B1 (en) 2011-12-22 2019-07-31 MIMEDX Group Inc. Cross-linked dehydrated placental tissue grafts and methods for making and using the same
US11338063B2 (en) * 2012-08-15 2022-05-24 Mimedx Group, Inc. Placental tissue grafts modified with a cross-linking agent and methods of making and using the same
US9789138B1 (en) 2013-03-06 2017-10-17 BioDlogics, LLC Neural repair construct and method of use
EP3349812B1 (en) 2015-09-17 2021-01-06 Stimlabs LLC Compositions derived from placenta and methods of producing the same
US11154641B2 (en) 2017-12-22 2021-10-26 Stimlabs Llc Translucent, dehydrated placental tissue and methods of producing and using the same
CN113304321B (en) * 2021-06-01 2022-08-26 山东隽秀生物科技股份有限公司 Biological membrane material, preparation method thereof and application thereof in nerve repair
US11925532B2 (en) 2021-12-10 2024-03-12 Vivex Biologics Group, Inc. Vented wound dressing barrier
EP4395798A4 (en) 2022-06-29 2025-09-17 Biostem Tech Inc STERILE HUMAN PLACENTAL ALLOGRANS WITH A MULTIPLE NUMBER OF SLITTS, OPENINGS AND/OR FENESTRATIONS THEREON
USD1085424S1 (en) 2022-11-18 2025-07-22 Biostem Technologies, Inc. Fenestrated human placental allograft
USD1085425S1 (en) 2022-11-18 2025-07-22 Biostem Technologies, Inc. Fenestrated human placental allograft

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4120649A (en) * 1975-04-10 1978-10-17 Israel Schechter Transplants
US4894063A (en) * 1983-05-24 1990-01-16 Baxter International Inc. Barrier layer for implantable tendons and ligaments
US5019087A (en) * 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4120649A (en) * 1975-04-10 1978-10-17 Israel Schechter Transplants
US4894063A (en) * 1983-05-24 1990-01-16 Baxter International Inc. Barrier layer for implantable tendons and ligaments
US5019087A (en) * 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060103B2 (en) 1995-04-07 2006-06-13 Organogenesis Inc. Tissue repair fabric
US6986735B2 (en) 1998-06-05 2006-01-17 Organogenesis Inc. Method of making a bioremodelable vascular graft prosthesis
US7041131B2 (en) 1998-06-05 2006-05-09 Organogenesis, Inc. Bioengineered vascular graft support prostheses
US7121999B2 (en) 1998-06-05 2006-10-17 Organogenesis Inc. Method of preparing layered graft prostheses
US7214242B2 (en) 1998-06-05 2007-05-08 Organogenesis, Inc. Bioengineered tubular graft prostheses
US9433647B2 (en) 2006-08-17 2016-09-06 Mimedx Group, Inc. Placental tissue grafts
US9463207B2 (en) 2006-08-17 2016-10-11 Mimedx Group, Inc. Placental tissue grafts
US9572839B2 (en) 2006-08-17 2017-02-21 Mimedx Group, Inc. Placental tissue grafts and methods of preparing and using the same
US9415074B2 (en) 2007-09-07 2016-08-16 Mimedx Group, Inc. Placental tissue grafts

Also Published As

Publication number Publication date
ZA929119B (en) 1994-09-21
NO941917L (en) 1994-05-24
NO941917D0 (en) 1994-05-24
TW310273B (en) 1997-07-11
JPH07501465A (en) 1995-02-16
NZ245286A (en) 1995-06-27
EP0614345A1 (en) 1994-09-14
CA2124190A1 (en) 1993-06-10
IL103893A0 (en) 1993-04-04
AU663150B2 (en) 1995-09-28
AU3224593A (en) 1993-06-28
FI942425L (en) 1994-05-25
RU94028108A (en) 1996-06-20
EP0614345A4 (en) 1994-12-07
IL103893A (en) 1997-02-18
FI942425A0 (en) 1994-05-25
FI942425A7 (en) 1994-05-25
CN1079912A (en) 1993-12-29
WO1993010722A2 (en) 1993-06-10

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