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WO1993015407A1 - Procede et appareil permettant l'automatisation integrale de laboratoires d'analyses - Google Patents

Procede et appareil permettant l'automatisation integrale de laboratoires d'analyses Download PDF

Info

Publication number
WO1993015407A1
WO1993015407A1 PCT/EP1993/000103 EP9300103W WO9315407A1 WO 1993015407 A1 WO1993015407 A1 WO 1993015407A1 EP 9300103 W EP9300103 W EP 9300103W WO 9315407 A1 WO9315407 A1 WO 9315407A1
Authority
WO
WIPO (PCT)
Prior art keywords
devices
operations
robot
computer
sample
Prior art date
Application number
PCT/EP1993/000103
Other languages
English (en)
Inventor
Guido Ruggeri
Lorenzo Stangoni
Original Assignee
Guido Ruggeri
Lorenzo Stangoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guido Ruggeri, Lorenzo Stangoni filed Critical Guido Ruggeri
Publication of WO1993015407A1 publication Critical patent/WO1993015407A1/fr

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00475Filters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00534Mixing by a special element, e.g. stirrer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0496Other details
    • G01N2035/0498Drawers used as storage or dispensing means for vessels or cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom

Definitions

  • This invention relates to a method and an apparatus for the full automation of a laboratory performing analyses, particularly, but not exclusively, in the field of the analyses executed for medical purpose.
  • the analyses executed for medical purpose are notoriously carried out on samples drawn out of patients, for instance blood or urine.
  • the clinical analyses are performed in special laboratories which are complex and always developing structures, which makes it impossible to frame them into a single operative pattern.
  • said laboratories may be either independent units or parts of a wider body; they may be structured either as a single unit or be divided in more sections, more or less interconnected; they can perform a variable number of analyses.
  • they can be placed either in a single room or in more rooms which, in turn, may be either adjoining or distant ones, also in different storeys of the same building or in different buildings.
  • their operational capacity they may perform a very different average number of analyses, ranging from one to one hundred or more.
  • patient's data recording patient's data recording, sample collection, taking on charge and checking of the sample, identification of its container;
  • the container standardization and sample preparation stages are at present normally carried out by hand: there are on the arket some devices which can perform some of the necessary operations on a single container, or on either one or many samples, but it is not known the availability of a device performing the complete sequence.
  • the delivery of the prepared samples to the analysers is normally carried out by hand, but it can certainly be automated with known techniques; nevertheless this stage cannot be framed into a general pattern because it is intrinsically determined by the structure of each laboratory, by its peculiar configuration, by its particular assortment of analysers and their disposition in the laboratory.
  • the sample analysis can already be implemented, in the majority of instances, by automated devices; the gathering of the results and the drawing up of the reports can already be managed by a computer.
  • One aim of the present invention is to overcome these drawba and to solve the aforementioned problems by providing a apparatus which, starting from the sample received, wil prepare it for the requested analysis or analyses, and ma possibly perform them, without any direct interference of human operator.
  • the apparatus is structured like a mosaic of tesserae arrayed frontally on a plane, each holding a particular device, and that the subsidiary devices are placed in an univocally determined position within the range of at least one robot and due to the fact that to each of these elements is biunivocally associated a set of subroutines, it is possible: - to assemble with the same building blocks equipments of radically different features, both as for their performances and for their operational capacity, by assembling different assortments of types and numbers of said devices to suit each case; - to include in said equipment as many devices available in the laboratory as possible, therefore saving on its capital cost and permitting its gradual introduction in the laboratory;
  • every tessera in the mosaic is equipped with a manual control in parallel to the central control of the computer, it is possible, when acting for instance on a sample so small that the skill of a human operator is needed, to move the robots to their rest position, disconnect the computer, connect the manual control and perform manually any desired sequence of operations.
  • This invention originates from the acknowledgment that every elementary operation composing the preparation cycles has been conceived either to be performed by a particular device, for instance a centrifugation, or to be carried out using two hands, one of which is always used in a support function, for instance to hold a test tube, and the other performs an operation, for instance either it inserts in said test tube the tip of a dispenser or it draws out either a part of its contents or the whole of it.
  • a structure formed by: a holding frame; a mosaic of tesserae arrayed frontally on a vertical plane; at least a rail, preferably overhead, which at least one robot runs along; at least a support table for the subsidiary devices and preferably a second support table at the foot of said mosaic of devices.
  • the mosaic of devices is formed by an assemblage of tesserae, both of modular or sub odular dimensions, each of which contains a particular device, respectively capable of carrying out either a single operation or a short sequence of single operations, for instance a test tube feeder or a dispenser.
  • Each of said tesserae is equipped with a suitable interface which enables it to exchange messages with a computer controlling its operations and coordinating them with all the other constituent elements of the system.
  • Said interfaces are electronic circuits, wholly designed with known techniques, converting the inputs to and the outputs from the device in messages coded according to a standard protocol, transmitted through a standard network.
  • the tesserae are placed on the wall in such a way to minimize number and length of the movements of the robot, or robots, which carry both the test tubes and the other objects from a tessera to another and from them to the subsidiary devices, so making the performance of the necessary operations as swift as possible.
  • the devices placed in the tesserae of a particular mosaic and the subsidiary devices on the whole must always be such as to be able to carry out all the single operations needed to prepare the samples for all the analyses foreseen in that particular laboratory.
  • the number of the devices placed in said tesserae and of said subsidiary devices may be suitably increased both to raise the productivity of the equipment, that is making it possible to perform the same operation simultaneously at two, or more, equal tesserae of the mosaic or with two, or more, subsidiary devices, and to increase its reliability, making it possible that in the event of breakdown of any element of the system it may always be substituted by another equal one.
  • Along the front of the mosaic there runs at least one robot supported by a horizontal rail parallel to the plane of said mosaic; the number of said robots is determined by the desired capacity of the device and may be increased to improve its reliability.
  • Said robot must be powered by controlled acceleration drives, so as to prevent in every case the transported materials from getting damaged, and must be equipped with a hand embodying suitable features, apt to handle small but easily damageable loads.
  • the subsidiary devices are to be placed in univocally determined positions within the working range of the robot, or robots. It's better not to place them at the mosaic foot to prevent the possibility of contamination in the case of rupture, due to failure, during the operations. The best solution is probably to place them on a supporting table parallel to said mosaic and located on the other side of the rail, or rails.
  • the computer controlling said equipment must be managed by a program such as to meet two different requirements: to make it perform as swiftly as possible all the sequences of operations determined by the particular requests as they come from the reception, so as to exploit in the best way the configuration of that particular pattern of equipment; to allow in a very simple way the removal of a whatever number of existing elements, both mosaic tesserae and robots and subsidiary devices, and the addition of a whatever number of new elements, in a very short time and without impairing the system efficiency.
  • pattern of a particular equipment it is meant: the definition of every tessera of the mosaic, in terms of both its location within said mosaic and of the list of the operations that the device placed in it can carry out? the definition of the position of the rail, or rails, in comparison to said mosaic; the definition of the model of robot, or robots; the definition of the position, of the space orientation of every subsidiary device and of the list of the operations performed by it. Said pattern must be input to the computer at the assembling of each particular equipment and must be updated every time that a change is made to it.
  • a set of subroutines is biunivocally associated with every single type of equipment element, be ; t both a device placed in a mosaic tessera or a robot or- ar subsidiary device.
  • a set comprises at least one subroutine and may include whatever number of them.
  • the set of subroutines correlated to a given element must be input to the computer when said element is added to the equipment and erased when it is removed.
  • Every subroutine controls one single operation or a sequence of single operations which can be carried out by said element, be it a device placed in a mosaic tessera or a robot or a subsidiary device, to which it is biunivocally associated.
  • These subroutines may be of very different complexity: from the simpler instance of checking a feeder contents, to a complex sequence of robot movements, to the calculation of the quantity of a given fraction of material contained in a test tube.
  • the control unit of the computer will establish a global strategy by recording the preparation to be performed on every sample received and splitting each of them into elementary operations, or sequences of elementary operations. Based on the number of devices and subsidiary devices of every kind at its disposal and on the actual position in space of each of them, it will determine the real sequence of operations that is to be carried out and will consequently call and set to action the necessary subroutines.
  • the computer will call and set to action successively the subroutines controllin the movements of the robot to take the test tube out of th centrifuge and its transfer to the tessera in which is place the measuring device of the volume of the upper transparen liquid and the measurement of said liquid.
  • the computer checks if said volume is sufficient t prepare the three requested secondary tubes. If not, it wil call and set to operation the subroutine controlling th movements of the robot for carrying the test tube to waiting location. If it is enough, it will call and set t operation successively the subroutines controlling the robo movements carrying the test tube to a dispenser, the suctio of the whole volume of upper transparent liquid contained i the test tube, the movements of the robot to carry the tes tube to a stated location, to take a particular secondar test tube out of its feeder and carry it to the dispenser the transfer from the dispenser to said secondary test tub of the correct quantity of liquid necessary to perform th requested analyses, the robot movements for carrying the tes tube to the rack of the test machine and its pluggin therein.
  • the last three subroutines are called and set t action three times in a sequence, taking every time th secondary test tube out of a generally different feeder an inserting it into a different rack.
  • the computer calls and sets to action th following subroutines: the robot movements for carrying t the dispenser the container used to store the residua material, the transfer of said material to said container the robot movements for carrying the container to the sealin station and its sealing.
  • the computer sets to action the subroutine for washing the dispenser, or alternatively, the robot movements to go back to the dispenser, to remove from it the used tip, to carry said tip to a defined position and drop it, to take a new tip out of its feeder, to carry the new tip to the dispenser and insert it thereon.
  • control unit When devising said strategy the control unit must take into account also the possible particular requests of the operator, for instance an order to prepare a particular sample with absolute priority. Naturally said strategy is to be revised to meet every new request of the reception.
  • the packaging of the residual material for the archive reserve is at present carried out by transferring all the residual sample into a container, which is later stored in a freezer.
  • This solution has the drawback to compel to thaw the whole reserve in order to use only a fraction of it. Therefore it is better to store the residual material by dividing it into many separate sections, which can be used independently, each of which will hold the quantity of sample necessary to repeat one or more of the analyses which may be requested.
  • the simplest method is to use for this purpose a sterile plastic hose, which is filled with the residual sample by removing the air, and which is then sealed by a tool, applying the required pressure at the required temperature, to partition said hose into many sealed sections separated one another.
  • Fig. 1 shows the axonometric outline of a preferre embodiment of an apparatus, according to the present invention.
  • Fig. 2 shows a functional schematic simplified block diagra of an embodiment of the computer configuration controllin said apparatus.
  • Fig. 1 shows the axonometric outline of a particular pattern of apparatus 10.
  • a bearing structure 11 supports: a mosaic of tesserae 12 divided into modules 21, six in th figure, each of which holds more tesserae of both modular and submodular (18',19') dimensions, each of which containing a particular device 18 or 19; a supporting table 15 sustains four subsidiary devices 16, for instance centrifuges or mixers; a second supporting table 17, fundamentally foresee to simplify the manual operations, equipped with two latera extensions 22 and 23 apt to sustain respectively th containers received and the samples ready to be transferre to the analysers; two rails 13, placed overhead, along each of which runs a robot 14 provided with a vertical arm 24 which moves vertically and causes a horizontal arm 25 to rotate around its axis 200.
  • the arm in its turn moves an hand 20 along a horizontal axis 100.
  • the computer, the interconnecting network, the interfaces and the manual controls being all completely featured with known techniques, are not shown in the figure.
  • the fig. 2 shows a functional schematic simplified block diagram of said computer.
  • a rectangle 26 representing the whole computer, including on its superior right angle a rectangle 28 and below a set of small rectangles 29, twenty in the figure.
  • the rectangle 28 portrays the memory section of the computer storing the pattern of a particular apparatus 10.
  • Each rectangle below represents a set 29 of subroutines 30, including a different number of subroutines in each case.
  • the remaining part of the area of the outer rectangle represents the control unit 27.
  • said apparatus can be placed in a room with a controlled atmosphere , if a particular degree of sterility is required .
  • the materials employed, as well as the dimensions, may be any according to the requirements.

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  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un procédé qui permet d'automatiser intégralement un laboratoire d'analyses, dans lequel un ensemble d'opérations élémentaires est créé, chaque opération étant effectuée par un dispositif généralement connu, et certaines séquences appropriées desdites opérations élémentaires sont sélectionnées en vue de réaliser les cycles de préparation et les analyses des échantillons testés requis, à l'aide d'un appareil construit par assemblage, selon certaines règles spécifiques, d'une sélection appropriée desdits dispositifs (18, 19) et de dispositifs accessoires complémentaires (16), le tout fonctionnant en interaction avec au moins un robot (14) et commandé par ordinateur grâce à un programme informatique approprié, lesdits dispositifs et dispositifs accessoires étant raccordés à cet ordinateur au moyen d'interfaces appropriées.
PCT/EP1993/000103 1992-01-27 1993-01-18 Procede et appareil permettant l'automatisation integrale de laboratoires d'analyses WO1993015407A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI92A000136 1992-01-27
ITMI920136A IT1260447B (it) 1992-01-27 1992-01-27 Procedimento e apparecchiatura per l'automazione integrale di un laboratorio di analisi

Publications (1)

Publication Number Publication Date
WO1993015407A1 true WO1993015407A1 (fr) 1993-08-05

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IT (1) IT1260447B (fr)
WO (1) WO1993015407A1 (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011406A1 (fr) * 1994-10-07 1996-04-18 Flinders Technologies Pty. Ltd. Appareil et procede de stockage, purification ou mise en reaction et traitement d'un biopolymere
EP0804730A4 (fr) * 1994-05-31 1997-11-05
FR2749662A1 (fr) * 1996-06-11 1997-12-12 Elf Aquitaine Laboratoire robotise d'analyses d'echantillons
WO1998001760A3 (fr) * 1996-07-05 1998-06-11 Beckman Instruments Inc Systeme automatise de traitement d'echantillons
EP0990906A1 (fr) * 1998-09-28 2000-04-05 F. Hoffmann-La Roche Ag Dispositif de transport de composants dans un système d'analyses automatisé
EP0973039A3 (fr) * 1998-07-14 2000-10-11 Bayer Corporation Système robotique pour transporter des conteneurs et des objets dans un instrument d'analyse automatique, et outil pour l'entretient du système robotique
WO2000060361A3 (fr) * 1999-04-02 2001-02-08 Sequenom Inc Ligne de traitement automatisé
EP0913465A4 (fr) * 1996-06-28 2001-04-18 Kasen Nozzle Mfg Co Ltd Appareil de test automatique
WO2001096863A3 (fr) * 2000-06-15 2003-06-26 Beckman Coulter Inc Procede et systeme permettant de transporter et de stocker de multiples paquets de reactifs et paquets de reactifs utilises dans ces procede et systeme
EP1403644A1 (fr) * 2002-09-25 2004-03-31 Agilent Technologies Inc. a Delaware Corporation Dispositif d'analyse de fluides
EP1582874A1 (fr) * 2004-03-31 2005-10-05 Roche Diagnostics GmbH Appareil modulaire pour analyses
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
WO2006055318A3 (fr) * 2004-11-12 2006-10-12 Beckman Coulter Inc Systeme ameliore de preparation d'echantillons pour appareil de laboratoire
US7198893B1 (en) 1996-11-06 2007-04-03 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
CN101995352A (zh) * 2009-08-21 2011-03-30 广州阳普医疗科技股份有限公司 血清分离方法及设备
WO2010130703A3 (fr) * 2009-05-15 2011-06-23 Basf Se Analyse automatique de fines particules de matière solide
US8315805B2 (en) 2001-04-20 2012-11-20 Sequenom, Inc. Systems and methods for testing a biological sample
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US9381524B2 (en) 2011-11-08 2016-07-05 Becton, Dickinson And Company System and method for automated sample preparation
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
CN114658728A (zh) * 2020-12-22 2022-06-24 豪夫迈·罗氏有限公司 用于连接实验室自动化系统的部件的连接接头
EP4276039A4 (fr) * 2021-01-08 2024-11-20 Hitachi High-Tech Corporation Système d'analyse automatique
WO2025131090A1 (fr) * 2023-12-22 2025-06-26 北京镁伽机器人科技有限公司 Procédé de traitement pour opérations dans un processus automatisé et procédé de planification pour processus automatisé

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Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0804730A4 (fr) * 1994-05-31 1997-11-05
WO1996011406A1 (fr) * 1994-10-07 1996-04-18 Flinders Technologies Pty. Ltd. Appareil et procede de stockage, purification ou mise en reaction et traitement d'un biopolymere
FR2749662A1 (fr) * 1996-06-11 1997-12-12 Elf Aquitaine Laboratoire robotise d'analyses d'echantillons
WO1997047974A3 (fr) * 1996-06-11 1998-01-29 Elf Aquitaine Laboratoire robotise d'analyses d'echantillons
US6673317B2 (en) 1996-06-28 2004-01-06 Kasen Nozzle Mfg. Co., Ltd. Automatic testing apparatus
EP0913465A4 (fr) * 1996-06-28 2001-04-18 Kasen Nozzle Mfg Co Ltd Appareil de test automatique
US8038942B2 (en) 1996-07-05 2011-10-18 Beckman Coulter, Inc. Automated sample processing system
WO1998001760A3 (fr) * 1996-07-05 1998-06-11 Beckman Instruments Inc Systeme automatise de traitement d'echantillons
US6060022A (en) * 1996-07-05 2000-05-09 Beckman Coulter, Inc. Automated sample processing system including automatic centrifuge device
US7501251B2 (en) 1996-11-06 2009-03-10 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7198893B1 (en) 1996-11-06 2007-04-03 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6293750B1 (en) 1998-07-14 2001-09-25 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
US6374982B1 (en) 1998-07-14 2002-04-23 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
US6332636B1 (en) 1998-07-14 2001-12-25 Bayer Corporation Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics
EP0973039A3 (fr) * 1998-07-14 2000-10-11 Bayer Corporation Système robotique pour transporter des conteneurs et des objets dans un instrument d'analyse automatique, et outil pour l'entretient du système robotique
US6403035B1 (en) 1998-09-28 2002-06-11 Roche Diagnostics Corporation Apparatus for transporting components within an automatic analyzer system
EP0990906A1 (fr) * 1998-09-28 2000-04-05 F. Hoffmann-La Roche Ag Dispositif de transport de composants dans un système d'analyses automatisé
WO2000060361A3 (fr) * 1999-04-02 2001-02-08 Sequenom Inc Ligne de traitement automatisé
US6730517B1 (en) 1999-04-02 2004-05-04 Sequenom, Inc. Automated process line
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US8017093B2 (en) 2000-06-15 2011-09-13 Beckman Coulter, Inc. Method and system for transporting and storing multiple reagent packs and reagent packs used therein
US6746648B1 (en) 2000-06-15 2004-06-08 Beckman Coulter, Inc. Method and system for transporting and storing multiple reagent packs and reagent packs used therein
WO2001096863A3 (fr) * 2000-06-15 2003-06-26 Beckman Coulter Inc Procede et systeme permettant de transporter et de stocker de multiples paquets de reactifs et paquets de reactifs utilises dans ces procede et systeme
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US8315805B2 (en) 2001-04-20 2012-11-20 Sequenom, Inc. Systems and methods for testing a biological sample
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
EP1403644A1 (fr) * 2002-09-25 2004-03-31 Agilent Technologies Inc. a Delaware Corporation Dispositif d'analyse de fluides
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
EP1582874A1 (fr) * 2004-03-31 2005-10-05 Roche Diagnostics GmbH Appareil modulaire pour analyses
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IT1260447B (it) 1996-04-09
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