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WO1993017110A3 - A recombinant hepatitis c virus polypeptide - Google Patents

A recombinant hepatitis c virus polypeptide Download PDF

Info

Publication number
WO1993017110A3
WO1993017110A3 PCT/GB1993/000345 GB9300345W WO9317110A3 WO 1993017110 A3 WO1993017110 A3 WO 1993017110A3 GB 9300345 W GB9300345 W GB 9300345W WO 9317110 A3 WO9317110 A3 WO 9317110A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
nanbh
coding region
antigen
viral genome
Prior art date
Application number
PCT/GB1993/000345
Other languages
French (fr)
Other versions
WO1993017110A2 (en
Inventor
David Parker
Brian Colin Rodgers
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of WO1993017110A2 publication Critical patent/WO1993017110A2/en
Publication of WO1993017110A3 publication Critical patent/WO1993017110A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a recombinant PT-NANBH polypeptide or recombinant PT-NANBH polypeptides which polypeptide comprises or which polypeptides together comprise (i) at least one antigen from the structural coding region of the viral genome, (ii) at least one antigen from the non-structural coding region of the viral genome; and (iii) at least one further antigen from either the structural or non-structural coding region of the viral genome and which is different from the antigens referred to in (i) and (ii), and the use of the polypeptide in an immuno assay for diagnosis PT-NANBH or in a vaccine for its prevention.
PCT/GB1993/000345 1992-02-21 1993-02-19 A recombinant hepatitis c virus polypeptide WO1993017110A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9203803.3 1992-02-21
GB929203803A GB9203803D0 (en) 1992-02-21 1992-02-21 A recombinant polypeptide

Publications (2)

Publication Number Publication Date
WO1993017110A2 WO1993017110A2 (en) 1993-09-02
WO1993017110A3 true WO1993017110A3 (en) 1993-10-14

Family

ID=10710857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/000345 WO1993017110A2 (en) 1992-02-21 1993-02-19 A recombinant hepatitis c virus polypeptide

Country Status (4)

Country Link
AU (1) AU3509693A (en)
GB (1) GB9203803D0 (en)
WO (1) WO1993017110A2 (en)
ZA (1) ZA931203B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
KR100312535B1 (en) * 1993-04-30 2002-06-20 성재갑 Antibody Diagnosis of Hepatitis C Virus Using Mixed Antigens
WO1995011918A1 (en) * 1993-10-29 1995-05-04 Srl, Inc. Antigen peptide compound and immunoassay method
AU5924396A (en) * 1995-05-22 1996-12-11 Bionova Corporation Compositions and methods for the diagnosis of, and vaccinati on against, hepatitis c virus (hcv)
DE60331226D1 (en) * 2002-05-24 2010-03-25 Medtronic Inc METHOD AND DNA CONSTRUCTIONS FOR PRODUCING POLYPEPTIDES HAVING HIGH PROFIT
WO2003099854A2 (en) 2002-05-24 2003-12-04 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
PL1704234T3 (en) 2003-11-21 2012-06-29 Nps Pharma Inc Production of glucagon like peptide 2 and analogs
BRPI0516356A (en) 2004-10-18 2008-09-02 Globeimmune Inc yeast therapy for chronic hepatitis c infections
JP2012503011A (en) 2008-09-19 2012-02-02 グローブイミューン，インコーポレイテッド Immunotherapy of chronic hepatitis C virus infection
US8809344B2 (en) 2008-10-29 2014-08-19 Apath, Llc Compounds, compositions, and methods for control of hepatitis C viral infections

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2239245A (en) * 1989-12-18 1991-06-26 Wellcome Found Post-transfusional non-A non-B hepatitis viral polypeptides
EP0445423A2 (en) * 1989-12-22 1991-09-11 Abbott Laboratories Hepatitis C assay
EP0450931A1 (en) * 1990-04-04 1991-10-09 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
EP0468527A2 (en) * 1990-07-26 1992-01-29 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and prevention thereof as vaccines
EP0472207A2 (en) * 1990-08-24 1992-02-26 Abbott Laboratories Hepatitis C assay utilizing recombinant antigens
EP0521318A2 (en) * 1991-06-10 1993-01-07 Lucky Ltd. Hepatitis C diagnostics and vaccines

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2239245A (en) * 1989-12-18 1991-06-26 Wellcome Found Post-transfusional non-A non-B hepatitis viral polypeptides
EP0445423A2 (en) * 1989-12-22 1991-09-11 Abbott Laboratories Hepatitis C assay
EP0450931A1 (en) * 1990-04-04 1991-10-09 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
EP0468527A2 (en) * 1990-07-26 1992-01-29 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and prevention thereof as vaccines
EP0472207A2 (en) * 1990-08-24 1992-02-26 Abbott Laboratories Hepatitis C assay utilizing recombinant antigens
EP0521318A2 (en) * 1991-06-10 1993-01-07 Lucky Ltd. Hepatitis C diagnostics and vaccines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCAND. J. GASTROENTEROL. vol. 26, 1991, pages 1257 - 1262 L. MATTSSON ET AL. 'Antibodies to recombinant and synthetic peptides derived from hepatitis C virus genome in long-term studied patients with posttransfusion hepatitis C' *

Also Published As

Publication number Publication date
ZA931203B (en) 1993-10-04
GB9203803D0 (en) 1992-04-08
AU3509693A (en) 1993-09-13
WO1993017110A2 (en) 1993-09-02

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