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WO1993017115A3 - Dysentery vaccine stimulating an immune response against shigatoxin, plasmids and host strains for it - Google Patents

Dysentery vaccine stimulating an immune response against shigatoxin, plasmids and host strains for it Download PDF

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Publication number
WO1993017115A3
WO1993017115A3 PCT/EP1993/000347 EP9300347W WO9317115A3 WO 1993017115 A3 WO1993017115 A3 WO 1993017115A3 EP 9300347 W EP9300347 W EP 9300347W WO 9317115 A3 WO9317115 A3 WO 9317115A3
Authority
WO
WIPO (PCT)
Prior art keywords
plasmids
shigatoxin
immune response
response against
host strains
Prior art date
Application number
PCT/EP1993/000347
Other languages
French (fr)
Other versions
WO1993017115A2 (en
Inventor
Guo-Fu Su
Himanshu Brahmbhatt
Juergen Wehland
Manfred Rohde
Kenneth Timmis
Original Assignee
Biotechnolog Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh
Publication of WO1993017115A2 publication Critical patent/WO1993017115A2/en
Publication of WO1993017115A3 publication Critical patent/WO1993017115A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention concerns dysentery vaccines, methods, plasmids and gene products for their production.
PCT/EP1993/000347 1992-02-18 1993-02-12 Dysentery vaccine stimulating an immune response against shigatoxin, plasmids and host strains for it WO1993017115A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92102693.6 1992-02-18
EP92102693 1992-02-18

Publications (2)

Publication Number Publication Date
WO1993017115A2 WO1993017115A2 (en) 1993-09-02
WO1993017115A3 true WO1993017115A3 (en) 1993-10-28

Family

ID=8209343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000347 WO1993017115A2 (en) 1992-02-18 1993-02-12 Dysentery vaccine stimulating an immune response against shigatoxin, plasmids and host strains for it

Country Status (2)

Country Link
AU (1) AU3628193A (en)
WO (1) WO1993017115A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
US7521063B2 (en) 2000-01-14 2009-04-21 The United States Of America As Represented By The Department Of Health And Human Services Multiple CPG oligodeoxynucleotides and their use to induce an immune response
US7615227B2 (en) 2001-12-20 2009-11-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce angiogenesis

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766193B1 (en) * 1997-07-18 2001-09-14 Inst Curie CHEMICAL POLYPEPTIDE COMPRISING FRAGMENT B OF TOXIN SHIGA AND PEPTIDES OF THERAPEUTIC INTEREST
ATE310750T1 (en) 1998-05-15 2005-12-15 Inst Curie VEROTOXIN B SUBUNIT FOR IMMUNIZATION
EP1176966B1 (en) * 1999-04-12 2013-04-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Oligodeoxynucleotide and its use to induce an immune response

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254905A2 (en) * 1986-07-06 1988-02-03 Yeda Research And Development Company Limited Shiga Vaccine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254905A2 (en) * 1986-07-06 1988-02-03 Yeda Research And Development Company Limited Shiga Vaccine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GENE vol. 70, 1988, pages 181 - 189 A. CHARBIT ET AL. 'Versatility of a vector for expressing foreign polypeptides at the surface of gram-negative bacteria' *
INF. IMMUN. vol. 56, no. 6, 1988, pages 1618 - 1624 I. HARARI ET AL. 'Synthetic peptides of shiga toxin B dubunit induce antibodies which neutralize its biological activity' *
INF. IMMUN. vol. 60, no. 8, 1992, pages 3345 - 3359 G.F. SU ET AL. 'Construction of stable lamB-shiga toxin hybrids' *
J. BACTERIOL. vol. 170, no. 3, 1988, pages 1116 - 1122 N. STROCKBINE ET AL. 'Cloning and sequencing of the genes for shiga toxin from S. dysenteriae type 1' *
MICROBIAL PATHOGENESIS vol. 12, no. 6, 1992, pages 399 - 407 M. RYD ET AL. 'Induction of a humoral immune response to a shiga toxin B subunit epitope expressed as a chimeric lamB protein' *
RES. MICROBIOL. vol. 141, 1990, pages 963 - 969 D. O'CALLAGHAN ET AL. 'Immunogenicity of foreign peptide epitopes expressed in bacterial envelope peptides' *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US7521063B2 (en) 2000-01-14 2009-04-21 The United States Of America As Represented By The Department Of Health And Human Services Multiple CPG oligodeoxynucleotides and their use to induce an immune response
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
US7615227B2 (en) 2001-12-20 2009-11-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce angiogenesis

Also Published As

Publication number Publication date
WO1993017115A2 (en) 1993-09-02
AU3628193A (en) 1993-09-13

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