WO1993018055B1 - Peptide stimulant la reponse des lymphocytes cytotoxiques a la gp160 du vih-1 - Google Patents
Peptide stimulant la reponse des lymphocytes cytotoxiques a la gp160 du vih-1Info
- Publication number
- WO1993018055B1 WO1993018055B1 PCT/US1993/001925 US9301925W WO9318055B1 WO 1993018055 B1 WO1993018055 B1 WO 1993018055B1 US 9301925 W US9301925 W US 9301925W WO 9318055 B1 WO9318055 B1 WO 9318055B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hiv
- acid sequence
- amino acid
- respone
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 9
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 230000004044 response Effects 0.000 claims abstract 3
- 229920001184 polypeptide Polymers 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 101710121417 Envelope glycoprotein Proteins 0.000 claims 2
- 108010036616 P18-I10 peptide Proteins 0.000 claims 2
- 102100021696 Syncytin-1 Human genes 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 238000001994 activation Methods 0.000 abstract 2
- 101710204610 Envelope glycoprotein gp160 Proteins 0.000 abstract 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
Abstract
L'invention se rapporte à des peptides possédant une activité élevée dans le déclenchement d'une réponse de lymphocytes T cytotoxiques par rapport à la glycoprotéine gp160 de l'enveloppe du VIH-1. L'invention se rapporte également à l'activation des peptides des restes 12 à 15 par dégradation protéolytique en peptides plus courts, ainsi qu'à des techniques générales destinées à caractériser ces procédés d'activation.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU37878/93A AU668927B2 (en) | 1992-03-06 | 1993-03-08 | Peptides stimulating cytotoxic lymphocytes response to HIV-I GP 160 |
CA002131153A CA2131153C (fr) | 1992-03-06 | 1993-03-08 | Peptides stimulant la reponse cytotoxique des lymphocytes a la gp 160 du virus vih-1 |
EP93907180A EP0630385A1 (fr) | 1992-03-06 | 1993-03-08 | Peptide puissant pour la stimulation des lymphocytes t cytotoxiques specifiques de l'enveloppe du vih-1 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/847,311 US5976541A (en) | 1988-01-26 | 1992-03-06 | Potent peptide for stimulation of cytotoxic T lymphocytes specific for the HIV-1 envelope |
US847,311 | 1992-03-06 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1993018055A2 WO1993018055A2 (fr) | 1993-09-16 |
WO1993018055A3 WO1993018055A3 (fr) | 1994-03-17 |
WO1993018055B1 true WO1993018055B1 (fr) | 1994-06-09 |
Family
ID=25300315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/001925 WO1993018055A2 (fr) | 1992-03-06 | 1993-03-08 | Peptide stimulant la reponse des lymphocytes cytotoxiques a la gp160 du vih-1 |
Country Status (5)
Country | Link |
---|---|
US (1) | US5976541A (fr) |
EP (1) | EP0630385A1 (fr) |
AU (1) | AU668927B2 (fr) |
CA (1) | CA2131153C (fr) |
WO (1) | WO1993018055A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6210873B1 (en) | 1987-08-28 | 2001-04-03 | Board Of Regents, The University Of Texas System | Methods and compositions for the priming of specific cytotoxic T-lymphocyte response |
US5128319A (en) | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
AU6363094A (en) * | 1993-03-15 | 1994-10-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptide coated dendritic cells as immunogens |
US5603933A (en) * | 1993-08-31 | 1997-02-18 | Board Of Regents, The University Of Texas | CD4 peptides for binding to viral envelope proteins |
NL9400384A (nl) * | 1994-03-11 | 1995-10-02 | Smit Victor | Retrovirus-vaccins, vaccinatie en immunotherapie tegen retrovirale infecties. |
GB9426153D0 (en) * | 1994-12-23 | 1995-02-22 | Medical Res Council | Improvements in or relating to vaccines |
US6395714B1 (en) * | 1999-02-24 | 2002-05-28 | Aventis Pasteur Limited | Expressing gp140 fragment of primary HIV-1 isolate |
MXPA02007478A (es) | 2000-02-04 | 2004-08-23 | Univ Duke | Vacuna contra el virus de inmunodeficiencia humana. |
WO2001072331A1 (fr) * | 2000-03-31 | 2001-10-04 | Vaccine Chip Technology Aps | Proprietes immunostimulantes d'un fragment de tgf-beta |
WO2003051285A2 (fr) * | 2001-10-29 | 2003-06-26 | Genzyme Corporation | Composes therapeutiques anti-vih (iv9) |
WO2003037264A2 (fr) * | 2001-10-29 | 2003-05-08 | Genzyme Corporation | Composes therapeutiques anti-vih (vpr) |
US20090214583A1 (en) * | 2004-04-30 | 2009-08-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Epitope-enhancement of a human cd4 hiv epitope |
EP2620446A1 (fr) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogènes pour la vaccination contre le VIH |
CN116322757A (zh) | 2019-11-14 | 2023-06-23 | 埃利克斯疗法公司 | 用于疫苗的剂量方案 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR930000189B1 (ko) * | 1984-10-18 | 1993-01-11 | 앵스뛰띠 빠스뙤르 | 임파선증과 후천성 면역 결핍증 바이러스의 항원을 제조하는 방법 및 이 항원에 대한 항체의 생산 방법 |
JPS63501716A (ja) * | 1985-10-24 | 1988-07-14 | サウスウエスト・ファウンデ−ション・フォア・バイオメディカル・リサ−チ | 合成ペプチドおよびaidsおよびarcの診断ならびにワクチン注射へのその使用 |
JPH01501547A (ja) * | 1986-06-12 | 1989-06-01 | バイオジェン ナームローズ ベンノットシャップ | Hiv感染の病因に関するペプチド |
WO1988005051A1 (fr) * | 1986-12-30 | 1988-07-14 | United States Of America, Represented By The Unite | Peptides synthetiques induisant une immunite cellulaire au virus du sida et aux proteines virales du sida |
US5013548A (en) * | 1987-09-08 | 1991-05-07 | Duke University | Production of antibodies to HIV |
US5019387A (en) * | 1987-09-08 | 1991-05-28 | Duke University | Production of antibodies to HIV |
JP2569185B2 (ja) * | 1988-01-26 | 1997-01-08 | アメリカ合衆国 | 抗hiv応答を喚起する合成抗原 |
US5820865A (en) * | 1988-01-26 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Method to induce cytotoxic T Lymphocytes specific for a broad array of HIV-1 isolates using hybrid synthetic peptides |
US5562905A (en) * | 1988-04-26 | 1996-10-08 | E. I. Du Pont De Nemours And Company | Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals |
IL94558A0 (en) * | 1989-06-06 | 1991-03-10 | Merck & Co Inc | Conjugate immunogen for aids and vaccine and pharmaceutical compositions containing it |
FR2650954B1 (fr) * | 1989-08-18 | 1992-02-28 | Pasteur Institut | Composition resultant de la reunion d'un epitope b de la glycoproteine d'enveloppe d'un retrovirus du type iv et d'un epitope t issu d'une proteine distincte codee par ce retrovirus et leur application a la production d'anticorps protecteurs contre le sida |
US5254682A (en) * | 1989-12-08 | 1993-10-19 | Merck & Co., Inc. | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
JPH03271233A (ja) * | 1990-03-19 | 1991-12-03 | Inst Pasteur | ウイルスエンベロープ糖タンパク質及びその糖タンパク質の中和エピトープに対応するペプチドの間の相乗作用による、ウイルス性感染に対する防御の誘発 |
CA2056911C (fr) * | 1990-12-11 | 1998-09-22 | Yuuichi Nagano | Inhibiteurs de la protease de vih |
-
1992
- 1992-03-06 US US07/847,311 patent/US5976541A/en not_active Expired - Lifetime
-
1993
- 1993-03-08 WO PCT/US1993/001925 patent/WO1993018055A2/fr not_active Application Discontinuation
- 1993-03-08 AU AU37878/93A patent/AU668927B2/en not_active Expired
- 1993-03-08 EP EP93907180A patent/EP0630385A1/fr not_active Withdrawn
- 1993-03-08 CA CA002131153A patent/CA2131153C/fr not_active Expired - Lifetime
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