WO1993018148A3 - Tumor necrosis factor with modified channel activity - Google Patents
Tumor necrosis factor with modified channel activity Download PDFInfo
- Publication number
- WO1993018148A3 WO1993018148A3 PCT/US1993/002475 US9302475W WO9318148A3 WO 1993018148 A3 WO1993018148 A3 WO 1993018148A3 US 9302475 W US9302475 W US 9302475W WO 9318148 A3 WO9318148 A3 WO 9318148A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tnf
- channel
- modified
- target
- activity
- Prior art date
Links
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title abstract 10
- 102000003390 tumor necrosis factor Human genes 0.000 title abstract 10
- 108091006146 Channels Proteins 0.000 title abstract 7
- 230000000694 effects Effects 0.000 title abstract 5
- 239000012528 membrane Substances 0.000 abstract 5
- 230000035699 permeability Effects 0.000 abstract 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000005829 trimerization reaction Methods 0.000 abstract 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
An improved form of tumor necrosis factor (TNF) can be employed to regulate TNF channel activity. The identity of the amino acids which line the channel of the TNF molecule and which exert significant control over the activity of the channel are disclosed. The improved form of TNF includes amino acid substitutions, additions, and/or deletions, and/or chemically modified amino acid residues within the channel region for enhancing, diminishing, and/or modulating its channel activity within target membranes. The modified form of TNF is capable of trimerization and of achieving intimate contact with a target membrane containing one or more types of TNF receptor. Contacting target membranes with forms of TNF having modified channel activities can be employed to regulate the permeability and/or response of the target membrane. Greater control over the regulation of the permeability and/or response of target membranes can be achieved with modified forms of TNF as compared to unmodified TNF.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85262592A | 1992-03-12 | 1992-03-12 | |
| US07/852,625 | 1992-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1993018148A2 WO1993018148A2 (en) | 1993-09-16 |
| WO1993018148A3 true WO1993018148A3 (en) | 1993-10-28 |
Family
ID=25313824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1993/002475 WO1993018148A2 (en) | 1992-03-12 | 1993-03-12 | Tumor necrosis factor with modified channel activity |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1993018148A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0815324A2 (en) | 2007-08-20 | 2015-07-14 | Protalix Ltd | "saccharide-containing protein conjugate, process for separating saccharide-containing protein conjugate, pharmaceutical composition for saccharide-containing protein conjugate, use of saccharide-containing protein conjugate and saccharide-containing protein conjugate compound" |
| US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
| US20120328589A1 (en) * | 2010-03-02 | 2012-12-27 | Ilya Ruderfer | Glucocerebrosidase multimers and uses thereof |
| PL3272861T3 (en) | 2011-01-20 | 2020-07-13 | Protalix Ltd. | Alpha-galactosidase compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990007579A1 (en) * | 1988-12-23 | 1990-07-12 | Basf Aktiengesellschaft | Tumour necrosis factor muteins |
-
1993
- 1993-03-12 WO PCT/US1993/002475 patent/WO1993018148A2/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990007579A1 (en) * | 1988-12-23 | 1990-07-12 | Basf Aktiengesellschaft | Tumour necrosis factor muteins |
Non-Patent Citations (6)
| Title |
|---|
| BIOCHIMICA ET BIOPHYSICA ACTA vol. 1096, no. 3, 15 April 1991, pages 245 - 252 RYOJI ITO ET AL 'Novel muteins of human Tumor Necrosis Factor-alpha' * |
| JOURNAL OF BIOCHEMISTRY. vol. 102, no. 5, 1987, TOKYO JP pages 1303 - 1310 N. OKU ET AL 'Tumor Necrosis Factor-induced permeability increase of negatively charged phospholipid vesicles' * |
| JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 264, no. 29, 15 October 1989, BALTIMORE US pages 17595 - 17605 M. J. ECK ET AL 'the structure of Tumor Necrosis Factor-alpha at 2.6 A resolution' * |
| JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 267, no. 4, 5 February 1992, BALTIMORE US pages 2119 - 2122 M. J. ECK ET AL 'The structure of human Lymphotoxin (Tumor Necrosis Factor-beta) at 1.9-A resolution' cited in the application * |
| JOURNAL OF IMMUNOLOGY. vol. 141, no. 7, 1 October 1988, BALTIMORE US pages 2352 - 2357 R. L. BALDWIN ET AL 'Capacity of Tumor Necrosis Factor to bind and penetrate menbranes is pH-dependent' * |
| SCIENCE vol. 255, 13 March 1992, LANCASTER, PA US pages 1427 - 1430 B. L. KAGAN ET AL 'formation of ion-permeable channels by tumor necrosis factor -alpha' cited in the application * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993018148A2 (en) | 1993-09-16 |
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