[go: up one dir, main page]

WO1995011995B1 - Arrays of nucleic acid probes on biological chips - Google Patents

Arrays of nucleic acid probes on biological chips

Info

Publication number
WO1995011995B1
WO1995011995B1 PCT/US1994/012305 US9412305W WO9511995B1 WO 1995011995 B1 WO1995011995 B1 WO 1995011995B1 US 9412305 W US9412305 W US 9412305W WO 9511995 B1 WO9511995 B1 WO 9511995B1
Authority
WO
WIPO (PCT)
Prior art keywords
array
probe
reference sequence
probes
sequence
Prior art date
Application number
PCT/US1994/012305
Other languages
French (fr)
Other versions
WO1995011995A1 (en
Filing date
Publication date
Application filed filed Critical
Priority to EP95900441A priority Critical patent/EP0730663B1/en
Priority to AU81266/94A priority patent/AU8126694A/en
Priority to JP7512811A priority patent/JPH09507121A/en
Priority to DE69433180T priority patent/DE69433180T2/en
Publication of WO1995011995A1 publication Critical patent/WO1995011995A1/en
Publication of WO1995011995B1 publication Critical patent/WO1995011995B1/en
Priority to US08/510,521 priority patent/US7115364B1/en
Priority to US08/630,427 priority patent/US6156501A/en
Priority to US08/648,709 priority patent/US6045996A/en
Priority to US08/778,794 priority patent/US6309823B1/en
Priority to US09/393,389 priority patent/US6632605B1/en
Priority to US09/510,378 priority patent/US7399584B2/en
Priority to US09/798,260 priority patent/US20030165830A1/en
Priority to US10/113,885 priority patent/US20030134291A1/en
Priority to US10/229,319 priority patent/US20030054393A1/en
Priority to US10/402,333 priority patent/US20030232361A1/en
Priority to US10/418,414 priority patent/US7375198B2/en
Priority to US11/367,800 priority patent/US20060229824A1/en
Priority to US11/388,199 priority patent/US20060263807A1/en
Priority to US11/401,482 priority patent/US7846659B2/en
Priority to US11/506,176 priority patent/US20120329677A9/en
Priority to US12/124,061 priority patent/US7794943B2/en
Priority to US12/878,743 priority patent/US20110092382A1/en
Priority to US12/959,359 priority patent/US20130150248A1/en

Links

Abstract

The invention provides chips of immobilized probes, and methods employing the chips, for comparing a reference polynucleotide sequence of known sequence with a target sequence showing substantial similarity with the reference sequence, but differing in the presence of e.g., mutations.

Claims

AMENDED CLAIMS
[received by the International Bureau on 19 April 1995 (19.04.95); original claims 1,2,65,79-108 amended; new claim 109 added other claims unchanged (9 pages)]
1. An array of oligonucleotide probes immobilized on a solid support, the array comprising at least two sets of oligonucleotide probes, (1) a first probe set comprising a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence, (2) a second probe set comprising a corresponding probe for each probe in the first probe set, the corresponding probe in the second probe set being identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the two corresponding probes from the first and second probe sets; wherein the probes in the first probe set have at least two interrogation positions respectively corresponding to each of two contiguous nucleotides in the reference sequence.
2. An array of oligonucleotide probes immobilized on a solid support, the array comprising at least four sets of oligonucleotide probes, (1) a first probe set comprising a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence, (2) second, third and fourth probe sets, each comprising a corresponding probe for each probe in the first probe set, the probes in the second, third and fourth probe sets being identical to a sequence comprising the corresponding probe from the first probe set or a subsequence (d) determining which probes, relative to one another, in the array bind specifically to the target sequence; wherein the relative specific binding of the probes to the reference and the target sequence indicates whether the reference sequence is the same or different from the target sequence.
64. The method of claim 63, wherein the reference sequence has a first label and the second reference sequence has a second label different from the first label, and steps (a) and (c) are performed simultaneously.
HIV Chip 65. The array of claim 1 or 2, wherein the reference sequence is from a human immunodeficiency virus.
66. The array of claim 65, wherein the reference sequence is from a reverse transcriptase gene of the human immunodeficiency virus.
67. The array of claim 66, wherein the reference sequence is from a protease gene of the human immunodeficiency virus.
68. The array of claim 66, wherein the reference sequence is a full-length reverse transcriptase gene.
69. The array of claim 68 comprising at least 3200 oligonucleotide probes.
70. The array of claim 66, wherein the HIV gene is from the BRU HIV strain.
71. The array of claim 66, wherein the HIV gene is from the SF2 HIV strain. 72. The array of claim 28, wherein the reference sequence is from the coding strand of a reverse transcriptase gene of a human immunodeficiency virus and the second reference sequence is from the noncoding strand of the reverse transcriptase gene.
73. The array of claim 28, wherein the first reference sequence is from a reverse transcriptase gene of a human immunodeficiency virus and the second reference sequence comprises a subsequence of the first reference sequence with a substitution of at least one nucleotide.
74. The array of claim 73, wherein the substitution confers drug resistance to a human immunodeficiency virus comprising the second reference sequence.
75. The array of claim 28, wherein the first and second reference sequences are from a reverse transcriptase gene from first and second strains of a human immunodeficiency virus.
76. The array of claim 28, wherein the first reference sequence is from a reverse transcriptase gene of a human immunodeficiency virus and the second reference sequence is from a 16S RNA, or DNA encoding the 16S RNA, from a pathogenic microorganism.
77. The array of claim 28, wherein the first reference sequence is from a reverse transcriptase gene of a human immunodeficiency virus and the second reference sequence is from a protease gene of the human immunodeficiency virus.
78. The method of claim 54, wherein the reference sequence is from a human immunodeficiency virus.
79. The method of claim 78, further comprising the step of altering a drug treatment program based on the relative specific binding of the probes. 80. The method of claim 78, wherein the target sequence is from a second human immunodeficiency virus.
81. The method of claim 80, wherein the target sequence has a substituted nucleotide relative to the reference sequence in at least one undetermined position, and the relative specific binding of the probes indicates the location of the position and the nucleotide occupying the position in the target sequence.
82. The method of claim 81, wherein the target sequence has a substituted nucleotide relative to the reference sequence in at least one position, the substitution conferring drug resistance to the human immunodeficiency virus, and the relative specific binding of the probes reveals the substitution.
83. The method of claim 78, wherein: the hybridizing step comprises hybridizing the target nucleic acid and a second target nucleic acid, the second target sequence being from a reverse transcriptase gene of a third human immunodeficiency virus, to the array; and the determining step comprises determining which probes, relative to one another, in the array bind specifically to the target nucleic acid or the second target nucleic acid, the relative specific binding of the probes indicating whether the target sequence is the same or different from the reference sequence and whether the second target sequence is the same or different from the reference sequence.
84. The method of claim 83, wherein the first target sequence has a first label and the second target sequence has a second label different from the first label.
85. The method of claim 83, wherein undetermined first and second proportions of the first and second target sequences are hybridized to the array and the specific binding indicates the proportions.
86. A method of treating a patient infected with an HIV virus, the method comprising: (a) hybridizing a tissue sample from the patient containing a target nucleic acid to an array of oligonucleotide probes immobilized on a solid support, the array comprising: (1) a first probe set comprising a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence comprising an HIV gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence, (2) a second probe set comprising a corresponding probe for each probe in the first probe set, the corresponding probe in the second probe set being identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the two corresponding probes from the first and second probe sets; wherein the probes in the first probe set have at least three interrogation positions respectively corresponding to each of at least three nucleotides in the reference sequence, and (b) determining which probes, relative to one another, in the array bind specifically to the target nucleic acid, the relative specific binding of the probes identifying a mutation in the target sequence relative to the reference sequence; and (c) administering to the patient a drug effective against an HIV virus bearing the mutation. CFTR Chip 87. The array of claim 1 or 2, wherein the reference sequence is from a CFTR gene.
88. The array of claim 87, wherein the reference sequence is exon 10 of a CFTR gene, and said array comprises over 1000 oligonucleotide probes, 10 to 18 nucleotides in length.
89. The array of claim 87, wherein said array comprises a set of probes comprising a specific nucleotide sequence selected from the group of sequences comprising: 3'-TTTATAXTAG; 3'- TTATAGXAGA; 3«- TATAGTXGAA; 3'- ATAGTAXAAA; 3'- TAGTAGXAAC; 3'- AGTAGAXACC; 3'- GTAGAAXCCA; 3'- TAGAAAXCAC; and 3'- AGAAACXACA; wherein each set comprises 4 probes, and X is individually A, G, C, and T for each set.
90. The array of claim 87, wherein said group of sequences comprises: 3•-TTTATAXTAGAAACC; 3'- TTATAGXAGAAACCA; 3'- TATAGTXGAAACCAC; 3'- ATAGTAXAAACCACA; 3«- TAGTAGXAACCACAA; 3'- AGTAGAXACCACAAA; 3'- GTAGAAXCCACAAAG; 3'- TAGAAAXCACAAAGG; and 3'- AGAAACXACAAAGGA; wherein each set comprises 4 probes, and X is individually A, G, C, and T for each set.
91. The array of claim 32, wherein the forty first reference sequences are from a CFTR gene. 5
92. The array of claim 91, wherein each of the forty first reference sequences includes a site of a mutation and at least one adjacent nucleotide.
93. The array of claim 92, wherein each of the forty first reference sequences comprises at least five contiguous nucleotides from a CFTR gene.
94. The array of claim 91, wherein at least one first reference sequence is a from the coding strand of the cystic fibrosis gene and at least one first reference sequence is from the noncoding strand of the CFTR gene.
95. An array of oligonucleotide probes immobilized on a solid support, the array comprising at least a group of probes comprising: a wildtype probe exactly complementary to a subsequence of a reference sequence from a CFTR gene, the segment having at least five interrogation positions corresponding to five contiguous nucleotides in the reference sequence, a first set of three mutant probes, each identical to the wildtype probe, except in a first of the five interrogation positions, which is occupied by a different nucleotide in each of the three mutant probes and the wildtype probe; a second set of three mutant probes, each identical to the wildtype probe, except in a second of the five interrogation positions, which is occupied by a different nucleotide in each of the three mutant probes and the wildtype probe; a third set of three mutant probes, each identical to the wildtype probe, except in a third of the five interrogation positions, which is occupied by a different nucleotide in each of the three mutant probes and the wildtype probe; a fourth set of three mutant probes, each identical to the wildtype probe, except in a fourth of the five interrogation positions, which is occupied by a different nucleotide in each of the three mutant probes and the wildtype probe; a fifth set of three mutant probes, each identical to the wildtype probe, except in a fifth of the five interrogation positions, which is occupied by a different nucleotide in each of the three mutant probes and the wildtype probe.
96. The array of claim 95 comprising first and second groups of probes, each group as defined by claim 93, the first group comprising a wildtype probe exactly complementary to a first reference sequence, and the second group comprising a wildtype probe exactly complementary to a second reference sequence, wherein the second reference sequence is a mutated form of the first reference sequence.
97. The method of claim 56, wherein the target sequence and the second target sequence are from heterozygous alleles of a CFTR gene.
F53 Chip 98. The array of claim 1 or 2, wherein the reference sequence is a sequence from a p53 gene.
99. The array of claim 2, wherein the reference sequence is from an h-MLHl gene.
100. The array of claim 2, wherein the reference sequence is from an MSH2 gene.
101. The array of claim 28, wherein the reference sequence is from a human P53 gene and the second reference sequence is from an hMLHl gene.
102. The array of claim 101, further comprising: ninth, tenth, eleventh and twelfth probe sets, (1) the ninth probe set comprising a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a third reference sequence, the segment including at least one 6
interrogation position complementary to a corresponding nucleotide in the third reference sequence, (2) the tenth, eleventh and twelfth probe sets, each comprising a corresponding probe for each probe in the ninth probe set, the probes in the tenth, eleventh and twelfth probe sets being identical to a sequence comprising the corresponding probe from the ninth probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the ninth, tenth, eleventh and twelfth probe sets.
103. The array of claim 98, wherein the first probe set has at least 60 interrogation positions corresponding to at 60 contiguous nucleotides from exon 6.
104. The array of claim 99, wherein the reference sequence is exon 5 of a p53 gene, the probes are 17 nucleotides long, and the first set of probes is exactly complementary to the reference sequence, and the at least one interrogation position is at position 7, relative to a 3'-end of each probe, which 3'-end is covalently attached to the substrate. Mitochondrial Chip 105. The array of claim 1 or 2, wherein the reference sequence is from a mitochondrial genome.
106. The array of claim 105, wherein said reference sequence is a sequence of a D-loop region. 107. The array of claim 106, wherein D-loop region is full-length. 108. The array of claim 105, wherein said reference sequence is at least 90% of a full-length mitochondrial genome. 109. The array of claim 105, wherein the reference sequence is bounded by positions 16280 to 356 of the mitochondrial genome.
PCT/US1994/012305 1993-06-25 1994-10-26 Arrays of nucleic acid probes on biological chips WO1995011995A1 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
EP95900441A EP0730663B1 (en) 1993-10-26 1994-10-26 Arrays of nucleic acid probes on biological chips
AU81266/94A AU8126694A (en) 1993-10-26 1994-10-26 Arrays of nucleic acid probes on biological chips
JP7512811A JPH09507121A (en) 1993-10-26 1994-10-26 Nucleic acid probe array on biological chip
DE69433180T DE69433180T2 (en) 1993-10-26 1994-10-26 FIELDS OF NUCLEIC ACID PROBE ON ORGANIC CHIPS
US08/510,521 US7115364B1 (en) 1993-10-26 1995-08-02 Arrays of nucleic acid probes on biological chips
US08/630,427 US6156501A (en) 1993-10-26 1996-04-03 Arrays of modified nucleic acid probes and methods of use
US08/648,709 US6045996A (en) 1993-10-26 1996-05-16 Hybridization assays on oligonucleotide arrays
US08/778,794 US6309823B1 (en) 1993-10-26 1997-01-03 Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US09/393,389 US6632605B1 (en) 1993-10-26 1999-09-10 Hybridization assays on oligonucleotide arrays
US09/510,378 US7399584B2 (en) 1993-10-26 2000-02-22 Method of comparing a target nucleic acid and a reference nucleic acid
US09/798,260 US20030165830A1 (en) 1993-10-26 2001-03-01 Arrays of nucleic acid probes for analyzing biotransformation genes
US10/113,885 US20030134291A1 (en) 1993-06-25 2002-03-28 Polymorphism detection
US10/229,319 US20030054393A1 (en) 1993-06-25 2002-08-27 Methods for polymorphism identification and profiling
US10/402,333 US20030232361A1 (en) 1993-10-26 2003-03-27 Nucleic acid array preparation using purified phosphoramidites
US10/418,414 US7375198B2 (en) 1993-10-26 2003-04-18 Modified nucleic acid probes
US11/367,800 US20060229824A1 (en) 1993-10-26 2006-03-03 Arrays of nucleic acid probes for analyzing biotransformation genes
US11/388,199 US20060263807A1 (en) 1993-06-25 2006-03-24 Methods for polymorphism identification and profiling
US11/401,482 US7846659B2 (en) 1993-10-26 2006-04-11 Arrays of nucleic acid probes for analyzing biotransformation genes
US11/506,176 US20120329677A9 (en) 1993-10-26 2006-08-18 Arrays of nucleic acid probes for detecting cystic fibrosis
US12/124,061 US7794943B2 (en) 1993-10-26 2008-05-20 Modified nucleic acid probes
US12/878,743 US20110092382A1 (en) 1993-10-26 2010-09-09 Modified Nucleic Acid Probes
US12/959,359 US20130150248A1 (en) 1993-10-26 2010-12-02 Arrays of Nucleic Acid Probes for Analyzing Biotransformation Genes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14331293A 1993-10-26 1993-10-26
US08/143,312 1993-10-26
US28406494A 1994-08-02 1994-08-02
US08/284,064 1994-08-02

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US14331293A Continuation-In-Part 1993-06-25 1993-10-26
US28406494A Continuation-In-Part 1993-06-25 1994-08-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US44074295A Continuation-In-Part 1993-10-26 1995-05-10
US08/510,521 Continuation-In-Part US7115364B1 (en) 1993-06-25 1995-08-02 Arrays of nucleic acid probes on biological chips

Publications (2)

Publication Number Publication Date
WO1995011995A1 WO1995011995A1 (en) 1995-05-04
WO1995011995B1 true WO1995011995B1 (en) 1995-05-18

Family

ID=26840907

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/012305 WO1995011995A1 (en) 1993-06-25 1994-10-26 Arrays of nucleic acid probes on biological chips

Country Status (5)

Country Link
EP (1) EP0730663B1 (en)
JP (1) JPH09507121A (en)
AU (1) AU8126694A (en)
DE (1) DE69433180T2 (en)
WO (1) WO1995011995A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846635B1 (en) 1999-07-30 2005-01-25 Large Scale Proteomics Corp. Microarrays and their manufacture
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US7442499B2 (en) 1994-06-17 2008-10-28 The Board Of Trustees Of The Leland Stanford Junior University Substrates comprising polynucleotide microarrays

Families Citing this family (433)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US20020048749A1 (en) * 1998-04-15 2002-04-25 Robert J. Lipshutz Methods for polymorphism identifcation and profiling
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US6045996A (en) * 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US7375198B2 (en) 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6741344B1 (en) 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
GB9417211D0 (en) * 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6600996B2 (en) * 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6720149B1 (en) 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
AU751557B2 (en) * 1995-09-15 2002-08-22 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6380434B1 (en) 1995-10-26 2002-04-30 Long Y. Chiang Fullerene derivatives
US6953663B1 (en) 1995-11-29 2005-10-11 Affymetrix, Inc. Polymorphism detection
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
US6660233B1 (en) 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc Nucleic acid analysis techniques
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US7527928B2 (en) 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US7432048B2 (en) 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
JP2000504575A (en) * 1996-02-08 2000-04-18 アフィメトリックス，インコーポレイテッド Chip-based speciation and phenotypic characterization of microorganisms
EP1728875A3 (en) 1996-02-08 2007-05-09 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6924094B1 (en) 1996-02-08 2005-08-02 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
EP0920440B1 (en) * 1996-02-09 2012-08-22 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6361937B1 (en) 1996-03-19 2002-03-26 Affymetrix, Incorporated Computer-aided nucleic acid sequencing
US6458530B1 (en) * 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
EP0902885A4 (en) 1996-05-16 2006-09-27 Affymetrix Inc Systems and methods for detection of labeled materials
US5858666A (en) * 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
US6329140B1 (en) * 1996-09-19 2001-12-11 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
JP3364230B2 (en) * 1996-11-14 2003-01-08 アフィメトリックス，インコーポレイテッド Chemical amplification for the synthesis of patterned arrays
EP1007969A4 (en) * 1996-12-17 2006-12-13 Affymetrix Inc Lithographic mask design and synthesis of diverse probes on a substrate
DE69830395T2 (en) 1997-03-20 2006-01-26 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara ITERATIVE RESEQUENCING
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
EP1009861A4 (en) 1997-07-25 2002-10-16 Affymetrix Inc Gene expression and evaluation system
US7068830B2 (en) 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
CA2267642A1 (en) * 1997-07-31 1999-02-11 Yoshihide Hayashizaki Methods for detecting mutation in base sequence
US6223127B1 (en) * 1997-08-15 2001-04-24 Affymetrix, Inc. Polymorphism detection utilizing clustering analysis
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6322968B1 (en) 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
US6013449A (en) 1997-11-26 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Probe-based analysis of heterozygous mutations using two-color labelling
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
WO1999047535A1 (en) 1998-03-16 1999-09-23 Millennium Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CHROMOSOME-18p RELATED DISORDERS
US6077673A (en) * 1998-03-31 2000-06-20 Clontech Laboratories, Inc. Mouse arrays and kits comprising the same
US6692909B1 (en) 1998-04-01 2004-02-17 Whitehead Institute For Biomedical Research Coding sequence polymorphisms in vascular pathology genes
WO1999054509A1 (en) * 1998-04-20 1999-10-28 Affymetrix, Inc. Methods for reducing non-specific binding to a nucleic acid probe array
US6525185B1 (en) 1998-05-07 2003-02-25 Affymetrix, Inc. Polymorphisms associated with hypertension
AU3984699A (en) * 1998-05-12 1999-11-29 Whitehead Institute For Biomedical Research Multiplex dna amplification using chimeric primers
US6322976B1 (en) * 1998-05-28 2001-11-27 Medical Research Council Compositions and methods of disease diagnosis and therapy
US6699659B2 (en) 1998-06-01 2004-03-02 Affymetrix, Inc. Products and methods for analyzing nucleic acids including identification of substitutions, insertions and deletions
US6872521B1 (en) 1998-06-16 2005-03-29 Beckman Coulter, Inc. Polymerase signaling assay
US6235473B1 (en) 1998-07-02 2001-05-22 Orchid Biosciences, Inc. Gene pen devices for array printing
US6245507B1 (en) 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
FR2783000B1 (en) * 1998-09-04 2002-07-05 Genolife METHOD FOR AMPLIFYING THE TOTAL DNA FRAGMENTS OF A SAMPLE
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
ATE316152T1 (en) * 1998-10-27 2006-02-15 Affymetrix Inc COMPLEXITY MANAGEMENT AND ANALYSIS OF GENOMIC DNA
US6670464B1 (en) 1998-11-17 2003-12-30 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
AU2395900A (en) * 1998-12-31 2000-07-31 Gene Logic, Inc. Assay device comprising mixed probes
EP1144684B1 (en) * 1999-01-06 2009-08-19 Callida Genomics, Inc. Enhanced sequencing by hybridization using pools of probes
US7005256B1 (en) 1999-03-10 2006-02-28 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
GB9906833D0 (en) * 1999-03-24 1999-05-19 Clatterbridge Cancer Res Trust Genetic analysis
WO2000056923A2 (en) * 1999-03-24 2000-09-28 Clatterbridge Cancer Research Trust Genetic analysis
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
US6518056B2 (en) 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
AU779752B2 (en) * 1999-05-19 2005-02-10 Eppendorf Array Technologies S.A. Method for the identification and/or the quantification of a target compound
EP1054259A1 (en) * 1999-05-19 2000-11-22 Remacle, José Method for the identification of a target compound
US20020086289A1 (en) * 1999-06-15 2002-07-04 Don Straus Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
EP1078993A1 (en) * 1999-08-24 2001-02-28 Biomerieux Method for biochip data analysis
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
WO2001025481A1 (en) 1999-10-04 2001-04-12 Olympus Optical Co., Ltd. Method of detecting nucleic acid
EP1235932A2 (en) 1999-10-08 2002-09-04 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US6423535B1 (en) 1999-11-24 2002-07-23 Incyte Genomics, Inc. Normalization control for hybridization reactions
JP2003516166A (en) 1999-11-24 2003-05-13 インサイト・ゲノミックス・インコーポレイテッド Standardized controls and duplex probes for hybridization reactions
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
EP1111069A1 (en) * 1999-12-22 2001-06-27 BioChip Technologies GmbH Modified nucleic acids and their use
DE60121567T2 (en) * 2000-01-31 2007-07-05 Epidauros Biotechnologie Ag POLYMORPHISMS IN THE PROMOTERREGION OF THE HUMAN CYP2D6 GENE AND THEIR DIAGNOSTIC AND THERAPEUTIC USES
GB0004312D0 (en) 2000-02-23 2000-04-12 Oxagen Limited Test and model for inflammatory disease
CA2402310A1 (en) 2000-03-08 2001-09-13 Complexe Hospitalier De La Sagamie Very low density lipoprotein receptor polymorphisms and uses therefor
WO2001068911A2 (en) * 2000-03-15 2001-09-20 Epigenomics Ag Diagnosis of diseases associated with the cell cycle
US6316608B1 (en) * 2000-03-20 2001-11-13 Incyte Genomics, Inc. Combined polynucleotide sequence as discrete assay endpoints
US7875442B2 (en) 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7205104B2 (en) 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
EP1136566A1 (en) * 2000-03-24 2001-09-26 Facultés Universitaires Notre-Dame de la Paix Method and kit for detection and/or quantification of homologus nucleotide sequences on arrays
WO2001077376A2 (en) * 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with metastasis
AU2001250572A1 (en) * 2000-04-07 2001-10-23 Epigenomics Ag Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
WO2001081633A1 (en) * 2000-04-25 2001-11-01 Whitehead Institute For Biomedical Research Association of protein kinase c zeta polymorphisms with diabetes
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
WO2002000926A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6960569B2 (en) 2000-08-17 2005-11-01 Tripep Ab Hepatitis C virus non-structural NS3/4A fusion gene
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
RU2286172C2 (en) 2000-08-17 2006-10-27 Трипеп Аб Ribavirin-containing vaccines and methods for their application
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
JP2003000268A (en) 2000-08-25 2003-01-07 Pfizer Prod Inc Method and composition for diagnosing and treating disease related to neovascularization
JP2002071687A (en) 2000-08-31 2002-03-12 Canon Inc Screening method for mutant gene
JP3467004B2 (en) 2000-08-31 2003-11-17 キヤノン株式会社 Analysis method of nucleic acid base sequence
JP2005512499A (en) * 2000-09-01 2005-05-12 エピゲノミクス アーゲー Diagnosing the onset of an ongoing or specific disease
KR100870486B1 (en) * 2000-09-01 2008-12-11 에피제노믹스 아게 METHOD FOR DETERMINING THE DEGREE OF METHYLATION OF DEFINED CYTOSINES IN GENOMIC DNA IN THE SEQUENCE CONTEXT 5'-CpG-3'
AU7104200A (en) 2000-09-01 2002-03-22 Gen Probe Inc Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US6849409B2 (en) 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
US6706867B1 (en) 2000-12-19 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services DNA array sequence selection
US6376225B1 (en) * 2001-01-05 2002-04-23 Pe Corporation (Ny) Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
WO2002057283A1 (en) * 2001-01-19 2002-07-25 Baylor College Of Medecine Methods and compositions in breast cancer diagnosis and therapeutics
US7054758B2 (en) 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
CA2440615A1 (en) 2001-03-12 2002-09-19 Affymetrix, Inc. Nucleic acid labeling compounds
FR2822476B1 (en) 2001-03-23 2004-04-02 Aventis Pharma Sa METHODS OF PURIFICATION AND DETECTION OF TARGET SEQUENCES OF DOUBLE-STRANDED DNA BY TRIPLE-HELICE INTERACTION
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US7115726B2 (en) 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
WO2002090599A1 (en) 2001-05-09 2002-11-14 Genetic Id, Inc. Universal microarray system
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
FR2828208A1 (en) * 2001-08-01 2003-02-07 Cytomics Systems New nucleic acids encoding F-box proteins, useful e.g. for treatment of cancer or inflammation, also new proteins, antibodies and modulators
IL160229A0 (en) 2001-08-10 2004-07-25 Genset Sa Polynucleotides, polypeptides encoded thereby and their use
MXPA04001460A (en) 2001-08-14 2005-02-17 Sentigen Biosciences Inc Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof.
US6799122B2 (en) 2001-08-31 2004-09-28 Conagra Grocery Products Company Method for identifying polymorphic markers in a population
CA2465953A1 (en) 2001-11-09 2003-05-15 Georgetown University Novel isoforms of vascular endothelial cell growth inhibitor
WO2003054226A2 (en) 2001-12-10 2003-07-03 Novartis Ag Methods of treating psychosis and schizophrenia based on a polymorphism in the ctf gene
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
DE10208770A1 (en) * 2002-02-28 2003-09-04 Febit Ag Increasing the sensitivity and specificity of hybridization experiments with nucleic acid chips
AU2003219994B2 (en) * 2002-03-04 2009-04-09 The Texas A & M University System Quantitative trait loci and somatostatin
US7935500B2 (en) 2002-03-26 2011-05-03 Massachusetts Institute Of Technology Identifying calcineurin activators for treatment of schizophrenia
WO2004022758A1 (en) * 2002-09-05 2004-03-18 Plant Bioscience Limited Genome partitioning
FR2846339B1 (en) * 2002-10-28 2007-09-07 Ipsogen METHOD FOR ANALYZING A COMPLEX BIOLOGICAL STATE OF A BIOSYSTEM AND SUPPORT FOR ITS DIRECT INTERPRETATION
EP2151507B1 (en) 2002-12-20 2013-02-13 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
CA2513191A1 (en) * 2003-01-30 2004-08-12 Research Development Foundation Methods and compositions for analysis of mitochondrial-related gene expression
FR2850669A1 (en) * 2003-02-05 2004-08-06 Centre Nat Rech Scient Preparation of nucleic acid probes for detecting expression of genes induced by inflammatory mediators, useful e.g. for adapting or optimizing treatment and for characterizing T cell responses
BR0318307A (en) 2003-05-21 2006-07-11 Ares Trading Sa polypeptide, purified nucleic acid molecule, vector, host cell, ligand, compound, method for diagnosing a disease in a patient, use of a polypeptide, pharmaceutical composition, vaccine composition, methods for treating a disease for monitoring therapeutic treatment of disease in a patient, method for identifying a compound that is effective in treating and / or diagnosing disease, kit, and transgenic, non-human animal or knockout
US20050014168A1 (en) * 2003-06-03 2005-01-20 Arcturus Bioscience, Inc. 3' biased microarrays
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005001125A1 (en) * 2003-06-27 2005-01-06 Olympus Corporation Method of judging mutation and polymorphism in nucleic acid
JPWO2005001091A1 (en) * 2003-06-27 2006-08-10 オリンパス株式会社 Probe set for detecting nucleic acid mutation and polymorphism, DNA array on which it is immobilized, and method for detecting mutation and polymorphism using the same
ZA200601330B (en) 2003-07-14 2010-10-27 Internat Livestock Res Inst East coast fever vaccine based on CTL-specific schizont antigens
US7329490B2 (en) 2003-09-15 2008-02-12 Bristol-Myers Squibb Company Methods for diagnosing schizophrenia by detecting a polymorphism in the KalphaM1 gene
US7964344B2 (en) 2003-09-17 2011-06-21 Canon Kabushiki Kaisha Stable hybrid
CA2541473A1 (en) 2003-10-10 2005-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusale M Method and kit for assessing anxiety or disposition thereto in a subject
WO2005056837A2 (en) 2003-11-26 2005-06-23 Applera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
JPWO2005056834A1 (en) * 2003-12-10 2007-07-05 オリンパス株式会社 Nucleic acid sequence analysis method
WO2005061711A1 (en) * 2003-12-24 2005-07-07 Samsung Electronics Co., Ltd. A polynucleotide associated with a type ii diabetes mellitus comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for analyzing polynucleotide using the same
GB0403039D0 (en) * 2004-02-11 2004-03-17 Health Prot Agency TB resistance assay
WO2005113815A2 (en) * 2004-04-26 2005-12-01 Uab Research Foundation Polymorphisms in the fcgr2b promoter and uses thereof
EP1745154B1 (en) 2004-05-07 2012-08-01 Celera Corporation Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
EP2290066B1 (en) 2004-05-28 2015-03-18 Asuragen, Inc. Methods and compositions involving microRNA
US7338763B2 (en) 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
US20060003345A1 (en) 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
KR101233565B1 (en) * 2004-08-04 2013-02-14 산토리 홀딩스 가부시키가이샤 Bacteria detection device, bacteria detection method and bacteria detection kit
GB0417887D0 (en) 2004-08-11 2004-09-15 Ares Trading Sa Protein
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
FI20041204A0 (en) 2004-09-16 2004-09-16 Riikka Lund Methods for the utilization of new target genes associated with immune-mediated diseases
FR2877013A1 (en) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris INDENTIFICATION OF A JAK2 MUTATION INVOLVED IN THE VAQUEZ POLYGLOBULIA
ES2534303T3 (en) 2004-11-12 2015-04-21 Asuragen, Inc. Procedures and compositions involving miRNA and miRNA inhibitor molecules
US7919093B2 (en) 2004-11-16 2011-04-05 Trustees Of Boston University Roles for dual endothelin-1/angiotensin II receptor (Dear) in hypertension and angiogenesis
JP4882074B2 (en) * 2005-02-28 2012-02-22 国立大学法人東京工業大学 Oligonucleotide derivative, gene detection probe and DNA chip
JP5590697B2 (en) 2005-03-11 2014-09-17 セレラ コーポレーション Genetic polymorphism associated with coronary heart disease, detection method and use thereof
MX2007011336A (en) * 2005-03-16 2007-11-23 Univ Guelph Bovine cast gene snp and meat tenderness.
KR20080011289A (en) * 2005-05-10 2008-02-01 시너젠즈 바이오사이언스 리미티드 Ingredients and methods for evaluating pulmonary function and lung disease
CA2618429A1 (en) 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
CA2611743C (en) 2005-06-15 2019-12-31 Callida Genomics, Inc. Nucleic acid analysis by forming and tracking aliquoted fragments of a target polynucleotide
US7897749B2 (en) * 2005-07-13 2011-03-01 Wisconsin Alumni Research Foundation Dairy cattle breeding for improved milk production traits in cattle
US7807361B2 (en) * 2005-07-13 2010-10-05 Wisconsin Alumni Research Foundation Dairy cattle breeding for improved milk production traits in cattle
BRPI0614851A2 (en) 2005-08-19 2011-04-19 Commw Scient Ind Res Org arachnocampa luciferases
WO2007028147A2 (en) 2005-09-01 2007-03-08 Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin Identification of a prostatic intraepithelial neoplasia (pin)-specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US20100292339A1 (en) * 2005-10-05 2010-11-18 Zeisel Steven H Genetic Polymorphisms Predictive of Nutritional Requirements for Choline in Subjects
WO2007047634A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of California Method to diagnose, predict treatment response and develop treatments for psychiatric disorders using markers
US8440695B2 (en) 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
EP1952147A2 (en) 2005-11-16 2008-08-06 Novartis AG Biomarkers for anti-nogo-a antibody treatment in spinal cord injury
EP1954821B1 (en) * 2005-11-21 2015-07-29 Haplomic Technologies Pty Ltd Method and probes for identifying a nucleotide sequence
CA2631621C (en) * 2005-11-29 2019-08-06 Cambridge Enterprise Limited Markers for breast cancer including rs2981582
US20110053789A1 (en) * 2006-01-05 2011-03-03 Simons Haplomics Limited Mircoarray methods
CA2635343C (en) 2006-01-27 2018-05-15 Athena Diagnostics, Inc. Methods of detecting mutations associated with ataxia-ocular apraxia 2 (aoa2)
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2041311A4 (en) * 2006-06-23 2010-07-07 Myriad Genetics Inc Dpyd gene variants and use thereof
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008060362A2 (en) 2006-09-27 2008-05-22 The Regents Of The University Of California Methods and compositions for the treatment of skin diseases and disorders
WO2008045251A2 (en) 2006-10-04 2008-04-17 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
EP2431483B1 (en) 2006-10-20 2015-04-01 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
DK2120543T3 (en) 2006-12-21 2019-01-14 Agriculture Victoria Serv Pty METHOD AND REAGENTS OF ARTIFICIAL SELECTION
WO2008084405A2 (en) 2007-01-11 2008-07-17 Erasmus University Medical Center Circular chromosome conformation capture (4c)
US20090203011A1 (en) * 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
CA2674907C (en) 2007-01-31 2017-04-04 Celera Corporation A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
EP2155907B1 (en) * 2007-04-30 2015-05-27 Decode Genetics EHF Genetic variants useful for risk assessment of coronary artery disease and myocardial infarction
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
EP2527472B1 (en) 2007-05-31 2016-09-28 Yale University A genetic lesion associated with cancer
AU2008255641B2 (en) 2007-05-31 2014-03-13 Board Of Regents Of The University Of Texas System Diagnostic markers for ankylosing spondylitis and uses thereof
US20100254973A1 (en) * 2007-06-21 2010-10-07 The Nemours Foundation Materials and Methods for Diagnosis of Asthma
CA2691166A1 (en) 2007-06-27 2008-12-31 Liu Dongxu Polypeptides and polynucleotides for artemin and related ligands, and methods of use thereof
US8685642B2 (en) * 2007-07-30 2014-04-01 Agilent Technologies, Inc. Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays
ES2453108T3 (en) 2007-08-06 2014-04-04 Orion Genomics, Llc New single nucleotide polymorphisms and combinations of new and known polymorphisms to determine the specific allele expression of the IGF2 gene
EP2185195A2 (en) 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US9296789B2 (en) 2007-09-25 2016-03-29 Pastoral Greenhouse Gas Research Ltd. Vaccines and vaccine components for inhibition of microbial cells
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
CA2705261A1 (en) * 2007-11-07 2009-05-14 Wisconsin Alumni Research Foundation Methods and compositions for improved cattle longevity and milk production
US20110143345A1 (en) * 2007-11-14 2011-06-16 Medtronic, Inc. Genetic Markers for SCD or SCA Therapy Selection
WO2009064970A1 (en) * 2007-11-14 2009-05-22 Medtronic, Inc. Genetic markers for scd or sca therapy selection
CA2705486C (en) 2007-11-19 2019-04-02 Celera Corporation Lung cancer markers and uses thereof
EP2570501A3 (en) 2008-01-02 2013-04-10 Suregene Llc Genetic markers of mental illness
CA2712075A1 (en) 2008-01-17 2009-07-23 Suregene Llc Genetic markers of mental illness
US8003328B2 (en) * 2008-02-01 2011-08-23 The Board Of Trustees Of The University Of Arkansas Bovine polymorphisms and methods of predicting bovine traits
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CA2716849A1 (en) * 2008-02-27 2009-09-03 University Of Saskatchewan Methods and kits for detecting congenital stationary night blindness and selecting different coat patterns
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
WO2009146203A1 (en) * 2008-04-18 2009-12-03 Wisconsin Alumni Research Foundation (Warf) Methods and compositions for improved fertilization and embryonic survival
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20110111417A1 (en) * 2008-05-14 2011-05-12 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
EP2993239A1 (en) 2008-05-16 2016-03-09 AstraZeneca AB Methods for identifying subjects with an increased likelihood of responding to dpp-iv inhibitors
EP2310525B1 (en) 2008-07-09 2014-02-26 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
WO2010010057A2 (en) * 2008-07-24 2010-01-28 Merck Serono S.A. Use of genetic markers for identifying the response to interferon treatment in multiple sclerosis patients
EP2172563A1 (en) * 2008-09-24 2010-04-07 bioMérieux S.A. Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
EP2868753A1 (en) 2008-09-25 2015-05-06 SureGene LLC Genetic markers for optimizing treatment for Schizophrenia
CA2743704A1 (en) 2008-12-15 2010-07-08 Wisconsin Alumni Research Foundation Methods and compositions for testing and breeding cattle for improved fertility and embryonic survival
JP5748672B2 (en) 2009-02-11 2015-07-15 オリオン ゲノミクス エルエルシー Combination of polymorphisms to determine allele-specific expression of IGF2
EP2221387A1 (en) 2009-02-19 2010-08-25 Université de la Méditerranée Fibrosis susceptibility gene and uses thereof
US20120165202A1 (en) * 2009-04-30 2012-06-28 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc Methods and compositions for evaluating genetic markers
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
ES2700098T3 (en) * 2009-05-15 2019-02-14 Insight Genetics Inc Methods related to ALK fusions to diagnose cancer
CA2763500C (en) 2009-06-01 2019-09-03 Genetic Technologies Limited Methods for breast cancer risk assessment
EP2264183B1 (en) 2009-06-09 2016-12-07 Gendiag.exe, S.L. Risk markers for cardiovascular disease
WO2010148115A1 (en) 2009-06-18 2010-12-23 The Penn State Research Foundation Methods, systems and kits for detecting protein-nucleic acid interactions
JP5817038B2 (en) * 2009-06-22 2015-11-18 洋孝 松尾 Uric acid transporter, uric acid transport-related disease predisposition and inflammation-related disease predisposition evaluation method and evaluation kit, test body and medicine
US20120156676A1 (en) 2009-06-25 2012-06-21 Weidhaas Joanne B Single nucleotide polymorphisms in brca1 and cancer risk
WO2011006169A1 (en) 2009-07-10 2011-01-13 Portola Pharmaceuticals, Inc. Methods for diagnosis and treatment of thrombotic disorders mediated by cyp2c19*2
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
NZ750559A (en) 2009-08-27 2023-01-27 Pastoral Greenhouse Gas Res Ltd Complete genome sequence of the methanogen methanobrevibacter ruminantium
WO2011027219A1 (en) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. High throughput detection of small genomic deletions and insertions
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
WO2011044162A1 (en) 2009-10-06 2011-04-14 Shire Human Genetic Therapies Assays for agents affecting megakaryocyte development
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
FR2954349A1 (en) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech SULFATASE SELECTIVELY MODIFYING GLYCOSAMINOGLYCANS
US20130071408A1 (en) 2010-02-01 2013-03-21 Atul J. Butte Methods for Diagnosis and Treatment of Non-Insulin Dependent Diabetes Mellitus
ES2631458T3 (en) 2010-03-04 2017-08-31 Interna Technologies B.V. MRNA molecule defined by its source and its therapeutic uses in cancer associated with EMT
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
US20130203054A1 (en) * 2010-05-04 2013-08-08 Universite D'aix-Marseille Antiviral treatment susceptibility gene and uses thereof
WO2011150228A1 (en) * 2010-05-26 2011-12-01 The Children's Hospital Of Philadelphia Research Institute Compositions and methods for the diagnosis and treatment of primary insulin-like growth factor deficiency (pigfd) and idiopathic short stature (iss)
EP2576837B1 (en) 2010-06-04 2017-09-06 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
CN103119176A (en) 2010-06-07 2013-05-22 霍夫曼-拉罗奇有限公司 Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
US8530157B2 (en) 2010-07-01 2013-09-10 Agilent Technologies, Inc. SNP-dependent end labeling method
NZ704322A (en) 2010-07-06 2016-07-29 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CN103140581A (en) 2010-07-16 2013-06-05 托卡根公司 Retrovirus detection
CN103392182B (en) 2010-08-02 2017-07-04 众有生物有限公司 System and method for finding pathogenic mutation in genetic disease
WO2012027302A2 (en) * 2010-08-21 2012-03-01 The Regents Of The University Of California Systems and methods for detecting antibiotic resistance
CA2819230A1 (en) 2010-10-28 2012-05-03 Yale University Methods and compositions for assessing and treating cancer
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
BR112013012265A2 (en) 2010-11-17 2016-08-02 Asuragen Inc mirnas as biomarkers to distinguish benign from malignant thyroid neoplasms
EP2643470B1 (en) 2010-11-24 2016-02-03 Yale University Compositions and methods for treating ischemic injury with d-dt
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
US9335289B2 (en) 2011-02-07 2016-05-10 The Governing Council Of The University Of Toronto Bioprobes and methods of use thereof
MX2013009863A (en) 2011-02-28 2013-12-06 Univ Iowa Res Found ANTI-MÃœLLERIAN HORMONE CHANGES IN PREGNANCY AND PREDICTION OFADVERSE PREGNANCY OUTCOMES AND GENDER.
PL2694959T3 (en) * 2011-04-01 2020-05-18 Genentech, Inc. Biomarkers for predicting susceptibility in cancer treatment
EP2694678A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
EP2694677A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
US10081658B2 (en) 2011-04-25 2018-09-25 Advanced Bioscience Laboratories, Inc. Truncated HIV envelope proteins (ENV), methods and compositions related thereto
DK2739748T3 (en) 2011-08-05 2019-06-24 Univ Aix Marseille IL22RA2 GEN WITH FIBROSE SENSITIVITY AND USE THEREOF
ES2589455T3 (en) 2011-08-31 2016-11-14 F. Hoffmann-La Roche Ag Method to predict the risk of hypertension associated with antiangiogenesis therapy
KR20140064923A (en) 2011-08-31 2014-05-28 에프. 호프만-라 로슈 아게 Responsiveness to angiogenesis inhibitors
EP2763540A4 (en) 2011-09-09 2015-04-22 Univ Yale COMPOSITIONS AND METHODS FOR EVALUATION AND TREATMENT OF DISEASES AND INFLAMMATORY DISORDERS
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
US20130090329A1 (en) 2011-10-07 2013-04-11 Suregene, Llc Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature
DK2766483T3 (en) 2011-10-10 2022-04-19 Hospital For Sick Children PROCEDURES AND COMPOSITIONS FOR SCREENING AND TREATING DEVELOPMENTAL DISORDERS
EP2768983A4 (en) 2011-10-17 2015-06-03 Good Start Genetics Inc Analysis methods
WO2013066641A1 (en) 2011-10-21 2013-05-10 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (en) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
SG11201402554SA (en) 2011-11-23 2014-06-27 Hoffmann La Roche Responsiveness to angiogenesis inhibitors
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
FR2984360B1 (en) * 2011-12-20 2017-11-24 Biomerieux Sa METHOD FOR IN VITRO DIAGNOSIS OR PROGNOSIS OF COLON CANCER
EP2807275A1 (en) 2012-01-24 2014-12-03 The United States of America, as represented by the Secretary, Department of Health and Human Services Schizophrenia-related isoform of knch2 and development of antipsycotic drugs
EP2812452B1 (en) 2012-02-09 2020-05-27 Population Bio, Inc. Methods and compositions for screening and treating developmental disorders
KR102018934B1 (en) 2012-02-27 2019-09-06 도레이 카부시키가이샤 Nucleic acid detection method
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
EP2834371B1 (en) 2012-04-05 2019-01-09 The Regents of The University of California Gene expression panel for breast cancer prognosis
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
ES2426517B1 (en) * 2012-04-20 2014-05-14 Genetracer Biotech S.L Method to predict the safety of a drug treatment
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
EP2870263A1 (en) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnostic portfolio and its uses
US20140066316A1 (en) 2012-08-28 2014-03-06 The Chinese University Of Hong Kong DACH1 as a Biomarker for Diabetes
WO2014043519A1 (en) 2012-09-14 2014-03-20 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
EP2900835B1 (en) 2012-09-27 2025-04-30 Population Bio, Inc. Method for screening and treating developmental disorders
WO2014049588A1 (en) 2012-09-27 2014-04-03 University College Dublin, National University Of Ireland, Dublin A method for treatment of pulmonary fibrosis and diagnosis or prognosis of an aggressive pulmonary fibrosis phenotype
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
WO2014074651A1 (en) * 2012-11-06 2014-05-15 The Trustees Of Columbia University In The City Of New York Techniques for treating acute lymphoblastic leukemia (all)
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
GB2547875B (en) 2013-02-01 2017-12-13 Univ California Methods for meta-genomics analysis of microbes
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
EP3366785A3 (en) 2013-03-15 2018-09-19 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
ES2685549T3 (en) 2013-03-15 2018-10-09 Illumina Cambridge Limited Nucleosides or modified nucleotides
EP2970909A4 (en) 2013-03-15 2017-02-15 The University of Chicago Methods and compositions related to t-cell activity
CA2907377A1 (en) 2013-03-15 2014-09-18 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
WO2014197377A2 (en) 2013-06-03 2014-12-11 Good Start Genetics, Inc. Methods and systems for storing sequence read data
IL273519B2 (en) 2013-07-01 2023-04-01 Illumina Inc Catalyst-free surface functionalization and polymer grafting
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
FI3511422T3 (en) 2013-11-12 2023-01-31 Methods and compositions for diagnosing, prognosing, and treating endometriosis
CN114089597B (en) 2013-12-19 2025-03-14 Illumina公司 Substrate comprising a nano-patterned surface and method for preparing the same
US20150184251A1 (en) * 2014-01-02 2015-07-02 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Methods for screening muscle invasive bladder cancer patients for neoadjuvant chemotherapy responsiveness
GB201403820D0 (en) * 2014-03-04 2014-04-16 Isis Innovation Assay
EP3122905B1 (en) 2014-03-27 2020-09-09 Yale University Circulating micrornas as biomarkers for endometriosis
EP3140429B1 (en) 2014-05-05 2020-02-19 Medtronic Inc. Methods for scd, crt, crt-d, or sca therapy identification and/or selection
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
EP3174980A4 (en) 2014-08-01 2018-01-17 Dovetail Genomics, LLC Tagging nucleic acids for sequence assembly
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
US20160046994A1 (en) * 2014-08-13 2016-02-18 Regents Of The University Of Minnesota Novel cd177 haplotypes, their role in hna-2 deficiency, and methods of using
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
CN107076739B (en) 2014-08-21 2018-12-25 伊卢米纳剑桥有限公司 Reversible surface functionalization
WO2016033439A2 (en) 2014-08-28 2016-03-03 Yale University Compositions and methods for the treating an inflammatory disease or disorder
GB2558326B (en) 2014-09-05 2021-01-20 Population Bio Inc Methods and compositions for inhibiting and treating neurological conditions
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
JP6639054B2 (en) * 2014-09-17 2020-02-05 ヴイアイティーオー エヌヴイ Methods and means for analyzing hybridization
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
WO2016049694A1 (en) 2014-09-30 2016-04-07 Genetic Technologies Limited Methods for assessing risk of developing breast cancer
EP3970849A1 (en) 2014-10-31 2022-03-23 Illumina Cambridge Limited Polymers and dna copolymer coatings
JP7231326B2 (en) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Therapeutic and diagnostic methods for IL-33-mediated disorders
EP3226869A4 (en) 2014-12-03 2018-07-18 Auckland UniServices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
US10066259B2 (en) 2015-01-06 2018-09-04 Good Start Genetics, Inc. Screening for structural variants
WO2016134034A1 (en) 2015-02-17 2016-08-25 Dovetail Genomics Llc Nucleic acid sequence assembly
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
TWI582240B (en) 2015-05-19 2017-05-11 鄭鴻鈞 Prediction of local and regional recurrence and response to radiotherapy in breast cancer by genomic prognostic kits
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
JP7300831B2 (en) 2015-10-19 2023-06-30 ダブテイル ゲノミクス エルエルシー Methods for Genome Assembly, Haplotype Phasing, and Target-Independent Nucleic Acid Detection
AU2017223600B2 (en) 2016-02-23 2023-08-03 Dovetail Genomics Llc Generation of phased read-sets for genome assembly and haplotype phasing
WO2017158141A1 (en) * 2016-03-17 2017-09-21 Vito Nv Methods for detecting nucleotide variants
DK3455356T3 (en) 2016-05-13 2021-11-01 Dovetail Genomics Llc RECOVERY OF LONG-TERM BINDING INFORMATION FROM PRESERVED SAMPLES
US10900076B2 (en) 2016-05-18 2021-01-26 Illumina, Inc. Self assembled patterning using patterned hydrophobic surfaces
US11725232B2 (en) 2016-10-31 2023-08-15 The Hong Kong University Of Science And Technology Compositions, methods and kits for detection of genetic variants for alzheimer's disease
WO2018098241A1 (en) 2016-11-22 2018-05-31 University Of Rochester Methods of assessing risk of recurrent prostate cancer
GB201701719D0 (en) 2017-02-02 2017-03-22 Neumann Diagnostics Ltd Method of assessing risk
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
EP3601602B1 (en) 2017-03-29 2024-04-10 Crown Bioscience, Inc. (Taicang) System and method for determining cetuximab sensitivity on gastric cancer
JP7377544B2 (en) 2017-05-17 2023-11-10 マイクロバイオ・プロプライエタリー・リミテッド Biomarkers and their use
WO2019043656A1 (en) 2017-09-01 2019-03-07 Genus Plc Methods and systems for assessing and/or quantifying sex skewed sperm cell populations
JP2021501594A (en) 2017-11-03 2021-01-21 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． MiRNA molecules, equivalents, antagomils, or sources thereof for treating and / or diagnosing conditions and / or diseases associated with neuronal defects, or for neuronal regeneration / development.
WO2019104155A2 (en) 2017-11-22 2019-05-31 The University Of Chicago Chemical probe-dependent evaluation of protein activity and uses thereof
EP3746566A1 (en) 2018-01-31 2020-12-09 Dovetail Genomics, LLC Sample prep for dna linkage recovery
EP3749362A1 (en) 2018-02-09 2020-12-16 F. Hoffmann-La Roche AG Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
FI3625368T3 (en) 2018-08-08 2023-01-13 Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing
WO2020053808A1 (en) 2018-09-12 2020-03-19 Georg Dewald Method of diagnosing vasoregulatory disorders
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
EP3947727A4 (en) 2019-04-05 2023-01-04 Board of Regents, The University of Texas System METHODS AND APPLICATIONS OF CELL BARCODING
JP7566775B2 (en) 2019-04-12 2024-10-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Compositions and methods for increasing muscle mass and oxidative metabolism
EP4545965A3 (en) 2019-06-27 2025-06-11 Dovetail Genomics, LLC Methods and compositions for proximity ligation
MX2022005327A (en) 2019-11-27 2022-08-04 Illumina Cambridge Ltd DYES AND COMPOSITIONS CONTAINING CYCLOOCTATETRAENE.
US20230110203A1 (en) 2020-03-13 2023-04-13 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
MA58991B1 (en) 2020-06-22 2024-09-30 Illumina Cambridge Limited NUCLEOSIDES AND NUCLEOTIDES WITH 3' ACETAL BLOCKING GROUP
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN111961763A (en) * 2020-09-17 2020-11-20 生捷科技(杭州)有限公司 Novel gene chip for detecting coronavirus
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
CA3215598A1 (en) 2021-05-05 2022-11-10 Michael Callingham Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
EP4341434A1 (en) 2021-05-20 2024-03-27 Illumina, Inc. Compositions and methods for sequencing by synthesis
CN117677435A (en) 2021-06-15 2024-03-08 伊鲁米纳公司 Surface functionalization of non-aqueous gels for sequencing
WO2023004357A1 (en) 2021-07-23 2023-01-26 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
AU2023240337A1 (en) 2022-03-22 2024-01-18 Illumina, Inc. Substrate with orthogonally functional nanodomains
CA3223115A1 (en) 2022-03-28 2023-10-05 Xiaolin Wu Labeled avidin and methods for sequencing
EP4499758A1 (en) 2022-03-29 2025-02-05 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
WO2023194369A1 (en) 2022-04-08 2023-10-12 Fundació Institut Mar D'investigacions Mèdiques (Imim) Genetic markers for severe covid-19
AU2023281871A1 (en) 2022-05-31 2024-11-14 Illumina, Inc Compositions and methods for nucleic acid sequencing
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
US20240140939A1 (en) 2022-09-30 2024-05-02 Illumina Cambridge Limited Compositions and methods for reducing photo damage during sequencing
US20240219835A1 (en) 2022-12-07 2024-07-04 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
WO2024137774A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
AU2023419253A1 (en) 2022-12-27 2024-10-03 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
WO2024206407A2 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
WO2024206394A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing
US20250010291A1 (en) 2023-06-28 2025-01-09 Illumina, Inc. Photoresist patterning in multi-depth nanowells
WO2025006460A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with modified bases
WO2025006464A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with alternative scatterplots
WO2025006466A1 (en) 2023-06-30 2025-01-02 Illumina, Inc. Systems and methods of sequencing polynucleotides with four labeled nucleotides
WO2025049700A1 (en) 2023-08-31 2025-03-06 Illumina, Inc. Compositions and methods for nucleic acid sequencing
US20250137048A1 (en) 2023-10-26 2025-05-01 Illumina, Inc. 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing
US20250163505A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Conjugated polymers or polymer dots as fluorescent labels
US20250197933A1 (en) 2023-12-18 2025-06-19 Illumina, Inc. Hydrogel nanoparticles as labeling scaffold in sequencing
WO2025144716A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
US20250215494A1 (en) 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing
WO2025184226A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. Nucleotides with terminal phosphate capping
WO2025188906A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Modified adenosine nucleotides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5002867A (en) * 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
EP1231282A3 (en) * 1990-12-06 2005-05-18 Affymetrix, Inc. Methods and compositions for identification of polymers
ATE278807T1 (en) * 1992-02-19 2004-10-15 New York Health Res Inst NEW ARRANGEMENTS OF OLIGONUCLEOTIDES AND THEIR USE FOR SORTING, ISOLATION, SEQUENCING AND MANIPULATION OF NUCLEIC ACIDS

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442499B2 (en) 1994-06-17 2008-10-28 The Board Of Trustees Of The Leland Stanford Junior University Substrates comprising polynucleotide microarrays
US6846635B1 (en) 1999-07-30 2005-01-25 Large Scale Proteomics Corp. Microarrays and their manufacture
US6887701B2 (en) 1999-07-30 2005-05-03 Large Scale Proteomics Corporation Microarrays and their manufacture
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing

Similar Documents

Publication Publication Date Title
WO1995011995B1 (en) Arrays of nucleic acid probes on biological chips
US6268147B1 (en) Nucleic acid analysis using sequence-targeted tandem hybridization
CA1340121E (en) Process for amplifying, detecting and/or cloning nucleic acid sequences
EP0164054B1 (en) Method for detection of polymorphic restriction sites and nucleic acid sequences
KR900008742B1 (en) How to Augment Nucleic Acid Sequences
EP2287308B1 (en) Materials and methods for identifying and analyzing intermediate tandem repeat DNA markers
CA1339979C (en) Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes
WO1998030883A2 (en) Analysis of genetic polymorphisms and gene copy number
WO1998030883A9 (en) Analysis of genetic polymorphisms and gene copy number
WO2000026412A1 (en) Nucleic acid analysis using sequence-targeted tandem hybridization
Arcot et al. Alu fossil relics--distribution and insertion polymorphism.
Arcot et al. Identification and analysis of a ‘young’polymorphic Alu element
EP0511559A1 (en) Oligonucleotide probe reagent
WO1998038846A2 (en) Genetic compositions and methods
US7056705B2 (en) Multiplex PCR primer set for human glucokinase gene amplification
Collick et al. Minisatellite binding protein Msbp-1 is a sequence-specific single-stranded DNA-binding protein
US20020182606A1 (en) Detection of single nucleotide polymorphisms
Giacomoni The origin of DNA: RNA hybridization
young Mun et al. SNPs detection by a single-strand specific nuclease on a PNA zip-code microarray
WO2003066827A2 (en) Methods and compositions for detecting differences between nucleic acids
Rogers et al. Variability in nuclear DNA among nonhuman primates: Application of molecular genetic techniques to intra‐and inter‐species genetic analyses
US20030129598A1 (en) Methods for detection of differences in nucleic acids
WO2003066870A2 (en) Method for detecting polymorphisms in nucleic acids
Irving et al. Mouse chromosome-specific markers generated by PCR and their mapping through interspecific backcrosses
JP2003199593A (en) Multiplex PCR primer set for human HNF-1α gene amplification