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WO1995027199A1 - Procede chromatographique et modes d'utilisation - Google Patents

Procede chromatographique et modes d'utilisation Download PDF

Info

Publication number
WO1995027199A1
WO1995027199A1 PCT/GB1995/000693 GB9500693W WO9527199A1 WO 1995027199 A1 WO1995027199 A1 WO 1995027199A1 GB 9500693 W GB9500693 W GB 9500693W WO 9527199 A1 WO9527199 A1 WO 9527199A1
Authority
WO
WIPO (PCT)
Prior art keywords
disc
channel
sample
chromatography system
bag
Prior art date
Application number
PCT/GB1995/000693
Other languages
English (en)
Inventor
Nils Magnus Hjelm
Original Assignee
Nils Magnus Hjelm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nils Magnus Hjelm filed Critical Nils Magnus Hjelm
Priority to AU20770/95A priority Critical patent/AU2077095A/en
Publication of WO1995027199A1 publication Critical patent/WO1995027199A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/204—Linearly moving valves, e.g. sliding valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G01N2030/8417—Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Ce procédé de chromatographie liquide comprend un disque (4) chromatographique destiné à dissoudre des molécules dans un échantillon liquide, un dispositif de chargement d'échantillon (2) dans lequel vient se loger le disque (4) et qui possède un ou plusieurs canaux (16) de stockage destinés à prendre un volume prédéterminé de l'échantillon par capillarité pour le distribuer au disque (4), ainsi que des moyens (18) destinés à distribuer un tampon et/ou éluant au disque. Le dispositif de chargement d'échantillon (2) peut comprendre un corps (6) servant en tant que logement du disque (4) et possédant: (i) un canal de chargement (8) destiné à diriger le liquide sur le disque (4) ou vers celui-ci, ce canal comprenant une portion afférente dotée d'un orifice d'entrée (10) destiné à diriger le liquide vers le disque (4) ainsi qu'une portion afférente dotée d'un orifice de sortie (12) destiné à diriger le liquide en dehors du disque, et (ii) un élément (14) sélecteur (par exemple un disque rotatif ou une tige coulissante) monté mobile sur le corps (6) de manière à interrompre la portion afférente du canal de chargement (8).
PCT/GB1995/000693 1994-03-31 1995-03-28 Procede chromatographique et modes d'utilisation WO1995027199A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU20770/95A AU2077095A (en) 1994-03-31 1995-03-28 Chromatography system and methodology

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9406551A GB9406551D0 (en) 1994-03-31 1994-03-31 Chromatography system and methodology
GB9406551.3 1994-03-31

Publications (1)

Publication Number Publication Date
WO1995027199A1 true WO1995027199A1 (fr) 1995-10-12

Family

ID=10752930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/000693 WO1995027199A1 (fr) 1994-03-31 1995-03-28 Procede chromatographique et modes d'utilisation

Country Status (3)

Country Link
AU (1) AU2077095A (fr)
GB (1) GB9406551D0 (fr)
WO (1) WO1995027199A1 (fr)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6597438B1 (en) 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
US6970245B2 (en) 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US7016022B2 (en) 2000-08-02 2006-03-21 Honeywell International Inc. Dual use detectors for flow cytometry
US7061595B2 (en) 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US7130046B2 (en) 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
US7215425B2 (en) 2000-08-02 2007-05-08 Honeywell International Inc. Optical alignment for flow cytometry
US7242474B2 (en) 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US7262838B2 (en) 2001-06-29 2007-08-28 Honeywell International Inc. Optical detection system for flow cytometry
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7283223B2 (en) 2002-08-21 2007-10-16 Honeywell International Inc. Cytometer having telecentric optics
US7420659B1 (en) 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
US7471394B2 (en) 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US7553453B2 (en) 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
US7612871B2 (en) 2004-09-01 2009-11-03 Honeywell International Inc Frequency-multiplexed detection of multiple wavelength light for flow cytometry
US7630075B2 (en) 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
US7630063B2 (en) 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7641856B2 (en) 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7978329B2 (en) 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US8980635B2 (en) 2011-12-27 2015-03-17 Honeywell International Inc. Disposable cartridge for fluid analysis
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
WO2017076817A1 (fr) * 2015-11-05 2017-05-11 Alere San Diego, Inc. Dispositif de préparation d'échantillons
US9823252B2 (en) 2004-12-03 2017-11-21 Cytonome/St, Llc Unitary cartridge for particle processing
US11027278B2 (en) 2002-04-17 2021-06-08 Cytonome/St, Llc Methods for controlling fluid flow in a microfluidic system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017328A1 (fr) * 1992-02-20 1993-09-02 Drew Scientific Limited Appareil de chromatographie en phase liquide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017328A1 (fr) * 1992-02-20 1993-09-02 Drew Scientific Limited Appareil de chromatographie en phase liquide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D. JOSIC ET AL.: "high-performance membrans chromatography of serum and plasma membrane proteins", JOURNAL OF CHROMATOGRAPHY, vol. 590, 1992, AMSTERDAM NL, pages 59 - 76 *

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7420659B1 (en) 2000-06-02 2008-09-02 Honeywell Interantional Inc. Flow control system of a cartridge
US7553453B2 (en) 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
US7978329B2 (en) 2000-08-02 2011-07-12 Honeywell International Inc. Portable scattering and fluorescence cytometer
US7471394B2 (en) 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US7016022B2 (en) 2000-08-02 2006-03-21 Honeywell International Inc. Dual use detectors for flow cytometry
US7061595B2 (en) 2000-08-02 2006-06-13 Honeywell International Inc. Miniaturized flow controller with closed loop regulation
US6597438B1 (en) 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
US7215425B2 (en) 2000-08-02 2007-05-08 Honeywell International Inc. Optical alignment for flow cytometry
US7630063B2 (en) 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US7671987B2 (en) 2000-08-02 2010-03-02 Honeywell International Inc Optical detection system for flow cytometry
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
WO2002010713A3 (fr) * 2000-08-02 2003-12-24 Honeywell Int Inc Cytometre de flux portatif
US7312870B2 (en) 2000-08-02 2007-12-25 Honeywell International Inc. Optical alignment detection system
US6970245B2 (en) 2000-08-02 2005-11-29 Honeywell International Inc. Optical alignment detection system
US7486387B2 (en) 2001-06-29 2009-02-03 Honeywell International Inc. Optical detection system for flow cytometry
US7262838B2 (en) 2001-06-29 2007-08-28 Honeywell International Inc. Optical detection system for flow cytometry
US11027278B2 (en) 2002-04-17 2021-06-08 Cytonome/St, Llc Methods for controlling fluid flow in a microfluidic system
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US7283223B2 (en) 2002-08-21 2007-10-16 Honeywell International Inc. Cytometer having telecentric optics
US7641856B2 (en) 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7242474B2 (en) 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US7612871B2 (en) 2004-09-01 2009-11-03 Honeywell International Inc Frequency-multiplexed detection of multiple wavelength light for flow cytometry
US7630075B2 (en) 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
US7130046B2 (en) 2004-09-27 2006-10-31 Honeywell International Inc. Data frame selection for cytometer analysis
US10794913B2 (en) 2004-12-03 2020-10-06 Cytonome/St, Llc Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US9823252B2 (en) 2004-12-03 2017-11-21 Cytonome/St, Llc Unitary cartridge for particle processing
US10065188B2 (en) 2004-12-03 2018-09-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US10994273B2 (en) 2004-12-03 2021-05-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US10222378B2 (en) 2004-12-03 2019-03-05 Cytonome/St, Llc Unitary cartridge for particle processing
US8980635B2 (en) 2011-12-27 2015-03-17 Honeywell International Inc. Disposable cartridge for fluid analysis
WO2017076817A1 (fr) * 2015-11-05 2017-05-11 Alere San Diego, Inc. Dispositif de préparation d'échantillons
JP2018538548A (ja) * 2015-11-05 2018-12-27 アリーア サン ディエゴ， インコーポレイテッド 試料調製装置
CN108430640A (zh) * 2015-11-05 2018-08-21 爱乐圣地亚哥公司 样品制备装置
JP2021092580A (ja) * 2015-11-05 2021-06-17 アボット・ダイアグノスティックス・スカボロー・インコーポレイテッド 試料調製装置
US11185864B2 (en) 2015-11-05 2021-11-30 Alere San Diego, Inc. Sample preparation device
CN108430640B (zh) * 2015-11-05 2022-01-11 雅培诊断产品士嘉堡公司 样品制备装置
CN114264538A (zh) * 2015-11-05 2022-04-01 雅培诊断产品士嘉堡公司 样品制备装置
EP3978120A1 (fr) * 2015-11-05 2022-04-06 Abbott Diagnostics Scarborough, Inc. Dispositif de préparation d'échantillon
JP2022160409A (ja) * 2015-11-05 2022-10-19 アボット・ダイアグノスティックス・スカボロー・インコーポレイテッド 試料調製装置
JP2024045194A (ja) * 2015-11-05 2024-04-02 アボット・ダイアグノスティックス・スカボロー・インコーポレイテッド 試料調製装置

Also Published As

Publication number Publication date
AU2077095A (en) 1995-10-23
GB9406551D0 (en) 1994-05-25

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