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WO1996040944A3 - Complexes solubles d'heterodimeres de lmh fusionnes et de peptides, et leur utilisation - Google Patents

Complexes solubles d'heterodimeres de lmh fusionnes et de peptides, et leur utilisation Download PDF

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Publication number
WO1996040944A3
WO1996040944A3 PCT/US1996/010102 US9610102W WO9640944A3 WO 1996040944 A3 WO1996040944 A3 WO 1996040944A3 US 9610102 W US9610102 W US 9610102W WO 9640944 A3 WO9640944 A3 WO 9640944A3
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WO
WIPO (PCT)
Prior art keywords
peptide complexes
soluble mhc
mhc heterodimer
fused
fused soluble
Prior art date
Application number
PCT/US1996/010102
Other languages
English (en)
Other versions
WO1996040944A2 (fr
Inventor
Wayne Kindsvogel
Eva Pia Reich
Jane A Gross
Shrinkant Deshpande
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Anergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Anergen Inc filed Critical Zymogenetics Inc
Priority to JP9502204A priority Critical patent/JPH11507238A/ja
Priority to EP96922445A priority patent/EP0833930A2/fr
Priority to AU63316/96A priority patent/AU6331696A/en
Publication of WO1996040944A2 publication Critical patent/WO1996040944A2/fr
Publication of WO1996040944A3 publication Critical patent/WO1996040944A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention porte sur des immunomodulateurs tels que des complexes solubles d'hétérodimères fusionnés de CMH et de peptides, et sur des procédés et peptides associés. Dans l'une des variantes préférées, ces médiateurs et procédés ont trait à l'autoimmunité.
PCT/US1996/010102 1995-06-07 1996-06-07 Complexes solubles d'heterodimeres de lmh fusionnes et de peptides, et leur utilisation WO1996040944A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP9502204A JPH11507238A (ja) 1995-06-07 1996-06-07 融合した可溶性のｍｈｃヘテロダイマー：ペプチド複合体およびその使用
EP96922445A EP0833930A2 (fr) 1995-06-07 1996-06-07 Complexes solubles d'heterodimeres de lmh fusionnes et de peptides, et leur utilisation
AU63316/96A AU6331696A (en) 1995-06-07 1996-06-07 Fused soluble mhc heterodimer:peptide complexes and their uses

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US48213395A 1995-06-07 1995-06-07
US48000295A 1995-06-07 1995-06-07
US48324195A 1995-06-07 1995-06-07
US596495P 1995-10-27 1995-10-27
US60/005,964 1995-10-27
US08/480,002 1995-10-27
US08/483,241 1995-10-27
US08/482,133 1995-10-27

Publications (2)

Publication Number Publication Date
WO1996040944A2 WO1996040944A2 (fr) 1996-12-19
WO1996040944A3 true WO1996040944A3 (fr) 1997-01-23

Family

ID=27485544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010102 WO1996040944A2 (fr) 1995-06-07 1996-06-07 Complexes solubles d'heterodimeres de lmh fusionnes et de peptides, et leur utilisation

Country Status (6)

Country Link
EP (1) EP0833930A2 (fr)
JP (1) JPH11507238A (fr)
KR (1) KR19990022641A (fr)
AU (1) AU6331696A (fr)
CA (1) CA2224205A1 (fr)
WO (1) WO1996040944A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074904B2 (en) 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
ES2152424T5 (es) * 1994-07-29 2010-07-05 Sunol Molecular Corporation Complejos del mhc y usos de los mismos.
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
JP2002513558A (ja) * 1998-05-05 2002-05-14 コリクサ コーポレイション ミエリン塩基性タンパク質ペプチドおよびその使用
FR2778669B1 (fr) * 1998-05-14 2002-06-14 Centre Nat Rech Scient Procede d'expression d'un complexe forme d'au moins un produit du complexe majeur d'histocompatibilite et d'un peptide chez un phage, phages et complexes ainsi obtenus et leurs applications
CA2537759C (fr) 2003-09-05 2015-03-24 Oregon Health & Science University Molecules mhc monomeres de recombinaison utiles pour la manipulation de lymphocytes t specifiques d'antigenes
US20090227516A1 (en) * 2005-11-17 2009-09-10 Ahlstrom Corporation Compound comprising an autoantigenic peptide and a carrier with a mhc binding motif
US8491913B2 (en) 2009-03-07 2013-07-23 Oregon Health & Science University Compositions and methods using recombinant MHC molecules for the treatment of stroke
US9260506B2 (en) 2011-04-07 2016-02-16 Oregon Health & Science University Treatment of retinal disorders with recombinant T cell receptor ligand (RTL)
EP3052526A4 (fr) 2013-10-03 2017-04-19 Oregon Health & Science University Polypeptides recombinés comprenant des domaines 1 du cmh de classe ii
CN116554342A (zh) * 2022-01-29 2023-08-08 元本(珠海横琴)生物科技有限公司 一种融合表达Tau-4R蛋白的大肠杆菌工程菌株

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018150A1 (fr) * 1991-04-23 1992-10-29 Anergen, Inc. Conjugues cmh permettant de traiter l'auto-immunite
WO1994024290A1 (fr) * 1993-04-08 1994-10-27 British Bio-Technology Limited Proteines resultant de la fusion entre des sequences d'acides amines antigeniques et la beta-2-microglobuline
WO1994025054A1 (fr) * 1993-04-29 1994-11-10 Andrew Atkin Vaccin de recombinaison
WO1995023814A1 (fr) * 1994-03-04 1995-09-08 National Jewish Center For Immunology And Respiratory Medicine Produit et procede de modulation de l'activite des lymphocytes t

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018150A1 (fr) * 1991-04-23 1992-10-29 Anergen, Inc. Conjugues cmh permettant de traiter l'auto-immunite
WO1994024290A1 (fr) * 1993-04-08 1994-10-27 British Bio-Technology Limited Proteines resultant de la fusion entre des sequences d'acides amines antigeniques et la beta-2-microglobuline
WO1994025054A1 (fr) * 1993-04-29 1994-11-10 Andrew Atkin Vaccin de recombinaison
WO1995023814A1 (fr) * 1994-03-04 1995-09-08 National Jewish Center For Immunology And Respiratory Medicine Produit et procede de modulation de l'activite des lymphocytes t

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
H. KOZONO ET AL.: "Production of soluble MHC class II proteins with covalently bound single peptides.", NATURE, vol. 369, no. 6476, 12 May 1994 (1994-05-12), LONDON, GB, pages 151 - 154, XP002018445 *
J. FAYEN ET AL.: "Soluble human CD8alpha binds to a recombinant fusion protein which incorporates the class I MHC alpha3 domain.", THE JOURNAL OF IMMUNOLOGY, vol. 150, no. 8 part II, 15 April 1993 (1993-04-15), BALTIMORE, MD, USA, pages 288A, XP002018446 *
S. SHARMA ET AL.: "Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 88, no. 24, 15 December 1991 (1991-12-15), WASHINGTON, DC, USA, pages 11465 - 11469, XP002018447 *

Also Published As

Publication number Publication date
CA2224205A1 (fr) 1996-12-19
AU6331696A (en) 1996-12-30
EP0833930A2 (fr) 1998-04-08
KR19990022641A (ko) 1999-03-25
WO1996040944A2 (fr) 1996-12-19
JPH11507238A (ja) 1999-06-29

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