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WO1996041649A1 - Construction de canule emoussee pour applications multiples - Google Patents

Construction de canule emoussee pour applications multiples Download PDF

Info

Publication number
WO1996041649A1
WO1996041649A1 PCT/US1996/009125 US9609125W WO9641649A1 WO 1996041649 A1 WO1996041649 A1 WO 1996041649A1 US 9609125 W US9609125 W US 9609125W WO 9641649 A1 WO9641649 A1 WO 9641649A1
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
syringe
liquid
blunt tip
outer diameter
Prior art date
Application number
PCT/US1996/009125
Other languages
English (en)
Inventor
Eli Shemesh
Jacob Nijinski
Original Assignee
Migada, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Migada, Inc. filed Critical Migada, Inc.
Priority to AU60906/96A priority Critical patent/AU6090696A/en
Priority to EP96918194A priority patent/EP0880371A4/fr
Publication of WO1996041649A1 publication Critical patent/WO1996041649A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/04—Access sites having pierceable self-sealing members
    • A61M39/045—Access sites having pierceable self-sealing members pre-slit to be pierced by blunt instrument
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips

Definitions

  • the present invention relates to a cannula construction, and more particularly to a blunt cannula of a construction enabling it to be used in a wide variety of different medical applications.
  • blunt cannulas made of stiff plastic material as a replacement for metal needles in syringes in order to minimize the possibility of accidental needle sticks which may cause infection of a person handling an infected needle.
  • Such blunt cannulas are now used to penetrate pre-slitted rubber plugs which self-seal as soon as the blunt cannula has been removed.
  • the blunt cannula of one manufacturer includes a cylindrical section of 10 mm in length and a tapered section of 2-3 mm in length, the tapered section having an outer diameter tapering from 2.0 to 1.8 mm and an inner diameter tapering from 1.5 to 1.2 mm.
  • the blunt cannula of another manufacturer includes a cylindrical section of 13 mm in length and formed with a rounded tip rather than with a tapered section, the rounded tip having an outer diameter of 1.8-2.0 mm.
  • These known blunt cannulas have heretofore been used for penetrating pre-slitted, self-sealing rubber plugs, such as provided at injection sites for injecting or withdrawing liquids.
  • Metal needles attached to syringes are also commonly used for puncturing the plug or septum of a vial in order to withdraw liquid from the vial.
  • a two-part cannula has been constructed for this application, including a pointed tip part slidably received within a blunt cannula part, such that the pointed tip part is used to puncture the plug of the vial and is retained in place, while the blunt cannula part is used for withdrawing the liquid from the vial via the pointed tip part.
  • Such a two-part construction is quite costly.
  • An object of the present invention is to provide a blunt cannula construction enabling it to have more universal application, not only for insertion through a pre-slitted, self-sealing plug, but also for puncturing unslitted plugs or septums in vials and for withdrawing liquids from ampules.
  • Another object of the invention is to provide a syringe including the novel blunt cannula construction.
  • a cannula having a hub at one end integrally formed with a Luer locking element for attachment to a syringe, and a tapered section terminating in a blunt tip at the opposite end; characterized in that the tapered section is of a length of 30-100 mm, and has an outer diameter of at least 3 mm at its large diameter end tapering therefrom to an outer diameter of at least 0.8 mm at the blunt tip, the cannula being of a plastic material sufficiently stiff and tapered such as to enable the cannula to be used not only for insertion through a pre-slitted, self-sealing plug, but also for puncturing a vial for withdrawing liquid therefrom, and also for withdrawing liquid from an ampule.
  • the inner diameter of the blunt tip is at least 0.3 mm, preferably 0.3 to 0.7 mm.
  • the cannula further includes a cylindrical section between the hub and the tapered section, the cylindrical section having an outer diameter equal to that of the enlarged diameter end of the tapered section.
  • the cylindrical section has a length of at least 2 mm, preferably 3-10 mm.
  • novel blunt cannula constructed in accordance with the present invention are substantially different from those of the blunt cannulas heretofore used only for penetrating pre-slitted rubber plugs; thus, the novel blunt cannula has a much longer tapered section, longer by at least one order of magnitude, and a significantly smaller blunt tip, than the blunt cannulas heretofore used only with respect to pre-slitted rubber plugs.
  • cannulas constructed in accordance with the foregoing features may be used not only for penetrating pre-slitted rubber plugs as the existing blunt cannulas, but also for vials, and for withdrawing liquids from a vial or from an ampule, heretofore done by metal needles. Further features and advantages of the invention will be apparent from the description below.
  • Fig. 1 illustrates a syringe including a cannula constructed in accordance with the present invention
  • Fig. 2 is an enlarged side elevational view of the cannula in the syringe of Fig. 1;
  • Fig. 3 is a sectional view of the cannula of Fig. 2;
  • Fig. 4 illustrates a syringe including a cannula according to Fig. 1 and a protector sleeve on the cannula;
  • Fig. 5 is a cross-sectional view of the protector sleeve of Fig. 4.
  • Figs. 6, 7, 8 and 9 illustrate a syringe including a cannula constructed as illustrated in Figs. 2 and 3 for use in a number of diverse applications.
  • a syringe generally designated 2, including a barrel 3 receiving a plunger 4 having a plunger head 5 movable towards and away from an end wall 6 of the barrel.
  • the plunger assembly has a thumbrest 7, and the barrel 3 has finger flanges 8, engageable by the thumb and fingers of the user for moving the plunger towards the end wall 6.
  • End wall 6 is integrally formed with a standard Luer connector normally used for attaching a standard metal hypodermic needle.
  • connector 9 of the syringe 2 is used for attaching the cannula 10 constructed in accordance with the present invention.
  • Figs. 2 and 3 more particularly illustrate the construction of cannula 10. It includes a hub 11 at one end having an outer cylindrical configuration and integrally formed with a female Luer locking element 12 cooperable with a male Luer locking element (not shown) in connector 9. Cannula 10 further includes a short cylindrical section 13, and a long tapered section 14 terminating in a blunt tip 15 at the end opposite to that of the hub 11.
  • the tapered section 14 includes a first segment 14a at the larger-diameter end of that section integrally joined to a second segment 14b at the smaller-diameter end of that section.
  • the smaller-diameter segment 14b has a longer length and a larger taper than the larger-diameter segment 14a.
  • the hub 11 should have an axial length of 7-10 mm, an outer diameter of 6 mm, and an inner diameter of 4.4. mm. This will make the cannula attachable to a standard Luer connector on a syringe.
  • the short cylindrical section 13 is used for receiving a protective sleeve (not shown) which is removed when the cannula is to be used.
  • sections 13 and 14 of the cannula should be as follows:
  • the cylindrical section 13 should have an axial length of at least 2 mm, preferably 3-10 mm, and an outer diameter of at least 3 mm, preferably 3-10 mm;
  • the tapering section 14, including its two segments 14a, 14b, should have an axial length of 30-100 mm;
  • blunt tip 15 should have an outer diameter of at least 0.8 mm, preferably 0.8-1.3 mm.
  • the cylindrical section 13 has an axial length of 3 mm and an outer diameter of 5 mm; and the tapering section 14 has a length of 50-55 mm, an outer diameter tapering from 5.0 mm at large-diameter end to 1.1 mm at its blunt tip 15.
  • the taper angle " ⁇ " of the outer surface of segment 14a should be 3°, and the taper angle ( ⁇ ) of segment 14b should be 5°.
  • the inner diameter of the blunt tip 15 is at least 0.3 mm, preferably 0.3-0.7 mm, best results being obtained when it is about 0.5 mm.
  • the complete cannula 10 illustrated in Figs. 1 and 2 is preferably made of a stiff plastics material, preferably polyethylene, nylon, polycarbonate, polyvinylchloride or ABS.
  • Fig. 4 illustrates the syringe 2 with the cannula 10 applied thereto, and with a protector sleeve 20 applied over the cannula 10.
  • the protector sleeve 20 has an inner diameter equal to the outer diameter of the cylindrical section 13 of the cannula 10, and has a length greater than the length of the tapered section 14 together with the cylindrical section 13 of the cannula; that is, the length of protector sleeve 20 should be at least 35 mm, and should project past the blunt tip 15 of the cannula by at least 5 mm.
  • protector sleeve 20 includes opposed flattened surfaces 21, 22 engageable with opposed flattened surfaces of the cylindrical section 13 of the cannula to permit the protector sleeve to rotate the cannula when attaching it to the syringe 10 or when detaching it from the syringe.
  • Figs. 6-9 illustrate the universal applicability of the blunt cannula when constructed as illustrated in Figs. 1 -3 according to the dimensions described above.
  • Fig. 6 illustrates the cannula 10, where attached to syringe 2, for withdrawing a liquid from a vial 30 closed by an unslitted rubber plug or septum 31.
  • a two-part cannula construction which includes a pointed tip part slidably received within a blunt cannula part, such that the pointed tip part is used to puncture the unslitted plug and, when while retained in place, the blunt cannula part is used for withdrawing the liquid from the vial via the pointed tip part. It was surprisingly found that a cannula constructed as illustrated in Figs.
  • Fig. 7 illustrates another application of the above-described blunt cannula, namely for withdrawing a liquid from an ampule 35 normally closed by an integrally formed cover (not shown).
  • a syringe 2 equipped with a blunt cannula 10 as described above may also be used for withdrawing the liquid from the ampule via the cannula.
  • Fig. 8 illustrates the use of a syringe equipped with a cannula 10 as described above for injecting liquid or withdrawing liquid with respect to an injection site, generally designated 40, via a pre-slitted plug 41.
  • the blunt cannula of the present invention can also be used in this application equally well as the previously-known blunt cannulas which included a much shorter tapering section, as described above.
  • Fig. 9 illustrates a similar application of a syringe equipped with a cannula 10 for introducing a liquid into, or withdrawing a liquid from, an infusion bag 50 via an injection site 51.
  • the injection site 51 includes a pre-slitted plug 52 and an unslitted separator layer, both of which are penetrated by the blunt cannula 10 attached to the syringe 2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention se rapporte à une canule (10) comportant une garde (11) à une extrémité solidaire d'un élément de raccord luer-lock (12) se fixant à une seringue (2), et une section effilée (14) se terminant en un bout émoussé (15) à l'autre extrémité. Ladite canule est caractérisée en ce que la section effilée (14) a une longueur de 30 à 100 mm et qu'elle présente un diamètre extérieur d'au moins 3 mm à son extrémité de plus grand diamètre diminuant jusqu'à un diamètre extérieur d'au moins 0,8 mm à la pointe emoussée (15). Ladite canule (10) est composée d'un matériau plastique suffisamment rigide et effilé pour permettre l'utilisation de ladite canule (10) non seulement pour une insertion dans un bouchon préalablement fendu et se fermant hermétiquement de lui-même, mais aussi pour perforer un flacon afin d'en retirer du liquide, et également pour retirer du liquide à partir d'une ampoule.
PCT/US1996/009125 1995-06-09 1996-06-05 Construction de canule emoussee pour applications multiples WO1996041649A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU60906/96A AU6090696A (en) 1995-06-09 1996-06-05 Blunt cannula construction for multiple applications
EP96918194A EP0880371A4 (fr) 1995-06-09 1996-06-05 Construction de canule emoussee pour applications multiples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL114093A IL114093A (en) 1995-06-09 1995-06-09 Blunt cannula construction for multiple applications
IL114093 1995-06-09

Publications (1)

Publication Number Publication Date
WO1996041649A1 true WO1996041649A1 (fr) 1996-12-27

Family

ID=11067595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009125 WO1996041649A1 (fr) 1995-06-09 1996-06-05 Construction de canule emoussee pour applications multiples

Country Status (4)

Country Link
EP (1) EP0880371A4 (fr)
AU (1) AU6090696A (fr)
IL (1) IL114093A (fr)
WO (1) WO1996041649A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319236B1 (en) 1998-11-06 2001-11-20 Millipore Corporation Universal outlet for filter units
WO2005072813A1 (fr) * 2004-01-22 2005-08-11 Boston Scientific Scimed, Inc. Catheter vanne destine a contourner un raccord
US6936031B2 (en) 2000-12-12 2005-08-30 Gambro Dasco S.P.A. Site for access to the inside of a channel, and corresponding cannula
USD571006S1 (en) 2007-03-23 2008-06-10 Smiths Medical Asd, Inc. Oval tapering blunt cannula proximal portion
USD571464S1 (en) 2007-03-23 2008-06-17 Smiths Medical Asd, Inc. Knife edge tapering blunt cannula proximal portion
USD574491S1 (en) 2007-03-23 2008-08-05 Smiths Medical, Asd, Inc. Multiple taper blunt cannula distal portion
WO2013052666A1 (fr) * 2011-10-06 2013-04-11 Becton, Dickinson And Company Pièce activatrice pour cathéters de contrôles sanguins
US9050435B2 (en) 2011-03-22 2015-06-09 Angiodynamics, Inc. High flow catheters
US9114241B2 (en) 2009-02-11 2015-08-25 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US9126012B2 (en) 2011-10-06 2015-09-08 Becton, Dickinson And Company Intravenous catheter with duckbill valve
US9149573B2 (en) 2007-03-16 2015-10-06 Smiths Medical Asd, Inc. Blunt cannula for accessing a slit septum
US9155863B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use stretching and non-penetrating blood control valves
US9155876B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Port valve of a blood control catheter
US9447892B2 (en) 2008-05-21 2016-09-20 Angiodynamics, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US9750925B2 (en) 2014-01-21 2017-09-05 Becton, Dickinson And Company Ported catheter adapter having combined port and blood control valve with venting
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906423A (en) * 1956-07-18 1959-09-29 American Cyanamid Co Closure puncturable by polyethylene needle
US4345596A (en) * 1981-12-23 1982-08-24 Janis Marie Young Arterial catherization device
US5178607A (en) * 1987-07-31 1993-01-12 Lynn Lawrence A Blood aspiration assembly septum and blunt needle aspirator
US5328041A (en) * 1993-06-30 1994-07-12 Abbott Laboratories Two piece stopper for blunt fluid connector
US5458614A (en) * 1991-09-03 1995-10-17 Humphrey; Bruce H. Augmented polymeric hypodermic devices

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66526B1 (en) * 1989-03-17 1996-01-24 Baxter Int A pre-slit injection site usable with a blunt cannula
US5223225A (en) * 1991-05-17 1993-06-29 Bio 101 Scale-marked pipet tip for precision dispensing of fluids over a large range of volumes
BR9307879A (pt) * 1993-08-27 1996-04-30 St Paul Medical Inc Aparelho para ministrar droga medicamentosa posiçao de injeçao e posiçao de injeçao para tubo de coleta de sangue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906423A (en) * 1956-07-18 1959-09-29 American Cyanamid Co Closure puncturable by polyethylene needle
US4345596A (en) * 1981-12-23 1982-08-24 Janis Marie Young Arterial catherization device
US5178607A (en) * 1987-07-31 1993-01-12 Lynn Lawrence A Blood aspiration assembly septum and blunt needle aspirator
US5458614A (en) * 1991-09-03 1995-10-17 Humphrey; Bruce H. Augmented polymeric hypodermic devices
US5328041A (en) * 1993-06-30 1994-07-12 Abbott Laboratories Two piece stopper for blunt fluid connector

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0880371A4 *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319236B1 (en) 1998-11-06 2001-11-20 Millipore Corporation Universal outlet for filter units
US6936031B2 (en) 2000-12-12 2005-08-30 Gambro Dasco S.P.A. Site for access to the inside of a channel, and corresponding cannula
WO2005072813A1 (fr) * 2004-01-22 2005-08-11 Boston Scientific Scimed, Inc. Catheter vanne destine a contourner un raccord
US9933079B2 (en) 2004-01-29 2018-04-03 Angiodynamics, Inc. Stacked membrane for pressure actuated valve
US9149573B2 (en) 2007-03-16 2015-10-06 Smiths Medical Asd, Inc. Blunt cannula for accessing a slit septum
USD571006S1 (en) 2007-03-23 2008-06-10 Smiths Medical Asd, Inc. Oval tapering blunt cannula proximal portion
USD582033S1 (en) 2007-03-23 2008-12-02 Smiths Medical Asd, Inc. Oval tapering blunt cannula proximal portion
USD582550S1 (en) 2007-03-23 2008-12-09 Smiths Medical Asd, Inc. Oval tapering blunt cannula proximal portion
USD605755S1 (en) 2007-03-23 2009-12-08 Smiths Medical Asd, Inc. Oval tapering blunt cannula proximal portion
USD574491S1 (en) 2007-03-23 2008-08-05 Smiths Medical, Asd, Inc. Multiple taper blunt cannula distal portion
USD571464S1 (en) 2007-03-23 2008-06-17 Smiths Medical Asd, Inc. Knife edge tapering blunt cannula proximal portion
US9447892B2 (en) 2008-05-21 2016-09-20 Angiodynamics, Inc. Pressure activated valve for high flow rate and pressure venous access applications
US9114241B2 (en) 2009-02-11 2015-08-25 Becton, Dickinson And Company Systems and methods for providing a flushable catheter assembly
US9050435B2 (en) 2011-03-22 2015-06-09 Angiodynamics, Inc. High flow catheters
US9126012B2 (en) 2011-10-06 2015-09-08 Becton, Dickinson And Company Intravenous catheter with duckbill valve
US9155876B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Port valve of a blood control catheter
US9358364B2 (en) 2011-10-06 2016-06-07 Becton, Dickinson And Company Activator attachment for blood control catheters
US9155863B2 (en) 2011-10-06 2015-10-13 Becton, Dickinson And Company Multiple use stretching and non-penetrating blood control valves
WO2013052666A1 (fr) * 2011-10-06 2013-04-11 Becton, Dickinson And Company Pièce activatrice pour cathéters de contrôles sanguins
EP3318302A1 (fr) * 2011-10-06 2018-05-09 Becton, Dickinson and Company Pièce activatrice pour cathéters de contrôles sanguins
US10118017B2 (en) 2011-10-06 2018-11-06 Becton, Dickinson And Company Activator attachment for blood control catheters
EP3482794A1 (fr) * 2011-10-06 2019-05-15 Becton, Dickinson and Company Fixation d'activateur pour cathéters de contrôle sanguin
US11135399B2 (en) 2011-10-06 2021-10-05 Becton, Dickinson And Company Activator attachment for blood control catheters
US12364842B2 (en) 2011-10-06 2025-07-22 Becton, Dickinson And Company Activator attachment for blood control catheters
US9750925B2 (en) 2014-01-21 2017-09-05 Becton, Dickinson And Company Ported catheter adapter having combined port and blood control valve with venting
US10543351B2 (en) 2014-01-21 2020-01-28 Becton, Dickinson And Company Ported catheter adapter having combined port and blood control valve with venting

Also Published As

Publication number Publication date
EP0880371A1 (fr) 1998-12-02
AU6090696A (en) 1997-01-09
EP0880371A4 (fr) 1999-04-14
IL114093A (en) 1998-06-15
IL114093A0 (en) 1995-10-31

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