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WO1996011054A3 - Process for the preparation of microspheres and microspheres made thereby - Google Patents

Process for the preparation of microspheres and microspheres made thereby Download PDF

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Publication number
WO1996011054A3
WO1996011054A3 PCT/US1995/012988 US9512988W WO9611054A3 WO 1996011054 A3 WO1996011054 A3 WO 1996011054A3 US 9512988 W US9512988 W US 9512988W WO 9611054 A3 WO9611054 A3 WO 9611054A3
Authority
WO
WIPO (PCT)
Prior art keywords
microsphere
microspheres
preparation
silica nanoparticles
surfactants
Prior art date
Application number
PCT/US1995/012988
Other languages
French (fr)
Other versions
WO1996011054A2 (en
WO1996011054A9 (en
Inventor
Shlomo Margel
Hanna Bamnolker
Original Assignee
Univ Bar Ilan
Lichtenstein Joseph
Shlomo Margel
Hanna Bamnolker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan, Lichtenstein Joseph, Shlomo Margel, Hanna Bamnolker filed Critical Univ Bar Ilan
Priority to DE19581787T priority Critical patent/DE19581787T1/en
Priority to AU41934/96A priority patent/AU4193496A/en
Priority to US08/809,957 priority patent/US6103379A/en
Publication of WO1996011054A2 publication Critical patent/WO1996011054A2/en
Publication of WO1996011054A3 publication Critical patent/WO1996011054A3/en
Publication of WO1996011054A9 publication Critical patent/WO1996011054A9/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

A process for the preparation of a microsphere comprising a coating composed of one or more silica nanoparticles layers, comprises the steps of: a) providing a microsphere of polymeric material, the said microsphere having adsorbed on its surface one or more surfactants; and b) causing a layer of silica nanoparticles to coat the surface of the said microsphere by means of seeded polymerization of alkyl silicates onto the surface of said microsphere.
PCT/US1995/012988 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby WO1996011054A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19581787T DE19581787T1 (en) 1994-10-06 1995-10-05 Process for the production of microspheres and microspheres produced thereby
AU41934/96A AU4193496A (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby
US08/809,957 US6103379A (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL111186 1994-10-06
IL11118694A IL111186A (en) 1994-10-06 1994-10-06 Process for the preparation of microspheres and microspheres made thereby

Publications (3)

Publication Number Publication Date
WO1996011054A2 WO1996011054A2 (en) 1996-04-18
WO1996011054A3 true WO1996011054A3 (en) 1996-05-23
WO1996011054A9 WO1996011054A9 (en) 1996-08-15

Family

ID=11066612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/012988 WO1996011054A2 (en) 1994-10-06 1995-10-05 Process for the preparation of microspheres and microspheres made thereby

Country Status (4)

Country Link
AU (1) AU4193496A (en)
DE (1) DE19581787T1 (en)
IL (1) IL111186A (en)
WO (1) WO1996011054A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6870047B2 (en) 1995-06-08 2005-03-22 Roche Diagnostics Gmbh Magnetic pigment

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100463475B1 (en) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 Magnetic Pigment
FR2747669B1 (en) 1996-04-22 1998-05-22 Rhone Poulenc Chimie PROCESS FOR THE PREPARATION OF HOLLOW SILICA PARTICLES
HU225261B1 (en) 1997-01-21 2006-08-28 Grace W R & Co Silica adsorbent on magnetic substrate
JP4092070B2 (en) * 2000-11-27 2008-05-28 独立行政法人科学技術振興機構 Organic-inorganic composite using sugar derivative and method for producing metal oxide
GB0107563D0 (en) 2001-03-27 2001-05-16 Amersham Pharm Biotech Uk Ltd NO synthase assay particles and method
US6890703B2 (en) 2002-03-06 2005-05-10 International Business Machines Corporation Preparation of crosslinked particles from polymers having activatible crosslinking groups
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
DE10355409A1 (en) 2003-11-25 2005-06-30 Magnamedics Gmbh Spherical, magnetic silica gel carriers with increased surface area for the purification of nucleic acids
US9278866B2 (en) 2005-08-10 2016-03-08 The Procter & Gamble Company Hollow silica particles, compositions comprising them, and methods for making same
KR101457287B1 (en) * 2010-04-20 2014-11-04 바스프 에스이 Capsule comprising active ingredient
JP6085035B2 (en) * 2012-11-16 2017-02-22 エスエヌユー アールアンドディービー ファウンデーションＳｎｕ Ｒ＆Ｄｂ Ｆｏｕｎｄａｔｉｏｎ Coded polymer particles
DE102016105122B4 (en) * 2016-03-18 2019-07-11 Bundesrepublik Deutschland, Vertreten Durch Den Bundesminister Für Wirtschaft Und Energie, Dieser Vertreten Durch Den Präsidenten Der Bundesanstalt Für Materialforschung Und -Prüfung (Bam) A method of synthesizing hybrid core-shell microparticles comprising a polymer core and a controlled-surface silica shell
CN110508222B (en) * 2019-08-02 2022-03-18 复旦大学 Monodisperse core-shell microspheres with mesoporous silica shell layer and preparation method thereof
CN113578214B (en) * 2021-08-11 2023-08-11 天津博蕴纯化装备材料科技有限公司 Micron-sized porous magnetic microsphere and preparation method and application thereof
CN115893980B (en) * 2022-09-30 2023-08-11 安徽华仕新材有限公司 Process for preparing porous support ceramic by using nodulizer micropowder
CN117164759A (en) * 2023-04-13 2023-12-05 中材锂膜有限公司 Polymer microsphere, composite separator and electrochemical device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564336A1 (en) * 1984-05-16 1985-11-22 Ohayon Hanania Device for separating blood and producing serum
EP0321322A1 (en) * 1987-12-18 1989-06-21 Rhone-Poulenc Chimie Magnetic composite particles from crosslinked organopolysiloxane, process for their preparation and use of them in biology
WO1992016838A1 (en) * 1991-03-20 1992-10-01 Gec-Marconi Limited Separation method
EP0573150A2 (en) * 1992-06-04 1993-12-08 Tioxide Group Services Limited Composite pigmentary material

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2564336A1 (en) * 1984-05-16 1985-11-22 Ohayon Hanania Device for separating blood and producing serum
EP0321322A1 (en) * 1987-12-18 1989-06-21 Rhone-Poulenc Chimie Magnetic composite particles from crosslinked organopolysiloxane, process for their preparation and use of them in biology
WO1992016838A1 (en) * 1991-03-20 1992-10-01 Gec-Marconi Limited Separation method
EP0573150A2 (en) * 1992-06-04 1993-12-08 Tioxide Group Services Limited Composite pigmentary material

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAWAHASHI ET AL.: "Preparation and Properties of Uniform Coated Colloidal Particles", J. OF COLLOID AND INTERFACE SCIENCE, vol. 138, no. 2, pages 53434 - 542, XP000561465 *
KAWAHASHI ET AL.: "Preparation of Hollow Spherical Particles of Yttrium Compounds", J. OF COLLOID AND INTERFACE SCIENCE, vol. 143, no. 1, pages 103 - 110, XP000561464 *
MATIJEVIC: "Uniform Inorganic Colloid Dispersions. Achievements and Challenges", LANGMUIR, vol. 10, no. 1, pages 8 - 16, XP000561075 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6870047B2 (en) 1995-06-08 2005-03-22 Roche Diagnostics Gmbh Magnetic pigment

Also Published As

Publication number Publication date
WO1996011054A2 (en) 1996-04-18
IL111186A0 (en) 1994-12-29
DE19581787T1 (en) 1997-11-27
AU4193496A (en) 1996-05-02
IL111186A (en) 1999-09-22

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