WO1996011709B1 - Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit - Google Patents
Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruitInfo
- Publication number
- WO1996011709B1 WO1996011709B1 PCT/US1995/012585 US9512585W WO9611709B1 WO 1996011709 B1 WO1996011709 B1 WO 1996011709B1 US 9512585 W US9512585 W US 9512585W WO 9611709 B1 WO9611709 B1 WO 9611709B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carrier
- modified
- oligogalacturonate
- polygalacturonate
- acetylated
- Prior art date
Links
- 235000013399 edible fruits Nutrition 0.000 title claims abstract 7
- 208000037386 Typhoid Diseases 0.000 title claims abstract 4
- 201000008297 typhoid fever Diseases 0.000 title claims abstract 4
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 229920001282 polysaccharide Polymers 0.000 title abstract 2
- 239000005017 polysaccharide Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000002163 immunogen Effects 0.000 claims abstract 10
- 238000000034 method Methods 0.000 claims abstract 10
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 8
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 235000010987 pectin Nutrition 0.000 claims 3
- 229920001277 pectin Polymers 0.000 claims 3
- 239000001814 pectin Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical group CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 claims 1
- 229940099500 cystamine Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Abstract
La présente invention concerne un oligosaccharide ou un polysaccharide modifié extrait de plante ou de fruit ou obtenu par synthèse et qui a été structurellement modifié pour rende le saccharide modifié antigéniquement semblable au polysaccharide capsulaire (Vi) de Salmonella Typhi. Le saccharide modifié peut se conjuguer avec un vecteur pour former un conjugué immunogène contre Salmonella Typhi. Les anticorps produits en réponse au conjugué immunogène apportent une protection contre la fièvre typhoïde. L'invention concerne également des procédés de fabrication du saccharide modifié et du conjugué immunogène.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95935689A EP0787015B1 (fr) | 1994-10-17 | 1995-09-28 | Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit |
| AU37607/95A AU3760795A (en) | 1994-10-17 | 1995-09-28 | Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide |
| DE69525638T DE69525638T2 (de) | 1994-10-17 | 1995-09-28 | Synthese eines typhusimpfstoffes unter verwendung eines polysaccharids aus einer pflanze oder einer frucht |
| AT95935689T ATE213647T1 (de) | 1994-10-17 | 1995-09-28 | Synthese eines typhusimpfstoffes unter verwendung eines polysaccharids aus einer pflanze oder einer frucht |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/323,918 | 1994-10-17 | ||
| US08/323,918 US5738855A (en) | 1994-10-17 | 1994-10-17 | Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996011709A1 WO1996011709A1 (fr) | 1996-04-25 |
| WO1996011709B1 true WO1996011709B1 (fr) | 1996-06-13 |
Family
ID=23261276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/012585 WO1996011709A1 (fr) | 1994-10-17 | 1995-09-28 | Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5738855A (fr) |
| EP (1) | EP0787015B1 (fr) |
| KR (1) | KR100433986B1 (fr) |
| AT (1) | ATE213647T1 (fr) |
| AU (1) | AU3760795A (fr) |
| DE (1) | DE69525638T2 (fr) |
| WO (1) | WO1996011709A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT848011E (pt) * | 1996-12-16 | 2001-08-30 | Staat Nl Verteg Door Min Welzi | Metodo para acoplar polisacaridos a proteinas |
| MXPA00003108A (es) * | 1997-10-03 | 2001-07-01 | Polisacaridos formadores de iminas, preparacion de los mismos y el uso como adyuvantes e inmunoestimulan | |
| US6258774B1 (en) * | 1998-03-19 | 2001-07-10 | University Of Medicine And Dentistry Of New Jersey | Carrier for in vivo delivery of a therapeutic agent |
| US6797275B1 (en) * | 1998-12-04 | 2004-09-28 | The United States Of America As Represented By The Department Of Health And Human Services | Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine |
| MXPA01006491A (es) | 1998-12-23 | 2003-06-06 | Thompson Boyce Plant Res | Expresion de antigenos de superficie de hepatitis b inmunogenicos en plantas transgenicas. |
| CA2434668A1 (fr) | 2003-07-04 | 2005-01-04 | Laurence Mulard | Nouvelle approche pour concevoir des glycopeptides a base de o-specifique polysaccharide de shigella flexneri serotype 2a |
| CN1645104B (zh) * | 2004-12-21 | 2011-03-16 | 兰州生物制品研究所 | 伤寒Vi-rEPA结合疫苗中高分子结合物含量的测定方法 |
| US8426567B2 (en) * | 2005-08-26 | 2013-04-23 | Econugenics, Inc. | Method for enhancing mammalian immunological function |
| GB0810894D0 (en) | 2008-06-13 | 2008-07-23 | Novartis Vaccines & Diagnostic | Conjugated saccharide |
| EP2386563A1 (fr) | 2010-05-12 | 2011-11-16 | Institut Pasteur | Nouveaux décasaccharides O-acétylés |
| MY177944A (en) | 2013-08-24 | 2020-09-28 | Bharat Biotech Int Ltd | Bacterial vaccine and methods for manufacture thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204098A (en) * | 1988-02-16 | 1993-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-protein conjugates |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| IL102687A (en) * | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
-
1994
- 1994-10-17 US US08/323,918 patent/US5738855A/en not_active Expired - Lifetime
-
1995
- 1995-09-28 AT AT95935689T patent/ATE213647T1/de not_active IP Right Cessation
- 1995-09-28 WO PCT/US1995/012585 patent/WO1996011709A1/fr active IP Right Grant
- 1995-09-28 EP EP95935689A patent/EP0787015B1/fr not_active Expired - Lifetime
- 1995-09-28 AU AU37607/95A patent/AU3760795A/en not_active Abandoned
- 1995-09-28 DE DE69525638T patent/DE69525638T2/de not_active Expired - Lifetime
- 1995-09-28 KR KR1019970702529A patent/KR100433986B1/ko not_active Expired - Lifetime
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