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WO1996013593A3 - Soluble single chain t cell receptors - Google Patents

Soluble single chain t cell receptors Download PDF

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Publication number
WO1996013593A3
WO1996013593A3 PCT/US1995/013770 US9513770W WO9613593A3 WO 1996013593 A3 WO1996013593 A3 WO 1996013593A3 US 9513770 W US9513770 W US 9513770W WO 9613593 A3 WO9613593 A3 WO 9613593A3
Authority
WO
WIPO (PCT)
Prior art keywords
tcr
single chain
fusion protein
soluble
proteins
Prior art date
Application number
PCT/US1995/013770
Other languages
French (fr)
Other versions
WO1996013593A2 (en
Inventor
Julian Banerji
Sanjay Khandekar
Brian Bettencourt
Jerome Naylor
Barry Jones
Una Mckeever
Michael Jesson
Donard Dwyer
Original Assignee
Procept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procept Inc filed Critical Procept Inc
Publication of WO1996013593A2 publication Critical patent/WO1996013593A2/en
Publication of WO1996013593A3 publication Critical patent/WO1996013593A3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A fusion protein, comprising a carrier protein connected by a peptide tether to a single chain T cell receptor molecule, consisting of a Vα segment linked to a Vβ segment of the T cell receptor, is disclosed. Also disclosed is a soluble single chain T cell receptor molecule with a conformation that is essentially functionally indistinguishable, based upon reactivity to clonotype-specific antibodies, from that appearing on the surface of T cells. The invention also concerns nucleic acid fragments encoding the fusion protein, expression vectors comprising a nucleic acid fragment encoding the fusion protein, host cells containing such expression vectors, and antibodies to the single chain T cell receptor or to the fusion protein. The invention further pertains to methods of isolating and purifying the fusion proteins, as well as isolating and purifying soluble, single chain T cell receptors. In addition the invention pertains to various uses of soluble TCR fusion protein and isolated single chain TCR. The proteins can be used in molecular assays designed to measure their binding to ligands, including MHC/HLA-peptide antigen complexes or TCR-specific antibodies. Such assays are useful for the detection of agents that block the TCR-ligand interaction. The soluble TCR proteins can also be used to immunize animals, including humans, to produce TCR-specific antibodies. In addition, either in their native or denatured conformation the proteins can be used to vaccinate animals, including humans, in order to suppress the immune response of T cells bearing TCR that share antigenic epitopes with the vaccinating protein.
PCT/US1995/013770 1994-10-26 1995-10-26 Soluble single chain t cell receptors WO1996013593A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US32931094A 1994-10-26 1994-10-26
US08/329,310 1994-10-26
US34789394A 1994-12-01 1994-12-01
US08/347,893 1994-12-01
US46813195A 1995-06-06 1995-06-06
US08/468,131 1995-06-06

Publications (2)

Publication Number Publication Date
WO1996013593A2 WO1996013593A2 (en) 1996-05-09
WO1996013593A3 true WO1996013593A3 (en) 1996-08-01

Family

ID=27406656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/013770 WO1996013593A2 (en) 1994-10-26 1995-10-26 Soluble single chain t cell receptors

Country Status (1)

Country Link
WO (1) WO1996013593A2 (en)

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US11590167B2 (en) 2016-12-03 2023-02-28 Juno Therapeutic, Inc. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors

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US20060235209A9 (en) 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US7749498B2 (en) 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en) 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
EP1019439B1 (en) * 1997-10-02 2011-11-16 Altor BioScience Corporation Soluble single-chain t-cell receptor proteins
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AU2008206442B2 (en) 2007-01-12 2012-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services gp100-specific T cell receptors and related materials and methods of use
US10654908B2 (en) 2014-04-15 2020-05-19 University Of Virginia Patent Foundation Isolated T cell receptors and methods of use therefor
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Cited By (2)

* Cited by examiner, † Cited by third party
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US11590167B2 (en) 2016-12-03 2023-02-28 Juno Therapeutic, Inc. Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors

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