[go: up one dir, main page]

WO1996014199A1 - Procede d'extrusion - Google Patents

Procede d'extrusion Download PDF

Info

Publication number
WO1996014199A1
WO1996014199A1 PCT/NZ1995/000110 NZ9500110W WO9614199A1 WO 1996014199 A1 WO1996014199 A1 WO 1996014199A1 NZ 9500110 W NZ9500110 W NZ 9500110W WO 9614199 A1 WO9614199 A1 WO 9614199A1
Authority
WO
WIPO (PCT)
Prior art keywords
cooling means
rod
passage
die
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NZ1995/000110
Other languages
English (en)
Inventor
Roderick Munro Mcdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Horticulture and Food Research Institute of New Zealand Ltd
New Zealand Institute for Bioeconomy Science Ltd
Original Assignee
Horticulture and Food Research Institute of New Zealand Ltd
New Zealand Institute for Plant and Food Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horticulture and Food Research Institute of New Zealand Ltd, New Zealand Institute for Plant and Food Research Ltd filed Critical Horticulture and Food Research Institute of New Zealand Ltd
Priority to AU38183/95A priority Critical patent/AU3818395A/en
Priority to NZ294951A priority patent/NZ294951A/en
Publication of WO1996014199A1 publication Critical patent/WO1996014199A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0068—Rumen, e.g. rumen bolus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/06—Rod-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/365—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using pumps, e.g. piston pumps
    • B29C48/37—Gear pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/375—Plasticisers, homogenisers or feeders comprising two or more stages
    • B29C48/387—Plasticisers, homogenisers or feeders comprising two or more stages using a screw extruder and a gear pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/793—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling upstream of the plasticising zone, e.g. heating in the hopper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
    • B29C48/83—Heating or cooling the cylinders
    • B29C48/834—Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
    • B29C48/911—Cooling

Definitions

  • the preferred extrusion device may be a single-screw or twin-screw extruder, in which materials are conveyed along a passage under the action of a rotating screw or screws.
  • the clearance between screws and passage walls, the shape of the screws and the viscosity of the mixture should be such that little of the conveyed material can escape the conveying effect, and very high pressures can be generated. These are necessary for the final rod- forming stage.
  • the mixture in the second section of the extruder the mixture can be melted and as a result of the reduced viscosity, or by a change in the clearance or shape of the screws a substantial flow of material against the conveying direction takes place, thereby achieving a high degree of homogeneity in the mixture.
  • an automatic means by which the rod is cut For example, it is envisaged that there will be provided continual extrusion of the rod. The length of the rod may be measured and then the rod may be clamped prior to being cut to a required length.
  • the rod may be cut by a variety of means, but in one embodiment a disc saw may be used.
  • the applicant has found that sometimes it is necessary to rest the rods for two to three days before dipping, otherwise there is a tendency for the wax coating to crack. The reason for this is unknown, but it is suspected that the boluses gradually leach compressed air contained within their matrix. If this is the case, then the applicant proposes in some embodiments of the present invention to subject the boluses to a vacuum system to extract the air before dipping.
  • the vacuum system may be applied to the whole of the apparatus or their may be provided a specialised chamber.
  • the extruder 1 has a number of parts.
  • the first part 2 is the reservoir of the extruder 1 in which the well mixed formulation 3 has a temperature in the order of 65 °C.
  • no pressure is applied to the material within the mixing auger and the only pressure applied is when a material passes through the gear pump before entering the extrusion dye.
  • the rod is then transferred by an arm to a weigh station. If the rod is outside a desired weight range, then a reject actuator disposes of the rod which may be recycled.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procédé d'extrusion de matières présentant un point de fusion précis, caractérisé en ce que (a) on extrude la matière à l'état fondu tout en la faisant passer par un premier moyen de refroidissement capable de refroidir la matière jusqu'à une température légèrement supérieure à son point de fusion, et (b) on extrude la matière fondue et refroidie tout en la faisant passer par un second moyen de refroidissement capable de geler la matière fondue de sorte qu'elle demeure pratiquement intacte à la fin du processus d'extrusion.
PCT/NZ1995/000110 1994-11-02 1995-10-27 Procede d'extrusion Ceased WO1996014199A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU38183/95A AU3818395A (en) 1994-11-02 1995-10-27 Extrusion method
NZ294951A NZ294951A (en) 1994-11-02 1995-10-27 General extrusion methods for materials with sharp melting points, in particular zinc oxide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ26484394 1994-11-02
NZ264843 1994-11-02

Publications (1)

Publication Number Publication Date
WO1996014199A1 true WO1996014199A1 (fr) 1996-05-17

Family

ID=19924999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NZ1995/000110 Ceased WO1996014199A1 (fr) 1994-11-02 1995-10-27 Procede d'extrusion

Country Status (2)

Country Link
AU (1) AU3818395A (fr)
WO (1) WO1996014199A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087273A1 (fr) * 2000-05-18 2001-11-22 New Zealand Pastoral Agriculture Research Institute Limited Mecanisme d'administration de substances biologiques aux animaux
JP2014046646A (ja) * 2012-09-03 2014-03-17 Sumitomo Rubber Ind Ltd ゴム押出装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3698844A (en) * 1969-08-01 1972-10-17 Metallgesellschaft Ag Automatic temperature control system for extruders for molten material
US4255419A (en) * 1979-09-27 1981-03-10 Allergan Pharmaceuticals, Inc. Zinc deficiency in multiple sclerosis
EP0184514A2 (fr) * 1984-12-07 1986-06-11 Societe Civile De Recherches Et D'etudes Therapeutiques Médicaments à base de gluconate de zinc utiles pour le traitement de la sclérose en plaques
JPS6396123A (ja) * 1986-10-13 1988-04-27 Kuraray Co Ltd ビタミンａ酸亜鉛塩を含有する抗炎症剤
US5000944A (en) * 1989-06-09 1991-03-19 Colgate-Palmolive Company Zinc-containing oral products with reduced astringency
WO1992011125A1 (fr) * 1990-12-20 1992-07-09 Woodhams Raymond T Procede de fabrication continue d'articles a haut module a partir de matieres plastiques de poids moleculaire eleve

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3698844A (en) * 1969-08-01 1972-10-17 Metallgesellschaft Ag Automatic temperature control system for extruders for molten material
US4255419A (en) * 1979-09-27 1981-03-10 Allergan Pharmaceuticals, Inc. Zinc deficiency in multiple sclerosis
EP0184514A2 (fr) * 1984-12-07 1986-06-11 Societe Civile De Recherches Et D'etudes Therapeutiques Médicaments à base de gluconate de zinc utiles pour le traitement de la sclérose en plaques
JPS6396123A (ja) * 1986-10-13 1988-04-27 Kuraray Co Ltd ビタミンａ酸亜鉛塩を含有する抗炎症剤
US5000944A (en) * 1989-06-09 1991-03-19 Colgate-Palmolive Company Zinc-containing oral products with reduced astringency
WO1992011125A1 (fr) * 1990-12-20 1992-07-09 Woodhams Raymond T Procede de fabrication continue d'articles a haut module a partir de matieres plastiques de poids moleculaire eleve

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, C-526, page 151; & JP,A,63 096 123, (KURARAY CO LTD), 27 April 1988. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087273A1 (fr) * 2000-05-18 2001-11-22 New Zealand Pastoral Agriculture Research Institute Limited Mecanisme d'administration de substances biologiques aux animaux
AU2001260829B2 (en) * 2000-05-18 2004-12-09 Agresearch Limited Delivery mechanism for the introduction of biological substances to animals
JP2014046646A (ja) * 2012-09-03 2014-03-17 Sumitomo Rubber Ind Ltd ゴム押出装置

Also Published As

Publication number Publication date
AU3818395A (en) 1996-05-31

Similar Documents

Publication Publication Date Title
DE60124077T2 (de) Verfahren und vorrichtung zum blasformen von kapseln aus polyvinylalkohol und blasgeformte polyvinylalkoholkapseln
US5720972A (en) Device for administration of beneficial materials to ruminants
Kittikunakorn et al. Twin-screw melt granulation: Current progress and challenges
EP2531176B1 (fr) Préparation de composition pharmaceutique en poudre au moyen d'une extrudeuse
KR100193003B1 (ko) 압출에 의한 활성성분 과립 제조 방법 및 이로써 얻어진 과립
US6544452B1 (en) Polymer processing method and tablet-forming apparatus
EP0960715A2 (fr) Appareil à vis et méthode d'utilisation de cet appareil pour distribuer de la résine fondue comprenant des fibres
US3482006A (en) Process for extruding a thermoplastic foam
CA2202510A1 (fr) Contenant a liberation lente avec noyau et enveloppe exterieure
US20230091824A1 (en) Manufacturing process and system for manufacturing a 3d printed drug delivery product
EP0497240A1 (fr) Préparation pour la libération contrôlée de principes actifs pour ruminants
JPH0694130B2 (ja) 熱可塑性樹脂及び繊維を配合するための押出機装置及び方法
CN1589155B (zh) 含有活性物质的动物饲料和使用方法
Singhal et al. Hot melt extrusion technique
EP2410970A1 (fr) Procédé et dispositif pour la fabrication de capsules molles
WO1996014199A1 (fr) Procede d'extrusion
EP1083196A1 (fr) Granulation sous l'eau à l'état fondu comprenant un principe actif
NZ294951A (en) General extrusion methods for materials with sharp melting points, in particular zinc oxide
KR0170770B1 (ko) 섬유상 어패류 연제품 제조방법 및 그 제조장치
CN1099837C (zh) 加工口香糖配方组分的方法
US3177820A (en) Tablet granulation apparatus
JPH08280333A (ja) エクストルーダを用いて加工された養魚用飼料
NZ278977A (en) Sustained release bolus for ruminants
CN108472854A (zh) 用于处理吸湿原料的挤出工艺及带有通气填塞器的系统
BR112016010482B1 (pt) Preparação de uma composição farmacêutica em pó por meio de criomoagem

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 294951

Country of ref document: NZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA