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WO1996014307A1 - Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1 - Google Patents

Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1 Download PDF

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Publication number
WO1996014307A1
WO1996014307A1 PCT/US1995/014472 US9514472W WO9614307A1 WO 1996014307 A1 WO1996014307 A1 WO 1996014307A1 US 9514472 W US9514472 W US 9514472W WO 9614307 A1 WO9614307 A1 WO 9614307A1
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WO
WIPO (PCT)
Prior art keywords
compound according
straight
cyclohexane
carbon atoms
branched chain
Prior art date
Application number
PCT/US1995/014472
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English (en)
Inventor
John M. Peterson
Charles A. Blum
Guolin Cai
Alan Hutchison
Original Assignee
Pfizer Inc.
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Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Priority to KR1019970702989A priority Critical patent/KR970707101A/ko
Priority to JP51549896A priority patent/JP3386814B2/ja
Priority to EP95940639A priority patent/EP0790989B1/fr
Priority to FI971931A priority patent/FI971931A0/fi
Priority to DK95940639T priority patent/DK0790989T3/da
Priority to DE69529419T priority patent/DE69529419T2/de
Priority to SK570-97A priority patent/SK57097A3/sk
Priority to AU42319/96A priority patent/AU692977B2/en
Priority to AT95940639T priority patent/ATE231138T1/de
Priority to CA002203878A priority patent/CA2203878C/fr
Priority to MXPA/A/1997/003349A priority patent/MXPA97003349A/xx
Priority to BR9509610A priority patent/BR9509610A/pt
Priority to US08/817,641 priority patent/US5900415A/en
Priority to IL11799796A priority patent/IL117997A0/xx
Priority to PCT/US1996/005843 priority patent/WO1996040660A1/fr
Priority to EP96913198A priority patent/EP0833823A1/fr
Priority to JP9500490A priority patent/JPH10507203A/ja
Priority to AU55787/96A priority patent/AU5578796A/en
Priority to BR9609334A priority patent/BR9609334A/pt
Priority to CA002220958A priority patent/CA2220958A1/fr
Priority to MA24226A priority patent/MA23860A1/fr
Priority to CO96022963A priority patent/CO4700426A1/es
Priority to PE1996000325A priority patent/PE34297A1/es
Priority to TR96/00382A priority patent/TR199600382A2/xx
Publication of WO1996014307A1 publication Critical patent/WO1996014307A1/fr
Priority to NO972091A priority patent/NO972091L/no
Priority to MXPA/A/1997/009980A priority patent/MXPA97009980A/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Definitions

  • This invention relates to certain substituted benzylamine derivatives which selectively bind to human Neuropeptide Y1 (NPY1) receptors.
  • This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds and compositions in treating feeding disorders and certain cardiovascular diseases.
  • Neuropeptide Y a peptide first isolated in 1982, is widely distributed in the central and peripheral neurons and is responsible for a multitude of biological effects in the brain and the periphery.
  • Various animal studies have shown that activation of Neuropeptide Y 1 receptors is related to vasoconstriction, Wahlestedt et al. Regul. Peptides, 13: 307-318 (1986), McCauley and Westfall, J. Pharmacol. Exp. Ther. 261:863-868 (1992). and Grundemar et al., Br. J. Pharmacol. 105: 45-50 (1992); and to stimulation of consummatory behavior.
  • Flood and Morley Peptides, 10: 963-966 (1989).
  • Leibowitz and Alexander Peptides, 12: 1251-1260 (1991), and Stanley et al., Peptides, 13: 581-587 (1992).
  • Neuropeptide Y is a powerful stimuli of food intake, and an inducer of vasoconstriction leading to hypertension. They further point out that low levels of Neuropeptide Y is associated with loss of appetite. These reports clearly indicate that compouds that inhibit the activity of this protein will reduce hypertension and appetite in animals.
  • Compounds that interact with NPY1 receptors and inhibit the activity of Neuropeptide Y at those receptors are useful in treating eating disorders such as, for example, obesity and bulimia, and certain cardiovascular diseases, such as, for example, hypertension.
  • This invention provides novel compounds of Formula I which selectively bind to
  • Neuropeptide Yl (NPY1) receptors Such compounds are useful in treating feeding disorders such as obesity and bulimia as well as certain cardiovascular diseases such as essential hypertension.
  • the invention also provides pharmaceutical compositions comprising compounds of Formula I.
  • the invention thus further relates to the use of such compounds and compositons in the treatment of eating as well as certain cardiovascular diseases. Accordingly, a broad embodiment of the invention is directed to a compound of Formula I:
  • Ar is an aryl group
  • B is sulfur, oxygen, a substituted nitrogen atom, or a mono- or disubstituted carbon atom;
  • n 1, 2, or 3;
  • n 2, 3, or 4;
  • W, X, Y, and T are the same or different and represent hydrogen, halogen, hydroxy. straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 1 and R 2 independently represent hydrogen, or straight or branched chain lower alkyl having 1-6 carbon atoms
  • R 3 and R 4 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms. These compounds are highly selective partial agonists or antagonists at human NPY1 receptors and are useful in the diagnosis and treatment of feeding disorders such as obesity and bulimia as well as certain cardiovascular diseases such as essential hypertension and congestive heart failure.
  • Figure 1 shows representative substituted benzylamines of the present invention.
  • Ar is an aryl group preferably selected from the group consisting of phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2-, 4- or 5-pyrimidyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • B is sulfur, oxygen, N(R 5 ) or C(R 5 )(R 6 );
  • n 1, 2, or 3;
  • n 2, 3, or 4;
  • W, X, Y, and T are the same or different and represent hydrogen, halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1 -6 carbon atoms;
  • R 1 and R 2 are the same or different and represent hydrogen, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • R 3 and R 4 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 5 represents straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl. 2-, 3-, or 4-pyridyl, or phenyl, 2-, 3-, or 4-pyridyl straight or branched chain lower alkyl having 1-6 carbon atoms; and
  • a and R 6 are the same or different and represent
  • p 0-5
  • q 1-5
  • A' is a direct bond, oxygen or sulfur
  • B' is hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having 1-6 carbon atoms, phenyl, 2-, 3-, or 4-pyridyl, phenoxy, 2-, 3-, or 4-pyridyloxy, carboxyl, carboalkoxy, carboxamido. mono or dialkylcarboxamido, amino, or mono or dialkylamino.
  • Preferred compounds according to Formula I are those where Ar is optionally substituted phenyl, pyrimidinyl or pyridyl, B is carbon optionally substituted with phenyl or alkyl, and W, X, Y, A, T, and R 1 -R 4 are hydrogen.
  • Particularly, preferred compounds or Formula I are those where Ar is phenyl, pyrimidinyl or pyridyl, B is carbon optionally substituted with phenyl or alkyl, and W, X, Y, A, T, and R 1 -R 4 are hydrogen.
  • the invention also relates to compounds of formula IA:
  • Ar is phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2-, 4- or 5-pyrimidyl, each of which is optionally mono- or disubstituted with halogen, hydroxy, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • A, W, X, Y, and T are the same or different and represent hydrogen, halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 1 and R 2 are the same or different and represent hydrogen, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • R 3 and R 4 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 9 represents hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl.
  • the invention further encompasses compounds of Formula II:
  • a and X independently represent alkoxy and Ar represents phenyl, pyrimidinyl, or pyridyl.
  • Preferred compounds of Formula II are those where X and A are methoxy, ethoxy, isopropoxy, or butoxy, and Ar represents phenyl, pyrimidinyl, or pyridyl.
  • the invention further includes compounds of Formula III
  • X and A independently represent alkoxy and R 7 and R 8 are different and represent hydrogen or fluorine.
  • the invention further encompasses compounds of Formula IV
  • X represents alkoxy and Ar represents phenyl, pyrimidinyl, or pyridyl.
  • Preferred compounds of Formula V are those where X is methoxy, ethoxy, isopropoxy, or butoxy, and Ar represents phenyl. Particularly preferred compounds of Formula V are those where X is methoxymethoxy or ethoxymethoxy.
  • the invention also includ xes compounds of Formula VI:
  • X represents alkoxy
  • R 9 is alkyl
  • Ar represents phenyl, pyrimidinyl, or pyridyl.
  • Preferred compounds of Formula VI are those where X is methoxy, ethoxy, isopropoxy, or butoxy, R 9 is alkyl, and Ar represents phenyl.
  • Particularly preferred compounds of Formula VI are those where X is methoxy, ethoxy, isopropoxy, or butoxy, R 9 is methyl, and Ar represents phenyl.
  • Other particularly preferred compounds of Formula VI are those where X is methoxymethoxy or ethoxymethoxy, R 9 is methyl, and Ar represents phenyl.
  • the invention also encompasses compounds of Formula VII:
  • Ar represents optionally substituted phenyl, pyrimidinyl, or pyridyl.
  • Preferred compounds of Formula Ar represents phenyl, pyrimidinyl, or pyridyl.
  • Non-toxic pharmaceutically acceptable salts include salts of acids such as hydrochloric, phosphoric, hydrobromic, sulfuric, sulfinic, formic, toluene sulfonic, hydroiodic, acetic and the like. Those skilled in the art will recognize a wide variety of non-toxic pharmaceutically acceptable addition salts.
  • the invention also relates to compounds of formula VIII:
  • Ar is phenyl, 2-, 3-, or 4-pyridyl.
  • A, X, Y, and T are the same or different and represent hydrogen, halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 9 represents hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or phenyl.
  • the present invention also encompasses the acylated prodrugs of the compounds of
  • the invention encompasses both diasteriomers of the compounds having 1,4-substitution on the cyclohexane ring. I.e, the invention encompasses both cis-, and trans- 1,4-cyclohexanes.
  • Preferred compounds of the invention having 1,4-substitution on the cyclohexane ring are those where the nitrogen atom forming the piperazine ring and the alkyl or phenyl group in the 4-position of the cyclohexane ring are "cis" with respect to each other.
  • preferred compounds of the invention having such substitution are those that are cis-1-piperazinyl-4-alkyl or phenyl- cyclohexanes.
  • aryl and “Ar” is meant an aromatic carbocyclic group having a single ring (e.g., phenyl), multiple rings (e.g., biphenyl), or multiple condensed rings in which at least one is aromatic, (e.g., 1,2-3,4-tetrahydronaphthyl, naphthyl, anthryl, or phenanthryl), which can optionally be unsubstituted or substituted with e.g., halogen, lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl, lower acyloxy, aryl, heteroaryl, and hydroxy.
  • alkyl and “lower alkyl” is meant s ⁇ aight and branched chain alkyl groups having from 1-6 carbon atoms.
  • lower alkoxy and “alkoxy” is meant straight and branched chain alkoxy groups having from 1-6 carbon atoms.
  • halogen is meant fluorine, chlorine, bromine and iodine.
  • SK-N-MC cells were purchased from ATCC (Rockville, MD). Cells were maintained at 37°C and 5% CO 2 in Dulbecco's modified essential media (DMEM) with L-glutamine and 110 mg/L sodium pyruvate, which was supplemented with 10% fetal bovine serum and 25 mM HEPES (pH 7.3). The binding assay was performed in 24-well plates (Falcon) when the cells were confluent.
  • DMEM Dulbecco's modified essential media
  • HEPES 25 mM HEPES
  • DPBS Dulbecco's phosphate buffered saline
  • binding buffer consisting of serum-free DMEM containing 0.5% bovine serum albumin, 0.1% bacitracin and 0.1 mM phenylmethylsulfonylfluoride was added to each well.
  • Nonspecific binding was defined with 1 mM NPY (porcine or human, Bachem California).
  • the plates were then put on ice and the wells were aspirated, The cells were washed 4-6 times with 0.5 ml of ice-cold DPBS. A dilute solution of Triton X-100 (1%) was then added to each well.
  • Compounds 13, 18, 20 and 29 are particularly preferred embodiments of the present invention because of their potency in binding to human NPY1 receptors.
  • the compounds of general formula I may be administered orally, topically, parenterally, by inhalation or spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles.
  • parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques.
  • a pharmaceutical formulation comprising a compound of general formula I and a pharmaceutically acceptable carrier.
  • One or more compounds of general formula I may be present in association with one or more non-toxic pharmaceutically acceptable carriers and/or diluents and/or adjuvants and if desired other active ingredients.
  • compositions containing compounds of general formula I may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsion, hard or soft capsules, or syrups or elixirs.
  • compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations.
  • Tablets contain the active ingredient in admixture with non-toxic phaxmaceutically acceptable excipients which are suitable for the manufacture of tablets.
  • excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, com starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc.
  • the tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period.
  • a time delay material such as glyceryl monosterate or glyceryl distearate may be employed
  • Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin or olive oil.
  • an inert solid diluent for example, calcium carbonate, calcium phosphate or kaolin
  • water or an oil medium for example peanut oil, liquid paraffin or olive oil.
  • Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions.
  • excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydropropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example, lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate
  • the aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl p-hydroxybenzoate, one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin.
  • preservatives for example ethyl, or n-propyl p-hydroxybenzoate
  • coloring agents for example ethyl, or n-propyl p-hydroxybenzoate
  • flavoring agents for example ethyl, or n-propyl p-hydroxybenzoate
  • sweetening agents such as sucrose or saccharin.
  • Oily suspensions may be formulated by suspending the active ingredients in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin.
  • the oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide palatable oral preparations. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid.
  • Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives.
  • a dispersing or wetting agent e.g., glycerol, glycerol, glycerol, glycerol, glycerol, glycerol, glycerin, glycerin, glycerin, glycerin, glycerin, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, glycerol, glycerol, glycerol, glycerol, glycerol, glycerol, glycerol, glycerol, glycerol
  • compositions of the invention may also be in the form of oil-in-water emulsions.
  • the oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these.
  • Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol, anhydrides, for example sorbitan monoleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monoleate.
  • the emulsions may also contain sweetening and flavoring agents.
  • Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents.
  • the pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulated according to the known an using those suitable dispersing or wetting agents and suspending agents which have been mentioned above.
  • the sterile injectable preparation may also be sterile injectable solution or suspension in a non-toxic parentally acceptable diluent or solvent, for example as a solution in 1,3-butanediol.
  • Suitable vehicles and solvents that may be employed are water. Ringer's solution and isotonic sodium chloride solution.
  • sterile, fixed oils are conventionally employed as a solvent or suspending medium.
  • any bland fixed oil may be employed including synthetic mono-or diglycerides.
  • fatty acids such as oleic acid find use in the preparation of injectables.
  • the compounds of general formula I may also be administered in the form of suppositories for rectal administration of the drug.
  • These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug.
  • suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug.
  • Such materials are cocoa butter and polyethylene glycols.
  • Compounds of general formula I may be administered parenterally in a sterile medium.
  • the drug depending on the vehicle and concentration used, can either be suspended or dissolved in the vehicle.
  • adjuvants such as local anaesthetics, preservatives and buffering agents can be dissolved in the vehicle.
  • Dosage levels of the order of from about 0.1 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the above-indicated conditions (about 0.5 mg to about 7 g per patient per day).
  • the amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient.
  • the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, and rate of excretion, drug combination and the severity of the particular disease undergoing therapy.
  • A is ArN or ArCH where Ar is phenyl, 2, 3, or 4 pyridyl, 2 or 3 thienyI, 2, 4 or 5 pyrimidyl either unsubstituted or mono or disubstituted with halogen, hydroxy, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • B is sulfur, oxygen NR 5 or CR 5 R 6
  • n 1, 2, or 3;
  • n 2, 3, or 4;
  • W, X, Y, Z, T are the same or different and represent hydrogen, halogen, hydroxy, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 1 and R 2 are the same or different and represent hydrogen, or straight or branched chain lower alkyl having 1-6 carbon atoms;
  • R 3 and R 4 are the same or different and represent hydrogen, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms;
  • R 5 represents straight or branched chain lower alkyl having 1-6 carbon atoms, phenyl, 2, 3, or 4 pyridyl, or phenyl, 2, 3, or 4 pyridyl straight or branched chain lower alkyl having 1-6 carbon atoms;
  • E and R 6 are the same or different and represent hydrogen, hydroxyl, amino, straight or branched chain lower alkyl having 1-6 carbon atoms, straight or branched chain lower alkoxy having

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Abstract

L'invention concerne des composés de la formule (I) ainsi que leurs sels pharmaceutiquement acceptables, formule dans laquelle W, X, Y, A et T représentent des substituants organiques ou inorganiques, n représente 1, 2 ou 3, m représente 2, 3 ou 4, R1-R4 représentent hydrogène ou des substituants organiques, et B représente azote, carbone, soufre ou oxygène. Les composés sont utiles dans le diagnostic et dans le traitement de dérèglements alimentaires tels que l'obésité et la boulimie, et de maladies cardiovasculaires telles que l'hypertension artérielle essentielle et l'insuffisance cardiaque congestive dues à la liaison de ces composés à des récepteurs humains des neuropeptides Y1.
PCT/US1995/014472 1994-11-07 1995-11-07 Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1 WO1996014307A1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
KR1019970702989A KR970707101A (ko) 1994-11-07 1995-11-07 치환된 벤질아민 유도체; 신규한 부류의 신경펩타이드 y1 특이적 리간드(certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands)
JP51549896A JP3386814B2 (ja) 1994-11-07 1995-11-07 ある種の置換ベンジルアミン誘導体：新種の神経ペプチドｙ１特異的リガンド
EP95940639A EP0790989B1 (fr) 1994-11-07 1995-11-07 Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1
FI971931A FI971931A0 (fi) 1994-11-07 1995-11-07 Tietyt substituoidut bentsyyliamiinijohdannaiset; neuropeptidi Y1:lle spesifisten ligandien uusi luokka
DK95940639T DK0790989T3 (da) 1994-11-07 1995-11-07 Visse substituerede benzylaminderivater; en ny klasse neuropeptid Y1 specifikke ligander
DE69529419T DE69529419T2 (de) 1994-11-07 1995-11-07 Bestimmte substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifischen liganden
SK570-97A SK57097A3 (en) 1994-11-07 1995-11-07 Certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands
AU42319/96A AU692977B2 (en) 1994-11-07 1995-11-07 Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
AT95940639T ATE231138T1 (de) 1994-11-07 1995-11-07 Bestimmte substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifischen liganden
CA002203878A CA2203878C (fr) 1994-11-07 1995-11-07 Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1
MXPA/A/1997/003349A MXPA97003349A (es) 1994-11-07 1995-11-07 Ligandos especificos del neuropeptido y1
BR9509610A BR9509610A (pt) 1994-11-07 1995-11-07 Ligandos específicos de neuropeptideo Y1
US08/817,641 US5900415A (en) 1994-11-07 1995-11-07 Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
IL11799796A IL117997A0 (en) 1995-06-07 1996-04-22 Neuropeptide Y1 specific ligands
PCT/US1996/005843 WO1996040660A1 (fr) 1995-06-07 1996-04-26 Derives de benzylamine substitues particuliers; une nouvelle classe de ligands specifiques des neuropeptides y1
EP96913198A EP0833823A1 (fr) 1995-06-07 1996-04-26 Derives de benzylamine substitues particuliers; une nouvelle classe de ligands specifiques des neuropeptides y1
JP9500490A JPH10507203A (ja) 1995-06-07 1996-04-26 ある種の置換ベンジルアミン誘導体；ニューロペプチドｙ１特異性リガンドの新規類
AU55787/96A AU5578796A (en) 1995-06-07 1996-04-26 Certain substituted benzylamine derivatives: a new class of neuropeptide y1 specific ligands
BR9609334A BR9609334A (pt) 1995-06-07 1996-04-26 Certos derivados de benzilamina substituída uma nova classe de ligadores específicos de neuropeptídeo Y1
CA002220958A CA2220958A1 (fr) 1995-06-07 1996-04-26 Derives de benzylamine substitues particuliers; une nouvelle classe de ligands specifiques des neuropeptides y1
MA24226A MA23860A1 (fr) 1995-06-07 1996-05-08 Derives de benzylamine substitues se liant specifiquement aux recepteurs du neuropeptide y1 et compositions les contenant
CO96022963A CO4700426A1 (es) 1995-06-07 1996-05-08 Ligandos especificos del neuropeptido y1
PE1996000325A PE34297A1 (es) 1995-06-07 1996-05-08 Ligandos especificos del neuropeptido y1
TR96/00382A TR199600382A2 (tr) 1995-06-07 1996-05-10 Nöropeptid Y1'e özgü baglar.
NO972091A NO972091L (no) 1994-11-07 1997-05-06 Bestemte substituerte benzylaminderivater; en ny klasse nouropeptid-yl-spesifikke ligander
MXPA/A/1997/009980A MXPA97009980A (en) 1995-06-07 1997-12-08 Certain substitute bencilamine derivatives: unanueva class of neuropeptide specific ligands

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US33547594A 1994-11-07 1994-11-07
US08/335,475 1994-11-07
US47438395A 1995-06-07 1995-06-07
US48497495A 1995-06-07 1995-06-07
US08/474,383 1995-06-07
US08/484,974 1995-06-07

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WO1996014307A1 true WO1996014307A1 (fr) 1996-05-17

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JP (1) JP3386814B2 (fr)
KR (1) KR970707101A (fr)
AU (1) AU692977B2 (fr)
BR (1) BR9509610A (fr)
CA (1) CA2203878C (fr)
CZ (1) CZ137297A3 (fr)
HU (1) HUT78089A (fr)
NO (1) NO972091L (fr)
NZ (1) NZ297211A (fr)
PL (1) PL321136A1 (fr)
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WO (1) WO1996014307A1 (fr)

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CA2203878C (fr) 2002-06-25
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PL321136A1 (en) 1997-11-24
NO972091D0 (no) 1997-05-06
NO972091L (no) 1997-07-02
BR9509610A (pt) 1997-10-28
CA2203878A1 (fr) 1996-05-17
NZ297211A (en) 1999-01-28
CZ137297A3 (cs) 1998-04-15
JP2001520625A (ja) 2001-10-30
SK57097A3 (en) 1998-10-07
AU4231996A (en) 1996-05-31
KR970707101A (ko) 1997-12-01
HUT78089A (hu) 1999-08-30
JP3386814B2 (ja) 2003-03-17

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