WO1996016663B1 - Derives de thionophosphate, procede de preparation et compositions pharmaceutiques les contenant - Google Patents
Derives de thionophosphate, procede de preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- WO1996016663B1 WO1996016663B1 PCT/US1995/015199 US9515199W WO9616663B1 WO 1996016663 B1 WO1996016663 B1 WO 1996016663B1 US 9515199 W US9515199 W US 9515199W WO 9616663 B1 WO9616663 B1 WO 9616663B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- group
- compound
- pharmaceutical composition
- composition according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 12
- 238000000034 method Methods 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 10
- 125000002252 acyl group Chemical group 0.000 claims abstract 4
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 239000001301 oxygen Substances 0.000 claims abstract 2
- 239000010452 phosphate Substances 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims 5
- 230000004792 oxidative damage Effects 0.000 claims 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000014644 Brain disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 208000029549 Muscle injury Diseases 0.000 claims 2
- PKUWKAXTAVNIJR-UHFFFAOYSA-N O,O-diethyl hydrogen thiophosphate Chemical compound CCOP(O)(=S)OCC PKUWKAXTAVNIJR-UHFFFAOYSA-N 0.000 claims 2
- 208000005374 Poisoning Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 206010044541 Traumatic shock Diseases 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000003412 degenerative effect Effects 0.000 claims 2
- 230000006866 deterioration Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 231100000040 eye damage Toxicity 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 239000000575 pesticide Substances 0.000 claims 2
- 231100000572 poisoning Toxicity 0.000 claims 2
- 230000000607 poisoning effect Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000003063 flame retardant Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 239000004009 herbicide Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 230000000590 parasiticidal effect Effects 0.000 claims 1
- 239000002297 parasiticide Substances 0.000 claims 1
- 230000008635 plant growth Effects 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Abstract
L'invention traite d'un composé de la formule (I) dans laquelle X1 et X2 représentent chacun indépendamment un atome d'oxygène ou d'azote; p, m et n représentent chacun indépendamment un nombre entier d'une valeur d'au moins 2; R, R1 et R2 représentent indépendamment un atome d'hydrogène; un atome halogène; un radical alkyle, alcényle ou alcynile éventuellement substitué, à chaîne droite ou ramifié; un groupe R3O dans lequel R3 est un atome d'hydrogène, un radical alkyle, alcényle ou alcynile éventuellement substitué, à chaîne droite ou ramifié; un acyle éventuellement substitué ou un aryle ou un hétéroaryle éventuellement substitué; un groupe R4O(O)C dans lequel R4 est un atome d'hydrogène ou un radical alkyle, alcényle ou alcynile éventuellement substitué, à chaîne droite ou ramifié; un groupe -SR5 dans lequel R5 est un atome d'hydrogène ou un radical alkyle, alcényle ou alcynile éventuellement substitué, à chaîne droite ou ramifié; un groupe -NR6R7 dans lequel R6 et R7 représentent indépendamment un atome d'hydrogène, un radical alkyle, alcényle ou alcynile éventuellement substitué, à chaîne droite ou ramifié; un acyle éventuellement substitué ou un groupe d'ester phosphorique éventuellement substitué. Cette invention traite également des procédés de préparation de composés de la formule susmentionnée et de compositions pharmaceutiques les contenant.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU44081/96A AU4408196A (en) | 1994-11-28 | 1995-11-13 | Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them |
| EP95942875A EP0813415A4 (fr) | 1994-11-28 | 1995-11-13 | Derives de thionophosphate, procede de preparation et compositions pharmaceutiques les contenant |
| US08/849,122 US6200962B1 (en) | 1994-11-28 | 1995-11-13 | Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11179794A IL111797A0 (en) | 1994-11-28 | 1994-11-28 | Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them |
| IL111,797 | 1994-11-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996016663A1 WO1996016663A1 (fr) | 1996-06-06 |
| WO1996016663B1 true WO1996016663B1 (fr) | 1996-08-08 |
Family
ID=11066823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/015199 WO1996016663A1 (fr) | 1994-11-28 | 1995-11-13 | Derives de thionophosphate, procede de preparation et compositions pharmaceutiques les contenant |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0813415A4 (fr) |
| AU (1) | AU4408196A (fr) |
| CA (1) | CA2206374A1 (fr) |
| IL (1) | IL111797A0 (fr) |
| WO (1) | WO1996016663A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10051983A1 (de) * | 2000-10-20 | 2002-06-13 | Beate Kehrel | Inhibierung der pathogenen Wirkung oxidierter Proteine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3087955A (en) * | 1960-02-08 | 1963-04-30 | Dow Chemical Co | O-haloalkyl o-alkyl phosphoramidothioates |
| US3251675A (en) * | 1961-12-28 | 1966-05-17 | Dow Chemical Co | Method of inhibiting plant growth |
| US3207661A (en) * | 1963-01-11 | 1965-09-21 | American Agricultural Chem Co | Bis-(aziridinyl)-phosphinothioic esters as chemical sterilants for insects and mites |
| US3531550A (en) * | 1965-08-12 | 1970-09-29 | Monsanto Co | Phosphorus ester amides |
| US3597476A (en) * | 1968-12-04 | 1971-08-03 | Dow Chemical Co | Process for preparing tris (2-mercaptoethylamino) phophine oxides and sulfides |
| FR2034207A1 (fr) * | 1969-02-20 | 1970-12-11 | Pepro | |
| US3670057A (en) * | 1969-11-10 | 1972-06-13 | Sumitomo Chemical Co | S(alkllthio ethyl) phosphorothioamidate |
-
1994
- 1994-11-28 IL IL11179794A patent/IL111797A0/xx unknown
-
1995
- 1995-11-13 WO PCT/US1995/015199 patent/WO1996016663A1/fr not_active Application Discontinuation
- 1995-11-13 EP EP95942875A patent/EP0813415A4/fr not_active Withdrawn
- 1995-11-13 AU AU44081/96A patent/AU4408196A/en not_active Abandoned
- 1995-11-13 CA CA002206374A patent/CA2206374A1/fr not_active Abandoned
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