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WO1996020690A3 - Monomeres de 3,3-(disubstitue)cyclohexan-1-ylidine acetate et composes apparentes - Google Patents

Monomeres de 3,3-(disubstitue)cyclohexan-1-ylidine acetate et composes apparentes Download PDF

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Publication number
WO1996020690A3
WO1996020690A3 PCT/US1995/016294 US9516294W WO9620690A3 WO 1996020690 A3 WO1996020690 A3 WO 1996020690A3 US 9516294 W US9516294 W US 9516294W WO 9620690 A3 WO9620690 A3 WO 9620690A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclohexan
disubstituted
related compounds
acetate monomers
ylidine
Prior art date
Application number
PCT/US1995/016294
Other languages
English (en)
Other versions
WO1996020690A2 (fr
Inventor
Siegfried B Christensen Iv
Joseph M Karpinski
M Dominic Ryan
Paul E Bender
Original Assignee
Smithkline Beecham Corp
Siegfried B Christensen Iv
Joseph M Karpinski
M Dominic Ryan
Paul E Bender
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Siegfried B Christensen Iv, Joseph M Karpinski, M Dominic Ryan, Paul E Bender filed Critical Smithkline Beecham Corp
Publication of WO1996020690A2 publication Critical patent/WO1996020690A2/fr
Publication of WO1996020690A3 publication Critical patent/WO1996020690A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux monomères de 3,3(disubstitué)-cyclohexan-1-ylidine acétate et des composés apparentés, des compositions pharmaceutiques contenant lesdits composés et leur utilisation pour traiter des maladies allergiques et inflammatoires, ainsi que pour inhiber la production du facteur de nécrose tumorale (TNF).
PCT/US1995/016294 1994-12-23 1995-12-14 Monomeres de 3,3-(disubstitue)cyclohexan-1-ylidine acetate et composes apparentes WO1996020690A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36366594A 1994-12-23 1994-12-23
US08/363,665 1994-12-23

Publications (2)

Publication Number Publication Date
WO1996020690A2 WO1996020690A2 (fr) 1996-07-11
WO1996020690A3 true WO1996020690A3 (fr) 1996-09-06

Family

ID=23431167

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1995/016293 WO1996020159A1 (fr) 1994-12-23 1995-12-14 Monomeres d'acetate 3,3-hexamethylene (bisubstitue)-1-ylidine et composes connexes
PCT/US1995/016294 WO1996020690A2 (fr) 1994-12-23 1995-12-14 Monomeres de 3,3-(disubstitue)cyclohexan-1-ylidine acetate et composes apparentes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1995/016293 WO1996020159A1 (fr) 1994-12-23 1995-12-14 Monomeres d'acetate 3,3-hexamethylene (bisubstitue)-1-ylidine et composes connexes

Country Status (3)

Country Link
JP (1) JP2002503200A (fr)
HU (1) HUT77003A (fr)
WO (2) WO1996020159A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796092A4 (fr) * 1994-12-23 1998-03-25 Smithkline Beecham Corp Dimeres de 3,3-(disubstitue)cyclohexan-one et composes apparentes
WO1996019985A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Dimeres de 3,3-(disubstitues)cyclohexan-1-ylidine acetate et composes correspondants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COLLECTION CZECHOSLOVAK CHEM. COMMUN., Volume 51, 1986, KUCHAR et al., "Synthesis of Cyclohexyl Aliphatic Acids and Their Pharmacological Properties", pages 2896-2908. *
LIEBIGS ANN. CHEM., Volume 8, 1980, ANTUS et al., "Oxadative Rearrangement of -Benzylideneketones with Thallium(III) Nitrate in Methanol", pages 1283-1295. *

Also Published As

Publication number Publication date
WO1996020159A1 (fr) 1996-07-04
WO1996020690A2 (fr) 1996-07-11
JP2002503200A (ja) 2002-01-29
HUT77003A (hu) 1998-03-02

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