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WO1996027015A3 - A novel gene for a protein kinase associated with drug resistance - Google Patents

A novel gene for a protein kinase associated with drug resistance Download PDF

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Publication number
WO1996027015A3
WO1996027015A3 PCT/US1996/002375 US9602375W WO9627015A3 WO 1996027015 A3 WO1996027015 A3 WO 1996027015A3 US 9602375 W US9602375 W US 9602375W WO 9627015 A3 WO9627015 A3 WO 9627015A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
drug resistance
novel gene
kinase associated
genes
Prior art date
Application number
PCT/US1996/002375
Other languages
French (fr)
Other versions
WO1996027015A2 (en
Inventor
Irene Abraham
Dale A Begley
Kathleen E Sampson
Original Assignee
Upjohn Co
Irene Abraham
Dale A Begley
Kathleen E Sampson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Irene Abraham, Dale A Begley, Kathleen E Sampson filed Critical Upjohn Co
Priority to AU49911/96A priority Critical patent/AU4991196A/en
Publication of WO1996027015A2 publication Critical patent/WO1996027015A2/en
Publication of WO1996027015A3 publication Critical patent/WO1996027015A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

This invention describes several DNA and amino acid sequences of novel protein kinase, genes and proteins. The principal protein is a 170 kDa kinase. Other embodiments, genes, fragments, proteins, peptides and various segments variants and substitutions are also described. The protein kinase described is associated with multidrug resistance.
PCT/US1996/002375 1995-02-28 1996-02-26 A novel gene for a protein kinase associated with drug resistance WO1996027015A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49911/96A AU4991196A (en) 1995-02-28 1996-02-26 A novel gene for a protein kinase associated with drug resistance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39639995A 1995-02-28 1995-02-28
US08/396,399 1995-02-28

Publications (2)

Publication Number Publication Date
WO1996027015A2 WO1996027015A2 (en) 1996-09-06
WO1996027015A3 true WO1996027015A3 (en) 1996-11-28

Family

ID=23567046

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/002375 WO1996027015A2 (en) 1995-02-28 1996-02-26 A novel gene for a protein kinase associated with drug resistance

Country Status (2)

Country Link
AU (1) AU4991196A (en)
WO (1) WO1996027015A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965420A (en) * 1997-03-05 1999-10-12 Smithkline Beecham Corporation Human protein kinases hYAK3
US6323318B1 (en) 1999-02-01 2001-11-27 Smithkline Beecham Corporation Human protein kinases hYAK3-2
WO2000044941A1 (en) * 1999-02-01 2000-08-03 Smithkline Beecham Corporation A method of treating anemia
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019008A1 (en) * 1990-06-01 1991-12-12 Regeneron Pharmaceuticals, Inc. A family of map2 protein kinases
WO1994029455A1 (en) * 1993-06-11 1994-12-22 Institut National De La Sante Et De La Recherche Medicale Mutant polypeptide of protein kinase c, nucleic acid sequences coding for said polypeptide and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019008A1 (en) * 1990-06-01 1991-12-12 Regeneron Pharmaceuticals, Inc. A family of map2 protein kinases
WO1994029455A1 (en) * 1993-06-11 1994-12-22 Institut National De La Sante Et De La Recherche Medicale Mutant polypeptide of protein kinase c, nucleic acid sequences coding for said polypeptide and use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHO, F.S. ET AL.: "Cloning of the rat cyclin-dependent kinase 4 cDNA: Implication in proliferation-dependent expression in rat tissues", BIOCHEM.BIOPHYS.RES.COMMUN., vol. 191, no. 3, March 1993 (1993-03-01), pages 860 - 865, XP002014778 *
GARRETT, S. ET AL.: "The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle", MOL.CELL.BIOL., vol. 11, no. 8, August 1991 (1991-08-01), pages 4045 - 4052, XP002014780 *
HANKS, S.K. ET AL.: "The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains", SCIENCE, vol. 241, 1988, pages 42 - 52, XP002014781 *
SAMPSON, K.E. ET AL.: "Identification of a 170 kDa membrane kinase with increased activity in KB-V1 multidrug resistant cells", J.CELL.BIOCHEM., vol. 52, 1993, pages 384 - 395, XP002014779 *

Also Published As

Publication number Publication date
AU4991196A (en) 1996-09-18
WO1996027015A2 (en) 1996-09-06

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