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WO1996029423A1 - Compositions et methodes pour induire une infection par des vecteurs retroviraux en dehors de leur gamme d'hotes - Google Patents

Compositions et methodes pour induire une infection par des vecteurs retroviraux en dehors de leur gamme d'hotes Download PDF

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Publication number
WO1996029423A1
WO1996029423A1 PCT/US1996/002015 US9602015W WO9629423A1 WO 1996029423 A1 WO1996029423 A1 WO 1996029423A1 US 9602015 W US9602015 W US 9602015W WO 9629423 A1 WO9629423 A1 WO 9629423A1
Authority
WO
WIPO (PCT)
Prior art keywords
retrovirus
cells
adenovirus
infection
virus
Prior art date
Application number
PCT/US1996/002015
Other languages
English (en)
Inventor
Fred Ledley
R. Mark Adams
Original Assignee
Baylor College Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Of Medicine filed Critical Baylor College Of Medicine
Publication of WO1996029423A1 publication Critical patent/WO1996029423A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Definitions

  • mixture of a retrovirus and adenovirus is meant a formulation comprising the retrovirus and adenovirus which is administered to an organism or cell simultaneously or the administration of a retrovirus and adenovirus separately, but in close temporal order such that the organism or cell will be exposed to both the retrovirus and adenovirus at substantially the same time.
  • nucleic acid By nucleic acid is meant both RNA and DNA including: cDNA, genomic DNA, plasmid DNA or condensed nucleic acid, nucleic acid formulated with cationic lipids, nucleic acid formulated with peptides, cationic polymers, RNA or mRNA.
  • the nucleic acid administered is plasmid DNA which comprises a vector, phosphoproteins.
  • Data are expressed as the apparent titer of the xenotropic retrovirus on the NIH3T3 cells (y-axis) as a function of the concentration of adenovirus (x-axis) , and dilution of the retrovirus stock

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention décrit des méthodes et des compositions pour augmenter la gamme des hôtes d'un rétrovirus ou d'un vecteur rétroviral administré à une cellule ou à un organisme par coadministration d'une formulation contenant, par exemple, un adénovirus. La gamme des hôtes des rétrovirus écotrope, xénotrope et amphotrope peut donc être élargie.
PCT/US1996/002015 1995-03-20 1996-02-13 Compositions et methodes pour induire une infection par des vecteurs retroviraux en dehors de leur gamme d'hotes WO1996029423A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40858695A 1995-03-20 1995-03-20
US08/408,586 1995-03-20

Publications (1)

Publication Number Publication Date
WO1996029423A1 true WO1996029423A1 (fr) 1996-09-26

Family

ID=23616885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/002015 WO1996029423A1 (fr) 1995-03-20 1996-02-13 Compositions et methodes pour induire une infection par des vecteurs retroviraux en dehors de leur gamme d'hotes

Country Status (1)

Country Link
WO (1) WO1996029423A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358742B1 (en) 1996-03-25 2002-03-19 Maxygen, Inc. Evolving conjugative transfer of DNA by recursive recombination

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007283A1 (fr) * 1991-09-30 1993-04-15 Boehringer Ingelheim International Gmbh Composition d'insertion de complexes d'acides nucleiques dans des cellules eucaryotes superieures
WO1994006923A1 (fr) * 1992-09-24 1994-03-31 The University Of Connecticut Modification d'un virus pour rediriger l'infectivite et amplifier l'apport cible de polynucleotides a des cellules
WO1994017832A1 (fr) * 1993-02-09 1994-08-18 The Scripps Research Institute Ciblage et transport de genes et d'agents antiviraux dans des cellules par l'adenovirus penton

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007283A1 (fr) * 1991-09-30 1993-04-15 Boehringer Ingelheim International Gmbh Composition d'insertion de complexes d'acides nucleiques dans des cellules eucaryotes superieures
WO1994006923A1 (fr) * 1992-09-24 1994-03-31 The University Of Connecticut Modification d'un virus pour rediriger l'infectivite et amplifier l'apport cible de polynucleotides a des cellules
WO1994017832A1 (fr) * 1993-02-09 1994-08-18 The Scripps Research Institute Ciblage et transport de genes et d'agents antiviraux dans des cellules par l'adenovirus penton

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMS ET AL: "ADENOVIRAL MEDIATED RETROVIRAL TRANSDUCTION INTO RESISTANT CELLS", ABSTRACTS OF THE AMERICAN SOCIETY FOR CELL BIOLOGY,33RD ANNUAL MEETING, 11 December 1993 (1993-12-11) - 15 December 1993 (1993-12-15), NEW ORLEANS,LOUISIANA, pages 89A, XP002004828 *
ADAMS ET AL: "INFECTION BY RETROVIRAL VECTORS OUTSIDE OF THEIR HOST RANGE IN THE PRESENCE OF REPLICATION-DEFECTIVE ADENOVIRUS", JOURNAL OF VIROLOGY, vol. 69, no. 3, March 1995 (1995-03-01), pages 1887 - 1894, XP002004830 *
ADAMS ET AL: "REPLICATION DEFECTIVE ADENOVIRUS ENABLES TRANSDUCTION BY RETROVIRAL VECTORS OF CELLS OUTSIDE OF THEIR HOST RANGE", JOURNAL OF CELLULAR BIOCHEMISTRY,SUPPLEMENT 0,18 PART A, 1994, pages 222, XP000572572 *
CURIEL ET AL: "ADENOVIRUS ENHANCEMENT OF TRANSFERRIN-POLYLYSINE-MEDIATED GENE DELIVERY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES,USA, vol. 88, October 1991 (1991-10-01), pages 8850 - 8854, XP002004829 *
DONG ET AL: "A CHIMERIC AVIAN RETROVIRUS CONTAINING THE INFLUENZA VIRUS HEMAGGLUTININ GENE HAS AN EXPANDED HOST RANGE", JOURNAL OF VIROLOGY, vol. 66, no. 12, December 1992 (1992-12-01), pages 7374 - 7382, XP000572226 *
MOLECULAR BIOLOGY OF THE CELL, vol. 4, October 1993 (1993-10-01) *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358742B1 (en) 1996-03-25 2002-03-19 Maxygen, Inc. Evolving conjugative transfer of DNA by recursive recombination
US6387702B1 (en) 1996-03-25 2002-05-14 Maxygen, Inc. Enhancing cell competence by recursive sequence recombination
US6391552B2 (en) 1996-03-25 2002-05-21 Maxygen, Inc. Enhancing transfection efficiency of vectors by recursive recombination
US6482647B1 (en) 1996-03-25 2002-11-19 Maxygen, Inc. Evolving susceptibility of cellular receptors to viral infection by recursive recombination

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