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WO1996031247A1 - Canules d'injection concues pour eviter tout risque de formation de fragments et d'enlevement de tissu - Google Patents

Canules d'injection concues pour eviter tout risque de formation de fragments et d'enlevement de tissu Download PDF

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Publication number
WO1996031247A1
WO1996031247A1 PCT/DE1996/000524 DE9600524W WO9631247A1 WO 1996031247 A1 WO1996031247 A1 WO 1996031247A1 DE 9600524 W DE9600524 W DE 9600524W WO 9631247 A1 WO9631247 A1 WO 9631247A1
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
opening
tip
cannula according
tissue
Prior art date
Application number
PCT/DE1996/000524
Other languages
German (de)
English (en)
Inventor
Johann Rull
Original Assignee
Johann Rull
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johann Rull filed Critical Johann Rull
Publication of WO1996031247A1 publication Critical patent/WO1996031247A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3286—Needle tip design, e.g. for improved penetration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B2017/3454—Details of tips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291—Shafts with additional lateral openings

Definitions

  • TITLE FRAGMENTATION-FREE, NON-PUNCHING INJECTION TUBES
  • the invention relates to injection cannulas which completely exclude tissue or material entrainment during the injection / puncture process both in human or animal tissues and in artificial membranes, balloons, etc. This tissue and particle-free puncture procedure is achieved through different shapes of the cannula tip geometry and cannula shaft changes.
  • REPLACEMENT BLA ⁇ (RULE 26) den (no punching effect, no penetration of particles into the cannula shaft).
  • US-A-2634. 726 describes such a cannula with a pencil tip and a lateral arrangement of the cannula opening.
  • the cannula tip geometry, cannula eye ensures no tissue freedom during the puncture procedure and is very painful, as are the needles of sprat and whitaker.
  • DE 3020926 C2 - is designed for spinal and lead anesthesia, lumbar puncture. Tissue freedom is achieved in that the cannula tube is closed with a mandrain. Not suitable for general use.
  • DE 3020.193 A 1 is not constructed for medical purposes.
  • EP 0301245 Surecan or Haindl cannula has a lacquer-shaped tip in the construction ground geometry
  • the rear cannula opening is preferably directed inwards. This cannula shape also does not provide complete freedom from particles and tissue during the injection process, and only results in a reduced punching effect. The tissue and material entrainment in the cannula types mentioned arise in approximately 80% at the distal rear cannula opening.
  • the new cannula shapes according to the invention are characterized in that the cannula tips, the cannula tubes in front are closed, which have no opening and the cannula itself can be made from different materials.
  • cannula shapes according to the invention in particular the cannula tip geometry, preferably have different types of cut, facet, lancet, scalpel cut and scalpel shape, in order to keep the trauma through the puncturing process as small as possible.
  • ERSATZBL TT (REGEL26)
  • the cannulas are equipped with side openings, made at different heights below the cannula tips.
  • the cannula tip cutting surface is designed and manufactured according to the invention such that the cannula opening lies on the contralateral side, that is to say opposite the cutting surface (cannula tip 12, 15).
  • the cutting surface cannula tip 12, 15.
  • the cannula according to the invention can be equipped with advantages in such a way that the cannula tip (15), cutting surface (12) extends in a cylindrical shape or in inclined planes to the heap grinding surface with a different bending angle, the cannula eye (17) on the shaft on the opposite side (contralateral) to the cutting surface. This creates a pronounced non-contact tissue zone. Constriction of the cannula lumen - cannula shaft is avoided (Fig. 2). Further cannula shapes according to the invention are designed so that the cannula shaft is bent, the bending of the shaft having different radii. The cannula opening (17) is opposite to the cannula tip (15), cutting surface.
  • this cannula manufacturing form can be designed in such a way that the cannula tip is also curved (2), bending angle (R) is different in size, the cannula eye is opposite to the cutting surface, so that an even larger zone without tissue contact can be created.
  • R bending angle
  • the cannula eye is opposite to the cutting surface, so that an even larger zone without tissue contact can be created.
  • a cannula shape is specified according to the invention, the cannula shaft running straight, the cannula tip - cutting surface being on the same side to the cannula opening.
  • the cannula opening is made in the curved concave part of the cannula shaft (Fig. 5).
  • the tip of the cannula can be curved inwards or straight towards the cannula eye, with the shaft of the cannula bent, which creates an even larger contact-free zone to prevent tissue particles from penetrating into the cannula shaft (FIG. 6).
  • a cannula shape is described, the main feature of which is that the cannula tip in the transition area to the cannula shaft is wider in its circumference than the cannula shaft itself.
  • the cannula tip is closed and manufactured with different tip geometry, facet and lancet grinding up to Scalpel shape to make the force-displacement diagram of the puncture cheap.
  • the wider cannula tip in the transition area to the cannula shaft offers a contact-free zone for the cannula opening located in the cannula shaft (FIG. 7).
  • the tissue particles are pushed further from the cannula opening in the shaft (Fig. 8). Due to the contact-free zone created, these cannula shapes and designs prevent tissue particles from penetrating into the cannula shaft, even with e.g. Portka ⁇ theder to prevent occlusion, punching out membrane parts (Fig. 9).
  • Embodiments of the invention are shown schematically as a drawing with references to manufacturing technology, as follows:
  • FIGS. 9b to 9d show different cross sections of the lance-shaped grind of the ninth embodiment in accordance with section AA in Fig. 9a
  • the cannula according to FIGS. 1 to 9 consists of a cylindrical cannula tube (11) with a solid tip closed at the top with a suitable Schuff geometry 12, 13, 14, 15, 16, with the cannula tube on the side below the tip or the puncture area the cannula is the opening 17.
  • a preferred cannula shape shown in FIG. 1 is designed according to the invention in such a way that the opening 17 is arranged on the contralateral to the main grinding surface 12. As a result, any tissue particles that have been planed off are pushed through the bevel of the main grinding surface 12 and kept away from the opening 17 - a contact-free zone is created between the opening 17 and the tissue when the cannula is inserted into the tissue.
  • a flat or slightly cylindrical main cut 12 and two additional lateral cuts 14 result in a sharp tip 15 or a further cutting edge 16, as shown in FIG. Id, results in an oval cutting surface (12). Since the cannula according to the invention, in contrast to conventional cannulas with a continuous bore, is closed or solid at the top, the main grinding surface 12 with the cutting edge course 13 is attached very cheaply in accordance with the manufacture so that a smooth cut without punching out is likewise made when the needle is inserted is generated in the tissue.
  • the cannula tube 11 is closed according to the manufacture by a stopper 18, alternatively by a finished, grooved part which is placed on top according to FIG. 1b. -
  • Fig. Lc The embodiment shown in Fig. Lc is produced by the original or forming process.
  • SPARE BLADE (RULE 26) in that the distance between the tip 15 and the opening 17 — shown larger in FIG. 1c than in FIG. 1b — is optimized by experiments.
  • the cross sections of the opening 17 are circular, as shown in Fig. La f lb f lc, or oval as shown in Fig. Lc. According to the manufacture, the oval opening 17 in FIG. 1 is produced by a cylindrical milling or grinding tool.
  • edges 17 of the opening 17 are deburred and rounded using the blasting, chemical deburring and polishing manufacturing processes, etc.
  • the cannula tube 11 is closed or solid, and the opening 17 is contralateral to the cylindrical main grinding surface 12 (FIGS. 2 & X alternatively to the flat main grinding surface 12 (FIG. 2b ) arranged.
  • the upper part of the cannula is bent with a radius R so that the tip is directed outwards.
  • the embodiment of the cannula shown in FIG. 3 differs from the previous shapes in that the cannula tube 11 is bent in the region of the opening 17 in such a way that that the left surface line of the cannula tube 11 has three radii of curvature there, the upper surface line — toward the tip 15 — the left surface line merging again into a straight region G that runs parallel to the straight main axis 20 of the cannula.
  • This bending of the cannula also creates a pronounced, contact-free zone.
  • the fourth embodiment shown in FIG. 4 differs from the previous one in that the cannula continuously has a bending radius R in the area between the opening 17 and the tip 15 and a weakly cylindrical
  • REPLACEMENT BUTT (RULE 26) has drisch curved main grinding surface 12. The contact-free zone is thus even more pronounced than in the third embodiment (FIG. 3).
  • the cannula tube 11 is triple bent in the area of the opening 17, while in the puncturing area at the top in the area G it runs again in a straight line and in alignment with the straight main axis 20.
  • the opening 17 is placed on the same side as the main ground surface 12 at the lowest point in the concave region of the central bend of the cannula tube 11. A pronounced contact-free zone is also present in this embodiment.
  • the embodiment of the cannula shown in FIG. 6 has only two bends in the cannula tube 11, which again has a straight region G in the insertion area at the top.
  • This straight region G is inclined laterally outwards to the straight main axis 20.
  • the main grinding surface 12 is either parallel to the straight main axis 20 or inclined inwards.
  • the opening 17 sits at the lowest point in the concave region of the second bend from below in the contact-free zone.
  • the seventh embodiment of the cannula shown in FIG. 7 differs from the previous embodiments particularly in that the circumference in the cross section of the piercing area is larger at the top than in the cylindrical area of the cannula tube 11 below the opening 17.
  • the cannula is once bent outwards in the area R 1.
  • a further concave curvature R 2 is provided in the area in front of the tip 15, so that the left surface line of the cannula runs weakly S-shaped or also straight to the tip 15. This straight line is shown in dashed lines in FIG. 7.
  • the opening 17 is located on the same side as the main grinding surface 12 at the transition from the straight cannula tube 11 to the bend in the area R 1.
  • This seventh embodiment produces a wider cut when piercing the tissue than in the previous embodiments, due to the larger one Scope in the plunge area and the larger main grinding surface 12.
  • the eighth embodiment of the cannula shown in FIG. 8 is a modification of the seventh embodiment - likewise with a larger cross section in the piercing area in front of the opening 17.
  • the piercing area above the opening 17 is only bent slightly.
  • the area R 1 of the left jacket line of the cannula has the same direction of curvature in the piercing area as in the area R 2 of the right jacket line of the cannula above the opening 17.
  • the tip 15 of the cannula moves onto an egg an arc when the cannula is inserted into the tissue. Since the opening 17 is located below the area R 2, in the narrower cross section of the cannula, a very pronounced contact-free zone around the opening 17 is created when the cannula is inserted into the tissue.
  • the ninth embodiment of the cannula shown in FIG. 9 is designed like a lance or scalpel in the piercing area.
  • the piercing part of the cannula is formed into a four-sided, pointed pyramid by four shaving surfaces 19, as shown in FIG. 9a, with a square or diamond-shaped cross-section, as corresponding to the section AA in FIG. 9a, in FIG 9b illustrates.
  • the cylindrical cannula tube 11 has a smaller circumference up to the opening 17 than the cross-sectional area in the region of the section A-A.
  • the transition area T from the lance-shaped or pyramid-shaped piercing area with a large cross section to the cylindrical cannula tube 11 with a smaller cross section is part of a toroidal surface.
  • Completely fragmentation-free, tissue-free and material-free cannula during injection and puncture procedures is characterized in that the puncture part is closed at the front with suitable grinding surfaces, the lines of intersection of which result in sharp cutting edges (Fig. 1-9).
  • the cannula shaft runs straight ( Fig. 1.2.9) or bent (Fig. 3.4.5.6,7.8) - the cannula shaft 11 is not constricted.
  • the cannula opening (17) is arranged laterally, either contralaterally, opposite the cannula tip (15), cutting surface (12) (Fig. L f 2.3.4) or in the same plane (Fig. 5.6.7).
  • the puncture part (15, 12) in the transition area to the cannula shaft (11) has a larger cross section than the cannula shaft (11) (FIGS. 7, 8, 9). Individual features of the cannula can be realized on their own or in a number of combinations in one embodiment of the invention.
  • the cannula shaft 11 runs straight, the oblique main grinding surface (12), cannula tip (15) is arranged in such a way that the cannula opening (17) is arranged on the contralateral side of the cannula shaft (Fig.l)
  • the main cut (12) is designed in one plane or slightly cylindrical, in addition two side cuts (13, 14) or a sharp cut by a further cutting edge (16), cuts (13, 14) or by a further cutting edge (16) Tip (15) results (Fig. La, lb, ld).
  • the cannula opening (17) is made in different sizes, distance from the cannula tip (15) (Fig. Lb, lc).
  • the cannula opening (17) is made circular (Fig. La-lb) or oval as in Fig. Le, as in all subsequent cannula shapes.
  • the opening is arranged contralaterally) opposite the cylindrical main ground surface (12) (FIG. 2a), alternatively to the flat main ground surface (12) (FIG. 2b).
  • the puncture part of the cannula is bent with a radius (R) in such a way that the tip (15) is directed outwards and thereby a contact-free zone for the cannula opening (17) arises. (Fig. 2a-2b).
  • the cannula differs from the previous forms in that the cannula tube (11) is bent in the area of the opening (17) in such a way that the left surface line of the cannula tube (11) has three radii of curvature there, in the upper area of the tip ( 15) the left surface line merges into a straight region which runs parallel to the main axis (20) of the cannula.
  • Figure 4
  • the cannula has a continuous bending radius (R) between the opening (17) and the tip (15) and has a slightly cylindrically curved main grinding surface (12) and the opening (17) is arranged on the contralateral side opposite the main grinding surface (12).
  • the cannula tube (11) is bent three times, while in the penetration area at the top in area (G) again runs in a straight line and in alignment with the main axis (20).
  • the opening (17) is on the same side to the main grinding surface (12, 14).
  • the opening (17) is placed at the lowest point in the concave area of the middle bend of the cannula tube.
  • the cannula tube (11) has only two bends and a straight region (G) at the top.
  • the straight area (G) is inclined laterally outwards to the main axis (20).
  • the main grinding surface (12) is either parallel to the straight main axis (20) or inclined inwards.
  • the cross section in the transition area (18) is larger than in the cylindrical part of the cannula tube (11).
  • the cannula in the piercing area (R1) is bent outwards.
  • a further concave curvature (R2) is attached in the area below the tip in such a way that the left surface line of the cannula (11) is weakly S-shaped or also straight (ge ⁇ dashed) to the top (15 b).
  • the opening (17) is on the same side to the main grinding surface (12) at the transition from the straight cannula tube (11) with a bend in the area R1.
  • the cross section in the piercing part is larger above the cannula opening (17) and is only bent once.
  • the area (R1) of the left jacket line of the cannula has the same direction of curvature in the penetration area as in area (R2) of the right jacket line of the cannula.
  • the penetration area (12, 15) above the opening (17) is simply bent.
  • the area (R1) of the left surface line of the cannula has the same direction of curvature as in the area R2.
  • the cannula in the piercing area is designed like a lance or scalpel, the transition area (AA), cannula tip (15), cutting surface (19) is larger than the cannula shaft (11), cannula opening (17), laterally below the wider cross-section (AA) placed.
  • the cannula tip (15), cutting surface (19) in this embodiment is designed in the shape of a tip pyramid (FIG. 9b) or in three areas (FIG. 9c).
  • the cannula is designed as a double-edged scalpel shape tapering to the front.
  • the cannula is designed as a double-edged scalpel shape tapering to the front.
  • the cannula is characterized in that, as its main claim 1 puts it, the individual features of the cannula can be realized individually or in several combinations in one embodiment (FIGS. 1-9).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne des canules d'injection conçues pour éviter tout risque de formation de fragments et d'enlèvement de tissu ou de matière lors d'une opération d'injection ou de ponction pratiquée sur des tissus humains ou animaux, membranes artificielles, ballons, etc. Cette opération de ponction sans enlèvement de tissu ni de formation de particules est rendue possible par un façonnage différent de la géométrie des pointes de canule et grâce à des modifications apportées aux tiges de canule. La face tranchante (12) de la pointe de la canule (15) est obturée (Fig. 1-9). La tige de canule (11) est rectiligne (Fig. 1, 2, 9) ou courbe (Fig. 3, 4, 5, 6, 7, 8) et ne présente pas de rétrécissement susceptible de gêner l'exécution. L'ouverture de la canule (17) est située soit sur le côté opposé au bord tranchant (12) de la pointe de la canule (Fig. 1, 2, 3, 4) soit dans le même plan (Fig. 5, 6, 7). La partie qui perce (12, 15) est caractérisée en ce que, dans la zone de transition A-A, la section est supérieure à celle de la tige de la canule (Fig. 9). La possibilité de pratiquer une telle opération sans risque de fragmentation ou d'enlèvement de tissu et de formation de particules est garantie par le fait que l'ouverture (17) de la canule (17) se situe dans la zone hors contact et que les particules/fragments de tissu sont écartés de l'ouverture (17) de la canule.
PCT/DE1996/000524 1995-04-04 1996-03-26 Canules d'injection concues pour eviter tout risque de formation de fragments et d'enlevement de tissu WO1996031247A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995112607 DE19512607A1 (de) 1995-04-04 1995-04-04 Völlig tragmentationsfreie Kanülen
DE19512607.6 1995-04-04

Publications (1)

Publication Number Publication Date
WO1996031247A1 true WO1996031247A1 (fr) 1996-10-10

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JP2001507134A (ja) * 1997-08-20 2001-05-29 ジュニア インストゥルメンツ 栓が為された試料管内部に対しての抽出及び／又は注入のための装置
WO2002078771A1 (fr) * 2001-04-02 2002-10-10 Pentaferte Spa Aiguille d'injection pour traitement sclerosant
US6547769B2 (en) 1999-12-20 2003-04-15 Tricardia Llc Catheter apparatus with weeping tip and method of use
DE202005006519U1 (de) * 2005-04-22 2005-07-28 Gerstenhauer, Christoph Gekrümmte sichere Kanüle/Injektionsnadel
US6969373B2 (en) 2001-04-13 2005-11-29 Tricardia, Llc Syringe system
JP2010537161A (ja) * 2007-08-17 2010-12-02 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 充填済み容器から物質を取り出す装置及び方法
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US6695821B1 (en) * 1998-06-17 2004-02-24 Raymond N. Sjaarda Surgical infusion tool with flow diffuser
DE19911970A1 (de) * 1999-03-17 2000-09-28 Medinorm Ag Kanüle für Ports
DE19933171A1 (de) * 1999-06-18 2000-12-21 Medos Medizintechnik Gmbh Verfahren zum Einbringen eines Fluides in ein Gefäß des menschlichen Körpers sowie entsprechende Kanüle
US8398666B2 (en) 2000-05-16 2013-03-19 Teleflex Medical Incorporated Penetrating tip for trocar assembly
WO2002001998A2 (fr) * 2000-05-16 2002-01-10 Taut, Inc. Embout penetrant pour assemblage de trocart
US7204828B2 (en) * 2001-09-14 2007-04-17 Zymequest, Inc. Collection needle
AU2003224782A1 (en) * 2002-04-05 2003-10-27 Allegiance Corporation Improved biopsy needle and biopsy device containing the same
ES2287517T3 (es) * 2002-09-10 2007-12-16 Becton Dickinson And Company Metodo y aparato para la administracion epidermica de una sustancia.
FR2845276B1 (fr) * 2002-10-04 2005-06-03 Vygon Canule anti-pique a usage medical
DE10247022B4 (de) * 2002-10-09 2016-09-08 Disetronic Licensing Ag Nadelspitze
CN100415312C (zh) * 2005-06-20 2008-09-03 王月安 一次性注射器或输液器针头
US8257323B2 (en) * 2005-08-03 2012-09-04 Medtronic, Inc. Cannula system and method
US20100016811A1 (en) * 2006-12-21 2010-01-21 Trevor Smith Needle tip
US20090125097A1 (en) * 2007-11-13 2009-05-14 Medtronic Vascular, Inc. Device and Method for Stent Graft Fenestration in Situ
US8172802B2 (en) 2008-11-24 2012-05-08 Dartmouth-Hitchcock Clinic Intravascular needle and catheter assembly
US8603037B1 (en) 2011-04-11 2013-12-10 Dartmouth-Hitchcock Clinic Intravascular needle and catheter assembly and grip for the same

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JP2001507134A (ja) * 1997-08-20 2001-05-29 ジュニア インストゥルメンツ 栓が為された試料管内部に対しての抽出及び／又は注入のための装置
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US6949087B2 (en) 1999-12-20 2005-09-27 Tricardia, Llc Apparatus with weeping tip and method of use
US7252654B2 (en) 1999-12-20 2007-08-07 Tricardia, Llc Apparatus with weeping tip and method of use
WO2002078771A1 (fr) * 2001-04-02 2002-10-10 Pentaferte Spa Aiguille d'injection pour traitement sclerosant
US7331943B2 (en) 2001-04-02 2008-02-19 Pentaferte Spa Injection needle for sclerotherapy
US6969373B2 (en) 2001-04-13 2005-11-29 Tricardia, Llc Syringe system
DE202005006519U1 (de) * 2005-04-22 2005-07-28 Gerstenhauer, Christoph Gekrümmte sichere Kanüle/Injektionsnadel
JP2010537161A (ja) * 2007-08-17 2010-12-02 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 充填済み容器から物質を取り出す装置及び方法
US20230001104A1 (en) * 2017-03-17 2023-01-05 Jasperate, Inc. Hollow needle for access in non-linear path

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