[go: up one dir, main page]

WO1996037601B1 - Agents de differenciation cellulaire - Google Patents

Agents de differenciation cellulaire

Info

Publication number
WO1996037601B1
WO1996037601B1 PCT/GB1996/001232 GB9601232W WO9637601B1 WO 1996037601 B1 WO1996037601 B1 WO 1996037601B1 GB 9601232 W GB9601232 W GB 9601232W WO 9637601 B1 WO9637601 B1 WO 9637601B1
Authority
WO
WIPO (PCT)
Prior art keywords
serum
differentiation
extract
extracellular milieu
bipotential
Prior art date
Application number
PCT/GB1996/001232
Other languages
English (en)
Other versions
WO1996037601A1 (fr
Inventor
Bradley Michael John Stringer
Original Assignee
Cellfactors Plc
Bradley Michael John Stringer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9510555.7A external-priority patent/GB9510555D0/en
Priority claimed from GB9522562A external-priority patent/GB2294946A/en
Priority claimed from GBGB9606373.0A external-priority patent/GB9606373D0/en
Application filed by Cellfactors Plc, Bradley Michael John Stringer filed Critical Cellfactors Plc
Priority to JP8535496A priority Critical patent/JPH11505713A/ja
Priority to AU59052/96A priority patent/AU5905296A/en
Priority to EP96916223A priority patent/EP0832187A1/fr
Publication of WO1996037601A1 publication Critical patent/WO1996037601A1/fr
Publication of WO1996037601B1 publication Critical patent/WO1996037601B1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Physiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

Cette invention concerne la pluripotentialité de cellules précurseurs et plus spécifiquement l'exploitation de cette pluripotentialité à l'aide de procédés et de systèmes qui permettent de produire sélectivement la différenciation le long de la voie prédéterminée afin de produire un phénotype différencié mature présélectionné.
PCT/GB1996/001232 1995-05-24 1996-05-22 Agents de differenciation cellulaire WO1996037601A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP8535496A JPH11505713A (ja) 1995-05-24 1996-05-22 細胞分化剤
AU59052/96A AU5905296A (en) 1995-05-24 1996-05-22 Cell differentiation agents
EP96916223A EP0832187A1 (fr) 1995-05-24 1996-05-22 Agents de differenciation cellulaire

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9510555.7A GB9510555D0 (en) 1995-05-24 1995-05-24 Human cell lines
GB9510555.7 1995-05-24
GB9522562.9 1995-11-03
GB9522562A GB2294946A (en) 1994-11-08 1995-11-03 Preparation of human cell-lines of fully-differentiated cells of specific tissue type
GB9606373.0 1996-03-26
GBGB9606373.0A GB9606373D0 (en) 1996-03-26 1996-03-26 Differentiation agents

Publications (2)

Publication Number Publication Date
WO1996037601A1 WO1996037601A1 (fr) 1996-11-28
WO1996037601B1 true WO1996037601B1 (fr) 2001-04-12

Family

ID=27267737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001232 WO1996037601A1 (fr) 1995-05-24 1996-05-22 Agents de differenciation cellulaire

Country Status (7)

Country Link
EP (1) EP0832187A1 (fr)
JP (1) JPH11505713A (fr)
AU (1) AU5905296A (fr)
CA (1) CA2218817A1 (fr)
CZ (1) CZ365097A3 (fr)
HU (1) HUP9900243A2 (fr)
WO (1) WO1996037601A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL57135A (en) * 1979-04-25 1982-12-31 Abic Project Partnership Method for the determination of a factor or factors which enhances the cortisol metabolism in lymphocytes or leucocytes
DE3590594T1 (fr) * 1984-11-29 1987-01-29
CA2064787A1 (fr) * 1989-08-11 1991-02-12 Joe E. Springer Facteur neurotrope dopaminergique pour le traitement de la maladie de parkinson
WO1991009936A1 (fr) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
EP0669973B9 (fr) * 1992-10-28 2007-10-10 NeuroSpheres Holdings Ltd. Facteurs biologiques et cellules souches neurales

Also Published As

Publication number Publication date
HUP9900243A2 (hu) 1999-05-28
EP0832187A1 (fr) 1998-04-01
CA2218817A1 (fr) 1996-11-28
JPH11505713A (ja) 1999-05-25
WO1996037601A1 (fr) 1996-11-28
MX9708833A (es) 1998-10-31
AU5905296A (en) 1996-12-11
CZ365097A3 (cs) 1998-02-18

Similar Documents

Publication Publication Date Title
Botchkarev et al. A new role for neurotrophins: involvement of brain‐derived neurotrophic factor and neurotrophin‐4 in hair cycle control
Ågren et al. Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent
Cotman et al. Reactive synaptogenesis in the adult nervous system: the effects of partial deafferentation on new synapse formation
Smith et al. Effect of 1α, 25-dihydroxyvitamin D3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions
Bodó et al. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control
Ghiani et al. Neurotransmitter receptor activation triggers p27Kip1 and p21CIP1 accumulation and G1 cell cycle arrest in oligodendrocyte progenitors
Maxwell et al. Regional synthesis of neurotransmitter candidates in the CNS of the moth Manduca sexta
Vogel-Sprott et al. Age, drinking habits and the effects of alcohol.
Yamamoto et al. Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis
Brinton et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism
Leal et al. Hormone replacement therapy for oxidative stress in postmenopausal women with hot flushes
Cortvrindt et al. Timed analysis of the nuclear maturation of oocytes in early preantral mouse follicle culture supplemented with recombinant gonadotropin
Sendera et al. Reduction in TrkA‐immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome
German et al. Mesopontine cholinergic and non-cholinergic neurons in schizophrenia
Parrott et al. Developmental and hormonal regulation of hepatocyte growth factor expression and action in the bovine ovarian follicle
PELTON et al. Effects of immunologically induced growth hormone deficiency on myelinogenesis in developing rat cerebrum
Studer et al. Noninvasive dopamine determination by reversed phase HPLC in the medium of free-floating roller tube cultures of rat fetal ventral mesencephalon: a tool to assess dopaminergic tissue prior to grafting
Oorschot et al. The trophic requirements of mature motoneurons
US5229271A (en) Method of testing of hair growth substances on hair follicles prepared by mechanically severing of hair shaft
Mohrmann et al. Developmental maturation of synaptic vesicle cycling as a distinctive feature of central glutamatergic synapses
Mase et al. Acute and transient increase of lipocalin-type prostaglandin D synthase (β-trace) level in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
Vedder et al. Regulation of glucocorticoidreceptor-mRNA in human blood cells by amitriptyline and dexamethasone
WO1996037601B1 (fr) Agents de differenciation cellulaire
DE3743405A1 (de) Verfahren zur bestimmung von fructosamin
DE3732688A1 (de) Verfahren zur spezifischen bestimmung des serumfructosamingehalts sowie hierfuer geeignetes reagenzgemisch

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2218817

Country of ref document: CA

Ref country code: CA

Ref document number: 2218817

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 309106

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PA/a/1997/008833

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: PV1997-3650

Country of ref document: CZ

ENP Entry into the national phase

Ref country code: JP

Ref document number: 1996 535496

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1019970708416

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1996916223

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV1997-3650

Country of ref document: CZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

ENP Entry into the national phase

Ref country code: US

Ref document number: 1998 952719

Date of ref document: 19980401

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1996916223

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019970708416

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV1997-3650

Country of ref document: CZ

AK Designated states

Kind code of ref document: B1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: B1

Designated state(s): KE LS MW SD SZ UG AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWW Wipo information: withdrawn in national office

Ref document number: 1996916223

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: 1019970708416

Country of ref document: KR