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WO1996039425A3 - Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity - Google Patents

Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity Download PDF

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Publication number
WO1996039425A3
WO1996039425A3 PCT/US1996/008923 US9608923W WO9639425A3 WO 1996039425 A3 WO1996039425 A3 WO 1996039425A3 US 9608923 W US9608923 W US 9608923W WO 9639425 A3 WO9639425 A3 WO 9639425A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
compounds
bradykinin antagonistic
opioid
bradykinin
Prior art date
Application number
PCT/US1996/008923
Other languages
French (fr)
Other versions
WO1996039425A2 (en
Inventor
John C Cheronis
Albert Gyorkos
Lyle W Spruce
Eric T Whalley
Original Assignee
Cortech Inc
John C Cheronis
Albert Gyorkos
Lyle W Spruce
Eric T Whalley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/465,672 external-priority patent/US5843900A/en
Application filed by Cortech Inc, John C Cheronis, Albert Gyorkos, Lyle W Spruce, Eric T Whalley filed Critical Cortech Inc
Priority to AU60444/96A priority Critical patent/AU6044496A/en
Priority to EP96918098A priority patent/EP0832106A2/en
Publication of WO1996039425A2 publication Critical patent/WO1996039425A2/en
Publication of WO1996039425A3 publication Critical patent/WO1996039425A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
PCT/US1996/008923 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity WO1996039425A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU60444/96A AU6044496A (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity
EP96918098A EP0832106A2 (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/465,672 1995-06-05
US08/465,672 US5843900A (en) 1991-04-01 1995-06-05 Bradykinin antagonists
US64716096A 1996-05-21 1996-05-21
US08/647,160 1996-05-21

Publications (2)

Publication Number Publication Date
WO1996039425A2 WO1996039425A2 (en) 1996-12-12
WO1996039425A3 true WO1996039425A3 (en) 1997-01-30

Family

ID=27041368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008923 WO1996039425A2 (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity

Country Status (4)

Country Link
EP (1) EP0832106A2 (en)
AU (1) AU6044496A (en)
TW (1) TW407159B (en)
WO (1) WO1996039425A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
EP1312923B1 (en) * 2001-11-16 2007-03-28 Randox Laboratories Ltd. Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
US7109310B2 (en) 2001-11-16 2006-09-19 Randox Laboratories, Ltd. Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
CA2581863A1 (en) * 2004-11-10 2006-05-26 Boehringer Ingelheim Chemicals, Inc. Process of making fentanyl intermediates
US7238791B1 (en) * 2005-12-16 2007-07-03 Roche Diagnostics Operations, Inc. 6-monoacetylmorphine derivatives useful in immunoassay
WO2011011543A1 (en) * 2009-07-21 2011-01-27 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370453A2 (en) * 1988-11-24 1990-05-30 Hoechst Aktiengesellschaft Peptides having a Brady kinine-inhibiting activity
WO1992017201A1 (en) * 1991-04-01 1992-10-15 Cortech, Inc. Bradykinin antagonists
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
WO1994011021A1 (en) * 1992-11-10 1994-05-26 Cortech, Inc. Bradykinin antagonists
WO1995024422A1 (en) * 1994-03-09 1995-09-14 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
WO1996016081A1 (en) * 1994-11-18 1996-05-30 University Technology Corporation Bradykinin antagonist peptides containing indane-substituted amino acids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370453A2 (en) * 1988-11-24 1990-05-30 Hoechst Aktiengesellschaft Peptides having a Brady kinine-inhibiting activity
WO1992017201A1 (en) * 1991-04-01 1992-10-15 Cortech, Inc. Bradykinin antagonists
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
WO1994011021A1 (en) * 1992-11-10 1994-05-26 Cortech, Inc. Bradykinin antagonists
WO1995024422A1 (en) * 1994-03-09 1995-09-14 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
WO1996016081A1 (en) * 1994-11-18 1996-05-30 University Technology Corporation Bradykinin antagonist peptides containing indane-substituted amino acids

Also Published As

Publication number Publication date
TW407159B (en) 2000-10-01
EP0832106A2 (en) 1998-04-01
AU6044496A (en) 1996-12-24
WO1996039425A2 (en) 1996-12-12

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