WO1997040165B1 - Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations - Google Patents
Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisationsInfo
- Publication number
- WO1997040165B1 WO1997040165B1 PCT/US1997/006866 US9706866W WO9740165B1 WO 1997040165 B1 WO1997040165 B1 WO 1997040165B1 US 9706866 W US9706866 W US 9706866W WO 9740165 B1 WO9740165 B1 WO 9740165B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunogenic composition
- pδrc
- group
- hcmv
- human cytomegalovirus
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title claims abstract 15
- 238000000034 method Methods 0.000 claims abstract 12
- 239000013612 plasmid Substances 0.000 claims abstract 7
- 230000028993 immune response Effects 0.000 claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract 3
- 230000002163 immunogen Effects 0.000 claims 20
- 108020004414 DNA Proteins 0.000 claims 9
- 102000053602 DNA Human genes 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 101150029683 gB gene Proteins 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Abstract
L'invention concerne des molécules d'ADN nouvelles servant à exprimer in vitro et in vivo le complexe gB du cytomégalovirus humain et des dérivés du complexe gB dont la transmembrane a été supprimée, tels que les protéines pp65, pp150 et IE-exon-4. Ces molécules sont de préférence des plasmides. L'invention concerne également des procédés d'utilisation de ces molécules d'ADN de façon à induire des réponses immunitaires en réaction au cytomégalovirus humain, et l'utilisation d'un plasmide de la présente invention, qui sert à amorcer des réponses immunitaires lors de l'administration de vaccins contre le cytomégalovirus humain.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/171,699 US6448389B1 (en) | 1996-04-23 | 1997-04-22 | Human cytomegalovirus DNA constructs and uses therefor |
| AU28098/97A AU2809897A (en) | 1996-04-23 | 1997-04-22 | Novel human cytomegalovirus dna constructs and uses therefor |
| EP97922429A EP0914441A2 (fr) | 1996-04-23 | 1997-04-22 | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1571796P | 1996-04-23 | 1996-04-23 | |
| US60/015,717 | 1996-04-23 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/171,699 A-371-Of-International US6448389B1 (en) | 1996-04-23 | 1997-04-22 | Human cytomegalovirus DNA constructs and uses therefor |
| US10/223,538 Division US20030120060A1 (en) | 1996-04-23 | 2002-08-19 | Human cytomegalovirus DNA constructs and uses therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997040165A1 WO1997040165A1 (fr) | 1997-10-30 |
| WO1997040165B1 true WO1997040165B1 (fr) | 1998-01-08 |
| WO1997040165A9 WO1997040165A9 (fr) | 1998-02-12 |
Family
ID=21773167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/006866 WO1997040165A1 (fr) | 1996-04-23 | 1997-04-22 | Nouveaux produits de construction d'adn de cytomegalovirus humain, et leurs utilisations |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US6448389B1 (fr) |
| EP (1) | EP0914441A2 (fr) |
| AU (1) | AU2809897A (fr) |
| WO (1) | WO1997040165A1 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448389B1 (en) | 1996-04-23 | 2002-09-10 | The Wistar Institute Of Anatomy And Biology | Human cytomegalovirus DNA constructs and uses therefor |
| CA2263316A1 (fr) | 1996-08-14 | 1998-02-19 | Klara Berencsi | Procedes et compositions pour empecher ou pour retarder le developpement de lesions atherosclereuses |
| US6562345B1 (en) * | 1996-11-12 | 2003-05-13 | City Of Hope | Immuno-reactive peptide CTL epitopes of human cytomegalovirus |
| AU4351900A (en) * | 1999-04-15 | 2000-11-02 | Board Of Regents, The University Of Texas System | Inducible vaccines |
| EP1612217A3 (fr) * | 2000-03-27 | 2006-01-18 | City of Hope | Epitopes ctl peptidiques immunoréactifs du cytomégalovirus |
| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| WO2002006529A2 (fr) | 2000-07-13 | 2002-01-24 | The Johns Hopkins University School Of Medicine | Detection et traitement de polykystose renale |
| AU2001293798B2 (en) * | 2000-09-09 | 2006-12-21 | Basf Plant Science Gmbh | Modified tet-inducible system for regulation of gene expression in plants |
| WO2002034769A2 (fr) | 2000-10-20 | 2002-05-02 | City Of Hope | Epitopes ctl peptidiques immunoreactifs du cytomegalovirus pp150 |
| CA2460269C (fr) * | 2001-09-06 | 2013-01-15 | Alphavax, Inc. | Systemes de vecteurs a base de replicons alphaviraux |
| PT2311848E (pt) * | 2002-12-23 | 2013-10-03 | Vical Inc | Vacinas à base de polinucleótido optimizadas por codão contra a infecção do citomegalovírus humano |
| RS20050614A (en) * | 2003-02-14 | 2007-12-31 | Biogen Idec Ma Inc., | An expression cassette and vector for transient or stable expression of exogenous molecules |
| WO2004076645A2 (fr) * | 2003-02-27 | 2004-09-10 | University Of Massachusetts | Compositions et methodes de traitement du cytomegalovirus |
| CN1791678A (zh) * | 2003-03-20 | 2006-06-21 | 阿尔法瓦克斯公司 | 改进的甲病毒复制子和辅助构建体 |
| US7419674B2 (en) * | 2003-07-11 | 2008-09-02 | Alpha Vax, Inc. | Alpha virus-based cytomegalovirus vaccines |
| EP1799255A4 (fr) * | 2004-06-25 | 2008-10-01 | Medimmune Vaccines Inc | Cytomegalovirus humain de recombinaison et vaccins contenant des antigenes heterologues |
| CN101802199B (zh) | 2007-06-21 | 2012-08-22 | 阿尔法瓦克斯公司 | 用于α病毒结构蛋白表达的无启动子盒 |
| EP4218806A1 (fr) | 2008-06-20 | 2023-08-02 | Duke University | Compositions et kits pour déclencher une réponse immunitaire |
| US8812387B1 (en) | 2013-03-14 | 2014-08-19 | Csidentity Corporation | System and method for identifying related credit inquiries |
| EP3052106A4 (fr) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
| WO2015089340A1 (fr) | 2013-12-11 | 2015-06-18 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Glycoprotéine b trimère d'herpèsvirus humain, complexes protéiques comprenant gb trimère et leur utilisation comme vaccins |
| CA3002922A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccin contre le cytomegalovirus humain |
| RU2616245C2 (ru) * | 2015-12-29 | 2017-04-13 | Сейфаддин Гашим Оглы Марданлы | Композиция для профилактики заболеваний, вызываемых цитомегаловирусной инфекцией |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| AU2017345766A1 (en) | 2016-10-21 | 2019-05-16 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| TWI871709B (zh) | 2020-06-21 | 2025-02-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959466A (en) | 1974-04-15 | 1976-05-25 | The Wistar Institute | Highly attenuated cytomegalovirus vaccine and production thereof |
| ZA858044B (en) | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
| US4689225A (en) | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
| CA1335429C (fr) | 1986-03-07 | 1995-05-02 | Geoffrey L. Smith | Procedes de fabrication de glycoproteines hcmv, les anticorps et les vaccins diriges contre ces glycoproteines hcmv, et leurs vecteurs recombinants |
| DE3782867D1 (en) * | 1986-06-12 | 1993-01-14 | Behringwerke Ag, 3550 Marburg, De | Human cytomegalovirus phospho-protein |
| DE3619720A1 (de) | 1986-06-12 | 1987-12-17 | Behringwerke Ag | Hauptglykoprotein des menschlichen cytomegalovirus, seine herstellung und verwendung |
| DE3619902A1 (de) | 1986-06-13 | 1988-03-03 | Biotechnolog Forschung Gmbh | Cmv-dna-strukturen, expressionsvektor dafuer, cmv-proteinstrukturen und deren verwendung |
| ZA878031B (en) | 1986-11-04 | 1988-04-28 | Scripps Clinic And Research Foundation | Nucleic acid probes for the detection of latent human cytomegalovirus in blood products |
| US5124440A (en) | 1986-11-24 | 1992-06-23 | The Childrens Hospital, Inc. | Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus |
| US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
| EP0277773A1 (fr) | 1987-01-30 | 1988-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Cytomégalovirus hybride et vaccin |
| JP2607712B2 (ja) * | 1988-01-29 | 1997-05-07 | カイロン コーポレイション | 組換えｃｍｖ中和タンパク |
| AU3849989A (en) | 1988-07-01 | 1990-01-23 | Children's Hospital Incorporated, The | Antibody recognition of fragments from cytomegalovirus |
| AU4664689A (en) | 1988-12-12 | 1990-07-10 | Children's Hospital Incorporated, The | Proteolytic fragments obtained from human cytomegalovirus glycoprotein complex i |
| US5552143A (en) | 1989-03-24 | 1996-09-03 | The Wistar Institute Of Anatomy & Biology | Recombinant cytomegalovirus vaccine |
| US5591439A (en) | 1989-03-24 | 1997-01-07 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| ATE140154T1 (de) | 1989-03-24 | 1996-07-15 | Wistar Inst | Rekombinanter cytomegalovirus-impfstoff |
| WO1991002004A1 (fr) | 1989-08-07 | 1991-02-21 | Children's Biomedical Research Center | GLYCOPROTEINES IMMUNOGENIQUES DU CYTOMEGALOVIRUS HUMAIN gCII |
| AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| GB9014652D0 (en) | 1990-07-02 | 1990-08-22 | Wellcome Found | Antigen |
| CA2088599A1 (fr) | 1990-08-02 | 1992-02-03 | Carol A. Pachl | Expression de la glycoproteine-h de cmv humain a l'aide de baculovirus/systeme d'expression cellulaire d'insecte |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| WO1994017810A1 (fr) | 1993-02-12 | 1994-08-18 | The Wistar Institute Of Anatomy And Biology | Vaccin recombine contre le cytomegalovirus |
| WO1994023744A1 (fr) | 1993-04-16 | 1994-10-27 | The Wistar Institute Of Anatomy And Biology | Vaccin contenant un cytomegalovirus de recombinaison |
| IT1266740B1 (it) | 1994-07-01 | 1997-01-14 | Maria Paola Landini | Materiale proteico ricombinante legante anticorpi contro il citomegalovirus umano, reagenti diagnostici derivati da tale |
| US6448389B1 (en) | 1996-04-23 | 2002-09-10 | The Wistar Institute Of Anatomy And Biology | Human cytomegalovirus DNA constructs and uses therefor |
-
1997
- 1997-04-22 US US09/171,699 patent/US6448389B1/en not_active Expired - Lifetime
- 1997-04-22 AU AU28098/97A patent/AU2809897A/en not_active Abandoned
- 1997-04-22 WO PCT/US1997/006866 patent/WO1997040165A1/fr not_active Application Discontinuation
- 1997-04-22 EP EP97922429A patent/EP0914441A2/fr not_active Withdrawn
-
2002
- 2002-08-19 US US10/223,538 patent/US20030120060A1/en not_active Abandoned
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