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WO1997041150A3 - Therapie genique pour defauts de l'adn mitochondrial utilisant des acides nucleiques peptidiques - Google Patents

Therapie genique pour defauts de l'adn mitochondrial utilisant des acides nucleiques peptidiques Download PDF

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Publication number
WO1997041150A3
WO1997041150A3 PCT/GB1997/001102 GB9701102W WO9741150A3 WO 1997041150 A3 WO1997041150 A3 WO 1997041150A3 GB 9701102 W GB9701102 W GB 9701102W WO 9741150 A3 WO9741150 A3 WO 9741150A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
peptide nucleic
mitochondrial dna
deffects
gene therapy
Prior art date
Application number
PCT/GB1997/001102
Other languages
English (en)
Other versions
WO1997041150A2 (fr
Inventor
Douglas Matthew Turnbull
Robert Neil Lightowlers
Robert William Taylor
Original Assignee
Univ Newcastle
Douglas Matthew Turnbull
Robert Neil Lightowlers
Robert William Taylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Newcastle, Douglas Matthew Turnbull, Robert Neil Lightowlers, Robert William Taylor filed Critical Univ Newcastle
Publication of WO1997041150A2 publication Critical patent/WO1997041150A2/fr
Publication of WO1997041150A3 publication Critical patent/WO1997041150A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant d'empêcher sélectivement la réplication de l'ADN mitochondrial à l'aide d'acides nucléiques peptidiques complémentaires, ainsi que les acides nucléiques peptidiques utilisés dans ledit procédé. Elle décrit également de nouveaux systèmes de ciblage permettant d'assurer le ciblage des acides nucléiques peptidiques dans les mitochondries.
PCT/GB1997/001102 1996-04-27 1997-04-22 Therapie genique pour defauts de l'adn mitochondrial utilisant des acides nucleiques peptidiques WO1997041150A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9608803.4A GB9608803D0 (en) 1996-04-27 1996-04-27 Mitochondrial dna defects
GB9608803.4 1996-04-27

Publications (2)

Publication Number Publication Date
WO1997041150A2 WO1997041150A2 (fr) 1997-11-06
WO1997041150A3 true WO1997041150A3 (fr) 1997-12-04

Family

ID=10792795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001102 WO1997041150A2 (fr) 1996-04-27 1997-04-22 Therapie genique pour defauts de l'adn mitochondrial utilisant des acides nucleiques peptidiques

Country Status (2)

Country Link
GB (1) GB9608803D0 (fr)
WO (1) WO1997041150A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472209B1 (en) 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
JP2002537102A (ja) 1999-02-26 2002-11-05 カイロン コーポレイション 吸着された高分子および微粒子を有するミクロエマルジョン

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020702A1 (fr) * 1991-05-24 1992-11-26 Ole Buchardt Acides nucleiques de peptides
WO1995034665A2 (fr) * 1994-06-16 1995-12-21 Peter Seibel Fragment chimerique d'acide nucleique-peptide, son procede de production et son utilisation afin d'introduire de maniere appropriee des acides nucleiques dans des organelles de cellules et dans des cellules
WO1996004000A1 (fr) * 1994-08-05 1996-02-15 The Regents Of The University Of California Analogues d'acides nucleiques a base de peptides (penam)
EP0700928A1 (fr) * 1994-08-08 1996-03-13 Bayer Ag Oligomères qui se lient aux acides nucléiques pour la thérapie et le diagnostic

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020702A1 (fr) * 1991-05-24 1992-11-26 Ole Buchardt Acides nucleiques de peptides
WO1995034665A2 (fr) * 1994-06-16 1995-12-21 Peter Seibel Fragment chimerique d'acide nucleique-peptide, son procede de production et son utilisation afin d'introduire de maniere appropriee des acides nucleiques dans des organelles de cellules et dans des cellules
WO1996004000A1 (fr) * 1994-08-05 1996-02-15 The Regents Of The University Of California Analogues d'acides nucleiques a base de peptides (penam)
EP0700928A1 (fr) * 1994-08-08 1996-03-13 Bayer Ag Oligomères qui se lient aux acides nucléiques pour la thérapie et le diagnostic

Also Published As

Publication number Publication date
GB9608803D0 (en) 1996-07-03
WO1997041150A2 (fr) 1997-11-06

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