WO1997042175B1 - Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteines - Google Patents
Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteinesInfo
- Publication number
- WO1997042175B1 WO1997042175B1 PCT/US1997/007466 US9707466W WO9742175B1 WO 1997042175 B1 WO1997042175 B1 WO 1997042175B1 US 9707466 W US9707466 W US 9707466W WO 9742175 B1 WO9742175 B1 WO 9742175B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- lower alkyl
- amino
- alkyl
- protein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 230000032683 aging Effects 0.000 title abstract 3
- 150000004693 imidazolium salts Chemical class 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000000033 alkoxyamino group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Abstract
La présente invention a trait à des compositions et à des procédéd permettant d'inhiber et d'inverser une réticulation non enzymatique (vieillissement de protéine). Ainsi, l'invention concerne des compositions contenant des composés d'imidazolium substitués pouvant inhiber la formation de produits terminaux de glycosylation évoluée de protéines cibles ou inverser le processus de cette formation lorsque ces produits sont déjà formés. Le procédé consiste à mettre en contact la protéine cible et la composition. Des applications tant industrielles que thérapeutiques de l'invention sont envisagées, étant donné que l'altération des aliments et le vieillissement de la protéine animale peuvent être inhibés.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54006297A JP2002515033A (ja) | 1996-05-08 | 1997-05-02 | 置換イミダゾリウム塩、及びタンパク質老化を阻止するためのそれらの使用 |
| AT97922635T ATE223384T1 (de) | 1996-05-08 | 1997-05-02 | Substituierte imidazoliunsalze und deren verwendung zur hemmung der proteinalterung |
| EP97922635A EP0920418B1 (fr) | 1996-05-08 | 1997-05-02 | Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteines |
| AU28258/97A AU724319B2 (en) | 1996-05-08 | 1997-05-02 | Substituted imidazolium salts and their use for the inhibition of protein ageing |
| CA002253788A CA2253788A1 (fr) | 1996-05-08 | 1997-05-02 | Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteines |
| DE69715218T DE69715218T2 (de) | 1996-05-08 | 1997-05-02 | Substituierte imidazoliunsalze und deren verwendung zur hemmung der proteinalterung |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64328896A | 1996-05-08 | 1996-05-08 | |
| US08/643,288 | 1996-05-08 | ||
| US84877697A | 1997-05-01 | 1997-05-01 | |
| US08/848,776 | 1997-05-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997042175A1 WO1997042175A1 (fr) | 1997-11-13 |
| WO1997042175B1 true WO1997042175B1 (fr) | 1997-12-18 |
Family
ID=27094226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/007466 WO1997042175A1 (fr) | 1996-05-08 | 1997-05-02 | Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteines |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1213282A1 (fr) |
| JP (1) | JP2002515033A (fr) |
| AT (1) | ATE223384T1 (fr) |
| AU (1) | AU724319B2 (fr) |
| CA (1) | CA2253788A1 (fr) |
| DE (1) | DE69715218T2 (fr) |
| ES (1) | ES2183171T3 (fr) |
| WO (1) | WO1997042175A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001052847A1 (fr) * | 2000-01-19 | 2001-07-26 | Alteon, Inc. | Composes thiazole, imidazole et oxazole et traitements de troubles associes au vieillissement des proteines |
| WO2002053161A1 (fr) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Procede de traitement de troubles fibrogenes et autres symptomes |
| PT1243581E (pt) * | 2001-03-21 | 2005-11-30 | Torrent Pharmaceuticals Ltd | Compostos de piridinio uteis no tratamento de doencas relacionadas com age |
| FR2984733B1 (fr) * | 2011-12-22 | 2016-09-30 | Oreal | Association d'un agent nucleophile et d'un agent azote ou phosphore de pka superieur a 11 pour la peau glyquee |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4983604A (en) * | 1987-11-13 | 1991-01-08 | The Rockefeller University | Inhibitors of nonenzymatic cross-linking |
| US5221683A (en) * | 1984-03-19 | 1993-06-22 | The Rockefeller University | Diaminopyridine compounds and methods of use |
| US5356895A (en) * | 1984-03-19 | 1994-10-18 | The Rockefeller University | 1,4 piperizino inhibitors of non-enzymatic cross-linking of proteins |
| US5514676A (en) * | 1984-03-19 | 1996-05-07 | The Rockefeller University | Amino-benzoic acids and derivatives, and methods of use |
| US5258381A (en) * | 1984-03-19 | 1993-11-02 | The Rockefeller University | 2-substituted-2-imidazolines |
| US5358960A (en) * | 1984-03-19 | 1994-10-25 | The Rockefeller University | Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles |
-
1997
- 1997-05-02 AT AT97922635T patent/ATE223384T1/de not_active IP Right Cessation
- 1997-05-02 CA CA002253788A patent/CA2253788A1/fr not_active Abandoned
- 1997-05-02 WO PCT/US1997/007466 patent/WO1997042175A1/fr active IP Right Grant
- 1997-05-02 AU AU28258/97A patent/AU724319B2/en not_active Ceased
- 1997-05-02 EP EP02075720A patent/EP1213282A1/fr not_active Withdrawn
- 1997-05-02 DE DE69715218T patent/DE69715218T2/de not_active Expired - Fee Related
- 1997-05-02 ES ES97922635T patent/ES2183171T3/es not_active Expired - Lifetime
- 1997-05-02 JP JP54006297A patent/JP2002515033A/ja not_active Ceased
- 1997-05-02 EP EP97922635A patent/EP0920418B1/fr not_active Expired - Lifetime
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