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WO1997048367A3 - Compositions for the treatment of chronic infections containing glucocorticoid and antiglucocorticoid - Google Patents

Compositions for the treatment of chronic infections containing glucocorticoid and antiglucocorticoid Download PDF

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Publication number
WO1997048367A3
WO1997048367A3 PCT/GB1997/001653 GB9701653W WO9748367A3 WO 1997048367 A3 WO1997048367 A3 WO 1997048367A3 GB 9701653 W GB9701653 W GB 9701653W WO 9748367 A3 WO9748367 A3 WO 9748367A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
antiglucocorticoid
compositions
chronic infections
glucocorticoid
Prior art date
Application number
PCT/GB1997/001653
Other languages
French (fr)
Other versions
WO1997048367A2 (en
Inventor
Graham Arthur William Rook
Hernandez Rogelio Pando
Original Assignee
Stanford Rook Ltd
Graham Arthur William Rook
Hernandez Rogelio Pando
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Rook Ltd, Graham Arthur William Rook, Hernandez Rogelio Pando filed Critical Stanford Rook Ltd
Priority to AU31030/97A priority Critical patent/AU3103097A/en
Publication of WO1997048367A2 publication Critical patent/WO1997048367A2/en
Publication of WO1997048367A3 publication Critical patent/WO1997048367A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A glucocorticoid, such as cortisol or a derivative or analogue thereof, and an anti-glucocorticoid, such as dehydroepiandrosterone (DHEA) or a derivative or analogue thereof, are used simultaneously, separately or sequentially in treatment of chronic infections such as tuberculosis, HIV infection, leishmaniasis and syphilis.
PCT/GB1997/001653 1996-06-20 1997-06-18 Compositions for the treatment of chronic infections containing glucocorticoid and antiglucocorticoid WO1997048367A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU31030/97A AU3103097A (en) 1996-06-20 1997-06-18 Compositions and methods for the treatment of chronic infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9612990.3A GB9612990D0 (en) 1996-06-20 1996-06-20 Compositions and methods for the treatment of chronic infections
GB9612990.3 1996-06-20

Publications (2)

Publication Number Publication Date
WO1997048367A2 WO1997048367A2 (en) 1997-12-24
WO1997048367A3 true WO1997048367A3 (en) 1998-02-05

Family

ID=10795646

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001653 WO1997048367A2 (en) 1996-06-20 1997-06-18 Compositions for the treatment of chronic infections containing glucocorticoid and antiglucocorticoid

Country Status (3)

Country Link
AU (1) AU3103097A (en)
GB (1) GB9612990D0 (en)
WO (1) WO1997048367A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60045751D1 (en) 1999-09-30 2011-04-28 Harbor Biosciences Inc Therapeutic treatment of androgen receptor-related conditions
AU2002303427A1 (en) 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
US7405207B2 (en) 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
US8084444B2 (en) * 2004-09-24 2011-12-27 Rxdino, Llc Treatment of dermatitis with dehydroepiandrosterone-glucocorticoid combinations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3812595A1 (en) * 1987-04-16 1988-10-27 Colthurst Ltd MEDICINES FOR PROPHYLAXIS AND THERAPY OF RETROVIRUS INFECTIONS
WO1991004030A1 (en) * 1989-09-25 1991-04-04 University Of Utah Use of steroid hormones in compositions for inducing t cell lymphokine production
US5077284A (en) * 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
WO1995030418A1 (en) * 1994-05-09 1995-11-16 The Johns Hopkins University Method of slowing the progression of hiv infection

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3812595A1 (en) * 1987-04-16 1988-10-27 Colthurst Ltd MEDICINES FOR PROPHYLAXIS AND THERAPY OF RETROVIRUS INFECTIONS
US5077284A (en) * 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
WO1991004030A1 (en) * 1989-09-25 1991-04-04 University Of Utah Use of steroid hormones in compositions for inducing t cell lymphokine production
US5540919A (en) * 1989-09-25 1996-07-30 University Of Utah Research Foundation Method for enhancement of production of lymphokines and applications thereof
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
WO1995030418A1 (en) * 1994-05-09 1995-11-16 The Johns Hopkins University Method of slowing the progression of hiv infection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAKER R.W. ET AL: "Tuberculosis, steroid metabolism and immunity", QJM - MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 1996, 89/5 (387-394), UNITED KINGDOM, XP002044502 *
ROOK G A W ET AL: "Pathogenetic role, in human and murine tuberculosis, of changes in the peripheral metabolism of glucocorticoids and antiglucocorticoids", PSYCHONEUROENDOCRINOLOGY, 22 (SUPPL. 1). 1997. S109-S113., XP002044516 *
WISNIEWSKI TL ET AL: "The relationship of serum DHEA-S and cortisol levels to measures of immune function in human immunodeficiency virus-related illness.", AM J MED SCI, FEB 1993, 305 (2) P79-83, UNITED STATES, XP002044510 *

Also Published As

Publication number Publication date
AU3103097A (en) 1998-01-07
WO1997048367A2 (en) 1997-12-24
GB9612990D0 (en) 1996-08-21

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