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WO1997048382A3 - Multiple-unit type prolonged action drug preparation - Google Patents

Multiple-unit type prolonged action drug preparation Download PDF

Info

Publication number
WO1997048382A3
WO1997048382A3 PCT/JP1997/001836 JP9701836W WO9748382A3 WO 1997048382 A3 WO1997048382 A3 WO 1997048382A3 JP 9701836 W JP9701836 W JP 9701836W WO 9748382 A3 WO9748382 A3 WO 9748382A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug preparation
unit type
cilostazol
prolonged action
action drug
Prior art date
Application number
PCT/JP1997/001836
Other languages
French (fr)
Other versions
WO1997048382A2 (en
Inventor
Tadashi Mukai
Masami Koike
Toshio Nakamura
Yuzo Kimura
Original Assignee
Otsuka Pharma Co Ltd
Tadashi Mukai
Masami Koike
Toshio Nakamura
Yuzo Kimura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd, Tadashi Mukai, Masami Koike, Toshio Nakamura, Yuzo Kimura filed Critical Otsuka Pharma Co Ltd
Priority to AU29768/97A priority Critical patent/AU2976897A/en
Publication of WO1997048382A2 publication Critical patent/WO1997048382A2/en
Publication of WO1997048382A3 publication Critical patent/WO1997048382A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a multiple-unit type prolonged release action drug preparation which is characterized by containing at least 2 small tablets of sustained release type drug preparation obtained by formulating cilostazol with hydroxypropylmethylcellulose as the base material of the drug preparation. By formulating cilostazol as in the form of a multiple-unit type prolonged release action drug preparation of the present invention, side-effects, such as headache and other symptoms caused by high blood concentration of cilostazol due to the rapid absorption, can be reduced.
PCT/JP1997/001836 1996-06-18 1997-05-29 Multiple-unit type prolonged action drug preparation WO1997048382A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29768/97A AU2976897A (en) 1996-06-18 1997-05-29 Multiple-unit type prolonged action drug preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15671896 1996-06-18
JP8/156718 1996-06-18

Publications (2)

Publication Number Publication Date
WO1997048382A2 WO1997048382A2 (en) 1997-12-24
WO1997048382A3 true WO1997048382A3 (en) 1998-02-19

Family

ID=15633827

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/001836 WO1997048382A2 (en) 1996-06-18 1997-05-29 Multiple-unit type prolonged action drug preparation

Country Status (3)

Country Link
AU (1) AU2976897A (en)
ID (1) ID17125A (en)
WO (1) WO1997048382A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865695B2 (en) 2009-01-08 2014-10-21 Lipocine Inc. Steroidal compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67802C2 (en) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION
EG23951A (en) * 1999-03-25 2008-01-29 Otsuka Pharma Co Ltd Cilostazol preparation
US20050186276A1 (en) * 2003-07-17 2005-08-25 Pfizer Inc Pharmaceutical formulations
WO2005023225A1 (en) * 2003-09-05 2005-03-17 Ranbaxy Laboratories Limited Cilostazol adsorbate
KR20080076440A (en) * 2007-02-16 2008-08-20 (주)아모레퍼시픽 Controlled-Release Formulation of Cilostazol and Method for Preparing the Same
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016205423A2 (en) 2015-06-15 2016-12-22 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. ORAL TESTOSTERONE UNDECANOATE THERAPY
CA3107214A1 (en) 2018-07-20 2020-01-23 Lipocine Inc. Liver disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60228410A (en) * 1984-04-26 1985-11-13 Otsuka Pharmaceut Co Ltd Long-acting drug preparation
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
EP0463173A1 (en) * 1990-01-08 1992-01-02 Otsuka Pharmaceutical Co., Ltd. Hair tonic and dressing composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60228410A (en) * 1984-04-26 1985-11-13 Otsuka Pharmaceut Co Ltd Long-acting drug preparation
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
EP0463173A1 (en) * 1990-01-08 1992-01-02 Otsuka Pharmaceutical Co., Ltd. Hair tonic and dressing composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9247, Derwent World Patents Index; Class A03, AN 86-003017 *
PATENT ABSTRACTS OF JAPAN vol. 010, no. 098 (C - 339) 15 April 1986 (1986-04-15) *
SUCKER H. ET AL: "Pharmazeutische Technologie", 1991, THIEME VERLAG, STUTTGART, XP002046215, 189560 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865695B2 (en) 2009-01-08 2014-10-21 Lipocine Inc. Steroidal compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9205057B2 (en) 2010-11-30 2015-12-08 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9480690B2 (en) 2010-11-30 2016-11-01 Lipocine Inc. High-strength testosterone undecanoate compositions
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters

Also Published As

Publication number Publication date
ID17125A (en) 1997-12-04
AU2976897A (en) 1998-01-07
WO1997048382A2 (en) 1997-12-24

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