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WO1997001634A3 - Polypeptide for repairing genetic information, nucleotidic sequence which codes for it and process for the preparation thereof (guanine thymine binding protein - gtbp) - Google Patents

Polypeptide for repairing genetic information, nucleotidic sequence which codes for it and process for the preparation thereof (guanine thymine binding protein - gtbp) Download PDF

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Publication number
WO1997001634A3
WO1997001634A3 PCT/IT1996/000131 IT9600131W WO9701634A3 WO 1997001634 A3 WO1997001634 A3 WO 1997001634A3 IT 9600131 W IT9600131 W IT 9600131W WO 9701634 A3 WO9701634 A3 WO 9701634A3
Authority
WO
WIPO (PCT)
Prior art keywords
gtbp
protein
binding protein
genetic information
polypeptide
Prior art date
Application number
PCT/IT1996/000131
Other languages
French (fr)
Other versions
WO1997001634A2 (en
Inventor
Josef Jiricny
Fabio Palombo
Paola Gallinari
Original Assignee
Angeletti P Ist Richerche Bio
Josef Jiricny
Fabio Palombo
Paola Gallinari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio, Josef Jiricny, Fabio Palombo, Paola Gallinari filed Critical Angeletti P Ist Richerche Bio
Priority to AU62412/96A priority Critical patent/AU6241296A/en
Publication of WO1997001634A2 publication Critical patent/WO1997001634A2/en
Publication of WO1997001634A3 publication Critical patent/WO1997001634A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a new protein, GTBP (Guanine Thymine Binding Protein), that binds to G/T DNA mismatches to mediate repair of genetic information, to methods for detection of this protein, to the nucleotidic sequence encoding this protein and to processes for obtaining the above-mentioned protein using genetic engineering techniques. Furthermore, the present invention has as its object the detection in tumor tissues of the mutant GTBP gene in order to prevent and provide rapid diagnosis of human colorectal tumor forms. The figure shows the absence of GTBP-specific activity in cells obtained from human colorectal tumors.
PCT/IT1996/000131 1995-06-27 1996-06-27 Polypeptide for repairing genetic information, nucleotidic sequence which codes for it and process for the preparation thereof (guanine thymine binding protein - gtbp) WO1997001634A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62412/96A AU6241296A (en) 1995-06-27 1996-06-27 Polypeptide for repairing genetic information, nucleotidic sequence which codes for it and process for the preparation thereof (guanine thymine binding protein - gtbp)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM95A000434 1995-06-27
IT95RM000434A IT1278118B1 (en) 1995-06-27 1995-06-27 POLYPEPTIDE FOR THE REPAIR OF GENETIC INFORMATION, NUCLEOTIDE SEQUENCE THAT CODES FOR IT AND PROCEDURE FOR ITS

Publications (2)

Publication Number Publication Date
WO1997001634A2 WO1997001634A2 (en) 1997-01-16
WO1997001634A3 true WO1997001634A3 (en) 1997-04-03

Family

ID=11403448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1996/000131 WO1997001634A2 (en) 1995-06-27 1996-06-27 Polypeptide for repairing genetic information, nucleotidic sequence which codes for it and process for the preparation thereof (guanine thymine binding protein - gtbp)

Country Status (3)

Country Link
AU (1) AU6241296A (en)
IT (1) IT1278118B1 (en)
WO (1) WO1997001634A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
CN1326986A (en) * 2000-06-07 2001-12-19 上海博德基因开发有限公司 New polypeptide-human base mismatch repair protein 13.2 and polynucleotide for encoding such polypeptide
CN119285699B (en) * 2024-11-13 2025-03-28 盐城工学院 Walnut meal-derived antibacterial polypeptide and its application

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A. UMAR ET AL.: "Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 20, 20 May 1994 (1994-05-20), pages 14367 - 14370, XP000615519 *
B. LIU ET AL.: "Analysis of mismatch repair genes in hereditary non-polposis colorectal cancer patients.", NATURE MEDICINE., vol. 2, no. 2, February 1996 (1996-02-01), pages 169 - 174, XP000615507 *
C. STEPHENSON ET AL.: "Selective binding to DNA base pair mismatches by proteins from human cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, no. 35, 15 December 1989 (1989-12-15), pages 21177 - 21182, XP000371702 *
F. PALOMBO ET AL.: "GTBP, a 160-Kilodalton protein essential for mismatich-binding activity in human cells.", SCIENCE, vol. 268, 30 June 1995 (1995-06-30), pages 1912 - 1914, XP000615504 *
F. PALOMBO ET AL.: "Mismatch repair and cancer.", NATURE, vol. 367, 3 February 1994 (1994-02-03), pages 417, XP000615506 *
G. AQUILINA ET AL.: "A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.", PROC. NATL. ACAD. SCI. USA., vol. 91, September 1994 (1994-09-01), pages 8905 - 8909, XP000615501 *
J. JIRICNY: "A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.", PROC. NATL. ACAD. SCI. USA, vol. 85, no. 23, December 1988 (1988-12-01), pages 8860 - 8864, XP000615500 *
M.J. HUGHES ET AL.: "The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 33, 25 November 1992 (1992-11-25), pages 23876 - 23882, XP000615520 *
N. PAPADOPUOLOS ET AL.: "Mutations of GTBP in genetically unstable cells.", SCIENCE, vol. 268, 30 June 1995 (1995-06-30), pages 1915 - 1917, XP000615505 *
N.C. NICOLAIDES ET AL.: "Molecular cloning of the N-terminus of GTBP", GENOMICS, vol. 31, no. 3, 1 February 1996 (1996-02-01), pages 395 - 397, XP000613760 *

Also Published As

Publication number Publication date
IT1278118B1 (en) 1997-11-17
ITRM950434A1 (en) 1996-12-27
ITRM950434A0 (en) 1995-06-27
WO1997001634A2 (en) 1997-01-16
AU6241296A (en) 1997-01-30

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