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WO1997002001A1 - Recipient pour fluides medicaux - Google Patents

Recipient pour fluides medicaux Download PDF

Info

Publication number
WO1997002001A1
WO1997002001A1 PCT/SE1996/000901 SE9600901W WO9702001A1 WO 1997002001 A1 WO1997002001 A1 WO 1997002001A1 SE 9600901 W SE9600901 W SE 9600901W WO 9702001 A1 WO9702001 A1 WO 9702001A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
forming
parison
collapsible
polymeric material
Prior art date
Application number
PCT/SE1996/000901
Other languages
English (en)
Inventor
Gunnar Andersson
Bert Pettersson
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to EP19960922365 priority Critical patent/EP0836466A1/fr
Publication of WO1997002001A1 publication Critical patent/WO1997002001A1/fr
Priority to NO980004A priority patent/NO980004L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Definitions

  • the present invention is directed to a collapsible medical container having an integrated non-collapsible capillary tube, formed by the production tools when blow moulding the container, for determining the level of remaining fluid during the administration to the patient.
  • Another object of the present invention is to provide a collapsible medical container from which it is easy to determine the remaining amount of medical fluid without being forced to any additional measures. This is attained by the container according to claim 1, having a capillary tube for liquid level measuring made in the same process and in the same material to make it cheap and environmental friendly by its capacity of being easy to recycle in a single process.
  • Fig. 1 schematically shows a side view of container according to the present invention.
  • Fig 2. is a schematical cross-sectional view of the container along the line A-A of the container shown in Fig. 1.
  • the present invention is related to a blow moulded, collapsible container made of a polymeric material intended to store and administer a medical fluid.
  • a predetermined part of the container comprises a stiffened capillary tube which when filled with said fluid together with a printed scale on the container wall, also formed with the same moulding step, enables a correct determination of the liquid level and the remaining volume of administerable fluid, when the container gradually collapses during the administration.
  • the collapsible container is preferably made sufficiently flexible so that its opposing sides readily come together when the medical liquid is administered by the gravity or by a pump device.
  • the stiffened capillary tube is formed as an integrated part of the container wall, when blow moulding the container from a parison of polymeric material by means of a moulding tool with a suitable correspondent shape.
  • the moulding tool preferably has a shape corresponding to the cross-sectional shape, as seen in Fig. 2. Two oppositely placed capillary tubes are thereby formed when the two rims of the polymeric material are stiffened in the tool. It is however, fully conceivable to, within the scope of invention, to select moulding tools with other shapes which for example forms a single capillary tubing.
  • a predetermined part of the parison is formed to parallel rims stiffened to capillary tubes, whereas the remaining part of the parison can be formed and conventionally sealed in its bottom and its top to a flexible container, for example to the illustrated bottle-formed shape.
  • the bottom of the container can be made with a means for mounting during the sealing, and after filling the container, the top can be formed with a cap by means of a top forming tool, for example as disclosed in the Swedish patent apphcation 9303123-5.
  • the top and the bottom parts of the container are preferably formed to shoulders and the capillary tubes will extend a predetermined distance into these curved parts.
  • the capillary tubes will extend to the point of said curved parts where the radius of curvature has its maximum.
  • the precise arrangement of this forming process can by means of conventional tools and the appropriate dimensions of the container and its parts therefore can be readily determined by the skilled person.
  • all the parts of the containers according to the invention are produced by essentially the same polyolefin or at least comprise the same polyolefin as an essential component. It is to be understood that to a certain degree other polymeric materials, such as the elastomers incorporated in Santoprene® may be used in resilient parts of the cap or the ports.
  • Preferred polymeric materials for forming the inventive containers are polyethylene or polypropylene of various medical grades with good transparency and capacity of withstanding heat or radiation sterilization without suffering from degradation and reduced compatibility with the liquid during storage.
  • the inventive containers are suitable for the storage of about
  • the method of producing preferred embodiments of containers according to the invention is a blow-fill-seal method, whereby a parison of polymeric material is formed in suitable tool with an extruder, in the same manner as disclosed in the Swedish patent application SE 9303123-5.
  • the capillary tubes thereafter are blow formed on a predetermined part of the parison by the stiffening of opposite rims in a moulding tool having a shape corresponding to the cross-sectional shape, as shown in Fig. 2, into straight, parallel capillary tubes.
  • the bottom of the parison is then formed to a desired container shape and sealed by a conventional welding process and optionally mounting a mounting device is formed to conveniently handle the container during the administration.
  • the container is thereafter filled with medical fluid with a conventional aseptic or sterile filling procedure and sealed at the top with a conventional top forming tool, whereupon a pierceable cap or a conventional saddle port for fluid communication is attached.
  • the remaining volume of medical fluid be easy to read accurately from containers produced in this manner, even if the container body successiveively collapses during the administration.
  • the containers are cheap and simple to produce from polymeric material possible to recycle in a single operation. They will have the advantage of a low residual volume, no introduction of environmental air to the admimstration system, when filled they have a low headspace and most importantly, they will enable a correct volumetric reading without any extra measures although the container gradually collapses during the administration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Récipient médical pliable comportant un tube capillaire non pliable formé au cours du processus de soufflage du récipient, ce dernier permettant de déterminer le niveau de fluide restant lorsque celui-ci est administré à un patient.
PCT/SE1996/000901 1995-07-04 1996-07-03 Recipient pour fluides medicaux WO1997002001A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19960922365 EP0836466A1 (fr) 1995-07-04 1996-07-03 Recipient pour fluides medicaux
NO980004A NO980004L (no) 1995-07-04 1998-01-02 Beholder for medisinske fluider

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502428-7 1995-07-04
SE9502428A SE9502428D0 (sv) 1995-07-04 1995-07-04 Container for medical fluids

Publications (1)

Publication Number Publication Date
WO1997002001A1 true WO1997002001A1 (fr) 1997-01-23

Family

ID=20398848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1996/000901 WO1997002001A1 (fr) 1995-07-04 1996-07-03 Recipient pour fluides medicaux

Country Status (4)

Country Link
EP (1) EP0836466A1 (fr)
NO (1) NO980004L (fr)
SE (1) SE9502428D0 (fr)
WO (1) WO1997002001A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025308A1 (fr) * 1997-11-14 1999-05-27 Schering Ag Reservoir pour appauvrir des substances coulantes
US6872197B1 (en) 1997-11-14 2005-03-29 Schering Ag Tank for administering flowable substances

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3304977A (en) * 1965-01-11 1967-02-21 Velikanje Moore & Countryman Blood container
GB2001276A (en) * 1977-07-22 1979-01-31 Baxter Travenol Lab Moulded flexible collapsible containers
DE3826456C1 (en) * 1988-08-04 1990-03-08 Fresenius Ag, 6380 Bad Homburg, De Bag arrangement
WO1991016861A1 (fr) * 1990-05-09 1991-11-14 Lifesource Advanced Blood Bank Systems, Inc. Poche amelioree pour le stockage du sang et de composants sanguins
DE4016144A1 (de) * 1990-05-18 1991-11-21 Fresenius Ag Behaelter zur enteralen ernaehrung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3304977A (en) * 1965-01-11 1967-02-21 Velikanje Moore & Countryman Blood container
GB2001276A (en) * 1977-07-22 1979-01-31 Baxter Travenol Lab Moulded flexible collapsible containers
DE3826456C1 (en) * 1988-08-04 1990-03-08 Fresenius Ag, 6380 Bad Homburg, De Bag arrangement
WO1991016861A1 (fr) * 1990-05-09 1991-11-14 Lifesource Advanced Blood Bank Systems, Inc. Poche amelioree pour le stockage du sang et de composants sanguins
DE4016144A1 (de) * 1990-05-18 1991-11-21 Fresenius Ag Behaelter zur enteralen ernaehrung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025308A1 (fr) * 1997-11-14 1999-05-27 Schering Ag Reservoir pour appauvrir des substances coulantes
AU741541B2 (en) * 1997-11-14 2001-12-06 Schering Aktiengesellschaft Tank for administering flowable substances
US6872197B1 (en) 1997-11-14 2005-03-29 Schering Ag Tank for administering flowable substances

Also Published As

Publication number Publication date
NO980004D0 (no) 1998-01-02
NO980004L (no) 1998-02-12
EP0836466A1 (fr) 1998-04-22
SE9502428D0 (sv) 1995-07-04

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