WO1997008178B1 - Nouveaux bisphosphonates, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
Nouveaux bisphosphonates, procede pour leur preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- WO1997008178B1 WO1997008178B1 PCT/IL1996/000087 IL9600087W WO9708178B1 WO 1997008178 B1 WO1997008178 B1 WO 1997008178B1 IL 9600087 W IL9600087 W IL 9600087W WO 9708178 B1 WO9708178 B1 WO 9708178B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- designates
- preparation
- pharmaceutical compositions
- compounds
- compositions containing
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000004663 bisphosphonates Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 claims 1
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- -1 Bisphosphonate compounds Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 abstract 1
Abstract
L'invention concerne des composés bisphosphonates, leur préparation et des compositions pharmaceutiques contenant de tels composés en tant qu'ingrédients actifs. Ces compositions s'administrent généralement par voie orale et elles permettent de traiter efficacement les anomalies du métabolisme du calcium. Les composés préférés comportent un cycle du type 2-aminopyrimidine. Il a été trouvé que des composés hétérocycliques similaires, substitués ou non, ont une activité similaire.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU68357/96A AU6835796A (en) | 1995-08-23 | 1996-08-22 | Novel bisphosphonates, process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL115041 | 1995-08-23 | ||
| IL11504195A IL115041A0 (en) | 1995-08-23 | 1995-08-23 | Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997008178A1 WO1997008178A1 (fr) | 1997-03-06 |
| WO1997008178B1 true WO1997008178B1 (fr) | 1997-05-01 |
Family
ID=11067907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IL1996/000087 WO1997008178A1 (fr) | 1995-08-23 | 1996-08-22 | Nouveaux bisphosphonates, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU6835796A (fr) |
| IL (1) | IL115041A0 (fr) |
| WO (1) | WO1997008178A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8012949B2 (en) | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
| US7358361B2 (en) | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| EP2001486A4 (fr) | 2006-03-17 | 2010-12-29 | Univ Illinois | Composés de biphosphonates et procédés |
| CN102453050B (zh) * | 2010-11-03 | 2015-01-07 | 成都云克药业有限责任公司 | 一种二膦酸化合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10199052I1 (de) * | 1986-11-21 | 2002-01-10 | Novartis Ag | Neue substituierte Alkandiphosphonsaeuren |
| EP0642517A1 (fr) * | 1992-05-29 | 1995-03-15 | THE PROCTER & GAMBLE PHARMACEUTICALS, INC. | Composes de phosphonate contenant de l'azote quaternaire destines au traitement d'un metabolisme anormal du calcium et du phosphate |
| TW401276B (en) * | 1993-10-07 | 2000-08-11 | Zeneca Ltd | Novel compounds and a method of controlling growth of plants |
-
1995
- 1995-08-23 IL IL11504195A patent/IL115041A0/xx unknown
-
1996
- 1996-08-22 AU AU68357/96A patent/AU6835796A/en not_active Abandoned
- 1996-08-22 WO PCT/IL1996/000087 patent/WO1997008178A1/fr active Application Filing
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