WO1997015679B1 - Virus recombines contenant des elements genetiques mobiles et procedes d'utilisation desdits virus en therapie genique - Google Patents
Virus recombines contenant des elements genetiques mobiles et procedes d'utilisation desdits virus en therapie geniqueInfo
- Publication number
- WO1997015679B1 WO1997015679B1 PCT/US1996/017176 US9617176W WO9715679B1 WO 1997015679 B1 WO1997015679 B1 WO 1997015679B1 US 9617176 W US9617176 W US 9617176W WO 9715679 B1 WO9715679 B1 WO 9715679B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- original
- virus
- cell
- expression
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 14
- 241000700605 Viruses Species 0.000 title claims 12
- 238000001415 gene therapy Methods 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 claims abstract 8
- 210000003483 chromatin Anatomy 0.000 claims abstract 6
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 12
- 230000001105 regulatory effect Effects 0.000 claims 8
- 241001068295 Replication defective viruses Species 0.000 claims 5
- 108010020764 Transposases Proteins 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 3
- 230000011278 mitosis Effects 0.000 claims 3
- 241001430294 unidentified retrovirus Species 0.000 claims 3
- 108010077544 Chromatin Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000000394 mitotic effect Effects 0.000 claims 2
- 238000004806 packaging method and process Methods 0.000 claims 2
- 108010057856 Adenovirus E2 Proteins Proteins 0.000 claims 1
- 101150005585 E3 gene Proteins 0.000 claims 1
- 102000008579 Transposases Human genes 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 241000713869 Moloney murine leukemia virus Species 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 2
- 230000018412 transposition, RNA-mediated Effects 0.000 abstract 1
Abstract
L'invention concerne des adénovirus recombinés, avec délétion de E1, qui contiennent un transgène associé aux éléments d'une séquence de transposon recombiné, par ex., provenant du virus de la leucémie murine de Moloney (Mo-MLV), nécessaire pour effectuer une rétrotransposition spécifique du transgène à partir de l'adénovirus recombiné dans la chromatine de la cellule cible. L'invention concerne également des procédés de production desdits adénovirus recombinés et leurs procédés d'utilisation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU76653/96A AU7665396A (en) | 1995-10-27 | 1996-10-24 | Recombinant viruses containing mobile genetic elements and methods of use in gene therapy |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US594295P | 1995-10-27 | 1995-10-27 | |
| US60/005,942 | 1995-10-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997015679A1 WO1997015679A1 (fr) | 1997-05-01 |
| WO1997015679B1 true WO1997015679B1 (fr) | 1997-07-17 |
| WO1997015679A9 WO1997015679A9 (fr) | 1997-08-14 |
Family
ID=21718478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/017176 WO1997015679A1 (fr) | 1995-10-27 | 1996-10-24 | Virus recombines contenant des elements genetiques mobiles et procedes d'utilisation desdits virus en therapie genique |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU7665396A (fr) |
| WO (1) | WO1997015679A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000076157A (ko) | 1997-03-11 | 2000-12-26 | 리전츠 오브 더 유니버스티 오브 미네소타 | 세포의 디엔에이로 핵산을 도입하는 디엔에이-기초 전이인자 시스템 |
| US7160682B2 (en) | 1998-11-13 | 2007-01-09 | Regents Of The University Of Minnesota | Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell |
| US6576463B1 (en) * | 1999-01-15 | 2003-06-10 | The Regents Of The University Of California | Hybrid vectors for gene therapy |
| DE19909156A1 (de) | 1999-03-02 | 2000-09-07 | Aventis Res & Tech Gmbh & Co | Testsystem zum Nachweis einer Spleißreaktion, sowie dessen Verwendung |
| WO2000068399A2 (fr) * | 1999-05-11 | 2000-11-16 | Regents Of The University Of Minnesota | Diffusion de sequences de transposon integratreur par des vecteurs |
| WO2001044280A2 (fr) * | 1999-12-14 | 2001-06-21 | Genovo, Inc. | Methodes et compositions destinees a la fabrication d'adenovirus incompetents pour la replication |
| WO2002092786A2 (fr) * | 2001-03-26 | 2002-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Systeme de vecteurs adenoviraux dependants d'un auxiliaire, et methodes d'utilisation |
| WO2003089618A2 (fr) | 2002-04-22 | 2003-10-30 | Regents Of The University Of Minnesota | Systeme de transposons, et procedes d'utilisation |
| US7291604B2 (en) | 2003-09-03 | 2007-11-06 | The General Hospital Corporation | Methods of treating restenosis |
| CN101437833A (zh) | 2006-02-10 | 2009-05-20 | 辛辛那提大学 | 作为心脏功能调节剂的磷酸酶抑制剂蛋白-1 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU651311B2 (en) * | 1988-03-21 | 1994-07-21 | Chiron Corporation | Recombinant retroviruses |
| US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
| FR2716893B1 (fr) * | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
| WO1996009399A2 (fr) * | 1994-09-23 | 1996-03-28 | Somatix Therapy Corporation | Adenovirus chimerique permettant l'apport de genes |
-
1996
- 1996-10-24 WO PCT/US1996/017176 patent/WO1997015679A1/fr active Application Filing
- 1996-10-24 AU AU76653/96A patent/AU7665396A/en not_active Abandoned
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